| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrew N Sharp, Alexander E P Heazell, Dora Baczyk, Caroline E Dunk, Helen A Lacey, Carolyn J P Jones, Jonathan E Perkins, John C P Kingdom, Philip N Baker, Ian P Crocke. Preeclampsia is associated with alterations in the p53-pathway in villous trophoblast. PloS one. vol 9. issue 1. 2014-09-08. PMID:24498154. |
since p53 is a critical regulator of apoptosis we hypothesized that excessive apoptosis in pe is mediated by abnormal expression of proteins participating in the p53 pathway and that modulation of the p53 pathway alters trophoblast apoptosis in vitro. |
2014-09-08 |
2023-08-12 |
Not clear |
| Kyle P Glover, Lauren K Markell, E Maria Donner, Xing Ha. Protein kinase C-activating tumor promoters modulate the DNA damage response in UVC-irradiated TK6 cells. Toxicology letters. vol 229. issue 1. 2014-09-08. PMID:24960060. |
nh32 (p53-null, isogenic to tk6) cells were resistant to the synergistic effects on apoptosis implicating p53 as a central mediator of the ddr modulating effects. |
2014-09-08 |
2023-08-13 |
human |
| Kyung-Hwa Cho, Ji-Hye Park, Kang-Beom Kwon, Young-Rae Lee, Hong-Seob So, Kang-Kyoo Lee, Sam-Youn Lee, Sun-Rock Moon, Sei-Hoon Yan. Autophagy induction by low-dose cisplatin: the role of p53 in autophagy. Oncology reports. vol 31. issue 1. 2014-09-05. PMID:24173208. |
however, cisplatin-induced apoptosis increased in wild-type p53 compared to null-type p53 cells. |
2014-09-05 |
2023-08-12 |
Not clear |
| Sun-Young Lee, Yun-Jeong Choe, Jik Young Park, Sang Sun Lee, Yoon-Hyoung Kim, Seok Joon Shin, Yeun Jun Chung, Ho-Shik Ki. Wilms' tumor gene 1 enhances nutlin-3-induced apoptosis. Oncology reports. vol 31. issue 1. 2014-09-05. PMID:24190574. |
nutlin-3, a human double minute 2 (hdm2) antagonist, induces cell cycle arrest or apoptosis by upregulating p53 in cancer cells. |
2014-09-05 |
2023-08-12 |
human |
| Sun-Young Lee, Yun-Jeong Choe, Jik Young Park, Sang Sun Lee, Yoon-Hyoung Kim, Seok Joon Shin, Yeun Jun Chung, Ho-Shik Ki. Wilms' tumor gene 1 enhances nutlin-3-induced apoptosis. Oncology reports. vol 31. issue 1. 2014-09-05. PMID:24190574. |
wt1, the product of wilms' tumor gene 1, has been shown to interact with p53, but the effect of wt1 on nutlin-3-induced apoptosis has yet to be examined. |
2014-09-05 |
2023-08-12 |
human |
| Gaetano Calì, Luigi Insabato, Domenico Conza, Giuseppe Bifulco, Luca Parrillo, Paola Mirra, Francesca Fiory, Claudia Miele, Gregory Alexander Raciti, Bruno Di Jeso, Giuseppe Terrazzano, Francesco Beguinot, Luca Ulianic. GRP78 mediates cell growth and invasiveness in endometrial cancer. Journal of cellular physiology. vol 229. issue 10. 2014-09-05. PMID:24526410. |
induction of apoptosis in an3ca cells was not mediated by the p53 pathway activation but was rather associated to reduced akt phosphorylation. |
2014-09-05 |
2023-08-12 |
Not clear |
| X Bi, D Feng, J Korczeniewska, N Alper, G Hu, B J Barne. Deletion of Irf5 protects hematopoietic stem cells from DNA damage-induced apoptosis and suppresses γ-irradiation-induced thymic lymphomagenesis. Oncogene. vol 33. issue 25. 2014-09-04. PMID:23912454. |
it is well known that ir-induced thymic lymphomagenesis is markedly enhanced by p53 deficiency, yet data also indicate that p53-dependent apoptosis can actively drive tumor formation in this model. |
2014-09-04 |
2023-08-12 |
mouse |
