| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kefeng Qin, Tianbing Ding, Yi Xiao, Wenyu Ma, Zhen Wang, Jimin Gao, Lili Zha. Differential responses of neuronal and spermatogenic cells to the doppel cytotoxicity. PloS one. vol 8. issue 12. 2014-09-19. PMID:24339999. |
we have further defined that, in n2a cells, dpl induces oxidative stress and apoptosis, which stimulate ataxia-telangiectasia mutated (atm)-modulating bindings of transcription factors, p53 and p21, to prnp promoter, resulting the prp(c) elevation for counteraction of the dpl cytotoxicity; in contrast, in gc-1 spg cells, phosphorylation of p21 and n-terminal truncated prp may play roles in the control of dpl-induced apoptosis, which may benefit the physiological function of dpl in the male reproduction system. |
2014-09-19 |
2023-08-12 |
mouse |
| Fang Cheng Wong, Chern Chiuh Woo, Annie Hsu, Benny Kwong Huat Ta. The anti-cancer activities of Vernonia amygdalina extract in human breast cancer cell lines are mediated through caspase-dependent and p53-independent pathways. PloS one. vol 8. issue 10. 2014-09-18. PMID:24205071. |
the apoptosis in mcf-7 cells was also likely to be caspase-dependent and not p53 transcriptional-dependent. |
2014-09-18 |
2023-08-12 |
human |
| Weiwei Guo, Lichong Yan, Ling Yang, Xiaoyu Liu, Qiukai E, Peiye Gao, Xiaofei Ye, Wen Liu, Ji Zu. Targeting GRP75 improves HSP90 inhibitor efficacy by enhancing p53-mediated apoptosis in hepatocellular carcinoma. PloS one. vol 9. issue 1. 2014-09-18. PMID:24465691. |
the inhibition of hsp90 on cancer cell growth largely through degrading client proteins, like akt and p53, therefore, triggering cancer cell apoptosis. |
2014-09-18 |
2023-08-12 |
Not clear |
| Rong Zheng, Qiwei Yao, Shasha Du, Chen Ren, Quanquan Sun, Zhixin Xu, Xiaoshan Lin, Yawei Yua. The status of p53 in cancer cells affects the role of autophagy in tumor radiosensitisation. Journal of B.U.ON. : official journal of the Balkan Union of Oncology. vol 19. issue 2. 2014-09-18. PMID:24965389. |
p53 is a pivotal tumor suppressor that induces apoptosis, cell cycle arrest, and senescence in response to various stresses, also playing an important role in the regulation of radiosensitivity. |
2014-09-18 |
2023-08-13 |
Not clear |
| Anna Comel, Giovanni Sorrentino, Valeria Capaci, Giannino Del Sa. The cytoplasmic side of p53's oncosuppressive activities. FEBS letters. vol 588. issue 16. 2014-09-17. PMID:24747877. |
the ability to induce apoptosis acting directly at mitochondria and the related mechanisms of p53 localization and translocation in the cytoplasm and mitochondria have been dissected. |
2014-09-17 |
2023-08-13 |
Not clear |
| Min Lu, Paul Miller, Xin L. Restoring the tumour suppressive function of p53 as a parallel strategy in melanoma therapy. FEBS letters. vol 588. issue 16. 2014-09-17. PMID:24844434. |
the tumour suppressor p53 is a master sensor of stress and it controls the expression of hundreds to thousands of genes with diverse biological functions including cell cycle arrest, apoptosis, and senescence. |
2014-09-17 |
2023-08-13 |
human |
| S B Mohammed, M A Bakheit, M Ernst, J S Ahmed, U Seitze. Identification and characterization of Theileria annulata heat-shock protein 90 (HSP90) isoforms. Transboundary and emerging diseases. vol 60 Suppl 2. 2014-09-16. PMID:24589114. |
upon ga treatment, p53 was observed to translocate into the host cell nucleus, a phenomenon that occurs in cells undergoing apoptosis. |
