| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hai-Yan Song, Xiao-Hui Deng, Guo-Yan Yuan, Xin-Fang Hou, Zhen-Dong Zhu, Li Zhou, Ming-Xin Re. Expression of bcl-2 and p53 in induction of esophageal cancer cell apoptosis by ECRG2 in combination with cisplatin. Asian Pacific journal of cancer prevention : APJCP. vol 15. issue 3. 2014-11-18. PMID:24606472. |
expression of bcl-2 and p53 in induction of esophageal cancer cell apoptosis by ecrg2 in combination with cisplatin. |
2014-11-18 |
2023-08-12 |
Not clear |
| Thamaraiselvan Rengarajan, Natarajan Nandakumar, Peramaiyan Rajendran, Lingaiah Haribabu, Ikuo Nishigaki, Maruthaiveeran Periyasamy Balasubramania. D-pinitol promotes apoptosis in MCF-7 cells via induction of p53 and Bax and inhibition of Bcl-2 and NF-κB. Asian Pacific journal of cancer prevention : APJCP. vol 15. issue 4. 2014-11-18. PMID:24641404. |
d-pinitol promotes apoptosis in mcf-7 cells via induction of p53 and bax and inhibition of bcl-2 and nf-κb. |
2014-11-18 |
2023-08-12 |
human |
| Thamaraiselvan Rengarajan, Natarajan Nandakumar, Peramaiyan Rajendran, Lingaiah Haribabu, Ikuo Nishigaki, Maruthaiveeran Periyasamy Balasubramania. D-pinitol promotes apoptosis in MCF-7 cells via induction of p53 and Bax and inhibition of Bcl-2 and NF-κB. Asian Pacific journal of cancer prevention : APJCP. vol 15. issue 4. 2014-11-18. PMID:24641404. |
the mechanism of apoptosis was studied with reference to expression of p53, bcl-2, bax and nf-kb proteins. |
2014-11-18 |
2023-08-12 |
human |
| Qingyu Zhang, Jie Liu, Bin Liu, Juan Xia, Nianping Chen, Xiaofeng Chen, Yi Cao, Chen Zhang, Caijie Lu, Mingyi Li, Runzhi Zh. Dihydromyricetin promotes hepatocellular carcinoma regression via a p53 activation-dependent mechanism. Scientific reports. vol 4. 2014-11-18. PMID:24717393. |
our results further demonstrated that this antitumor activity was caused by the activation of the p53-dependent apoptosis pathway via p53 phosphorylation at serine (15ser). |
2014-11-18 |
2023-08-13 |
mouse |
| Xinbing Sui, Na Kong, Xian Wang, Yong Fang, Xiaotong Hu, Yinghua Xu, Wei Chen, Kaifeng Wang, Da Li, Wei Jin, Fang Lou, Yu Zheng, Hong Hu, Liu Gong, Xiaoyun Zhou, Hongming Pan, Weidong Ha. JNK confers 5-fluorouracil resistance in p53-deficient and mutant p53-expressing colon cancer cells by inducing survival autophagy. Scientific reports. vol 4. 2014-11-18. PMID:24733045. |
inhibition of jnk by the compound sp600125 or jnk sirna suppressed autophagy and phosphorylation of c-jun and bcl-2 but increased 5-fu-induced apoptosis in both hct116 p53(-/-) and ht29 cells. |
2014-11-18 |
2023-08-13 |
human |
| Benoît Tessoulin, Géraldine Descamps, Philippe Moreau, Sophie Maïga, Laurence Lodé, Catherine Godon, Séverine Marionneau-Lambot, Thibauld Oullier, Steven Le Gouill, Martine Amiot, Catherine Pellat-Deceunync. PRIMA-1Met induces myeloma cell death independent of p53 by impairing the GSH/ROS balance. Blood. vol 124. issue 10. 2014-11-18. PMID:25006124. |
the aim of this study was to assess the efficiency of p53 reactivation and induction of massive apoptosis (prima-1(met)) in inducing myeloma cell death, using 27 human myeloma cell lines (hmcls) and 23 primary samples. |
2014-11-18 |
2023-08-13 |
mouse |
| Chun-Yu Chang, Chao-Yu Shen, Chao-Kai Kang, Yuh-Pyng Sher, Wayne H-H Sheu, Chia-Che Chang, Tsung-Han Le. Taurine protects HK-2 cells from oxidized LDL-induced cytotoxicity via the ROS-mediated mitochondrial and p53-related apoptotic pathways. Toxicology and applied pharmacology. vol 279. issue 3. 2014-11-17. PMID:25018059. |
the inhibition of oxldl-induced epithelial apoptosis by taurine was at least partially due to its anti-oxidant activity and its ability to modulate the erk and p53 apoptotic pathways. |
