| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alessandra Insinga, Angelo Cicalese, Pier Giuseppe Pelicc. DNA damage response in adult stem cells. Blood cells, molecules & diseases. vol 52. issue 4. 2014-11-06. PMID:24484934. |
moreover, inhibition of apoptosis and symmetric stem cell division are the consequence of the down-regulation of the tumor suppressor p53, as a direct result of p21 up-regulation. |
2014-11-06 |
2023-08-12 |
human |
| Johanna Pflaum, Sophie Schlosser, Martina Mülle. p53 Family and Cellular Stress Responses in Cancer. Frontiers in oncology. vol 4. 2014-11-06. PMID:25374842. |
upon activation, p53 leads to cell-cycle arrest and promotes dna repair or induces apoptosis via several pathways. |
2014-11-06 |
2023-08-13 |
Not clear |
| Yudan Chi, Xiang Wang, Yong Yang, Chao Zhang, Hildegund C J Ertl, Dongming Zho. Survivin-targeting Artificial MicroRNAs Mediated by Adenovirus Suppress Tumor Activity in Cancer Cells and Xenograft Models. Molecular therapy. Nucleic acids. vol 3. 2014-11-05. PMID:25368912. |
further studies showed that apoptosis was associated with increases in caspase 3 and cleaved poly (adp-ribose) polymerase, and activation of the p53 signaling pathway. |
2014-11-05 |
2023-08-13 |
mouse |
| Eman El Ete. NQDI 1, an inhibitor of ASK1 attenuates acute ischemic renal injury by modulating oxidative stress and cell death. Cardiovascular & hematological agents in medicinal chemistry. vol 11. issue 3. 2014-11-04. PMID:23952292. |
apoptosis of renal tissues, as detected by tunel staining, was also reduced together with p53 protein expression, and renal levels of mda and sod with nqdi 1 administration and bcl2 was up regulated. |
2014-11-04 |
2023-08-12 |
rat |
| B Wang, D Niu, T H Lam, Z Xiao, E C Re. Mapping the p53 transcriptome universe using p53 natural polymorphs. Cell death and differentiation. vol 21. issue 4. 2014-11-04. PMID:24076587. |
the tumor suppressor p53 has defined roles in varied cellular processes including apoptosis and dna repair. |
2014-11-04 |
2023-08-12 |
Not clear |
| Kanwal Rehman, Muhammad Tariq, Muhammad S H Akash, Zeeshan Gillani, Mehmood H Qaz. Effect of HA14-1 on apoptosis-regulating proteins in HeLa cells. Chemical biology & drug design. vol 83. issue 3. 2014-11-04. PMID:24118733. |
the results suggested p53 pathway to be the probable mechanism of action for the induction of apoptosis in hela cell by downregulating the effect of anti-apoptotic proteins suggesting that ha14-1 may provide therapeutic potential for the treatment of human cervical cancer. |
2014-11-04 |
2023-08-12 |
human |
| Soma Sengupta, Shyamal Dilhan Weeraratne, Hongyu Sun, Jillian Phallen, Sundari K Rallapalli, Natalia Teider, Bela Kosaras, Vladimir Amani, Jessica Pierre-Francois, Yujie Tang, Brian Nguyen, Furong Yu, Simone Schubert, Brianna Balansay, Dimitris Mathios, Mirna Lechpammer, Tenley C Archer, Phuoc Tran, Richard J Reimer, James M Cook, Michael Lim, Frances E Jensen, Scott L Pomeroy, Yoon-Jae Ch. α5-GABAA receptors negatively regulate MYC-amplified medulloblastoma growth. Acta neuropathologica. vol 127. issue 4. 2014-11-04. PMID:24196163. |
furthermore, qhii066 sensitized gabra5 positive medulloblastoma cells to radiation and chemotherapy consistent with the role of hoxa5 in directly regulating p53 expression and inducing apoptosis. |
2014-11-04 |
2023-08-12 |
Not clear |
| Y Shi, F Nikulenkov, J Zawacka-Pankau, H Li, R Gabdoulline, J Xu, S Eriksson, E Hedström, N Issaeva, A Kel, E S J Arnér, G Selivanov. ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis. Cell death and differentiation. vol 21. issue 4. 2014-11-04. PMID:24413150. |
ros-dependent activation of jnk converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis. |
2014-11-04 |
2023-08-12 |
Not clear |