| X Bi, D Feng, J Korczeniewska, N Alper, G Hu, B J Barne. Deletion of Irf5 protects hematopoietic stem cells from DNA damage-induced apoptosis and suppresses γ-irradiation-induced thymic lymphomagenesis. Oncogene. vol 33. issue 25. 2014-09-04. PMID:23912454. |
similar to puma, the transcription factor interferon regulatory factor 5 (irf5) has been reported as a p53 target gene and is required for dna damage-induced apoptosis. |
2014-09-04 |
2023-08-12 |
mouse |
| Tilman Polonio-Vallon, Joanna Kirkpatrick, Jeroen Krijgsveld, Thomas G Hofman. Src kinase modulates the apoptotic p53 pathway by altering HIPK2 localization. Cell cycle (Georgetown, Tex.). vol 13. issue 1. 2014-09-04. PMID:24196445. |
homeodomain-interacting protein kinase 2 (hipk2) is a tumor suppressor mediating growth suppression and apoptosis upon genotoxic stress through phosphorylation of p53 at ser46. |
2014-09-04 |
2023-08-12 |
Not clear |
| Tilman Polonio-Vallon, Joanna Kirkpatrick, Jeroen Krijgsveld, Thomas G Hofman. Src kinase modulates the apoptotic p53 pathway by altering HIPK2 localization. Cell cycle (Georgetown, Tex.). vol 13. issue 1. 2014-09-04. PMID:24196445. |
accordingly, we find that hyperactive src decreases chemotherapeutic drug-induced p53 ser46 phosphorylation and apoptosis activation. |
2014-09-04 |
2023-08-12 |
Not clear |
| Sun Hwa Lee, Yong Jung Kang, Dong Hwan Kim, Bokyung Sung, Jin Ah Kang, Pusoon Chun, Jeong-Hyun Yoon, Hyung Ryong Moon, Hyung Sik Kim, Hae Young Chung, Nam Deuk Ki. A novel oxiranylchromenone derivative, MHY336, induces apoptosis and cell cycle arrest via a p53- and p21-dependent pathway in HCT116 human colon cancer cells. International journal of oncology. vol 44. issue 3. 2014-09-04. PMID:24365999. |
in this study, we compared cytotoxicity, cell cycle distribution, and apoptosis on mhy336 treatment in three human colorectal carcinoma hct116 cells: p53+/+ (p53‑wt), p53-/- (p53-null), and p21-/- (p21-null), as well as investigated the roles of p53 and p21 in cell death. |
2014-09-04 |
2023-08-12 |
human |
| Sun Hwa Lee, Yong Jung Kang, Dong Hwan Kim, Bokyung Sung, Jin Ah Kang, Pusoon Chun, Jeong-Hyun Yoon, Hyung Ryong Moon, Hyung Sik Kim, Hae Young Chung, Nam Deuk Ki. A novel oxiranylchromenone derivative, MHY336, induces apoptosis and cell cycle arrest via a p53- and p21-dependent pathway in HCT116 human colon cancer cells. International journal of oncology. vol 44. issue 3. 2014-09-04. PMID:24365999. |
the same result was achieved by knocking down p53 and p21 with sirna in p53-wt cells, indicating that p53 and p21 play a crucial role in mhy336-induced cell cycle arrest and apoptosis. |
2014-09-04 |
2023-08-12 |
human |
| Yun-Jeong Choe, Sun-Young Lee, Kyung Won Ko, Seok Joon Shin, Ho-Shik Ki. Nutlin-3 induces HO-1 expression by activating JNK in a transcription-independent manner of p53. International journal of oncology. vol 44. issue 3. 2014-09-04. PMID:24366007. |
collectively, these results suggest that nutlin-3 induces ho-1 expression via the activation of both jnk which is dependent on ros generated by p53 translocated to the mitochondria and p38 mapk which appears to be stimulated by a ros-independent mechanism, and this ho-1 induction may inhibit nutlin-3-induced apoptosis, constituting a negative feedback loop of p53-induced apoptosis. |
2014-09-04 |
2023-08-12 |
human |
