| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| De-Yong Zhang, Xiu-Ying Shen, Qin Ruan, Xiao-Lu Xu, San-Ping Yang, Yin Lu, Hui-Ying Xu, Fei-Lin Ha. Effects of subchronic samarium exposure on the histopathological structure and apoptosis regulation in mouse testis. Environmental toxicology and pharmacology. vol 37. issue 2. 2014-12-01. PMID:24561534. |
and expression up-regulation of p53 and bax, and down-regulation of bcl-2 were observed (p<0.05), indicating the apoptosis is related to p53 mediated pathway. |
2014-12-01 |
2023-08-12 |
mouse |
| Nur Diyana Md Zamri, Mustapha Umar Imam, Siti Aisyah Abd Ghafar, Maznah Ismai. Antioxidative Effects of Germinated Brown Rice-Derived Extracts on H2O2-Induced Oxidative Stress in HepG2 Cells. Evidence-based complementary and alternative medicine : eCAM. vol 2014. 2014-11-28. PMID:25431609. |
in addition, h2o2 produced transcriptional changes in p53, jnk, p38 mapk, akt, bax, and cdk4 that were inclined towards apoptosis, while gbr-extracts showed some transcriptional changes (upregulation of bax and p53) that suggested an inclination for apoptosis although other changes (upregulation of antioxidant genes, akt, jnk, and p38 mapk) suggested that gbr-extracts favored survival of the hepg2 cells. |
2014-11-28 |
2023-08-13 |
Not clear |
| Ki-Woong Park, Juthika Kundu, In-Gyeong Chae, Do-Hee Kim, Mi-Hee Yu, Joydeb Kumar Kundu, Kyung-Soo Chu. Carnosol induces apoptosis through generation of ROS and inactivation of STAT3 signaling in human colon cancer HCT116 cells. International journal of oncology. vol 44. issue 4. 2014-11-26. PMID:24481553. |
taken together, our study provides the first report that carnosol induced apoptosis in hct116 cells via generation of ros, induction of p53, activation of caspases and inhibition of stat3 signaling pathway. |
2014-11-26 |
2023-08-12 |
human |
| Alessia Garufi, Valerio D'Orazi, Jack L Arbiser, Gabriella D'Oraz. Gentian violet induces wtp53 transactivation in cancer cells. International journal of oncology. vol 44. issue 4. 2014-11-26. PMID:24535435. |
the tumor suppressor p53 is a transcription factor that, upon cellular stress, is activated to induce target genes involved in tumor cell growth inhibition and apoptosis. |
2014-11-26 |
2023-08-12 |
human |
| Hiba El Hajj, Bariaa Khalil, Botheina Ghandour, Rihab Nasr, Sharif Shahine, Akram Ghantous, Rana Abdel-Samad, Ansam Sinjab, Hideki Hasegawa, Mark Jabbour, William W Hall, Ghazi Zaatari, Ghassan Dbaibo, Claudio Pisano, Ali Bazarbachi, Nadine Darwich. Preclinical efficacy of the synthetic retinoid ST1926 for treating adult T-cell leukemia/lymphoma. Blood. vol 124. issue 13. 2014-11-26. PMID:25035162. |
st1926 induced apoptosis, dna damage, and upregulation of p53 proteins in malignant t cells, whereas it caused an early downregulation of tax proteins in htlv-1-positive cells. |
2014-11-26 |
2023-08-13 |
human |
| Yohko Nakamura, Akiko Suganami, Mayu Fukuda, Md Kamrul Hasan, Tomoki Yokochi, Atsushi Takatori, Shunpei Satoh, Tyuji Hoshino, Yutaka Tamura, Akira Nakagawar. Identification of novel candidate compounds targeting TrkB to induce apoptosis in neuroblastoma. Cancer medicine. vol 3. issue 1. 2014-11-25. PMID:24403123. |
the terminal deoxynucleotidyl transferase dutp nick end labeling (tunel) assay showed that these molecules induce apoptosis accompanied by p53 activation in nb cell lines. |
2014-11-25 |
2023-08-12 |
mouse |
