| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yang Dong, Aili Cao, Jianrong Shi, Peihao Yin, Li Wang, Guang Ji, Jianqun Xie, Dazheng W. Tangeretin, a citrus polymethoxyflavonoid, induces apoptosis of human gastric cancer AGS cells through extrinsic and intrinsic signaling pathways. Oncology reports. vol 31. issue 4. 2014-10-28. PMID:24573532. |
in addition, pft-α (a p53 inhibitor) reduced the apoptotic rates and the expression of p53, p21, caspase-3 and caspase-9 induced by tangeretin, indicating that tangeretin-induced apoptosis was p53-dependent. |
2014-10-28 |
2023-08-12 |
human |
| Jie Yin, Yi-An Zhang, Tao-Tao Liu, Ji-Min Zhu, Xi-Zhong She. DNA damage induces down-regulation of Prp19 via impairing Prp19 stability in hepatocellular carcinoma cells. PloS one. vol 9. issue 2. 2014-10-28. PMID:24587161. |
prp19 overexpression in cells with functional p53 leads to decreased apoptosis and increases cell survival after dna damage. |
2014-10-28 |
2023-08-12 |
Not clear |
| Rebeca Fernandez-Ruiz, Elaine Vieira, Pablo M Garcia-Roves, Ramon Gomi. Protein tyrosine phosphatase-1B modulates pancreatic β-cell mass. PloS one. vol 9. issue 2. 2014-10-28. PMID:24587334. |
furthermore, the ablation of ptp1b is able to regulate key proteins involved in the proliferation and/or apoptosis pathways, such as stat3, akt, erk1/2 and p53 in isolated islets from ptp1b knockout (ptp1b (-)/(-)) mice. |
2014-10-28 |
2023-08-12 |
mouse |
| Sung Wook Park, Jang-Hyuk Yun, Jin Hyoung Kim, Kyu-Won Kim, Chung-Hyun Cho, Jeong Hun Ki. Angiopoietin 2 induces pericyte apoptosis via α3β1 integrin signaling in diabetic retinopathy. Diabetes. vol 63. issue 9. 2014-10-28. PMID:24722242. |
ang2 induced pericyte apoptosis via the p53 pathway under high glucose, whereas ang2 alone did not induce apoptosis. |
2014-10-28 |
2023-08-13 |
mouse |
| Sung Wook Park, Jang-Hyuk Yun, Jin Hyoung Kim, Kyu-Won Kim, Chung-Hyun Cho, Jeong Hun Ki. Angiopoietin 2 induces pericyte apoptosis via α3β1 integrin signaling in diabetic retinopathy. Diabetes. vol 63. issue 9. 2014-10-28. PMID:24722242. |
furthermore, ang2-induced pericyte apoptosis in vitro was effectively attenuated via p53 suppression by blocking integrin α3 and β1. |
2014-10-28 |
2023-08-13 |
mouse |
| Ling Liu, Ping Wang, Xinwei Liu, Dongwei He, Canxin Liang, Ying Y. Exogenous NAD(+) supplementation protects H9c2 cardiac myoblasts against hypoxia/reoxygenation injury via Sirt1-p53 pathway. Fundamental & clinical pharmacology. vol 28. issue 2. 2014-10-27. PMID:23384296. |
nad(+) replenishment restored sirt1 activity, reduced the acetylation level of p53 (lys373 & 382), and attenuated cell apoptosis in hr-stressed h9c2 cells, whereas inhibition of sirt1 activity alleviated the effects of nad(+) replenishment. |
2014-10-27 |
2023-08-12 |
Not clear |
| Ling Liu, Ping Wang, Xinwei Liu, Dongwei He, Canxin Liang, Ying Y. Exogenous NAD(+) supplementation protects H9c2 cardiac myoblasts against hypoxia/reoxygenation injury via Sirt1-p53 pathway. Fundamental & clinical pharmacology. vol 28. issue 2. 2014-10-27. PMID:23384296. |
