| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Helmut Schweikl, Christine Petzel, Carola Bolay, Karl-Anton Hiller, Wolfgang Buchalla, Stephanie Krifk. 2-Hydroxyethyl methacrylate-induced apoptosis through the ATM- and p53-dependent intrinsic mitochondrial pathway. Biomaterials. vol 35. issue 9. 2014-09-26. PMID:24411679. |
transcription-dependent and transcription-independent mechanisms of p53-regulated apoptosis were activated, and p53 was translocated from the cytosol to mitochondria. |
2014-09-26 |
2023-08-12 |
mouse |
| Helmut Schweikl, Christine Petzel, Carola Bolay, Karl-Anton Hiller, Wolfgang Buchalla, Stephanie Krifk. 2-Hydroxyethyl methacrylate-induced apoptosis through the ATM- and p53-dependent intrinsic mitochondrial pathway. Biomaterials. vol 35. issue 9. 2014-09-26. PMID:24411679. |
hema-induced transcriptional activity of p53 was indicated by increased levels of puma localized to mitochondria as a potent inducer of apoptosis. |
2014-09-26 |
2023-08-12 |
mouse |
| Helmut Schweikl, Christine Petzel, Carola Bolay, Karl-Anton Hiller, Wolfgang Buchalla, Stephanie Krifk. 2-Hydroxyethyl methacrylate-induced apoptosis through the ATM- and p53-dependent intrinsic mitochondrial pathway. Biomaterials. vol 35. issue 9. 2014-09-26. PMID:24411679. |
these findings demonstrate that hema-induced apoptosis is mediated through the intrinsic mitochondrial pathway as a consequence of p53 activation via atm signaling upon oxidative dna damage. |
2014-09-26 |
2023-08-12 |
mouse |
| Ravshan Burikhanov, Tripti Shrestha-Bhattarai, Nikhil Hebbar, Shirley Qiu, Yanming Zhao, Gerard P Zambetti, Vivek M Rangneka. Paracrine apoptotic effect of p53 mediated by tumor suppressor Par-4. Cell reports. vol 6. issue 2. 2014-09-26. PMID:24412360. |
specific activation of p53 in normal fibroblasts selectively induced apoptosis in p53-deficient cancer cells. |
2014-09-26 |
2023-08-12 |
mouse |
| Ravshan Burikhanov, Tripti Shrestha-Bhattarai, Nikhil Hebbar, Shirley Qiu, Yanming Zhao, Gerard P Zambetti, Vivek M Rangneka. Paracrine apoptotic effect of p53 mediated by tumor suppressor Par-4. Cell reports. vol 6. issue 2. 2014-09-26. PMID:24412360. |
accordingly, the activation of p53 in normal mice, but not p53(-)/(-) or par-4(-)/(-) mice, caused systemic elevation of par-4, which induced apoptosis of p53-deficient tumor cells. |
2014-09-26 |
2023-08-12 |
mouse |
| Fangfang Jiang, Wei Zhao, Lijie Zhou, Lin Zhang, Zifeng Liu, Dongsheng Y. miR-222 regulates the cell biological behavior of oral squamous cell carcinoma by targeting PUMA. Oncology reports. vol 31. issue 3. 2014-09-26. PMID:24452416. |
previous reports have shown that low expression of p53 upregulated modulator of apoptosis (puma) and abnormal expression patterns of a number of mirnas may be associated with poor prognosis in various types of human malignancies. |
2014-09-26 |
2023-08-12 |
human |
| Clare M Adams, Christine M Eische. Inactivation of p53 is insufficient to allow B cells and B-cell lymphomas to survive without Dicer. Cancer research. vol 74. issue 14. 2014-09-26. PMID:24840646. |
however, here, we report that loss of p53 did not provide a survival advantage to b cells, as they underwent rapid apoptosis upon dicer deletion. |
2014-09-26 |
2023-08-13 |
mouse |
| Clare M Adams, Christine M Eische. Inactivation of p53 is insufficient to allow B cells and B-cell lymphomas to survive without Dicer. Cancer research. vol 74. issue 14. 2014-09-26. PMID:24840646. |