| Xiao-Ming Zhou, Xin Zhang, Xiang-Sheng Zhang, Zong Zhuang, Wei Li, Qing Sun, Tao Li, Chun-Xi Wang, Lin Zhu, Ji-Xin Shi, Meng-Liang Zho. SIRT1 inhibition by sirtinol aggravates brain edema after experimental subarachnoid hemorrhage. Journal of neuroscience research. vol 92. issue 6. 2014-11-25. PMID:24482345. |
endothelial cell apoptosis, caspase 3 protein expression, p53 acetylation, and matrix metalloproteinase-9 (mmp-9) activity were examined. |
2014-11-25 |
2023-08-12 |
rat |
| Kay Kotkamp, Esther Kur, Björn Wendik, Bożena K Polok, Shifra Ben-Dor, Daria Onichtchouk, Wolfgang Drieve. Pou5f1/Oct4 promotes cell survival via direct activation of mych expression during zebrafish gastrulation. PloS one. vol 9. issue 3. 2014-11-25. PMID:24643012. |
similarly, p53 knockdown only partially suppressed apoptosis in mzspg gastrula embryos. |
2014-11-25 |
2023-08-12 |
zebrafish |
| Kay Kotkamp, Esther Kur, Björn Wendik, Bożena K Polok, Shifra Ben-Dor, Daria Onichtchouk, Wolfgang Drieve. Pou5f1/Oct4 promotes cell survival via direct activation of mych expression during zebrafish gastrulation. PloS one. vol 9. issue 3. 2014-11-25. PMID:24643012. |
however, combined knockdown of p53 and overexpression of mych completely rescued the mzspg apoptosis phenotype. |
2014-11-25 |
2023-08-12 |
zebrafish |
| Basil Smith, Diandra Randle, Roman Mezencev, LeeShawn Thomas, Cimona Hinton, Valerie Odero-Mara. Camalexin-induced apoptosis in prostate cancer cells involves alterations of expression and activity of lysosomal protease cathepsin D. Molecules (Basel, Switzerland). vol 19. issue 4. 2014-11-25. PMID:24699144. |
immunocytochemical analysis revealed cd relocalization from the lysosome to the cytosol subsequent to camalexin treatments, which was associated with increased protein expression of mature cd; p53, a transcriptional activator of cd; bax, a downstream effector of cd, and cleaved parp, a hallmark for apoptosis. |
2014-11-25 |
2023-08-13 |
Not clear |
| Edward M Kennedy, Anand V R Kornepati, Michael Goldstein, Hal P Bogerd, Brigid C Poling, Adam W Whisnant, Michael B Kastan, Bryan R Culle. Inactivation of the human papillomavirus E6 or E7 gene in cervical carcinoma cells by using a bacterial CRISPR/Cas RNA-guided endonuclease. Journal of virology. vol 88. issue 20. 2014-11-25. PMID:25100830. |
previous work has shown that loss of e6 function in cervical cancer cells induces p53 expression as well as downstream effectors that induce apoptosis and cell cycle arrest. |
2014-11-25 |
2023-08-13 |
human |
| Yanling Sui, Zichun Zhao, Rong Liu, Bin Cai, Dongsheng Fa. Adenosine monophosphate-activated protein kinase activation enhances embryonic neural stem cell apoptosis in a mouse model of amyotrophic lateral sclerosis. Neural regeneration research. vol 9. issue 19. 2014-11-25. PMID:25422638. |
these results suggest that embryonic neural stem cells from sod1(g93a) mice are more susceptible to apoptosis in the presence of oxidative stress compared with those from wild-type controls, and the effects are mainly mediated by pax3 and p53 in the ampkα pathway. |
2014-11-25 |
2023-08-13 |
mouse |
| Xiali Zhang, Shuo Tu, Yibing Wang, Baohua Xu, Fusheng Wa. Mechanism of taurine-induced apoptosis in human colon cancer cells. Acta biochimica et biophysica Sinica. vol 46. issue 4. 2014-11-24. PMID:24610575. |
in the present study, we treated human colorectal cancer cells ht-29 (mutant p53) and lovo (wild-type p53) with different concentrations of tau, which led to the repression of cell proliferation and induction of apoptosis in both cell lines. |
2014-11-24 |
2023-08-12 |
human |