| Helen Jayne Susan Stewart, Gillian Abigail Horne, Sarah Bastow, Timothy James Telfer Chevassu. BRD4 associates with p53 in DNMT3A-mutated leukemia cells and is implicated in apoptosis by the bromodomain inhibitor JQ1. Cancer medicine. vol 2. issue 6. 2014-09-04. PMID:24403256. |
brd4 associates with p53 in dnmt3a-mutated leukemia cells and is implicated in apoptosis by the bromodomain inhibitor jq1. |
2014-09-04 |
2023-08-12 |
Not clear |
| Helen Jayne Susan Stewart, Gillian Abigail Horne, Sarah Bastow, Timothy James Telfer Chevassu. BRD4 associates with p53 in DNMT3A-mutated leukemia cells and is implicated in apoptosis by the bromodomain inhibitor JQ1. Cancer medicine. vol 2. issue 6. 2014-09-04. PMID:24403256. |
instead, we propose that jq1 acts to prevent brd4-mediated recruitment of p53 to chromatin targets following its activation in oci-aml3 cells resulting in cell cycle arrest and apoptosis in a c-myc-independent manner. |
2014-09-04 |
2023-08-12 |
Not clear |
| Lei Zhao, Hong-Yan Zhang, Ya-Kun Pang, Hai-Hui Gu, Jing Xu, Wei-Ping Yuan, Tao Chen. [Knockdown of Puma protects cord blood CD34(+) cells against γ- irradiation]. Zhongguo shi yan xue ye xue za zhi. vol 22. issue 2. 2014-09-04. PMID:24763015. |
puma (p53 upregulated modulator of apoptosis) is a bcl-2 homology 3 (bh3)-only bcl-1 family member and a critical mediator of p53-dependent and -independent apoptosis. |
2014-09-04 |
2023-08-13 |
mouse |
| Yuan Ming Di, Zhi-Wei Zhou, Chun Guang Li, Shu-Feng Zho. Current and future therapeutic targets of rheumatoid arthritis. Anti-inflammatory & anti-allergy agents in medicinal chemistry. vol 10. issue 2. 2014-09-04. PMID:25182058. |
according to the panther analysis, most commonly involved pathways in current ra targeting includes inflammation mediated by chemokine and cytokine signalling pathways, angiogenesis, p53 pathway, de novo purine biosynthesis, t-cell activation, apoptosis signalling pathway and vascular endothelial growth factor (vegf) receptor signalling pathway. |
2014-09-04 |
2023-08-13 |
Not clear |
| He-Qi Bu, Dian-Lei Liu, Wei-Tian Wei, Liang Chen, Hai Huang, Ye Li, Jun-Hui Cu. Oridonin induces apoptosis in SW1990 pancreatic cancer cells via p53- and caspase-dependent induction of p38 MAPK. Oncology reports. vol 31. issue 2. 2014-09-03. PMID:24297112. |
additionally, cell apoptosis was markedly inhibited by pft α (pifithrin α), a p53-specific inhibitor, which was applied to evaluate the function of p53, showing that p53 was responsible for the cytotoxity of oridonin. |
2014-09-03 |
2023-08-12 |
Not clear |
| David B Wang, Chizuru Kinoshita, Yoshito Kinoshita, Richard S Morriso. p53 and mitochondrial function in neurons. Biochimica et biophysica acta. vol 1842. issue 8. 2014-09-03. PMID:24412988. |
although it was previously believed that p53 induces apoptotic mitochondrial changes exclusively through transcription-dependent mechanisms, recent studies suggest that p53 also regulates apoptosis via a transcription-independent action at the mitochondria. |
2014-09-03 |
2023-08-12 |
Not clear |
| David B Wang, Chizuru Kinoshita, Yoshito Kinoshita, Richard S Morriso. p53 and mitochondrial function in neurons. Biochimica et biophysica acta. vol 1842. issue 8. 2014-09-03. PMID:24412988. |
thus, p53 may have a much wider influence on mitochondrial integrity and function than one would expect from its well-established ability to transcriptionally induce mitochondrial apoptosis. |
2014-09-03 |
2023-08-12 |
Not clear |