| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li Yuan, Shuping Wei, Jing Wang, Xuebo Li. Isoorientin induces apoptosis and autophagy simultaneously by reactive oxygen species (ROS)-related p53, PI3K/Akt, JNK, and p38 signaling pathways in HepG2 cancer cells. Journal of agricultural and food chemistry. vol 62. issue 23. 2015-01-21. PMID:24841907. |
furthermore, iso-induced apoptosis by activating the fas receptor-mediated apoptotic pathway and suppressing the p53 and pi3k/akt-dependent nf-κb signaling pathway, with the subsequent increase in the release of cytochrome c, caspase-3 activation, and parp cleavage. |
2015-01-21 |
2023-08-13 |
human |
| Nana Pei, Feilong Jie, Jie Luo, Renqiang Wan, Yanling Zhang, Xinglu Chen, Zhibing Liang, Hongyan Du, Andrew Li, Baihong Chen, Yi Zhang, Colin Sumners, Jinlong Li, Weiwang Gu, Hongwei L. Gene expression profiling associated with angiotensin II type 2 receptor-induced apoptosis in human prostate cancer cells. PloS one. vol 9. issue 3. 2015-01-20. PMID:24658029. |
we also found that the effects on at2r-mediated apoptosis caused by downregulation of gadd45a, trail-r2 and hrk were independent in activation of p38 mapk, p44/42 mapk and p53. |
2015-01-20 |
2023-08-12 |
human |
| Matthias Wirth, Natasa Stojanovic, Jan Christian, Mariel C Paul, Roland H Stauber, Roland M Schmid, Georg Häcker, Oliver H Krämer, Dieter Saur, Günter Schneide. MYC and EGR1 synergize to trigger tumor cell death by controlling NOXA and BIM transcription upon treatment with the proteasome inhibitor bortezomib. Nucleic acids research. vol 42. issue 16. 2015-01-20. PMID:25147211. |
we provide evidence that in our apoptosis models cell death occurs independently of p53 or arf. |
2015-01-20 |
2023-08-13 |
Not clear |
| Zhihao Liu, Huiling Liu, Jie Jiang, Siwei Tan, Yidong Yang, Yashi Zhan, Bin W. PDGF-BB and bFGF ameliorate radiation-induced intestinal progenitor/stem cell apoptosis via Akt/p53 signaling in mice. American journal of physiology. Gastrointestinal and liver physiology. vol 307. issue 11. 2015-01-20. PMID:25301184. |
treatment with platelet-derived growth factor (pdgf-bb) or bfgf activated akt phosphorylation in the intestinal crypt, lessened intestinal crypt p53 expression, decreased radiation-induced apoptosis in mouse intestinal progenitor/stem cell marker leucine-rich repeat-containing g protein-coupled receptor 5 (lgr5)-positive cells by an average of 50%, and increased the survival rate of mice with abdominal radiation by 3 days in average. |
2015-01-20 |
2023-08-13 |
mouse |
| Zhihao Liu, Huiling Liu, Jie Jiang, Siwei Tan, Yidong Yang, Yashi Zhan, Bin W. PDGF-BB and bFGF ameliorate radiation-induced intestinal progenitor/stem cell apoptosis via Akt/p53 signaling in mice. American journal of physiology. Gastrointestinal and liver physiology. vol 307. issue 11. 2015-01-20. PMID:25301184. |
consistently, pdgf-bb and bfgf both upregulated akt activation, suppressed radiation-induced p53 expression, and abrogated radiation-induced apoptosis in iec-6 cells, although p53 overexpression in iec-6 cells partially counteracted the radioprotection of pdgf-bb and bfgf. |
2015-01-20 |
2023-08-13 |
mouse |
| Florentina Bocaneti, Gennaro Altamura, Annunziata Corteggio, Elena Velescu, Giuseppe Borzacchiell. Expression of bcl-2 and p53 in bovine cutaneous fibropapillomas. Infectious agents and cancer. vol 10. issue 1. 2015-01-20. PMID:25601891. |
in contrary, p53 is a tumour suppressor protein that mediates cell cycle arrest, apoptosis and senescence in response to cellular stresses. |
2015-01-20 |
2023-08-13 |
cattle |
| Kuei-Chuan Chan, Hsieh-Hsun Ho, Ming-Cheng Lin, Cheng-Hsun Wu, Chien-Ning Huang, Wen-Chun Chang, Chau-Jong Wan. Mulberry water extracts inhibit rabbit atherosclerosis through stimulation of vascular smooth muscle cell apoptosis via activating p53 and regulating both intrinsic and extrinsic pathways. Journal of agricultural and food chemistry. vol 62. issue 22. 2015-01-19. PMID:24833292. |
