| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bao Kong, Qi Wang, Ella Fung, Kai Xue, Benjamin K Tsan. p53 is required for cisplatin-induced processing of the mitochondrial fusion protein L-Opa1 that is mediated by the mitochondrial metallopeptidase Oma1 in gynecologic cancers. The Journal of biological chemistry. vol 289. issue 39. 2014-12-11. PMID:25112877. |
the requirements of oma1 and p53 for cddp-induced l-opa1 processing, mitochondrial fragmentation, and apoptosis were examined by sirna or cdna. |
2014-12-11 |
2023-08-13 |
Not clear |
| Bao Kong, Qi Wang, Ella Fung, Kai Xue, Benjamin K Tsan. p53 is required for cisplatin-induced processing of the mitochondrial fusion protein L-Opa1 that is mediated by the mitochondrial metallopeptidase Oma1 in gynecologic cancers. The Journal of biological chemistry. vol 289. issue 39. 2014-12-11. PMID:25112877. |
silencing p53 expression attenuated the effects of cddp in oma1 (40 kda) increase, l-opa1 processing, mitochondrial fragmentation, and apoptosis in chemosensitive ovca cells, whereas reconstitution of p53 in p53 mutant or null chemoresistant ovca cells induced oma1 (40 kda) increase, l-opa1 processing, mitochondrial fragmentation, and apoptosis irrespective of the presence of cddp. |
2014-12-11 |
2023-08-13 |
Not clear |
| Bao Kong, Qi Wang, Ella Fung, Kai Xue, Benjamin K Tsan. p53 is required for cisplatin-induced processing of the mitochondrial fusion protein L-Opa1 that is mediated by the mitochondrial metallopeptidase Oma1 in gynecologic cancers. The Journal of biological chemistry. vol 289. issue 39. 2014-12-11. PMID:25112877. |
these findings demonstrate that (a) p53 and oma1 mediate l-opa1 processing, (b) mitochondrial fragmentation is involved in cddp-induced apoptosis in ovca and ceca cells, and (c) dysregulated mitochondrial dynamics may in part be involved in the pathophysiology of cddp resistance. |
2014-12-11 |
2023-08-13 |
Not clear |
| Juan Ren, Yongli Chu, Hongbing Ma, Yuelang Zhang, Xiaozhi Zhang, Dongli Zhao, Zongfang Li, Jiansheng Wang, Yan-E Gao, Lisha Xiao, Rui Liu, Jiansheng Qian, Yan Liu, Hongxia Wei, Shiwen Jian. Epigenetic interventions increase the radiation sensitivity of cancer cells. Current pharmaceutical design. vol 20. issue 11. 2014-12-10. PMID:23888958. |
the genes expression of the p53, rassf1, and dapk gene families was increased by 5-aza-cdr, which induces g2-m phase arrest and increased apoptosis. |
2014-12-10 |
2023-08-12 |
Not clear |
| Seung-Wook Ch. Structural insights into the transcription-independent apoptotic pathway of p53. BMB reports. vol 47. issue 3. 2014-12-10. PMID:24499665. |
in response to diverse cellular stresses, the tumor suppressor p53 mediates apoptosis in a transcription-independent and transcription-dependent manner. |
2014-12-10 |
2023-08-12 |
Not clear |
| Seung-Wook Ch. Structural insights into the transcription-independent apoptotic pathway of p53. BMB reports. vol 47. issue 3. 2014-12-10. PMID:24499665. |
molecular interactions between p53 and bcl-2 family proteins in the mitochondria play an essential role in the transcription-independent apoptosis of p53. |
2014-12-10 |
2023-08-12 |
Not clear |
| Sung-Hsin Kuo, Ann-Lii Chen. Helicobacter pylori and mucosa-associated lymphoid tissue: what's new. Hematology. American Society of Hematology. Education Program. vol 2013. 2014-12-09. PMID:24319171. |
recent studies have also demonstrated that the translocation of caga into b lymphocytes inhibits apoptosis through p53 accumulation, bad phosphorylation, and the up-regulation of bcl-2 and bcl-xl expression. |
2014-12-09 |
2023-08-12 |
Not clear |
| Cristiane Oliveira, Gustavo Jacob Lourenço, José Augusto Rinck-Junior, Maria Letícia Cintra, Aparecida Machado Moraes, Carmen Silvia Passos Lim. Association between genetic polymorphisms in apoptosis-related genes and risk of cutaneous melanoma in women and men. Journal of dermatological science. vol 74. issue 2. 2014-12-09. PMID:24461648. |
the p53 arg72pro, mdm2 c.+309t>g, bax c.-248g>a, and bcl2 c.-717c>a polymorphisms have variable roles in the apoptosis pathways. |
2014-12-09 |
2023-08-12 |
Not clear |
| Dongshan Zhang, Yu Liu, Qingqing Wei, Yuqing Huo, Kebin Liu, Fuyou Liu, Zheng Don. Tubular p53 regulates multiple genes to mediate AKI. Journal of the American Society of Nephrology : JASN. vol 25. issue 10. 2014-12-09. PMID:24700871. |
proximal tubule p53 knockout (pt-p53-ko) mice were resistant to ischemic and cisplatin nephrotoxic aki, which was indicated by the analysis of renal function, histology, apoptosis, and inflammation. |
2014-12-09 |
2023-08-13 |
mouse |
| Atsuko Nakanishi, Yasuko Kitagishi, Yasunori Ogura, Satoru Matsud. The tumor suppressor PTEN interacts with p53 in hereditary cancer (Review). International journal of oncology. vol 44. issue 6. 2014-12-09. PMID:24718924. |