| Kogularamanan Suntharalingam, Justin J Wilson, Wei Lin, Stephen J Lippar. A dual-targeting, p53-independent, apoptosis-inducing platinum(II) anticancer complex, [Pt(BDI(QQ))]Cl. Metallomics : integrated biometal science. vol 6. issue 3. 2014-11-04. PMID:24514456. |
[pt(bdi(qq))]cl induces dna damage, leading to p53 enrichment, mitochondrial membrane potential depolarisation, and caspase-mediated apoptosis. |
2014-11-04 |
2023-08-12 |
Not clear |
| Akinori Morita, Shinya Ariyasu, Bing Wang, Tetsuo Asanuma, Takayoshi Onoda, Akiko Sawa, Kaoru Tanaka, Ippei Takahashi, Shotaro Togami, Mitsuru Nenoi, Toshiya Inaba, Shin Aok. AS-2, a novel inhibitor of p53-dependent apoptosis, prevents apoptotic mitochondrial dysfunction in a transcription-independent manner and protects mice from a lethal dose of ionizing radiation. Biochemical and biophysical research communications. vol 450. issue 4. 2014-11-04. PMID:25026551. |
in a previous study, we reported that some tetradentate zinc(ii) chelators inhibit p53 through the denaturation of its zinc-requiring structure but a chelator, bispicen, a potent inhibitor of in vitro apoptosis, failed to show any efficient radioprotective effect against irradiated mice because the toxicity of the chelator to mice. |
2014-11-04 |
2023-08-13 |
mouse |
| Akinori Morita, Shinya Ariyasu, Bing Wang, Tetsuo Asanuma, Takayoshi Onoda, Akiko Sawa, Kaoru Tanaka, Ippei Takahashi, Shotaro Togami, Mitsuru Nenoi, Toshiya Inaba, Shin Aok. AS-2, a novel inhibitor of p53-dependent apoptosis, prevents apoptotic mitochondrial dysfunction in a transcription-independent manner and protects mice from a lethal dose of ionizing radiation. Biochemical and biophysical research communications. vol 450. issue 4. 2014-11-04. PMID:25026551. |
a mechanistic study using cells with different p53 characteristics revealed that the suppressive effect of as-2 on apoptosis is specifically mediated through p53. |
2014-11-04 |
2023-08-13 |
mouse |
| Akinori Morita, Shinya Ariyasu, Bing Wang, Tetsuo Asanuma, Takayoshi Onoda, Akiko Sawa, Kaoru Tanaka, Ippei Takahashi, Shotaro Togami, Mitsuru Nenoi, Toshiya Inaba, Shin Aok. AS-2, a novel inhibitor of p53-dependent apoptosis, prevents apoptotic mitochondrial dysfunction in a transcription-independent manner and protects mice from a lethal dose of ionizing radiation. Biochemical and biophysical research communications. vol 450. issue 4. 2014-11-04. PMID:25026551. |
in addition, as-2 was less effective in preventing p53-mediated transcription-dependent events than pifithrin-μ (pftμ), an inhibitor of transcription-independent apoptosis by p53. |
2014-11-04 |
2023-08-13 |
mouse |
| Tarek M K Motawi, Yasser Bustanji, Shohda El-Maraghy, Mutasem O Taha, Mohamed A S Al-Ghussei. Evaluation of naproxen and cromolyn activities against cancer cells viability, proliferation, apoptosis, p53 and gene expression of survivin and caspase-3. Journal of enzyme inhibition and medicinal chemistry. vol 29. issue 2. 2014-11-03. PMID:23368763. |
evaluation of naproxen and cromolyn activities against cancer cells viability, proliferation, apoptosis, p53 and gene expression of survivin and caspase-3. |
2014-11-03 |
2023-08-12 |
Not clear |
| Tarek M K Motawi, Yasser Bustanji, Shohda El-Maraghy, Mutasem O Taha, Mohamed A S Al-Ghussei. Evaluation of naproxen and cromolyn activities against cancer cells viability, proliferation, apoptosis, p53 and gene expression of survivin and caspase-3. Journal of enzyme inhibition and medicinal chemistry. vol 29. issue 2. 2014-11-03. PMID:23368763. |
additionally, we performed cellular viability tests using trypan blue, proliferation mtt assay, apoptosis, p53 and real-time polymerase chain reaction for gene expression of survivin and caspase-3. |
2014-11-03 |
2023-08-12 |
Not clear |
