| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xia Wang, Shunying Zhu, Lan Qian, Jing Gao, Mingyuan Wu, Jin Gao, Yang Zhang, Gerald L Chan, Yan Yu, Wei Ha. IL-1Ra selectively protects intestinal crypt epithelial cells, but not tumor cells, from chemotoxicity via p53-mediated upregulation of p21(WAF1) and p27(KIP1.). Pharmacological research. vol 82. 2014-12-29. PMID:24681512. |
rhil-1ra pretreatment reduced the incidence, severity, and duration of chemotherapy-induced diarrhea, through attenuating crypt apoptosis and improving crypt survival in wild-type mice, but not in il-1ri(-/-), p53(-/-), and p21(-/-) mice. |
2014-12-29 |
2023-08-12 |
mouse |
| Dezhi Hu, Shuo Zhang, Yingjie Zhao, Shiming Wang, Qihan Wang, Xiao Song, Daru Lu, Ying Mao, Hongyan Che. Association of genetic variants in the retinoblastoma binding protein 6 gene with the risk of glioma: a case-control study in a Chinese Han population. Journal of neurosurgery. vol 121. issue 5. 2014-12-29. PMID:25127414. |
the retinoblastoma binding protein 6 (rbbp6) gene plays an important role in the induction of apoptosis and regulation of the cell cycle, and interacts with both p53 and retinoblastoma protein in carcinogenesis. |
2014-12-29 |
2023-08-13 |
Not clear |
| Diana Merino, David Malki. p53 and hereditary cancer. Sub-cellular biochemistry. vol 85. 2014-12-29. PMID:25201186. |
the roles of p53 as "guardian of the genome" are extensive, encompassing regulation of the cell cycle, dna repair, apoptosis, cellular metabolism, and senescence - ultimately steering cells through a balance of death and proliferation. |
2014-12-29 |
2023-08-13 |
mouse |
| Kazushi Inoue, Elizabeth A Fr. Alterations of p63 and p73 in human cancers. Sub-cellular biochemistry. vol 85. 2014-12-29. PMID:25201187. |
interestingly, several studies have shown that both p63 and p73 are involved in cellular response to cancer therapy and others have indicated that both of these molecules are required for p53-induced apoptosis, suggesting functional interplay among p53 family proteins. |
2014-12-29 |
2023-08-13 |
mouse |
| Rebecca A Frum, Steven R Grossma. Mechanisms of mutant p53 stabilization in cancer. Sub-cellular biochemistry. vol 85. 2014-12-29. PMID:25201195. |
p53 transactivates cell cycle inhibitory, apoptosis or senescence-related genes in response to dna damage to protect the genetic integrity of the cell. |
2014-12-29 |
2023-08-13 |
Not clear |
| Vijay Menon, Lawrence Povir. Involvement of p53 in the repair of DNA double strand breaks: multifaceted Roles of p53 in homologous recombination repair (HRR) and non-homologous end joining (NHEJ). Sub-cellular biochemistry. vol 85. 2014-12-29. PMID:25201202. |
through this discussion, we will try to establish that p53 acts as an important linchpin between upstream dna damage signaling cues and downstream cellular events that include repair, recombination, and apoptosis. |
2014-12-29 |
2023-08-13 |
Not clear |
| Venkat Sundar Gadepalli, Swati Palit Deb, Sumitra Deb, Raj R Ra. Lung cancer stem cells, p53 mutations and MDM2. Sub-cellular biochemistry. vol 85. 2014-12-29. PMID:25201204. |
in humans, about 50 % or more cancers have a mutated tumor suppressor p53 gene thereby resulting in accumulation of p53 protein and losing its function to activate the target genes that regulate cell cycle and apoptosis. |
2014-12-29 |
2023-08-13 |
Not clear |
| Hoda M EI-Emshaty, Entsar A Saad, Elshahat A Toson, Camelia A Abdel Malak, Nabil A Gadelha. Apoptosis and cell proliferation: correlation with BCL-2 and P53 oncoprotein expression in human hepatocellular carcinoma. Hepato-gastroenterology. vol 61. issue 133. 2014-12-29. PMID:25436317. |
apoptosis and cell proliferation: correlation with bcl-2 and p53 oncoprotein expression in human hepatocellular carcinoma. |
2014-12-29 |
2023-08-13 |
human |
| Hoda M EI-Emshaty, Entsar A Saad, Elshahat A Toson, Camelia A Abdel Malak, Nabil A Gadelha. Apoptosis and cell proliferation: correlation with BCL-2 and P53 oncoprotein expression in human hepatocellular carcinoma. Hepato-gastroenterology. vol 61. issue 133. 2014-12-29. PMID:25436317. |
the present study was suggested to evaluate the correlation between p53 and bcl-2 oncoprotein expression with apoptosis and cell proliferative activity in hcc patients. |
2014-12-29 |
2023-08-13 |
human |
| Yubin Luo, Zhifeng Wei, Guixin Chou, Zhengtao Wang, Yufeng Xia, Yue Da. Norisoboldine induces apoptosis of fibroblast-like synoviocytes from adjuvant-induced arthritis rats. International immunopharmacology. vol 20. issue 1. 2014-12-28. PMID:24613208. |
additionally, the expression of p53 protein was up-regulated by nor, and pretreatment with pft-α, a p53 specific inhibitor, reversed the increase in fls apoptosis caused by nor. |
2014-12-28 |
2023-08-12 |
rat |
