| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| George J Burghel, Wei-Yu Lin, Helen Whitehouse, Ian Brock, David Hammond, Jonathan Bury, Yvonne Stephenson, Rina George, Angela Co. Identification of candidate driver genes in common focal chromosomal aberrations of microsatellite stable colorectal cancer. PloS one. vol 8. issue 12. 2014-10-13. PMID:24367615. |
pathway analysis showed that apoptosis and p53 signalling pathways were commonly affected by deleted fmcr, and mapk and potassium channel pathways by gains of fmcr. |
2014-10-13 |
2023-08-12 |
Not clear |
| Retraction notice to: the Skp2 promoter integrates signaling through the NF-kB, p53, and Akt/GSK3β pathways to regulate autophagy and apoptosis. Molecular Cell 38, 524-38; May 28, 2010. Molecular cell. vol 55. issue 2. 2014-10-13. PMID:25165777. |
retraction notice to: the skp2 promoter integrates signaling through the nf-kb, p53, and akt/gsk3β pathways to regulate autophagy and apoptosis. |
2014-10-13 |
2023-08-13 |
Not clear |
| Jing-bo Li, Zhi-gang Lu, Li Xu, Qi Wang, Zu-hai Zhang, Jia-hua Fan. Neuroprotective effects of bis(7)-tacrine in a rat model of pressure-induced retinal ischemia. Cell biochemistry and biophysics. vol 68. issue 2. 2014-10-09. PMID:23832279. |
protein levels of p53, the tumor suppressor gene known to induce apoptosis, were increased after ischemic injury, and treatment with bis(7)-tacrine reduced the expression of the protein. |
2014-10-09 |
2023-08-12 |
rat |
| Yinkai Xu, Fengjuan Zhang, Lei Qin, Jingcheng Miao, Weihua Sheng, Yufeng Xie, Xiaolan Xu, Jicheng Yang, Haixin Qia. Enhanced in-vitro and in-vivo suppression of A375 melanoma by combined IL-24/OSM adenoviral-mediated gene therapy. Melanoma research. vol 24. issue 1. 2014-10-08. PMID:24300090. |
the bicistronic adenovirus-mediated coexpression of il-24 and osm induced additive growth suppression and apoptosis and an overlapping effect on the upregulation of p21, p53, bax, and cleaved caspase-3 in vitro and in vivo. |
2014-10-08 |
2023-08-12 |
mouse |
| Manuel Eguren, Eva Porlan, Eusebio Manchado, Irene García-Higuera, Marta Cañamero, Isabel Fariñas, Marcos Malumbre. The APC/C cofactor Cdh1 prevents replicative stress and p53-dependent cell death in neural progenitors. Nature communications. vol 4. 2014-10-07. PMID:24301385. |
concomitant ablation of p53 rescues apoptosis but not replicative stress, resulting in the presence of damaged neurons throughout the adult brain. |
2014-10-07 |
2023-08-12 |
Not clear |
| Jianmei Chen, Weining Wang, Yangde Zhang, Tiehui Hu, Yuxiang Che. The roles of miR-200c in colon cancer and associated molecular mechanisms. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 7. 2014-10-06. PMID:24682933. |
in conclusion, mir-200c functions as an oncogene in colon cancer cells through regulating tumor cell apoptosis, survival, invasion, and metastasis as well as xenograft tumor growth through inhibition of pten expression and p53 phosphorylation. |
2014-10-06 |
2023-08-12 |
Not clear |
| Anugerah Budipratama Adina, Fina Aryani Goenadi, Franciscus Feby Handoko, Dwi Ana Nawangsari, Adam Hermawan, Riris Istighfari Jenie, Edy Meiyant. Combination of Ethanolic Extract of Citrus aurantifolia Peels with Doxorubicin Modulate Cell Cycle and Increase Apoptosis Induction on MCF-7 Cells. Iranian journal of pharmaceutical research : IJPR. vol 13. issue 3. 2014-10-03. PMID:25276192. |
