| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Malvika H Solanki, Prodyot K Chatterjee, Madhu Gupta, Xiangying Xue, Andrei Plagov, Margot H Metz, Rachel Mintz, Pravin C Singhal, Christine N Met. Magnesium protects against cisplatin-induced acute kidney injury by regulating platinum accumulation. American journal of physiology. Renal physiology. vol 307. issue 4. 2014-10-21. PMID:24944268. |
magnesium deficiency significantly increased cisplatin-associated weight loss and markers of renal damage (plasma blood urea nitrogen and creatinine), histological changes, inflammation, and renal cell apoptosis and modulated signaling pathways (e.g., erk1/2, p53, and stat3). |
2014-10-21 |
2023-08-13 |
mouse |
| Frédéric Checler, Cristine Alves da Cost. p53 in neurodegenerative diseases and brain cancers. Pharmacology & therapeutics. vol 142. issue 1. 2014-10-20. PMID:24287312. |
thousands of papers later, p53 evolved as the main tumor suppressor involved in growth arrest and apoptosis. |
2014-10-20 |
2023-08-12 |
Not clear |
| Frédéric Checler, Cristine Alves da Cost. p53 in neurodegenerative diseases and brain cancers. Pharmacology & therapeutics. vol 142. issue 1. 2014-10-20. PMID:24287312. |
particularly important is the observation that in totally distinct pathologies where apoptosis is either exacerbated or impaired, p53 appears to play a central role. |
2014-10-20 |
2023-08-12 |
Not clear |
| Frédéric Checler, Cristine Alves da Cost. p53 in neurodegenerative diseases and brain cancers. Pharmacology & therapeutics. vol 142. issue 1. 2014-10-20. PMID:24287312. |
conversely, in cancers, about half of the cases are linked to mutations in p53 leading to the impairment of p53-dependent apoptosis. |
2014-10-20 |
2023-08-12 |
Not clear |
| Juan Liu, Cen Zhang, Zhaohui Fen. Tumor suppressor p53 and its gain-of-function mutants in cancer. Acta biochimica et biophysica Sinica. vol 46. issue 3. 2014-10-20. PMID:24374774. |
recent studies have revealed that in addition to apoptosis, cell cycle arrest and senescence, p53's functions in the regulation of energy metabolism and anti-oxidant defense contribute significantly to its role in tumor suppression. |
2014-10-20 |
2023-08-12 |
human |
| Mariko Yoshimura, Jo Ishizawa, Vivian Ruvolo, Archana Dilip, Alfonso Quintás-Cardama, Timothy J McDonnell, Sattva S Neelapu, Larry W Kwak, Sharon Shacham, Michael Kauffman, Yoko Tabe, Masako Yokoo, Shinya Kimura, Michael Andreeff, Kensuke Kojim. Induction of p53-mediated transcription and apoptosis by exportin-1 (XPO1) inhibition in mantle cell lymphoma. Cancer science. vol 105. issue 7. 2014-10-20. PMID:24766216. |
given that p53 is a cargo protein of xpo1, we sought to determine the significance of p53 activation through xpo1 inhibition in sine-induced apoptosis of mcl cells. |
2014-10-20 |
2023-08-13 |
Not clear |
| Mariko Yoshimura, Jo Ishizawa, Vivian Ruvolo, Archana Dilip, Alfonso Quintás-Cardama, Timothy J McDonnell, Sattva S Neelapu, Larry W Kwak, Sharon Shacham, Michael Kauffman, Yoko Tabe, Masako Yokoo, Shinya Kimura, Michael Andreeff, Kensuke Kojim. Induction of p53-mediated transcription and apoptosis by exportin-1 (XPO1) inhibition in mantle cell lymphoma. Cancer science. vol 105. issue 7. 2014-10-20. PMID:24766216. |
the significance of p53 mutational/functional status on sensitivity to xpo1 inhibition in cell models and primary mcl samples, and the functional role of p53-mediated apoptosis signaling, were also examined. |
2014-10-20 |
