| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bo Liu, Susanta K Behura, Rollie J Clem, Anette Schneemann, James Becnel, David W Severson, Lei Zho. P53-mediated rapid induction of apoptosis conveys resistance to viral infection in Drosophila melanogaster. PLoS pathogens. vol 9. issue 2. 2014-09-02. PMID:23408884. |
recapitulating a similar response in drosophila, we found that this rapid induction of apoptosis requires the function of p53 and is mediated by a stress-responsive regulatory region upstream of reaper. |
2014-09-02 |
2023-08-12 |
drosophila_melanogaster |
| Geetha Parthasarathy, Mario T Philip. The MEK/ERK pathway is the primary conduit for Borrelia burgdorferi-induced inflammation and P53-mediated apoptosis in oligodendrocytes. Apoptosis : an international journal on programmed cell death. vol 19. issue 1. 2014-09-02. PMID:24114360. |
while inhibition of p53 had a minimal effect in reducing inflammation, suppression of the erk pathway or p53 reduced apoptosis as measured by active caspase-3 activity and the tunel assay. |
2014-09-02 |
2023-08-12 |
human |
| Geetha Parthasarathy, Mario T Philip. The MEK/ERK pathway is the primary conduit for Borrelia burgdorferi-induced inflammation and P53-mediated apoptosis in oligodendrocytes. Apoptosis : an international journal on programmed cell death. vol 19. issue 1. 2014-09-02. PMID:24114360. |
a similar result was seen in primary human oligodendrocytes wherein suppression of erk or p53 reduced apoptosis. |
2014-09-02 |
2023-08-12 |
human |
| Maki Tokumoto, Jin-Yong Lee, Yasuyuki Fujiwara, Masanobu Uchiyama, Masahiko Sato. Inorganic arsenic induces apoptosis through downregulation of Ube2d genes and p53 accumulation in rat proximal tubular cells. The Journal of toxicological sciences. vol 38. issue 6. 2014-09-02. PMID:24212999. |
inorganic arsenic induces apoptosis through downregulation of ube2d genes and p53 accumulation in rat proximal tubular cells. |
2014-09-02 |
2023-08-12 |
rat |
| Maki Tokumoto, Jin-Yong Lee, Yasuyuki Fujiwara, Masanobu Uchiyama, Masahiko Sato. Inorganic arsenic induces apoptosis through downregulation of Ube2d genes and p53 accumulation in rat proximal tubular cells. The Journal of toxicological sciences. vol 38. issue 6. 2014-09-02. PMID:24212999. |
here we examined the effects of inorganic arsenic and inorganic mercury, which induce apoptosis in proximal tubular cells, on cellular protein level of p53 and gene expression of ube2d family. |
2014-09-02 |
2023-08-12 |
rat |
| Maki Tokumoto, Jin-Yong Lee, Yasuyuki Fujiwara, Masanobu Uchiyama, Masahiko Sato. Inorganic arsenic induces apoptosis through downregulation of Ube2d genes and p53 accumulation in rat proximal tubular cells. The Journal of toxicological sciences. vol 38. issue 6. 2014-09-02. PMID:24212999. |
inorganic arsenic induced apoptosis with p53 accumulation, and suppressed ube2d1, ube2d2 and ube2d4 expression, but not ube2d3. |
2014-09-02 |
2023-08-12 |
rat |
| Maki Tokumoto, Jin-Yong Lee, Yasuyuki Fujiwara, Masanobu Uchiyama, Masahiko Sato. Inorganic arsenic induces apoptosis through downregulation of Ube2d genes and p53 accumulation in rat proximal tubular cells. The Journal of toxicological sciences. vol 38. issue 6. 2014-09-02. PMID:24212999. |
on the other hand, although apoptosis was induced in response to inorganic mercury in proximal tubular cells, protein level of p53 was not elevated by inorganic mercury. |
2014-09-02 |
2023-08-12 |
rat |
| Richard L Carpenter, Woody Han, Ivy Paw, Hui-Wen L. HER2 phosphorylates and destabilizes pro-apoptotic PUMA, leading to antagonized apoptosis in cancer cells. PloS one. vol 8. issue 11. 2014-09-02. PMID:24236056. |
to elucidate the mechanisms for her2-mediated survival, we investigated the relationship between her2 and p53 upregulated modulator of apoptosis (puma), a potent apoptosis inducer. |
2014-09-02 |
2023-08-12 |
Not clear |
| L K J Stadler, D C Tomlinson, T Lee, M A Knowles, P Ko Ferrign. The use of a neutral peptide aptamer scaffold to anchor BH3 peptides constitutes a viable approach to studying their function. Cell death & disease. vol 5. 2014-09-02. PMID:24481451. |
in this study, we report the successful use of a novel peptide aptamer scaffold - stefin a quadruple mutant - to anchor and present the bh3 domains from bcl-2-interacting mediator of cell death (bim), p53 upregulated modulator of apoptosis (puma), bcl-2-associated death promoter (bad) and noxa, and demonstrate its usefulness in the study of the bh3 domains in vivo. |
2014-09-02 |
2023-08-12 |
Not clear |
| M A Maynard, R Ferretti, K I Hilgendorf, C Perret, P Whyte, J A Lee. Bmi1 is required for tumorigenesis in a mouse model of intestinal cancer. Oncogene. vol 33. issue 28. 2014-09-01. PMID:23955081. |
this was accompanied by significant upregulation of p53, which was confirmed by sequencing to be wild-type, and also elevated apoptosis within the smallest bmi1(-/-) adenomas. |
2014-09-01 |
2023-08-12 |