moreover, p53 loss in transformed b cells did not confer protection from apoptosis, as dicer deletion in established p53-null b-cell lymphomas induced apoptosis, and all of the 1,260 b-cell lymphoma clones analyzed that survived cre-mediated dicer deletion retained at least one allele of dicer. |
2014-09-26 |
2023-08-13 |
mouse |
| Morito Kurata, Shinya Abe, Shiho Suzuki, Na Li, Iichiro Ohnishi, Maki Hasegawa, Kouhei Yamamoto, Masanobu Kitagaw. DNA damage-induced apoptosis and genetic background of the host: host-specific signaling enhancers of apoptosis. Journal of medical and dental sciences. vol 58. issue 2. 2014-09-25. PMID:23896790. |
furthermore, p53 or atm knockout mice of c3h background and dna-pk-deficient c3h scid mice did not show the enhanced apoptosis by flv. |
2014-09-25 |
2023-08-12 |
mouse |
| Juhua Wang, Hongguo Cao, Xiuheng Xue, Caiyun Fan, Fugui Fang, Jie Zhou, Yunhai Zhang, Xiaorong Zhan. Effect of vitamin C on growth of caprine spermatogonial stem cells in vitro. Theriogenology. vol 81. issue 4. 2014-09-25. PMID:24368149. |
further, the intracellular reactive oxygen species (ros) level was measured at the 3rd, 6th, and 9th day after culture, and expression of bax, bcl-2, and p53, factors involved in the regulation of apoptosis, were analyzed on the 7th day after culture using reverse transcription polymerase chain reaction and quantitative real-time polymerase chain reaction. |
2014-09-25 |
2023-08-12 |
Not clear |
| Chun-Lin Wang, Jun-Yu Wang, Zhen-Yang Liu, Xiao-Mei Ma, Xiao-Wen Wang, Hai Jin, Xiao-Ping Zhang, Da Fu, Li-Jun Hou, Yi-Cheng L. Ubiquitin-specific protease 2a stabilizes MDM4 and facilitates the p53-mediated intrinsic apoptotic pathway in glioblastoma. Carcinogenesis. vol 35. issue 7. 2014-09-25. PMID:24445145. |
our results suggest that usp2a binds to and stabilizes mdm4; thus in turn, it enhances the mitochondrial localization of p53 and promotes apoptosis in glioma cells. |
2014-09-25 |
2023-08-12 |
mouse |
| T Qin, C J Liu, H W Zhang, Y F Pan, Q Tang, J K Liu, Y Z Wang, M X Hu, F Xu. Effect of the IkBα mutant gene delivery to mesenchymal stem cells on rat chronic pancreatitis. Genetics and molecular research : GMR. vol 13. issue 1. 2014-09-25. PMID:24535864. |
ikbαm-mscs influenced the proliferation and apoptosis of pancreatic stellate cells by regulating the activation of the ppar, mapk, mtor, tgf-β, nod-like receptor, notch, wnt, tgf-β1-smad-2/3, and p53 signal transduction pathways. |
2014-09-25 |
2023-08-12 |
rat |
| Yujiao Jia, Leiwen Peng, Qing Rao, Haiyan Xing, Lei Huai, Pei Yu, Yirui Chen, Cuicui Wang, Min Wang, Yingchang Mi, Jianxiang Wan. Oncogene iASPP enhances self-renewal of hematopoietic stem cells and facilitates their resistance to chemotherapy and irradiation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 28. issue 7. 2014-09-25. PMID:24668753. |
in addition, the hematopoietic cells from iaspp transgenic mice exhibited a significantly lower level of p53 dependent apoptosis. |
2014-09-25 |
2023-08-12 |
mouse |
| Zbigniew Korwek, Olga Alste. [The role of the DNA damage response in apoptosis and cell senescence]. Postepy biochemii. vol 60. issue 2. 2014-09-25. PMID:25134360. |
in apoptosis p53 participates in the activation of caspases, which are responsible for the degradation of many proteins. |
2014-09-25 |
2023-08-13 |
Not clear |
| Kausik Bishayee, Avijit Paul, Samrat Ghosh, Sourav Sikdar, Avinaba Mukherjee, Raktim Biswas, N Boujedaini, Anisur Rahman Khuda-Bukhs. Condurango-glycoside-A fraction of Gonolobus condurango induces DNA damage associated senescence and apoptosis via ROS-dependent p53 signalling pathway in HeLa cells. Molecular and cellular biochemistry. vol 382. issue 1-2. 2014-09-23. PMID:23807740. |