2014-11-17 |
2023-08-13 |
human |
| Hsin-Yu Chung, Chin-Teng Chang, Huay-Win Young, Shing P Hu, Wen-Shyong Tzou, Chin-Hwa H. Ethanol inhibits retinal and CNS differentiation due to failure of cell cycle exit via an apoptosis-independent pathway. Neurotoxicology and teratology. vol 38. 2014-11-14. PMID:23714372. |
although continuous ethanol exposure induces substantial accumulation of reactive oxygen species (ros) and increases p53 expression, depletion of p53 did not eliminate ethanol-induced apoptosis. |
2014-11-14 |
2023-08-12 |
zebrafish |
| Akinori Morita, Shinya Ariyasu, Soichiro Ohya, Ippei Takahashi, Bing Wang, Kaoru Tanaka, Takatoshi Uchida, Haruna Okazaki, Kengo Hanaya, Atsushi Enomoto, Mitsuru Nenoi, Masahiko Ikekita, Shin Aoki, Yoshio Hoso. Evaluation of zinc (II) chelators for inhibiting p53-mediated apoptosis. Oncotarget. vol 4. issue 12. 2014-11-12. PMID:24280450. |
based on the fact that p53 denaturation can be induced by the dissociation of a zinc ion, which is used as a structural factor of p53, we screened some zinc (ii) chelators for the suppression of the dna binding activity of p53 in vitro and the inhibition of radiation-induced p53-dependent apoptosis in molt-4 cells. |
2014-11-12 |
2023-08-12 |
mouse |
| Akinori Morita, Shinya Ariyasu, Soichiro Ohya, Ippei Takahashi, Bing Wang, Kaoru Tanaka, Takatoshi Uchida, Haruna Okazaki, Kengo Hanaya, Atsushi Enomoto, Mitsuru Nenoi, Masahiko Ikekita, Shin Aoki, Yoshio Hoso. Evaluation of zinc (II) chelators for inhibiting p53-mediated apoptosis. Oncotarget. vol 4. issue 12. 2014-11-12. PMID:24280450. |
a mechanistic study using cells bearing different p53 status or functions (i.e., p53-knockdown molt-4 transformant and its revertants, p53 mutant cells, p53-null cells), and p53-independent apoptotic stimuli revealed that the suppressive effect of bispicen on apoptosis is specifically mediated through p53. |
2014-11-12 |
2023-08-12 |
mouse |
| Yuan-Hao Lee, Exing Wang, Neeru Kumar, Randolph D Glickma. Ursolic acid differentially modulates apoptosis in skin melanoma and retinal pigment epithelial cells exposed to UV-VIS broadband radiation. Apoptosis : an international journal on programmed cell death. vol 19. issue 5. 2014-11-12. PMID:24375173. |
these results were consistent with reduced proliferation observed in the clonogenic assay, indicating that ua treatment enhanced the phototoxicity of uvr, by modulating the activation of p53 and nf-κb and initiating a mitogenic response to optical radiation that triggered mitochondria-dependent apoptosis, particularly in skin melanoma cells. |
2014-11-12 |
2023-08-12 |
Not clear |
| Khaldon Bodoor, Yazan Haddad, Asem Alkhateeb, Abdullah Al-Abbadi, Mohammad Dowairi, Ahmad Magableh, Nazzal Bsoul, Abdulhameed Ghabkar. DNA hypermethylation of cell cycle (p15 and p16) and apoptotic (p14, p53, DAPK and TMS1) genes in peripheral blood of leukemia patients. Asian Pacific journal of cancer prevention : APJCP. vol 15. issue 1. 2014-11-12. PMID:24528084. |
interestingly, methylation of p15 increased the risk of methylation in p53, and vice versa, by five folds (p=0.03) indicating possible synergistic epigenetic disruption of different phases of the cell cycle or between the cell cycle and apoptosis. |
2014-11-12 |
2023-08-12 |
human |
| Ha Ryong Kim, Da Young Shin, Yong Joo Park, Chang We Park, Seung Min Oh, Kyu Hyuck Chun. Silver nanoparticles induce p53-mediated apoptosis in human bronchial epithelial (BEAS-2B) cells. The Journal of toxicological sciences. vol 39. issue 3. 2014-11-12. PMID:24849675. |