mulberry water extracts inhibit rabbit atherosclerosis through stimulation of vascular smooth muscle cell apoptosis via activating p53 and regulating both intrinsic and extrinsic pathways. |
2015-01-19 |
2023-08-13 |
rabbit |
| Kuei-Chuan Chan, Hsieh-Hsun Ho, Ming-Cheng Lin, Cheng-Hsun Wu, Chien-Ning Huang, Wen-Chun Chang, Chau-Jong Wan. Mulberry water extracts inhibit rabbit atherosclerosis through stimulation of vascular smooth muscle cell apoptosis via activating p53 and regulating both intrinsic and extrinsic pathways. Journal of agricultural and food chemistry. vol 62. issue 22. 2015-01-19. PMID:24833292. |
we also found that mwes initially activate jnk/p38 and p53, which in turn activate both fas-ligand and mitochondria pathways, thereby causing mitochondria translocation of bax and the reduction of bcl-2 that trigger the cleavage of procaspases, finally resulting in apoptosis of vsmcs. |
2015-01-19 |
2023-08-13 |
rabbit |
| Dong Yu, Zi-Wei Zhang, Hai-Dong Yao, Shu Li, Shi-Wen X. Antioxidative role of selenoprotein W in oxidant-induced chicken splenic lymphocyte death. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. vol 27. issue 2. 2015-01-16. PMID:24515840. |
the lymphocytes were examined for cell viability, cell apoptosis and mrna expression levels of selw and apoptosis-related genes (bcl-2, bax, bak-1, caspase-3 and p53). |
2015-01-16 |
2023-08-12 |
chicken |
| Lin Zhao, Yanlin Li, Miao He, Zhiguo Song, Shu Lin, Zhaojin Yu, Xuefeng Bai, Enhua Wang, Minjie We. The Fanconi anemia pathway sensitizes to DNA alkylating agents by inducing JNK-p53-dependent mitochondrial apoptosis in breast cancer cells. International journal of oncology. vol 45. issue 1. 2015-01-15. PMID:24789349. |
furthermore, p53 inhibition using pifithrin-α abolished the induction of caspase-3 and parp by fancf shrna and mmc, indicating that mmc-induced apoptosis is substantially enhanced by fancf shrna via p53-dependent mechanisms. |
2015-01-15 |
2023-08-13 |
Not clear |
| Jingjing Wu, Qin Tang, Shunyu Zhao, Fang Zheng, Yan Wu, Ge Tang, Swei Sunny Hah. Extracellular signal-regulated kinase signaling-mediated induction and interaction of FOXO3a and p53 contribute to the inhibition of nasopharyngeal carcinoma cell growth by curcumin. International journal of oncology. vol 45. issue 1. 2015-01-15. PMID:24806432. |
together, our studies show that curcumin inhibits growth and induces apoptosis of npc cells through erk1/2-mediated increase in the protein expression and interaction of p53 and foxo3a. |
2015-01-15 |
2023-08-13 |
human |
| Barbara Dziegielewska, David L Brautigan, James M Larner, Jaroslaw Dziegielewsk. T-type Ca2+ channel inhibition induces p53-dependent cell growth arrest and apoptosis through activation of p38-MAPK in colon cancer cells. Molecular cancer research : MCR. vol 12. issue 3. 2015-01-14. PMID:24362252. |
selective t-type ca(2+) channel antagonists caused growth inhibition and apoptosis more effectively in hct116 cells expressing wild-type p53 (p53wt), than in hct116 mutant p53(-/-) cells. |
2015-01-14 |
2023-08-12 |
Not clear |
| Zhaoshi Bao, Ying Feng, Hongjun Wang, Chuanbao Zhang, Lihua Sun, Zhuohong Yan, Qingyang Liu, Tianzhu Guo, Mingyang Li, Xue Yang, Chuanlu Jiang, Quangeng Zhang, Tao Jian. Integrated analysis using methylation and gene expression microarrays reveals PDE4C as a prognostic biomarker in human glioma. Oncology reports. vol 32. issue 1. 2015-01-14. PMID:24842301. |
on the basis of these observations and the results from subset analysis, it is reasonable to conclude that pde4c may function as a tumor suppressor by promoting apoptosis through the wt p53 pathway and inhibiting cell migration. |
