| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hong Wang, Qiong Wu, Shuang Li, Bin Zhang, Zuofei Chi, Liangchun Ha. Unc5D regulates p53-dependent apoptosis in neuroblastoma cells. Molecular medicine reports. vol 9. issue 6. 2015-01-05. PMID:24691657. |
unc5d is thus a newly identified transcriptional target of pro‑apoptotic p53 and may also act upstream of p53 to induce p53‑dependent apoptosis by phosphorylation at ser‑15. |
2015-01-05 |
2023-08-13 |
human |
| Bu-Shan Xie, Xing-Xing He, Zheng-Lin Ai, Shu-Kun Ya. Involvement of β-catenin in matrine-induced autophagy and apoptosis in WB-F344 cells. Molecular medicine reports. vol 9. issue 6. 2015-01-05. PMID:24718323. |
these results demonstrate that β-catenin is involved in matrine-induced autophagy and apoptosis in wb-f344 cells, while β-catenin is negatively regulated by autophagy and positively by p53, indicating that β-catenin may be involved in the crosstalk between autophagy and apoptosis in wb-f344 cells. |
2015-01-05 |
2023-08-13 |
rat |
| Yuying Li, Shizhao Duan, Haiyan Jia, Chongzhi Bai, Liwei Zhang, Zhuanhua Wan. Flavonoids from tartary buckwheat induce G2/M cell cycle arrest and apoptosis in human hepatoma HepG2 cells. Acta biochimica et biophysica Sinica. vol 46. issue 6. 2015-01-05. PMID:24760952. |
quercetin-induced cell apoptosis was shown to involve p53 and p21 up-regulation, cyclin d1, cdk2, and cdk7 down-regulation. |
2015-01-05 |
2023-08-13 |
human |
| Yuying Li, Shizhao Duan, Haiyan Jia, Chongzhi Bai, Liwei Zhang, Zhuanhua Wan. Flavonoids from tartary buckwheat induce G2/M cell cycle arrest and apoptosis in human hepatoma HepG2 cells. Acta biochimica et biophysica Sinica. vol 46. issue 6. 2015-01-05. PMID:24760952. |
these results suggested that the induction of g2/m arrest, apoptosis, and cell death by quercetin may associate with increased expression of p53 and p21, decrease of cyclin d1, cdk2, and cdk7 levels, and generation of reactive oxygen species in cells. |
2015-01-05 |
2023-08-13 |
human |
| Yuki Kagoya, Akihide Yoshimi, Takako Tsuruta-Kishino, Shunya Arai, Takashi Satoh, Shizuo Akira, Mineo Kurokaw. JAK2V617F+ myeloproliferative neoplasm clones evoke paracrine DNA damage to adjacent normal cells through secretion of lipocalin-2. Blood. vol 124. issue 19. 2015-01-05. PMID:25217696. |
normal hematopoietic cells showed elevated ros levels through increased intracellular iron levels when treated with lipocalin-2, which led to p53 pathway activation, increased apoptosis, and decreased cellular proliferation. |
2015-01-05 |
2023-08-13 |
Not clear |
| Jing Sun, Kyle Knickelbein, Kan He, Dongshi Chen, Crissy Dudgeon, Yongqian Shu, Jian Yu, Lin Zhan. Aurora kinase inhibition induces PUMA via NF-κB to kill colon cancer cells. Molecular cancer therapeutics. vol 13. issue 5. 2015-01-02. PMID:24563542. |
in this study, we found that inhibition of aurora kinases by sirna or small-molecule inhibitors led to induction of p53 upregulated modulator of apoptosis (puma), a bh3-only bcl-2 family protein, in colorectal cancer cells irrespective of p53 status. |
2015-01-02 |
2023-08-12 |
Not clear |