condurango-glycoside-a fraction of gonolobus condurango induces dna damage associated senescence and apoptosis via ros-dependent p53 signalling pathway in hela cells. |
2014-09-23 |
2023-08-12 |
Not clear |
| Kausik Bishayee, Avijit Paul, Samrat Ghosh, Sourav Sikdar, Avinaba Mukherjee, Raktim Biswas, N Boujedaini, Anisur Rahman Khuda-Bukhs. Condurango-glycoside-A fraction of Gonolobus condurango induces DNA damage associated senescence and apoptosis via ROS-dependent p53 signalling pathway in HeLa cells. Molecular and cellular biochemistry. vol 382. issue 1-2. 2014-09-23. PMID:23807740. |
expression of p53 was also up-regulated, indicating that apoptosis could have been mediated through p53 pathway. |
2014-09-23 |
2023-08-12 |
Not clear |
| Kausik Bishayee, Avijit Paul, Samrat Ghosh, Sourav Sikdar, Avinaba Mukherjee, Raktim Biswas, N Boujedaini, Anisur Rahman Khuda-Bukhs. Condurango-glycoside-A fraction of Gonolobus condurango induces DNA damage associated senescence and apoptosis via ROS-dependent p53 signalling pathway in HeLa cells. Molecular and cellular biochemistry. vol 382. issue 1-2. 2014-09-23. PMID:23807740. |
overall results suggest that cga initiates ros generation, promoting up-regulation of p53 expression, thus resulting in apoptosis and pre-mature senescence associated with dna damage. |
2014-09-23 |
2023-08-12 |
Not clear |
| Francesca Cottini, Teru Hideshima, Chunxiao Xu, Martin Sattler, Martina Dori, Luca Agnelli, Elisa ten Hacken, Maria Teresa Bertilaccio, Elena Antonini, Antonino Neri, Maurilio Ponzoni, Magda Marcatti, Paul G Richardson, Ruben Carrasco, Alec C Kimmelman, Kwok-Kin Wong, Federico Caligaris-Cappio, Giovanni Blandino, W Michael Kuehl, Kenneth C Anderson, Giovanni Tono. Rescue of Hippo coactivator YAP1 triggers DNA damage-induced apoptosis in hematological cancers. Nature medicine. vol 20. issue 6. 2014-09-23. PMID:24813251. |
oncogene-induced dna damage elicits genomic instability in epithelial cancer cells, but apoptosis is blocked through inactivation of the tumor suppressor p53. |
2014-09-23 |
2023-08-13 |
Not clear |
| Pingyuan Xie, Yi Sun, Qi Ouyang, Liang Hu, Yueqiu Tan, Xiaoying Zhou, Bo Xiong, Qianjun Zhang, Ding Yuan, Yi Pan, Tiancheng Liu, Ping Liang, Guangxiu Lu, Ge Li. Physiological oxygen prevents frequent silencing of the DLK1-DIO3 cluster during human embryonic stem cells culture. Stem cells (Dayton, Ohio). vol 32. issue 2. 2014-09-19. PMID:24123616. |
silencing of the dlk1-dio3 cluster did not seem to compromise the multilineage differentiation ability of hescs, but was associated with reduced dna damage-induced apoptosis in ehescs and their differentiated hepatocyte-like cell derivatives, possibly through attenuation of the expression and phosphorylation of p53. |
2014-09-19 |
2023-08-12 |
human |
| Yu Chen, Meng-Ying Qin, Jing-Heng Wu, Lei Wang, Hui Chao, Liang-Nian Ji, An-Long X. Synthesis, characterization, and anticancer activity of ruthenium(II)-β-carboline complex. European journal of medicinal chemistry. vol 70. 2014-09-19. PMID:24141202. |
flow cytometry and signaling pathways analysis demonstrated that these complexes induced apoptosis via the mitochondrial pathway, as evidenced by the loss of mitochondrial membrane potential and the release of cytochrome c. the resulting accumulation of p53 proteins from phosphorylation at serine-15 and serine-392 was correlated with an increase in p21 and caspase activation. |
2014-09-19 |
2023-08-12 |
human |