| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qian Cheng, Xiaoxiao Cao, Fuwen Yuan, Guodong Li, Tanjun Ton. Knockdown of WWP1 inhibits growth and induces apoptosis in hepatoma carcinoma cells through the activation of caspase3 and p53. Biochemical and biophysical research communications. vol 448. issue 3. 2014-08-20. PMID:24792179. |
all together these results indicate that protein levels of wwp1 in most hcc tissues are higher than non-tumor tissues, and knockdown of wwp1 inhibits growth and induces apoptosis in hcc cells through the activation of caspase3 and p53. |
2014-08-20 |
2023-08-13 |
human |
| Sujoy Bhattacharya, Ramesh M Ray, Leonard R Johnso. Cyclin-dependent kinases regulate apoptosis of intestinal epithelial cells. Apoptosis : an international journal on programmed cell death. vol 19. issue 3. 2014-08-19. PMID:24242917. |
previous studies from our group have shown that polyamine-depletion of intestinal epithelial cells (iec-6) decreases cyclin-dependent kinase 2 (cdk2) activity, increases p53 and p21cip1 protein levels, induces g1 arrest, and protects cells from camptothecin (cpt)-induced apoptosis. |
2014-08-19 |
2023-08-12 |
Not clear |
| Sujoy Bhattacharya, Ramesh M Ray, Leonard R Johnso. Cyclin-dependent kinases regulate apoptosis of intestinal epithelial cells. Apoptosis : an international journal on programmed cell death. vol 19. issue 3. 2014-08-19. PMID:24242917. |
in this study, we report that inhibition of cdk1, 2, and 9 (with the broad range cdk inhibitor, azd5438) in proliferating iec-6 cells triggered dna damage, activated p53 signaling, inhibited proliferation, and induced apoptosis. |
2014-08-19 |
2023-08-12 |
Not clear |
| Sujoy Bhattacharya, Ramesh M Ray, Leonard R Johnso. Cyclin-dependent kinases regulate apoptosis of intestinal epithelial cells. Apoptosis : an international journal on programmed cell death. vol 19. issue 3. 2014-08-19. PMID:24242917. |
by contrast, inhibition of cdk2 (with nu6140) increased p53 protein and activity, inhibited proliferation, but had no effect on apoptosis. |
2014-08-19 |
2023-08-12 |
Not clear |
| Sujoy Bhattacharya, Ramesh M Ray, Leonard R Johnso. Cyclin-dependent kinases regulate apoptosis of intestinal epithelial cells. Apoptosis : an international journal on programmed cell death. vol 19. issue 3. 2014-08-19. PMID:24242917. |
in serum starved quiescent iec-6 cells, both azd5438 and nu6140 decreased tnf-α/cpt-induced activation of p53 and, consequently, rescued cells from apoptosis, indicating that sustained cdk activity is required for apoptosis of quiescent cells. |
2014-08-19 |
2023-08-12 |
Not clear |
| Yiyan He, Yu Nie, Li Xie, Hongmei Song, Zhongwei G. p53 mediated apoptosis by reduction sensitive shielding ternary complexes based on disulfide linked PEI ternary complexes. Biomaterials. vol 35. issue 5. 2014-08-19. PMID:24268202. |
p53 mediated apoptosis by reduction sensitive shielding ternary complexes based on disulfide linked pei ternary complexes. |
2014-08-19 |
2023-08-12 |
Not clear |
| Yiyan He, Yu Nie, Li Xie, Hongmei Song, Zhongwei G. p53 mediated apoptosis by reduction sensitive shielding ternary complexes based on disulfide linked PEI ternary complexes. Biomaterials. vol 35. issue 5. 2014-08-19. PMID:24268202. |
tumor cells transfected by dps complexes containing p53 gene displayed almost 50% higher suppression in proliferation compared to those untreated cells, accompanied with a 46% elevation in the number of cells at sub-g1 phase and remarkable p53 dependent cell cycle perturbations prior to apoptosis. |
2014-08-19 |
2023-08-12 |
Not clear |
| Su-xia Han, Jing Wang, Li-juan Wang, Gui-hua Jin, Xia Ying, Chen-chen He, Xi-jing Guo, Jian-ying Zhang, Ying Zhang, Qing Zh. The role of RCAS1 as a biomarker in diagnosing CRC and monitoring tumor recurrence and metastasis. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 6. 2014-08-19. PMID:24652591. |
silencing rcas1 gene in human colonic adenocarcinoma cells decreased cell proliferation and enhanced apoptosis through the p53 signaling pathway. |
2014-08-19 |
2023-08-12 |
human |
| Peiyuan Jia, Yu Zhao, Shaoping Wu, Junhua Wu, Shan Gao, Ying Tong, Yuxia Wan. The novel fusion proteins, GnRH-p53 and GnRHIII-p53, expression and their anti-tumor effect. PloS one. vol 8. issue 11. 2014-08-18. PMID:24223939. |
p53, one of the most well studied tumor suppressor factor, is responsible to a variety of damage owing to the induction of apoptosis and cell cycle arrest in the tumor cells. |
2014-08-18 |
2023-08-12 |
human |
| Peiyuan Jia, Yu Zhao, Shaoping Wu, Junhua Wu, Shan Gao, Ying Tong, Yuxia Wan. The novel fusion proteins, GnRH-p53 and GnRHIII-p53, expression and their anti-tumor effect. PloS one. vol 8. issue 11. 2014-08-18. PMID:24223939. |
their anti-tumor effect was functioned by the apoptosis and cell cycle arrest induced by p53. |
2014-08-18 |
2023-08-12 |
human |