| Xiaolei Ye, Changsong Zhang, Yichen Chen, Tianbao Zho. Upregulation of Acetylcholinesterase Mediated by p53 Contributes to Cisplatin-Induced Apoptosis in Human Breast Cancer Cell. Journal of Cancer. vol 6. issue 1. 2015-01-01. PMID:25553088. |
upregulation of acetylcholinesterase mediated by p53 contributes to cisplatin-induced apoptosis in human breast cancer cell. |
2015-01-01 |
2023-08-13 |
human |
| Esther Diaz-Rodriguez, Angela R Garcia-Rendueles, Alejandro Ibáñez-Costa, Ester Gutierrez-Pascual, Montserrat Garcia-Lavandeira, Alfonso Leal, Miguel A Japon, Alfonso Soto, Eva Venegas, Francisco J Tinahones, Juan A Garcia-Arnes, Pedro Benito, Maria Angeles Galvez, Luis Jimenez-Reina, Ignacio Bernabeu, Carlos Dieguez, Raul M Luque, Justo P Castaño, Clara V Alvare. Somatotropinomas, but not nonfunctioning pituitary adenomas, maintain a functional apoptotic RET/Pit1/ARF/p53 pathway that is blocked by excess GDNF. Endocrinology. vol 155. issue 11. 2014-12-31. PMID:25137025. |
apoptosis was accompanied by ret processing, pit1 accumulation, and p14arf and p53 induction. |
2014-12-31 |
2023-08-13 |
mouse |
| Francesca Forini, Claudia Kusmic, Giuseppina Nicolini, Laura Mariani, Riccardo Zucchi, Marco Matteucci, Giorgio Iervasi, Letizia Pitt. Triiodothyronine prevents cardiac ischemia/reperfusion mitochondrial impairment and cell loss by regulating miR30a/p53 axis. Endocrinology. vol 155. issue 11. 2014-12-31. PMID:25137026. |
the concomitant decrease in p53 protein content reduces bax expression and limits mitochondrial membrane depolarization resulting in preserved mitochondrial function and decreased apoptosis and necrosis extent in the aar. |
2014-12-31 |
2023-08-13 |
rat |
| Lei Li, Ya-Chao Yao, Shu-Huan Fang, Cai-Qi Ma, Yi Cen, Zu-Min Xu, Zhi-Yu Dai, Cen Li, Shuai Li, Ting Zhang, Hong-Hai Hong, Wei-Wei Qi, Ti Zhou, Chao-Yang Li, Xia Yang, Guo-Quan Ga. Pigment epithelial-derived factor (PEDF)-triggered lung cancer cell apoptosis relies on p53 protein-driven Fas ligand (Fas-L) up-regulation and Fas protein cell surface translocation. The Journal of biological chemistry. vol 289. issue 44. 2014-12-31. PMID:25225287. |
pigment epithelial-derived factor (pedf)-triggered lung cancer cell apoptosis relies on p53 protein-driven fas ligand (fas-l) up-regulation and fas protein cell surface translocation. |
2014-12-31 |
2023-08-13 |
human |
| Houria Boulaiz, Pablo J Alvarez, Jose Prados, Juan Marchal, Consolación Melguizo, Esmeralda Carrillo, Macarena Peran, Fernando Rodríguez, Alberto Ramírez, Raúl Ortíz, Antonia Aráneg. gef gene expression in MCF-7 breast cancer cells is associated with a better prognosis and induction of apoptosis by p53-mediated signaling pathway. International journal of molecular sciences. vol 12. issue 11. 2014-12-30. PMID:22174609. |
it also increased p53 expression, suggesting that gef-induced apoptosis is regulated by a p53-mediated signaling pathway. |
2014-12-30 |
2023-08-12 |
human |
| Takuji Tanaka, Masashi Hosokawa, Yumiko Yasui, Rikako Ishigamori, Kazuo Miyashit. Cancer chemopreventive ability of conjugated linolenic acids. International journal of molecular sciences. vol 12. issue 11. 2014-12-30. PMID:22174613. |
cln are able to induce apoptosis through decrease of bcl-2 protein in certain human cancer cell lines, increase expression of peroxisome proliferator-activated receptor (ppar)-γ, and up-regulate gene expression of p53. |