li-fraumeni syndrome results from germline mutations of the tumor suppressor p53 gene encoding a transcriptional factor able to regulate cell cycle and apoptosis when dna damage occurs. |
2014-12-09 |
2023-08-13 |
human |
| Qingyu Huang, Jie Zhang, Siyuan Peng, Meiping Tian, Jinsheng Chen, Heqing She. Effects of water soluble PM2.5 extracts exposure on human lung epithelial cells (A549): A proteomic study. Journal of applied toxicology : JAT. vol 34. issue 6. 2014-12-08. PMID:23943255. |
it is further proposed that induction of apoptosis through p53, c-myc and p21 pathways may be one of the key toxicological events occurred in a549 cells under wspe stress. |
2014-12-08 |
2023-08-12 |
human |
| Chun-Hong Zhou, Xiao-Peng Zhang, Feng Liu, Wei Wan. Involvement of miR-605 and miR-34a in the DNA damage response promotes apoptosis induction. Biophysical journal. vol 106. issue 8. 2014-12-04. PMID:24739178. |
mir-605 promotes p53 activation by repressing the expression of mdm2, whereas mir-34a promotes p53-dependent apoptosis by suppressing the expression of antiapoptotic genes such as bcl-2. |
2014-12-04 |
2023-08-13 |
Not clear |
| Chun-Hong Zhou, Xiao-Peng Zhang, Feng Liu, Wei Wan. Involvement of miR-605 and miR-34a in the DNA damage response promotes apoptosis induction. Biophysical journal. vol 106. issue 8. 2014-12-04. PMID:24739178. |
the amplitude of p53 pulses rises to various extents depending on mir-605 expression, and mir-605 accelerates the switching behavior of p53 levels to induce apoptosis. |
2014-12-04 |
2023-08-13 |
Not clear |
| Chun-Hong Zhou, Xiao-Peng Zhang, Feng Liu, Wei Wan. Involvement of miR-605 and miR-34a in the DNA damage response promotes apoptosis induction. Biophysical journal. vol 106. issue 8. 2014-12-04. PMID:24739178. |
moreover, mir-605 and pten complement each other in elevating p53 levels to trigger apoptosis. |
2014-12-04 |
2023-08-13 |
Not clear |
| Pinar Mega Tiber, Latife Baloglu, Sevgi Ozden, Zerrin Ozgen, Hazan Ozyurt, Makbule Eren, Oya Oru. The association of apoptotic protein expressions sensitive to apoptosis gene, p73 and p53 with the prognosis of cervical carcinoma. OncoTargets and therapy. vol 7. 2014-12-04. PMID:25473298. |
the association of apoptotic protein expressions sensitive to apoptosis gene, p73 and p53 with the prognosis of cervical carcinoma. |
2014-12-04 |
2023-08-13 |
Not clear |
| Han Liu, Mounica Yanamandala, Tiffany C Lee, Jin Kyung Ki. Mitochondrial p38β and manganese superoxide dismutase interaction mediated by estrogen in cardiomyocytes. PloS one. vol 9. issue 1. 2014-12-03. PMID:24465521. |
we have previously shown that 17β-estradiol (e2) protects cardiomyocytes exposed to hypoxia-reoxygenation (h/r) by inhibiting p38α - p53 signaling in apoptosis and activating pro-survival p38β mitogen activated protein kinase (p38β mapk), leading to suppression of reactive oxygen species (ros) post h/r. |
2014-12-03 |
2023-08-12 |
Not clear |
| P J Teoh, T H Chung, S Sebastian, S N Choo, J Yan, S B Ng, R Fonseca, W J Chn. p53 haploinsufficiency and functional abnormalities in multiple myeloma. Leukemia. vol 28. issue 10. 2014-12-03. PMID:24625551. |
the pathway deficiency was manifested as defective p53 transcriptional activities, together with significant resistance to apoptosis. |
2014-12-03 |
2023-08-12 |
human |
| Jen-Hao Yang, Yi-Ying Chiou, Shu-Ling Fu, I-Yun Shih, Tsai-Hsuan Weng, Wey-Jinq Lin, Chao-Hsiung Li. Arginine methylation of hnRNPK negatively modulates apoptosis upon DNA damage through local regulation of phosphorylation. Nucleic acids research. vol 42. issue 15. 2014-12-03. PMID:25104022. |
while such elevated apoptosis can be diminished through addition with wild-type hnrnpk, we further demonstrated that this increased apoptosis occurred through both intrinsic and extrinsic pathways and was p53 independent, at least in part. |
2014-12-03 |
2023-08-13 |
Not clear |
| Jianguo Yan, Yali Zhou, Xuekun Xing, Fang Fang, Zhendong Zhu, Songtao Wan. [Effects on DNA damage and apoptosis and P53 protein expression induced by phoxim in rat bone marrow stem cells]. Wei sheng yan jiu = Journal of hygiene research. vol 42. issue 4. 2014-12-01. PMID:24024385. |
[effects on dna damage and apoptosis and p53 protein expression induced by phoxim in rat bone marrow stem cells]. |
2014-12-01 |
2023-08-12 |
rat |
| Jianguo Yan, Yali Zhou, Xuekun Xing, Fang Fang, Zhendong Zhu, Songtao Wan. [Effects on DNA damage and apoptosis and P53 protein expression induced by phoxim in rat bone marrow stem cells]. Wei sheng yan jiu = Journal of hygiene research. vol 42. issue 4. 2014-12-01. PMID:24024385. |
to study the dna damage and oxidative damage and apoptosis and p53 protein expression in rat bone marrow stem cells cultured in vitro induced by phoxim. |
2014-12-01 |
2023-08-12 |
rat |