| Agnieszka Gorska, Agata Swiatkowska, Mariola Dutkiewicz, Jerzy Ciesiolk. Modulation of p53 expression using antisense oligonucleotides complementary to the 5'-terminal region of p53 mRNA in vitro and in the living cells. PloS one. vol 8. issue 11. 2014-08-18. PMID:24244378. |
recently, antisense oligonucleotides have been used to reduce the p53 level in tumour cells which facilitates their radiation-induced apoptosis. |
2014-08-18 |
2023-08-12 |
rabbit |
| Srijayaprakash B Uppada, Terrianne Erickson, Luke Wojdyla, David N Moravec, Ziyuan Song, Jianjun Cheng, Neelu Pur. Novel delivery system for T-oligo using a nanocomplex formed with an alpha helical peptide for melanoma therapy. International journal of nanomedicine. vol 9. 2014-08-18. PMID:24391441. |
oligonucleotides homologous to 3'-telomere overhang (t-oligos) trigger inherent telomere-based dna damage responses mediated by p53 and/or atm and induce senescence or apoptosis in various cancerous cells. |
2014-08-18 |
2023-08-12 |
mouse |
| Emilia Coppari, Tohru Yamada, Anna Rita Bizzarri, Craig W Beattie, Salvatore Cannistrar. A nanotechnological, molecular-modeling, and immunological approach to study the interaction of the anti-tumorigenic peptide p28 with the p53 family of proteins. International journal of nanomedicine. vol 9. 2014-08-18. PMID:24748790. |
as p63 and p73, additional members of the p53 superfamily of proteins, also appear to be involved in the cellular response to cancer therapy and are reportedly required for p53-induced apoptosis, we asked whether p28 also binds to p63 and p73. |
2014-08-18 |
2023-08-13 |
human |
| Aishath Maharath, Suthat Fucharoen, Dalina I Tanyon. p53 and nitric oxide are involved in cytokine-induced apoptosis in Kasumi-1 and Molt-4 Leukemics cells. Asian Pacific journal of allergy and immunology. vol 32. issue 2. 2014-08-18. PMID:25003726. |
p53 and nitric oxide are involved in cytokine-induced apoptosis in kasumi-1 and molt-4 leukemics cells. |
2014-08-18 |
2023-08-13 |
Not clear |
| Hyang Nam, Moon-Moo Ki. Ursolic acid induces apoptosis of SW480 cells via p53 activation. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 62. 2014-08-15. PMID:24071474. |
ursolic acid induces apoptosis of sw480 cells via p53 activation. |
2014-08-15 |
2023-08-12 |
human |
| Hyang Nam, Moon-Moo Ki. Ursolic acid induces apoptosis of SW480 cells via p53 activation. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 62. 2014-08-15. PMID:24071474. |
above results demonstrate that ursolic acid induces the activation of p53, nf-κb and bax, leading to the enhancement of p21 transcriptional activity and activation of caspase-9 and -3, thus finally induces apoptosis of sw480 cells. |
2014-08-15 |
2023-08-12 |
human |
| Shun Zhang, Gang Kuang, Guodong Zhao, Xue Wu, Cheng Zhang, Rongrong Lei, Tao Xia, Jianbin Chen, Zhenglun Wang, Rulin Ma, Bei Li, Lu Yang, Aiguo Wan. Involvement of the mitochondrial p53 pathway in PBDE-47-induced SH-SY5Y cells apoptosis and its underlying activation mechanism. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 62. 2014-08-15. PMID:24140468. |
involvement of the mitochondrial p53 pathway in pbde-47-induced sh-sy5y cells apoptosis and its underlying activation mechanism. |
2014-08-15 |
2023-08-12 |
human |
| Shun Zhang, Gang Kuang, Guodong Zhao, Xue Wu, Cheng Zhang, Rongrong Lei, Tao Xia, Jianbin Chen, Zhenglun Wang, Rulin Ma, Bei Li, Lu Yang, Aiguo Wan. Involvement of the mitochondrial p53 pathway in PBDE-47-induced SH-SY5Y cells apoptosis and its underlying activation mechanism. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 62. 2014-08-15. PMID:24140468. |
to investigate whether the mitochondrial p53 pathway is involved in neuronal apoptosis induced by pbde-47 and to correlate dna hypomethylation with p53 activation, human neuroblastoma (sh-sy5y) cells were treated with different concentrations of pbde-47 (1, 5, 10 μmol/l) for 24h in vitro. |
2014-08-15 |
2023-08-12 |
human |
| Shun Zhang, Gang Kuang, Guodong Zhao, Xue Wu, Cheng Zhang, Rongrong Lei, Tao Xia, Jianbin Chen, Zhenglun Wang, Rulin Ma, Bei Li, Lu Yang, Aiguo Wan. Involvement of the mitochondrial p53 pathway in PBDE-47-induced SH-SY5Y cells apoptosis and its underlying activation mechanism. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 62. 2014-08-15. PMID:24140468. |
the apoptosis and ultrastructural alterations in cells, levels of p53, bcl-2, bax, cytochrome c (cyt c), caspase-3 and methylation status of p53 promoter were determined. |
2014-08-15 |
2023-08-12 |
human |
| Shun Zhang, Gang Kuang, Guodong Zhao, Xue Wu, Cheng Zhang, Rongrong Lei, Tao Xia, Jianbin Chen, Zhenglun Wang, Rulin Ma, Bei Li, Lu Yang, Aiguo Wan. Involvement of the mitochondrial p53 pathway in PBDE-47-induced SH-SY5Y cells apoptosis and its underlying activation mechanism. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 62. 2014-08-15. PMID:24140468. |
collectively, these results suggest that the mitochondrial p53 pathway is involved in pbde-47-induced sh-sy5y cells apoptosis, nevertheless p53 promoter hypomethylation may not be implicated in this process. |
2014-08-15 |
2023-08-12 |
human |