these results indicated that exogenous nad(+) supplementation attenuated hr-induced cell apoptosis, which was at least partly mediated by restoring sirt1 activity and subsequently inhibiting p53 activity via deacetylating p53 at lysine 373 and 382. |
2014-10-27 |
2023-08-12 |
Not clear |
| Toshiyuki Hamada, Tomoko Niki, Norio Ishid. Role of p53 in the entrainment of mammalian circadian behavior rhythms. Genes to cells : devoted to molecular & cellular mechanisms. vol 19. issue 5. 2014-10-27. PMID:24698115. |
p53 protein plays a role for control of cell proliferation and the induction of apoptosis in normal cells. |
2014-10-27 |
2023-08-13 |
mouse |
| Shiva Akbari-Birgani, Saman Hosseinkhani, Sepideh Mollamohamadi, Hossein Baharvan. Delay in apoptosome formation attenuates apoptosis in mouse embryonic stem cell differentiation. The Journal of biological chemistry. vol 289. issue 24. 2014-10-24. PMID:24755221. |
p53 expression, cytochrome c release, apoptosome formation, and caspase-3/7 activation are observed upon induction of both apoptosis and differentiation. |
2014-10-24 |
2023-08-13 |
mouse |
| Karolin von der Chevallerie, Sarah Rolfes, Bernd Schierwate. Inhibitors of the p53-Mdm2 interaction increase programmed cell death and produce abnormal phenotypes in the placozoon Trichoplax adhaerens (F.E. Schulze). Development genes and evolution. vol 224. issue 2. 2014-10-23. PMID:24522962. |
the findings of this study suggest a conserved role of the p53/mdm2 network for programmed cell death since the origin of the metazoa and advocate the deployment of placozoa as a model for p53, apoptosis, and possibly cancer research. |
2014-10-23 |
2023-08-12 |
human |
| Yun Wang, Shunchang Wang, Xun Luo, Yanan Yang, Fenglei Jian, Xuemin Wang, Lucheng Xi. The roles of DNA damage-dependent signals and MAPK cascades in tributyltin-induced germline apoptosis in Caenorhabditis elegans. Chemosphere. vol 108. 2014-10-22. PMID:24534158. |
checkpoint proteins hus-1 and clk-2 exerted proapoptotic effects, and the null mutation of cep-1, the homologue of tumor suppressor gene p53, significantly inhibited tbt-induced apoptosis. |
2014-10-22 |
2023-08-12 |
caenorhabditis_elegans |
| Min Hyun Kim, Hyeyoung Ki. Oncogenes and tumor suppressors regulate glutamine metabolism in cancer cells. Journal of cancer prevention. vol 18. issue 3. 2014-10-22. PMID:25337549. |
on the other hand, glutamine stimulates the activation of the tumor suppressor p53, which induces apoptosis and tumor regression. |
2014-10-22 |
2023-08-13 |
Not clear |
| Won Sup Lee, Sang Mi Yi, Jeong Won Yun, Ji Hyun Jung, Dong Hoon Kim, Hye Jung Kim, Seong-Hwan Chang, GonSup Kim, Chung Ho Ryu, Sung Chul Shin, Soon Chan Hong, Yung Hyun Choi, Jin-Myung Jun. Polyphenols Isolated from Allium cepa L. Induces Apoptosis by Induction of p53 and Suppression of Bcl-2 through Inhibiting PI3K/Akt Signaling Pathway in AGS Human Cancer Cells. Journal of cancer prevention. vol 19. issue 1. 2014-10-22. PMID:25337568. |
polyphenols isolated from allium cepa l. induces apoptosis by induction of p53 and suppression of bcl-2 through inhibiting pi3k/akt signaling pathway in ags human cancer cells. |
2014-10-22 |
2023-08-13 |
human |