| Emily Powell, David Piwnica-Worms, Helen Piwnica-Worm. Contribution of p53 to metastasis. Cancer discovery. vol 4. issue 4. 2014-11-24. PMID:24658082. |
p53 loss not only prevents incipient tumor cells from undergoing oncogene-induced senescence and apoptosis, but also perturbs cell-cycle checkpoints. |
2014-11-24 |
2023-08-12 |
human |
| Siyuan Jiang, Lianfang Zhao, Yilu Lu, Meiling Wang, Yuan Chen, Dachang Tao, Yunqiang Liu, Huaqin Sun, Sizhong Zhang, Yongxin M. Piwil2 inhibits keratin 8 degradation through promoting p38-induced phosphorylation to resist Fas-mediated apoptosis. Molecular and cellular biology. vol 34. issue 21. 2014-11-24. PMID:25113562. |
our present study indicates that piwil2 plays a role in fas-mediated apoptosis for the first time and also can affect p53 phosphorylation in tumor cells, revealing a novel mechanism of piwil2 in apoptosis, and supports that piwil2 plays an active role in tumorigenesis. |
2014-11-24 |
2023-08-13 |
Not clear |
| Junzhe Jin, Guofu Lin, Hong Huang, Dong Xu, Hao Yu, Xu Ma, Lisi Zhu, Dongyan Ma, Honglei Jian. Capsaicin mediates cell cycle arrest and apoptosis in human colon cancer cells via stabilizing and activating p53. International journal of biological sciences. vol 10. issue 3. 2014-11-21. PMID:24643130. |
capsaicin mediates cell cycle arrest and apoptosis in human colon cancer cells via stabilizing and activating p53. |
2014-11-21 |
2023-08-12 |
human |
| Junzhe Jin, Guofu Lin, Hong Huang, Dong Xu, Hao Yu, Xu Ma, Lisi Zhu, Dongyan Ma, Honglei Jian. Capsaicin mediates cell cycle arrest and apoptosis in human colon cancer cells via stabilizing and activating p53. International journal of biological sciences. vol 10. issue 3. 2014-11-21. PMID:24643130. |
the results of p53-shrna experiment further demonstrated that p53 knockdown severely impaired the sensitivity of tested cells to capsaicin, g0/g1 phase arrest and the apoptosis induced by capsaicin in p53-knockdown cells was also dramatically decreased, implicating the important role of p53 played in capsaicin's antitumor activity. |
2014-11-21 |
2023-08-12 |
human |
| Emad F Eskander, Ahmed A Abd-Rabou, Mervat S Mohamed, Shaymaa M M Yahya, Ashraf El Sherbini, Olfat G Shake. The potential impact of P53 and APO-1 genetic polymorphisms on hepatitis C genotype 4a susceptibility. Gene. vol 550. issue 1. 2014-11-21. PMID:25108128. |
tumor suppressor gene (p53) induces the expression of apoptotic antigen-1 gene (apo-1) by binding to its promoter for mediating apoptosis; an important mechanism for limiting viral replication. |
2014-11-21 |
2023-08-13 |
human |
| Yiping Li, Qiuli Wu, Yunli Zhao, Yunfei Bai, Pingsheng Chen, Tian Xia, Dayong Wan. Response of microRNAs to in vitro treatment with graphene oxide. ACS nano. vol 8. issue 3. 2014-11-18. PMID:24512264. |
by combining both information on targeted genes for dysregulated mirnas and known signaling pathways for apoptosis control, we hypothesize that the dysregulated mirnas could activate both a death receptor pathway by influencing functions of tumor necrosis factor α receptor and caspase-3 and a mitochondrial pathway by affecting functions of p53 and bcl-2 in go-exposed glc-82 cells. |
2014-11-18 |
2023-08-12 |
Not clear |
| Ziyi Zhao, Lan Wu, Huimin Shi, Chuanfang W. p53 N‑terminal binding and stabilisation by PIAS3 inhibits MDM2‑induced p53 ubiquitination and regulates cell growth. Molecular medicine reports. vol 9. issue 5. 2014-11-18. PMID:24584189. |
mdm2 thus destabilises p53 and inhibits the effect of p53 on cell cycle arrest and apoptosis. |
2014-11-18 |
2023-08-12 |
mouse |