we investigated oxidative stress and apoptosis in human normal bronchial epithelial (beas-2b) cells to elucidate the role of p53 in apoptosis by ag-nps. |
2014-11-12 |
2023-08-13 |
human |
| Ha Ryong Kim, Da Young Shin, Yong Joo Park, Chang We Park, Seung Min Oh, Kyu Hyuck Chun. Silver nanoparticles induce p53-mediated apoptosis in human bronchial epithelial (BEAS-2B) cells. The Journal of toxicological sciences. vol 39. issue 3. 2014-11-12. PMID:24849675. |
beas-2b cells were treated with p53-specific short interfering rna (sirna) or p53 inhibitor (pifithrin-α) to investigate whether p53 is involved in apoptosis by ag-nps. |
2014-11-12 |
2023-08-13 |
human |
| C Antognelli, I Palumbo, C Aristei, V N Tales. Glyoxalase I inhibition induces apoptosis in irradiated MCF-7 cells via a novel mechanism involving Hsp27, p53 and NF-κB. British journal of cancer. vol 111. issue 2. 2014-11-11. PMID:24918814. |
glyoxalase i inhibition induces apoptosis in irradiated mcf-7 cells via a novel mechanism involving hsp27, p53 and nf-κb. |
2014-11-11 |
2023-08-13 |
Not clear |
| Radosław Polański, Aidan P Noon, Jeremy Blaydes, Anna Phillips, Carlos P Rubbi, Keith Parsons, Nikolina Vlatković, Mark T Boy. Senescence induction in renal carcinoma cells by Nutlin-3: a potential therapeutic strategy based on MDM2 antagonism. Cancer letters. vol 353. issue 2. 2014-11-11. PMID:25067787. |
we have therefore examined whether an mdm2 antagonist; nutlin-3, might rescue/increase p53 expression and induce growth inhibition or apoptosis in rcc cells that retain wild-type p53. |
2014-11-11 |
2023-08-13 |
Not clear |
| Jonathan D Bartlett, Graeme L Close, Barry Drust, James P Morto. The emerging role of p53 in exercise metabolism. Sports medicine (Auckland, N.Z.). vol 44. issue 3. 2014-11-10. PMID:24264057. |
often referred to as the guardian of the genome, the list of known functions of p53 include regulatory roles in cell cycle arrest, apoptosis, angiogenesis, dna repair and cell senescence. |
2014-11-10 |
2023-08-12 |
mouse |
| Feng Wang, Lin He, Peiwei Huangyang, Jing Liang, Wenzhe Si, Ruorong Yan, Xiao Han, Shumeng Liu, Bin Gui, Wanjin Li, Di Miao, Chao Jing, Zhihua Liu, Fei Pei, Luyang Sun, Yongfeng Shan. JMJD6 promotes colon carcinogenesis through negative regulation of p53 by hydroxylation. PLoS biology. vol 12. issue 3. 2014-11-07. PMID:24667498. |
depletion of jmjd6 enhances p53 transcriptional activity, arrests cells in the g1 phase, promotes cell apoptosis, and sensitizes cells to dna damaging agent-induced cell death. |
2014-11-07 |
2023-08-12 |
human |
| Hongmei Peng, Jiang Xu, Xiao-Ping Yang, Xiangguo Dai, Edward L Peterson, Oscar A Carretero, Nour-Eddine Rhale. Thymosin-β4 prevents cardiac rupture and improves cardiac function in mice with myocardial infarction. American journal of physiology. Heart and circulatory physiology. vol 307. issue 5. 2014-11-07. PMID:25015963. |
mice were assessed for 1) cardiac remodeling and function by echocardiography; 2) inflammatory cell infiltration, capillary density, myocyte apoptosis, and interstitial collagen fraction histopathologically; 3) gelatinolytic activity by in situ zymography; and 4) expression of icam-1 and p53 by immunoblot analysis. |
2014-11-07 |
2023-08-13 |
mouse |
| Guan-Yu Lu, Shih-Ming Huang, Shu-Ting Liu, Pei-Yao Liu, Wei-Yuan Chou, Wei-Shiang Li. Caffeine induces tumor cytotoxicity via the regulation of alternative splicing in subsets of cancer-associated genes. The international journal of biochemistry & cell biology. vol 47. 2014-11-06. PMID:24333670. |
in this study, we investigated how caffeine modulated cell cycle arrest and apoptosis via the expression of various alternatively spliced p53 isoforms. |
2014-11-06 |
2023-08-12 |
Not clear |