evidence of apoptosis and protein expression of p53 and bcl-2 indicated that both single applications and combinations of cpe and doxorubicin are able to increase apoptotic bodies of mcf-7 cells by increasing the proteins expression. |
2014-10-03 |
2023-08-13 |
Not clear |
| Wugang Hou, Yushu Dong, Jinshan Zhang, Zhongmin Yin, Hua Wen, Lize Xiong, Wei L. Hypoxia-induced deacetylation is required for tetraploid differentiation in response to testicular ischemia-reperfusion (IR) injury. Journal of andrology. vol 33. issue 6. 2014-10-01. PMID:22556385. |
p53-mediated apoptosis was inhibited by deacetylation of p53 in differentiating pachytene spermatocytes in response to ischemic stress. |
2014-10-01 |
2023-08-12 |
Not clear |
| Asuki Fukatsu, Futoshi Ishiguro, Ichidai Tanaka, Takumi Kudo, Kentaro Nakagawa, Keiko Shinjo, Yutaka Kondo, Makiko Fujii, Yoshinori Hasegawa, Kenji Tomizawa, Tetsuya Mitsudomi, Hirotaka Osada, Yutaka Hata, Yoshitaka Sekid. RASSF3 downregulation increases malignant phenotypes of non-small cell lung cancer. Lung cancer (Amsterdam, Netherlands). vol 83. issue 1. 2014-10-01. PMID:24246507. |
recently, we found that rassf3 interacts with mdm2 and facilitates its ubiquitination, which induces apoptosis through p53 stabilization. |
2014-10-01 |
2023-08-12 |
human |
| Ching-Yi Weng, Shu-Yuan Chiou, Lisu Wang, Mei-Chun Kou, Ying-Jan Wang, Ming-Jiuan W. Arsenic trioxide induces unfolded protein response in vascular endothelial cells. Archives of toxicology. vol 88. issue 2. 2014-09-30. PMID:23892647. |
arsenic also induced er stress-inducible genes, bax, puma (p53 upregulated modulator of apoptosis), trb3 (tribbles-related protein 3), and snat2 (sodium-dependent neutral amino acid transporter 2). |
2014-09-30 |
2023-08-12 |
mouse |
| M A Siddiqui, J Ahmad, N N Farshori, Q Saquib, S Jahan, M P Kashyap, M Ahamed, J Musarrat, A A Al-Khedhair. Rotenone-induced oxidative stress and apoptosis in human liver HepG2 cells. Molecular and cellular biochemistry. vol 384. issue 1-2. 2014-09-30. PMID:23963993. |
the data obtain in this study indicate that rotenone-induced cytotoxicity in hepg2 cells via ros-induced oxidative stress and mitochondria-mediated apoptosis involving p53, bax/bcl-2, and caspase-3. |
2014-09-30 |
2023-08-12 |
human |
| Franck Pellesto. Chromothripsis: how does such a catastrophic event impact human reproduction? Human reproduction (Oxford, England). vol 29. issue 3. 2014-09-30. PMID:24452388. |
several causative mechanisms, involving abortive apoptosis, telomere erosion, mitotic errors, micronuclei formation and p53 inactivation, have been proposed. |
2014-09-30 |
2023-08-12 |
human |
| Krzysztof Kułak, Marcin Bobiński, Grzegorz Polak, Barbara Jodłowska Jedrych, Jan Kotarski, Wiesława Bednare. [Expression of caspase 9 and p53 in uterine leiomyosarcomas]. Ginekologia polska. vol 85. issue 8. 2014-09-30. PMID:25219140. |
caspase 9 and p53 protein play an important role in the process of cell apoptosis. |
2014-09-30 |
2023-08-13 |
Not clear |
| Hasan Caglar Ugur, Mehmet Taspinar, Seda Ilgaz, Fatma Sert, Hande Canpinar, Juan A Rey, Javier S Castresana, Asuman Sungurogl. Chemotherapeutic resistance in anaplastic astrocytoma cell lines treated with a temozolomide-lomeguatrib combination. Molecular biology reports. vol 41. issue 2. 2014-09-29. PMID:24368590. |