| Tarek M K Motawi, Yasser Bustanji, Shohda El-Maraghy, Mutasem O Taha, Mohamed A S Al-Ghussei. Evaluation of naproxen and cromolyn activities against cancer cells viability, proliferation, apoptosis, p53 and gene expression of survivin and caspase-3. Journal of enzyme inhibition and medicinal chemistry. vol 29. issue 2. 2014-11-03. PMID:23368763. |
viability and proliferation results clearly correlated with apoptosis and p53 experiments in showing that both drugs significantly raised apoptotic percentages. |
2014-11-03 |
2023-08-12 |
Not clear |
| Jeanine L Van Nostrand, Colleen A Brady, Heiyoun Jung, Daniel R Fuentes, Margaret M Kozak, Thomas M Johnson, Chieh-Yu Lin, Chien-Jung Lin, Donald L Swiderski, Hannes Vogel, Jonathan A Bernstein, Tania Attié-Bitach, Ching-Pin Chang, Joanna Wysocka, Donna M Martin, Laura D Attard. Inappropriate p53 activation during development induces features of CHARGE syndrome. Nature. vol 514. issue 7521. 2014-11-03. PMID:25119037. |
we found that the p53(25,26,53,54) mutant protein stabilized and hyperactivated wild-type p53, which then inappropriately induced its target genes and triggered cell-cycle arrest or apoptosis during development. |
2014-11-03 |
2023-08-13 |
mouse |
| Romi Gupta, Yuying Dong, Peter D Solomon, Hiromi I Wettersten, Christopher J Cheng, Jin-Na Min, Jeremy Henson, Shaillay Kumar Dogra, Sung H Hwang, Bruce D Hammock, Lihua J Zhu, Roger R Reddel, W Mark Saltzman, Robert H Weiss, Sandy Chang, Michael R Green, Narendra Wajapeye. Synergistic tumor suppression by combined inhibition of telomerase and CDKN1A. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 30. 2014-10-31. PMID:25024194. |
here, we show that loss of the p53 target gene cyclin-dependent kinase inhibitor 1a (cdkn1a, also known as p21(waf1/cip1)) increases apoptosis induction following telomerase inhibition in a variety of cancer cell lines and mouse xenografts. |
2014-10-31 |
2023-08-13 |
mouse |
| Romi Gupta, Yuying Dong, Peter D Solomon, Hiromi I Wettersten, Christopher J Cheng, Jin-Na Min, Jeremy Henson, Shaillay Kumar Dogra, Sung H Hwang, Bruce D Hammock, Lihua J Zhu, Roger R Reddel, W Mark Saltzman, Robert H Weiss, Sandy Chang, Michael R Green, Narendra Wajapeye. Synergistic tumor suppression by combined inhibition of telomerase and CDKN1A. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 30. 2014-10-31. PMID:25024194. |
collectively, our results establish that inactivation of p21 leads to increased apoptosis upon telomerase inhibition and thus identify a genetic vulnerability that can be exploited to treat many human cancers containing either wild-type or mutant p53. |
2014-10-31 |
2023-08-13 |
mouse |
| Juliane Winkler, Alessandro Ori, Kerstin Holzer, Carsten Sticht, Daniel Dauch, Eva Maria Eiteneuer, Federico Pinna, Robert Geffers, Volker Ehemann, Amparo Andres-Pons, Kai Breuhahn, Thomas Longerich, Justo Lorenzo Bermejo, Norbert Gretz, Lars Zender, Peter Schirmacher, Martin Beck, Stephan Singe. Prosurvival function of the cellular apoptosis susceptibility/importin-α1 transport cycle is repressed by p53 in liver cancer. Hepatology (Baltimore, Md.). vol 60. issue 3. 2014-10-30. PMID:24799195. |
prosurvival function of the cellular apoptosis susceptibility/importin-α1 transport cycle is repressed by p53 in liver cancer. |
2014-10-30 |
2023-08-13 |
Not clear |
| b' Robert Domitrovi\\xc4\\x87, Olga Cvijanovi\\xc4\\x87, Vesna \\xc5\\xa0u\\xc5\\xa1ni\\xc4\\x87, Nata\\xc5\\xa1a Katalini\\xc4\\x8. Renoprotective mechanisms of chlorogenic acid in cisplatin-induced kidney injury. Toxicology. vol 324. 2014-10-30. PMID:25043994.' |
additionally, ca significantly suppressed p53, bax active caspase-3, cyclin d1 and microtubule-associated protein 1 light chain 3 isoform b (lc3b) expression, suggesting the inhibition of both apoptosis and autophagy. |
2014-10-30 |
2023-08-13 |
mouse |