2014-09-16 |
2023-08-12 |
rabbit |
| Jashdeep Bhattacharjee, Jerald Mahesh Kumar, Shailendra Arindkar, Barun Das, Upadhyay Pramod, Ramesh C Juyal, Subeer S Majumdar, Perumal Nagaraja. Role of immunodeficient animal models in the development of fructose induced NAFLD. The Journal of nutritional biochemistry. vol 25. issue 2. 2014-09-15. PMID:24445047. |
further, the percentage of cd3, b220 and nk cells in peripheral-blood mononuclear cell, terminal deoxynucleotidyl transferase dutp nick end labeling assay, immunodetection for hepatic apoptosis (p53) and for inflammation (tnfα) and quantitative real-time polymerase chain reaction for putative and inflammatory genes involved were determined. |
2014-09-15 |
2023-08-12 |
mouse |
| b' Josko Zekan, Mihael Skerlev, Lukrecija Mili\\xc4\\x87, Deni Karelovi\\xc4\\x8. Human papillomavirus-related diseases of the female lower genital tract: oncogenic aspects and molecular interaction. Collegium antropologicum. vol 38. issue 2. 2014-09-15. PMID:25145023.' |
unscheduled s-phase would normally lead to apoptosis by the action of p53. |
2014-09-15 |
2023-08-13 |
human |
| b' Josko Zekan, Mihael Skerlev, Lukrecija Mili\\xc4\\x87, Deni Karelovi\\xc4\\x8. Human papillomavirus-related diseases of the female lower genital tract: oncogenic aspects and molecular interaction. Collegium antropologicum. vol 38. issue 2. 2014-09-15. PMID:25145023.' |
besides blocking p53 function in regulation of apoptosis, high-risk hpv proteins interact with both extrinsic and intrinsic apoptotic pathways. |
2014-09-15 |
2023-08-13 |
human |
| Haiyan Zhai, Andrew Fesler, Kristina Schee, Oystein Fodstad, Kjersti Flatmark, Jingfang J. Clinical significance of long intergenic noncoding RNA-p21 in colorectal cancer. Clinical colorectal cancer. vol 12. issue 4. 2014-09-12. PMID:24012455. |
one of them, lincrna-p21, was regulated by p53 and contributed to apoptosis in mouse embryonic fibroblasts. |
2014-09-12 |
2023-08-12 |
mouse |
| Yuan Liu, Yan Chen, Lu Wen, Guohui Cu. Molecular mechanisms underlying the time-dependent autophagy and apoptosis induced by nutrient depletion in multiple myeloma: a pilot study. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 32. issue 1. 2014-09-11. PMID:22282237. |
transcriptional levels of raf-1, jnk1, jnk2, p53 and p21 were increased time-dependently at 0, 6, 12, 18, 24 and 48 h accompanying with the increase of apoptosis. |
2014-09-11 |
2023-08-12 |
human |
| Lital Rachmany, David Tweedie, Vardit Rubovitch, Qian-Sheng Yu, Yazhou Li, Jia-Yi Wang, Chaim G Pick, Nigel H Grei. Cognitive impairments accompanying rodent mild traumatic brain injury involve p53-dependent neuronal cell death and are ameliorated by the tetrahydrobenzothiazole PFT-α. PloS one. vol 8. issue 11. 2014-09-11. PMID:24312187. |
to elucidate the involvement of reversible p53-dependent apoptosis in this neuronal loss and associated cognitive deficits, mice were subjected to experimental mtbi followed by the systemic administration of the tetrahydrobenzothiazole p53 inactivator, pft-α, or vehicle. |
2014-09-11 |
2023-08-12 |
mouse |
| Hai Gu, Zequn Jiang, Mingyan Wang, Haiying Jiang, Fengming Zhao, Xia Ding, Baochang Cai, Zhen Zha. 5-Hydroxymethylfurfural from wine-processed Fructus corni inhibits hippocampal neuron apoptosis. Neural regeneration research. vol 8. issue 28. 2014-09-10. PMID:25206571. |