2023-08-13 |
Not clear |
| Mariko Yoshimura, Jo Ishizawa, Vivian Ruvolo, Archana Dilip, Alfonso Quintás-Cardama, Timothy J McDonnell, Sattva S Neelapu, Larry W Kwak, Sharon Shacham, Michael Kauffman, Yoko Tabe, Masako Yokoo, Shinya Kimura, Michael Andreeff, Kensuke Kojim. Induction of p53-mediated transcription and apoptosis by exportin-1 (XPO1) inhibition in mantle cell lymphoma. Cancer science. vol 105. issue 7. 2014-10-20. PMID:24766216. |
the xpo1 inhibitor kpt-185 induced apoptosis in mcl cells through p53-dependent and -independent mechanisms, and p53 status was a critical determinant of its apoptosis induction. |
2014-10-20 |
2023-08-13 |
Not clear |
| Marzia Leotta, Lavinia Biamonte, Lavinia Raimondi, Domenica Ronchetti, Maria Teresa Di Martino, Cirino Botta, Emanuela Leone, Maria Rita Pitari, Antonino Neri, Antonio Giordano, Pierosandro Tagliaferri, Pierfrancesco Tassone, Nicola Amodi. A p53-dependent tumor suppressor network is induced by selective miR-125a-5p inhibition in multiple myeloma cells. Journal of cellular physiology. vol 229. issue 12. 2014-10-20. PMID:24819167. |
lentiviral-mediated stable inhibition of mir-125a-5p expression in wild-type p53 mm cells dampened cell growth, increased apoptosis and reduced cell migration. |
2014-10-20 |
2023-08-13 |
Not clear |
| Bidyut Chakrobarty, Jay Gopal Roy, Sumit Majumdar, Divya Uppal. Relationship among tobacco habits, human papilloma virus (HPV) infection, p53 polymorphism/mutation and the risk of oral squamous cell carcinoma. Journal of oral and maxillofacial pathology : JOMFP. vol 18. issue 2. 2014-10-20. PMID:25328301. |
p53 is a tumor suppressor gene that checks the cell and promotes apoptosis and cell repair that can be deactivated by mutations and a viral interaction leading to cancer and individuals with particular polymorphic variant of p53 is more susceptible to hpv-induced carcinogenesis. |
2014-10-20 |
2023-08-13 |
human |
| Joana Ribeiro, Hugo Sous. MicroRNAs as biomarkers of cervical cancer development: a literature review on miR-125b and miR-34a. Molecular biology reports. vol 41. issue 3. 2014-10-17. PMID:24402874. |
mir-34a is directly regulated by p53 and acts as tumor suppressor while mir-125b plays a significant role in immune response and apoptosis. |
2014-10-17 |
2023-08-12 |
human |
| Ying Zhang, Yanrong Lv, Yongyang Zhang, Haidong Ga. Regulation of p53 level by UBE4B in breast cancer. PloS one. vol 9. issue 2. 2014-10-16. PMID:24587254. |
in this study, ube4b promoted the degradation and ubiquitination of p53 to inhibit the apoptosis of cancer cells and promote tumorigenesis. |
2014-10-16 |
2023-08-12 |
human |
| Caroline T Cheung, Rumani Singh, Rajkumar S Kalra, Sunil C Kaul, Renu Wadhw. Collaborator of ARF (CARF) regulates proliferative fate of human cells by dose-dependent regulation of DNA damage signaling. The Journal of biological chemistry. vol 289. issue 26. 2014-10-16. PMID:24825908. |
collaborator of arf (carf) has been shown to directly bind to and regulate p53, a central protein that controls tumor suppression via cellular senescence and apoptosis. |
2014-10-16 |
2023-08-13 |
human |
| Mohini Gore, N S Desa. Characterization of phytochemicals and evaluation of anti-cancer potential of Blumea eriantha DC. Physiology and molecular biology of plants : an international journal of functional plant biology. vol 20. issue 4. 2014-10-16. PMID:25320470. |
the expressions of p53 and bcl-2 genes were also determined by reverse transcriptase-polymerase chain reaction to establish apoptosis. |