2015-01-14 |
2023-08-13 |
human |
| Michele Carrett-Dias, Ana Paula de Souza Votto, Daza de Moraes Vaz Batista Filgueira, Daniela Volcan Almeida, Adriana Lima Vallochi, Marcelo Gonçalves Montes D'Oca, Luis Fernando Marins, Gilma Santos Trindad. Anti-MDR and antitumoral action of acetylsalicylic acid on leukaemic cells. Bioscience reports. vol 31. issue 5. 2015-01-13. PMID:21361874. |
the mechanism of action of different concentrations of asa were compared in k562 (non-mdr) and lucena (mdr) cells by analysing cell viability, apoptosis and necrosis, intracellular ros (reactive oxygen species) formation and bcl-2, p53 and cox-2 gene expression. |
2015-01-13 |
2023-08-12 |
Not clear |
| Cristhian Toruno, Seth Carbonneau, Rodney A Stewart, Cicely Jett. Interdependence of Bad and Puma during ionizing-radiation-induced apoptosis. PloS one. vol 9. issue 2. 2015-01-13. PMID:24516599. |
proliferating zebrafish embryonic neurons are highly sensitive to ir-induced apoptosis, and both p53 and its transcriptional target puma are essential mediators of the response. |
2015-01-13 |
2023-08-12 |
mouse |
| Min Yao, Jingbo Yang, Lanqing Cao, Lian Zhang, Shanshan Qu, Hongwen Ga. Saikosaponin‑d inhibits proliferation of DU145 human prostate cancer cells by inducing apoptosis and arresting the cell cycle at G0/G1 phase. Molecular medicine reports. vol 10. issue 1. 2015-01-13. PMID:24736800. |
further mechanistic experiments demonstrated that ssd arrested the cell cycle at g0/g1 phase via upregulation of p53 and p21 and induced apoptosis by modulating b‑cell lymphoma 2 family proteins, dissipation of the mitochondrial membrane potential, release of cytochrome c into the cytosol and activation of caspase‑3. |
2015-01-13 |
2023-08-13 |
human |
| Jun-Bo Tu, Quan-Yan Li, Fei Jiang, Xiao-Yi Hu, Rui-Zhao Ma, Qiang Dong, Hao Zhang, Parukjan Pattar, Shi-Xian L. Pingyangmycin stimulates apoptosis in human hemangioma-derived endothelial cells through activation of the p53 pathway. Molecular medicine reports. vol 10. issue 1. 2015-01-13. PMID:24789513. |
pingyangmycin stimulates apoptosis in human hemangioma-derived endothelial cells through activation of the p53 pathway. |
2015-01-13 |
2023-08-13 |
human |
| Jun-Bo Tu, Quan-Yan Li, Fei Jiang, Xiao-Yi Hu, Rui-Zhao Ma, Qiang Dong, Hao Zhang, Parukjan Pattar, Shi-Xian L. Pingyangmycin stimulates apoptosis in human hemangioma-derived endothelial cells through activation of the p53 pathway. Molecular medicine reports. vol 10. issue 1. 2015-01-13. PMID:24789513. |
quantitative polymerase chain reaction confirmed that pingyangmycin significantly upregulated the expression of p53, p53‑induced protein with death domain, bax, p53 upregulated modulator of apoptosis and p53 inducible gene 3, and downregulated the expression of murine double minute 2. |
2015-01-13 |
2023-08-13 |
human |
| Masashi Idogawa, Tomoko Ohashi, Yasushi Sasaki, Reo Maruyama, Lisa Kashima, Hiromu Suzuki, Takashi Tokin. Identification and analysis of large intergenic non-coding RNAs regulated by p53 family members through a genome-wide analysis of p53-binding sites. Human molecular genetics. vol 23. issue 11. 2015-01-12. PMID:24403050. |
p53 family members execute various functions, such as apoptosis induction and cell cycle arrest, by modulating transcriptional regulation. |
2015-01-12 |
2023-08-12 |
human |
| Bei Wang, Jianli Li, Zhanying Ye, Zhe Li, Xiaohua W. N-myc downstream regulated gene 1 acts as a tumor suppressor in ovarian cancer. Oncology reports. vol 31. issue 5. 2015-01-12. PMID:24626771. |
in accordance with these data, we found that ndrg1 overexpression decreased proliferation, adhesion and apoptosis, and induced g0/g1 cell cycle arrest in ovcar3 cells; expression of p21 and p53 was also increased. |
2015-01-12 |
2023-08-12 |
mouse |