| Bo-Min Kim, Do-Hee Kim, Jeong-Hill Park, Young-Joon Surh, Hye-Kyung N. Ginsenoside Rg3 Inhibits Constitutive Activation of NF-κB Signaling in Human Breast Cancer (MDA-MB-231) Cells: ERK and Akt as Potential Upstream Targets. Journal of cancer prevention. vol 19. issue 1. 2014-10-22. PMID:25337569. |
these findings suggest that rg3 induced apoptosis in mda-mb-231 cells, which is mediated by blocking nf-κb signaling via inactivation of erk and akt as well as destabilization of mutant p53. |
2014-10-22 |
2023-08-13 |
human |
| Vanessa Palermo, Eleonora Mangiapelo, Cristina Piloto, Luisa Pieri, Michela Muscolini, Loretta Tuosto, Cristina Mazzon. p53 death signal is mainly mediated by Nuc1(EndoG) in the yeast Saccharomyces cerevisiae. FEMS yeast research. vol 13. issue 7. 2014-10-21. PMID:23875998. |
the tumor suppressor p53 plays a central role in the regulation of cellular growth and apoptosis. |
2014-10-21 |
2023-08-12 |
human |
| Guen Tae Kim, Se Hee Lee, Jong Il Kim, Young Min Ki. Quercetin regulates the sestrin 2-AMPK-p38 MAPK signaling pathway and induces apoptosis by increasing the generation of intracellular ROS in a p53-independent manner. International journal of molecular medicine. vol 33. issue 4. 2014-10-21. PMID:24535669. |
the increased expression of sestrin 2 induced apoptosis through the ampk/p38 signaling pathway in the ht-29 colon cancer cells, which are p53 mutant, treated with quercetin. |
2014-10-21 |
2023-08-12 |
Not clear |
| Guangqing Xia, Nian Xin, Wei Liu, Huimin Yao, Yi Hou, Jie Q. Inhibitory effect of Lycium barbarum polysaccharides on cell apoptosis and senescence is potentially mediated by the p53 signaling pathway. Molecular medicine reports. vol 9. issue 4. 2014-10-21. PMID:24549741. |
inhibitory effect of lycium barbarum polysaccharides on cell apoptosis and senescence is potentially mediated by the p53 signaling pathway. |
2014-10-21 |
2023-08-12 |
zebrafish |
| Xiaoai Zhang, Pengbo Cao, Yun Zhai, Hongxing Zhang, Ying Cui, Zhihao Wu, Xiaoyan Yuan, Zhifu Wang, Peiyao Li, Lixa Yu, Xia Xia, Fuchu He, Gangqiao Zho. Association between the p73 G4C14-to-A4T14 polymorphism and risk of nasopharyngeal carcinoma: a case-control and family-based study. Carcinogenesis. vol 35. issue 9. 2014-10-21. PMID:24590897. |
p73, a structural and functional homolog of p53, plays an important role in modulating cell cycle control and apoptosis. |
2014-10-21 |
2023-08-12 |
Not clear |
| S Sane, A Abdullah, D A Boudreau, R K Autenried, B K Gupta, X Wang, H Wang, E H Schlenker, D Zhang, C Telleria, L Huang, S C Chauhan, K Rezvan. Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells. Cell death & disease. vol 5. 2014-10-21. PMID:24625977. |
biochemical analysis and functional assays showed that the overexpression of ubxn2a and the functional consequences of unsequestered p53 trigger p53-dependent apoptosis. |
2014-10-21 |
2023-08-12 |
mouse |
| N Dashzeveg, N Taira, Z-G Lu, J Kimura, K Yoshid. Palmdelphin, a novel target of p53 with Ser46 phosphorylation, controls cell death in response to DNA damage. Cell death & disease. vol 5. 2014-10-21. PMID:24810057. |
the tumor suppressor gene p53 regulates apoptosis in response to dna damage. |
2014-10-21 |
2023-08-13 |
Not clear |