| Yubin Luo, Zhifeng Wei, Guixin Chou, Zhengtao Wang, Yufeng Xia, Yue Da. Norisoboldine induces apoptosis of fibroblast-like synoviocytes from adjuvant-induced arthritis rats. International immunopharmacology. vol 20. issue 1. 2014-12-28. PMID:24613208. |
these findings indicated that nor-induced apoptosis in aia fls is achieved via a mitochondrial-dependent pathway, which may be mediated by promoting the release of cytochrome c and by regulating the expression of bax and bcl-2 proteins, and p53 might also be required for nor-induced apoptosis in aia fls. |
2014-12-28 |
2023-08-12 |
rat |
| H M Hassan, B J Dave, R K Sing. TP73, an under-appreciated player in non-Hodgkin lymphoma pathogenesis and management. Current molecular medicine. vol 14. issue 4. 2014-12-28. PMID:24730526. |
the transcriptionally active isoforms of p73 are capable of inducing apoptosis in cancer cells independent of p53 status. |
2014-12-28 |
2023-08-13 |
Not clear |
| Xiao-Peng Zhang, Feng Liu, Wei Wan. Interplay between Mdm2 and HIPK2 in the DNA damage response. Journal of the Royal Society, Interface. vol 11. issue 96. 2014-12-28. PMID:24829283. |
the tumour suppressor p53 is activated to induce cell-cycle arrest or apoptosis in the dna damage response (ddr). |
2014-12-28 |
2023-08-13 |
Not clear |
| Xiao-Peng Zhang, Feng Liu, Wei Wan. Interplay between Mdm2 and HIPK2 in the DNA damage response. Journal of the Royal Society, Interface. vol 11. issue 96. 2014-12-28. PMID:24829283. |
p53 phosphorylation at ser46 by hipk2 (homeodomain-interacting protein kinase 2) is a critical event in apoptosis induction. |
2014-12-28 |
2023-08-13 |
Not clear |
| Xiao-Peng Zhang, Feng Liu, Wei Wan. Interplay between Mdm2 and HIPK2 in the DNA damage response. Journal of the Royal Society, Interface. vol 11. issue 96. 2014-12-28. PMID:24829283. |
meanwhile, the concentration of p53 switches from moderate to high levels, contributing to apoptosis induction. |
2014-12-28 |
2023-08-13 |
Not clear |
| Christopher J Brown, Soo T Quah, Janice Jong, Amanda M Goh, Poh C Chiam, Kian H Khoo, Meng L Choong, May A Lee, Larisa Yurlova, Kourosh Zolghadr, Thomas L Joseph, Chandra S Verma, David P Lan. Stapled peptides with improved potency and specificity that activate p53. ACS chemical biology. vol 8. issue 3. 2014-12-24. PMID:23214419. |
unlike nutlin, a small molecule inhibitor of mdm2/mdm4, the phage derived compounds can arrest cells resistant to p53 induced apoptosis over a wide concentration range without cellular toxicity, suggesting they are highly suitable for cyclotherapy. |
2014-12-24 |
2023-08-12 |
Not clear |
| Gengze Wu, Jin Cai, Yu Han, Jinghai Chen, Zhan-Peng Huang, Caiyu Chen, Yue Cai, Hefei Huang, Yujia Yang, Yukai Liu, Zaicheng Xu, Duofen He, Xiaoqun Zhang, Xiaoyun Hu, Luca Pinello, Dan Zhong, Fengtian He, Guo-Cheng Yuan, Da-Zhi Wang, Chunyu Zen. LincRNA-p21 regulates neointima formation, vascular smooth muscle cell proliferation, apoptosis, and atherosclerosis by enhancing p53 activity. Circulation. vol 130. issue 17. 2014-12-23. PMID:25156994. |
lincrna-p21 regulates neointima formation, vascular smooth muscle cell proliferation, apoptosis, and atherosclerosis by enhancing p53 activity. |
2014-12-23 |
2023-08-13 |
Not clear |
| Dong-Hu Zhou, Xuemin Wang, Qing Fen. EGCG enhances the efficacy of cisplatin by downregulating hsa-miR-98-5p in NSCLC A549 cells. Nutrition and cancer. vol 66. issue 4. 2014-12-22. PMID:24712372. |
meanwhile, as a critical regulator in the cisplatin-induced apoptosis, p53 was elevated by silencing of hsa-mir-98-5p. |
2014-12-22 |
2023-08-13 |
Not clear |
| Suwakon Wongjaikam, Ratasak Summart, Teera Chewonari. Apoptosis induction in colon cancer cell lines and alteration of aberrant crypt foci in rat colon by purple rice (Oryza sativa L. var. glutinosa) extracts. Nutrition and cancer. vol 66. issue 4. 2014-12-22. PMID:24742104. |
however, hsf exhibited strong antiproliferation and apoptosis induction against colon cancer cell lines, both p53 wild-type (rko) and mutant (sw620) strains. |
2014-12-22 |
2023-08-13 |
rat |
| Shaomeng Wang, Wei Sun, Yujun Zhao, Donna McEachern, Isabelle Meaux, Cédric Barrière, Jeanne A Stuckey, Jennifer L Meagher, Longchuan Bai, Liu Liu, Cassandra Gianna Hoffman-Luca, Jianfeng Lu, Sanjeev Shangary, Shanghai Yu, Denzil Bernard, Angelo Aguilar, Odette Dos-Santos, Laurent Besret, Stéphane Guerif, Pascal Pannier, Dimitri Gorge-Bernat, Laurent Debussch. SAR405838: an optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression. Cancer research. vol 74. issue 20. 2014-12-22. PMID:25145672. |
sar405838 effectively activates wild-type p53 in vitro and in xenograft tumor tissue of leukemia and solid tumors, leading to p53-dependent cell-cycle arrest and/or apoptosis. |
2014-12-22 |
2023-08-13 |
mouse |