2014-10-16 |
2023-08-13 |
Not clear |
| Isuru Wijesekara, Chen Zhang, Quang Van Ta, Thanh-Sang Vo, Yong-Xin Li, Se-Kwon Ki. Physcion from marine-derived fungus Microsporum sp. induces apoptosis in human cervical carcinoma HeLa cells. Microbiological research. vol 169. issue 4. 2014-10-15. PMID:24071573. |
physcion has shown cytotoxic effect on human cervical carcinoma hela cells and its apoptosis induction in hela cells was investigated by the expressions of p53, p21, bax, bcl-2, caspase-9, and caspase-3 proteins. |
2014-10-15 |
2023-08-12 |
human |
| Junsheng Fu, Huadong Chen, Dominique N Soroka, Renaud F Warin, Shengmin San. Cysteine-conjugated metabolites of ginger components, shogaols, induce apoptosis through oxidative stress-mediated p53 pathway in human colon cancer cells. Journal of agricultural and food chemistry. vol 62. issue 20. 2014-10-15. PMID:24786146. |
cysteine-conjugated metabolites of ginger components, shogaols, induce apoptosis through oxidative stress-mediated p53 pathway in human colon cancer cells. |
2014-10-15 |
2023-08-13 |
mouse |
| Junsheng Fu, Huadong Chen, Dominique N Soroka, Renaud F Warin, Shengmin San. Cysteine-conjugated metabolites of ginger components, shogaols, induce apoptosis through oxidative stress-mediated p53 pathway in human colon cancer cells. Journal of agricultural and food chemistry. vol 62. issue 20. 2014-10-15. PMID:24786146. |
our results show that oxidative stress activates a p53 pathway that ultimately leads to p53 up-regulated modulator of apoptosis (puma) induction and down-regulation of b-cell lymphoma 2 (bcl-2), followed by cytochrome c release, perturbation of inhibitory interactions of x-linked inhibitor of apoptosis protein (xiap) with caspases, and finally caspase 9 and 3 activation and cleavage. |
2014-10-15 |
2023-08-13 |
mouse |
| P Dey, A Ström, J-Å Gustafsso. Estrogen receptor β upregulates FOXO3a and causes induction of apoptosis through PUMA in prostate cancer. Oncogene. vol 33. issue 33. 2014-10-14. PMID:24077289. |
in human prostate cancer cells, we found that erβ causes apoptosis by increasing the expression of pro-apoptotic factor p53-upregulated modulator of apoptosis (puma), independent of p53, but dependent on the forkhead transcription factor class-o family member, foxo3a. |
2014-10-14 |
2023-08-12 |
mouse |
| Gina Marcela Méndez-Callejas, Stefano Leone, Caterina Tanzarella, Antonio Antocci. Combretastatin A-4 induces p53 mitochondrial-relocalisation independent-apoptosis in non-small lung cancer cells. Cell biology international. vol 38. issue 3. 2014-10-14. PMID:24155061. |
nevertheless, the contribution of p53 and bim proteins in the ca-4-induced apoptosis in non-small lung cancer cells (nsclc) remains unresolved, specifically on involving of p53 in the mitochondrial pathway activation by a transcription-independent mechanism. |
2014-10-14 |
2023-08-12 |
Not clear |
| Gina Marcela Méndez-Callejas, Stefano Leone, Caterina Tanzarella, Antonio Antocci. Combretastatin A-4 induces p53 mitochondrial-relocalisation independent-apoptosis in non-small lung cancer cells. Cell biology international. vol 38. issue 3. 2014-10-14. PMID:24155061. |
overall, the data support a model of ca-4-induced apoptosis in nsclc, for which the expression of p53 protein is essential, but its mitochondrial function, linked to p53-transcription independent apoptosis pathway, is negligible. |
2014-10-14 |
2023-08-12 |
Not clear |