these results suggested that 5-hydroxymethylfurfural could inhibit apoptosis of cultured rat hippocampal neurons injured by h2o2 via increase in bcl-2 levels and decrease in p53, bax and caspase-3 protein expression levels. |
2014-09-10 |
2023-08-13 |
rat |
| Hassan I H El-Sayyad, Soad A Khalifa, Asma S Al-Gebaly, Ahmed A El-Mans. Aging related changes of retina and optic nerve of Uromastyx aegyptia and Falco tinnunculus. ACS chemical neuroscience. vol 5. issue 1. 2014-09-09. PMID:24215233. |
concomitantly, there was a marked increase of oxidative stress involved reduction of neurotransmitters and antioxidant enzymes and an increase of lipid peroxidation, caspase-3 and -7, subg0/g1 apoptosis, and p53. |
2014-09-09 |
2023-08-12 |
Not clear |
| Hassan I H El-Sayyad, Soad A Khalifa, Asma S Al-Gebaly, Ahmed A El-Mans. Aging related changes of retina and optic nerve of Uromastyx aegyptia and Falco tinnunculus. ACS chemical neuroscience. vol 5. issue 1. 2014-09-09. PMID:24215233. |
we conclude that aging showed an inverse relationship with the neurotransmitters and antioxidant enzymes and a linear relationship of caspases, malondialdhyde, dna apoptosis, and p53 markers of cell death. |
2014-09-09 |
2023-08-12 |
Not clear |
| Rui Lan, Yong Zhang, Jun Xiang, Wen Zhang, Guo-Hua Wang, Wen-Wei Li, Li-Li Xu, Ding-Fang Ca. Xiao-Xu-Ming decoction preserves mitochondrial integrity and reduces apoptosis after focal cerebral ischemia and reperfusion via the mitochondrial p53 pathway. Journal of ethnopharmacology. vol 151. issue 1. 2014-09-08. PMID:24189031. |
xiao-xu-ming decoction preserves mitochondrial integrity and reduces apoptosis after focal cerebral ischemia and reperfusion via the mitochondrial p53 pathway. |
2014-09-08 |
2023-08-12 |
Not clear |
| Kaushik Banerjee, Avishek Ganguly, Paramita Chakraborty, Avijit Sarkar, Suryabhan Singh, Mitali Chatterjee, Subrato Bhattacharya, Soumitra Kumar Choudhur. ROS and RNS induced apoptosis through p53 and iNOS mediated pathway by a dibasic hydroxamic acid molecule in leukemia cells. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 52. 2014-09-08. PMID:24269727. |
ros and rns induced apoptosis through p53 and inos mediated pathway by a dibasic hydroxamic acid molecule in leukemia cells. |
2014-09-08 |
2023-08-12 |
Not clear |
| Kaushik Banerjee, Avishek Ganguly, Paramita Chakraborty, Avijit Sarkar, Suryabhan Singh, Mitali Chatterjee, Subrato Bhattacharya, Soumitra Kumar Choudhur. ROS and RNS induced apoptosis through p53 and iNOS mediated pathway by a dibasic hydroxamic acid molecule in leukemia cells. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 52. 2014-09-08. PMID:24269727. |
along with the induction of caspase 3 mediated intrinsic apoptosis; obpha also activates p53 dependent signalling cascade and downregulates hdac3 expression in a time dependent manner possibly due to increased ros and no production and simultaneous decrease in cellular gsh level. |
2014-09-08 |
2023-08-12 |
Not clear |
| Kaushik Banerjee, Avishek Ganguly, Paramita Chakraborty, Avijit Sarkar, Suryabhan Singh, Mitali Chatterjee, Subrato Bhattacharya, Soumitra Kumar Choudhur. ROS and RNS induced apoptosis through p53 and iNOS mediated pathway by a dibasic hydroxamic acid molecule in leukemia cells. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 52. 2014-09-08. PMID:24269727. |
therefore obpha, having a structurally relevant pharmacophore provides important insight into the development of new ros and rns generating chemicals inducing p53 dependent apoptosis. |
2014-09-08 |
2023-08-12 |
Not clear |