the lomeguatrib-tmz combination did not have any effect on the cell cycle and caused apoptosis by increasing p53 expression and decreasing mgmt expression. |
2014-09-29 |
2023-08-12 |
Not clear |
| K R Sumalatha, G Abiramasundari, G K Chetan, T Divya, G Sudhandiran, M Sreepriy. XIAP inhibitor and antiestrogen embelin abrogates metastasis and augments apoptosis in estrogen receptor positive human breast adenocarcinoma cell line MCF-7. Molecular biology reports. vol 41. issue 2. 2014-09-29. PMID:24390234. |
results revealed that, embelin at a concentration of 65 μg/ml attenuated proliferation, inhibited metastatic migration, modulated the expression of bcl2, caspases and induced apoptosis in mcf-7 cells which was found to be p53 mediated. |
2014-09-29 |
2023-08-12 |
human |
| Min Lu, Lijuan Xia, Yan Li, Xiaoli Wang, Ronald Hoffma. The orally bioavailable MDM2 antagonist RG7112 and pegylated interferon α 2a target JAK2V617F-positive progenitor and stem cells. Blood. vol 124. issue 5. 2014-09-29. PMID:24869939. |
the effects of rg7112 and peg-ifnα 2a on mpn progenitor cells were dependent on blocking p53-mdm2 interactions and activating the p53 pathway, thereby increasing mpn cd34(+) cell apoptosis. |
2014-09-29 |
2023-08-13 |
mouse |
| Nadia Godin-Heymann, Yihua Wang, Elizabeth Slee, Xin L. Phosphorylation of ASPP2 by RAS/MAPK pathway is critical for its full pro-apoptotic function. PloS one. vol 8. issue 12. 2014-09-27. PMID:24312625. |
in contrast, an aspp2 phosphorylation mutant exhibits reduced p53 binding and fails to enhance transactivation and apoptosis. |
2014-09-27 |
2023-08-12 |
Not clear |
| Nadia Godin-Heymann, Yihua Wang, Elizabeth Slee, Xin L. Phosphorylation of ASPP2 by RAS/MAPK pathway is critical for its full pro-apoptotic function. PloS one. vol 8. issue 12. 2014-09-27. PMID:24312625. |
thus phosphorylation of aspp2 by ras/mapk pathway provides a novel link between ras and p53 in regulating apoptosis. |
2014-09-27 |
2023-08-12 |
Not clear |
| Weidong Shi, Zhiqiang Meng, Zhen Chen, Yongqiang Hua, Huifeng Gao, Peng Wang, Junhua Lin, Zhenhua Zhou, Jianmin Luo, Luming Li. RNA interference against MDM2 suppresses tumor growth and metastasis in pancreatic carcinoma SW1990HM cells. Molecular and cellular biochemistry. vol 387. issue 1-2. 2014-09-26. PMID:22200978. |
moreover, we also show that the down-regulation of mdm2 induced a significant decrease in mmp9, ki-67 and increase in p53, e-cadherin expression, and results in an altered expression of genes involved in metastasis, apoptosis, and cell proliferation. |
2014-09-26 |
2023-08-12 |
mouse |
| Ligia Petrolini De Oliveira, Ignacio López, Erika Maria Monteiro Dos Santos, Paula Tucci, Mónica Marín, Fernando Augusto Soares, Benedito Mauro Rossi, Renata De Almeida Coudr. Association of the p53 codon 72 polymorphism with clinicopathological characteristics of colorectal cancer through mRNA analysis. Oncology reports. vol 31. issue 3. 2014-09-26. PMID:24366026. |
the polymorphism in the p53 72nd codon involves a proline to arginine substitution, leading to changes in gene transcription activity, interaction with other proteins and modulation of apoptosis. |
2014-09-26 |
2023-08-12 |
Not clear |