mouse |
| M A Maynard, R Ferretti, K I Hilgendorf, C Perret, P Whyte, J A Lee. Bmi1 is required for tumorigenesis in a mouse model of intestinal cancer. Oncogene. vol 33. issue 28. 2014-09-01. PMID:23955081. |
by crossing arf into this cancer model, we showed that arf is required for the induction of both p53 and apoptosis, and it is a key determinant of the ability of bmi1 deficiency to suppress intestinal tumorigenesis. |
2014-09-01 |
2023-08-12 |
mouse |
| Giuseppe Barone, Deborah A Tweddle, Jason M Shohet, Louis Chesler, Lucas Moreno, Andrew D J Pearson, Tom Van Maerke. MDM2-p53 interaction in paediatric solid tumours: preclinical rationale, biomarkers and resistance. Current drug targets. vol 15. issue 1. 2014-08-29. PMID:24387312. |
p53 is one of the main regulators of apoptosis, senescence, cell cycle arrest and dna repair. |
2014-08-29 |
2023-08-12 |
Not clear |
| Bo Hong, A Pieter J van den Heuvel, Varun V Prabhu, Shengliang Zhang, Wafik S El-Deir. Targeting tumor suppressor p53 for cancer therapy: strategies, challenges and opportunities. Current drug targets. vol 15. issue 1. 2014-08-29. PMID:24387333. |
generally, p53 functions as a transcription factor that is stabilized and activated by various genotoxic and cellular stress signals, such as dna damage, hypoxia, oncogene activation and nutrient deprivation, consequently leading to cell cycle arrest, apoptosis, senescence and metabolic adaptation. |
2014-08-29 |
2023-08-12 |
human |
| Hongbo Wang, Liang Kong, Jianqiao Zhang, Guohua Yu, Guangyao Lv, Fangxi Zhang, Xiaoguang Chen, Jingwei Tian, Fenghua F. The pseudoginsenoside F11 ameliorates cisplatin-induced nephrotoxicity without compromising its anti-tumor activity in vivo. Scientific reports. vol 4. 2014-08-29. PMID:24832194. |
further studies showed that f11 could suppress p53 activation, inverse the ratio of bax/bcl2 and the anti-oxidative and free radical levels induced by cisplatin, which in turn inhibited tubular cell apoptosis. |
2014-08-29 |
2023-08-13 |
Not clear |
| Tzi-Peng Yang, Huei-Jane Lee, Ting-Tsz Ou, Ya-Ju Chang, Chau-Jong Wan. Mulberry leaf polyphenol extract induced apoptosis involving regulation of adenosine monophosphate-activated protein kinase/fatty acid synthase in a p53-negative hepatocellular carcinoma cell. Journal of agricultural and food chemistry. vol 60. issue 27. 2014-08-28. PMID:22676643. |
it was reported that the p53 status plays an important role in switching apoptosis and the cell cycle following adenosine monophosphate-activated protein kinase (ampk) activation. |
2014-08-28 |
2023-08-12 |
Not clear |
| Tzi-Peng Yang, Huei-Jane Lee, Ting-Tsz Ou, Ya-Ju Chang, Chau-Jong Wan. Mulberry leaf polyphenol extract induced apoptosis involving regulation of adenosine monophosphate-activated protein kinase/fatty acid synthase in a p53-negative hepatocellular carcinoma cell. Journal of agricultural and food chemistry. vol 60. issue 27. 2014-08-28. PMID:22676643. |
transient transfection of p53 into hep3b cells led to switching autophagy instead of apoptosis by mlpe treatment. |
2014-08-28 |
2023-08-12 |
Not clear |
| Tzi-Peng Yang, Huei-Jane Lee, Ting-Tsz Ou, Ya-Ju Chang, Chau-Jong Wan. Mulberry leaf polyphenol extract induced apoptosis involving regulation of adenosine monophosphate-activated protein kinase/fatty acid synthase in a p53-negative hepatocellular carcinoma cell. Journal of agricultural and food chemistry. vol 60. issue 27. 2014-08-28. PMID:22676643. |
these results implied induction of apoptosis or autophagy in mlpe-treated hepatocellular carcinoma cells can be due to the p53 status. |
2014-08-28 |
2023-08-12 |
Not clear |
| Justine Renaud, Julie Bournival, Ximena Zottig, Maria-Grazia Martinol. Resveratrol protects DAergic PC12 cells from high glucose-induced oxidative stress and apoptosis: effect on p53 and GRP75 localization. Neurotoxicity research. vol 25. issue 1. 2014-08-28. PMID:24218232. |
resveratrol protects daergic pc12 cells from high glucose-induced oxidative stress and apoptosis: effect on p53 and grp75 localization. |
2014-08-28 |
2023-08-12 |
Not clear |
| Yoko Tabe, Kensuke Kojim. [Abnormal p53-HDM2 interaction in hematological malignancy]. Nihon rinsho. Japanese journal of clinical medicine. vol 72. issue 6. 2014-08-27. PMID:25016801. |
this stabilization of p53 results in its activation, leading to cell cycle arrest, growth inhibition, and apoptosis in wild type p53-haboring hematological malignant cells. |
2014-08-27 |
2023-08-13 |
human |
| Jie Zhang, Rui Song, Yanfei Li, Jian Feng, Luying Peng, Jue L. Integration of microarray profiles associated with cardiomyopathy and the potential role of Ube3a in apoptosis. Molecular medicine reports. vol 9. issue 2. 2014-08-26. PMID:24337433. |
therefore, in the present study, h2o2 was utilized to induce apoptosis in h9c2 cells in order to understand the interrelation between ube3a and the apoptosis-related protein p53. |
2014-08-26 |
2023-08-12 |
Not clear |