2014-12-30 |
2023-08-12 |
human |
| Takuji Tanaka, Masashi Hosokawa, Yumiko Yasui, Rikako Ishigamori, Kazuo Miyashit. Cancer chemopreventive ability of conjugated linolenic acids. International journal of molecular sciences. vol 12. issue 11. 2014-12-30. PMID:22174613. |
findings in our preclinical animal studies have indicated that feeding with cln resulted in inhibition of colorectal tumorigenesis through modulation of apoptosis and expression of pparγ and p53. |
2014-12-30 |
2023-08-12 |
human |
| T J Phesse, K B Myant, A M Cole, R A Ridgway, H Pearson, V Muncan, G R van den Brink, K H Vousden, R Sears, L T Vassilev, A R Clarke, O J Sanso. Endogenous c-Myc is essential for p53-induced apoptosis in response to DNA damage in vivo. Cell death and differentiation. vol 21. issue 6. 2014-12-30. PMID:24583641. |
remarkably, c-myc deletion completely abrogated the immediate wave of apoptosis following both ionizing irradiation and cisplatin treatment, recapitulating the phenotype of p53 deficiency in the intestine. |
2014-12-30 |
2023-08-12 |
mouse |
| T J Phesse, K B Myant, A M Cole, R A Ridgway, H Pearson, V Muncan, G R van den Brink, K H Vousden, R Sears, L T Vassilev, A R Clarke, O J Sanso. Endogenous c-Myc is essential for p53-induced apoptosis in response to DNA damage in vivo. Cell death and differentiation. vol 21. issue 6. 2014-12-30. PMID:24583641. |
together, we have elucidated for the first time in vivo an essential role for endogenous c-myc in signalling dna damage-induced apoptosis through the control of the p53 tumour suppressor protein. |
2014-12-30 |
2023-08-12 |
mouse |
| Eleonora Da Pozzo, Valeria La Pietra, Barbara Cosimelli, Federico Da Settimo, Chiara Giacomelli, Luciana Marinelli, Claudia Martini, Ettore Novellino, Sabrina Taliani, Giovanni Grec. p53 functional inhibitors behaving like pifithrin-β counteract the Alzheimer peptide non-β-amyloid component effects in human SH-SY5Y cells. ACS chemical neuroscience. vol 5. issue 5. 2014-12-30. PMID:24646317. |
for the first time, the increase in the level of p53 target gene transcription, the cell cycle arrest, and the induction of apoptosis elicited by nac were evidenced. |
2014-12-30 |
2023-08-12 |
human |
| Ming Chen, Mengye He, Yinjing Song, Luoquan Chen, Peng Xiao, Xiaopeng Wan, Feng Dai, Peng She. The cytoprotective role of gemcitabine-induced autophagy associated with apoptosis inhibition in triple-negative MDA-MB-231 breast cancer cells. International journal of molecular medicine. vol 34. issue 1. 2014-12-30. PMID:24804820. |
furthermore, as shown by our results, the inhibition of gemcitabine-induced autophagy by chloroquine shifts the expression of the p53 protein, bcl-2 family proteins and the relative bax/bcl-xl ratio in favor of promoting apoptosis. |
2014-12-30 |
2023-08-13 |
human |
| Tae-Wook Chung, Hee-Jung Choi, Seok-Jo Kim, Choong-Hwan Kwak, Kwon-Ho Song, Un-Ho Jin, Young-Chae Chang, Hyeun Wook Chang, Young-Choon Lee, Ki-Tae Ha, Cheorl-Ho Ki. The ganglioside GM3 is associated with cisplatin-induced apoptosis in human colon cancer cells. PloS one. vol 9. issue 5. 2014-12-30. PMID:24829158. |
cddp induced apoptosis within cells through the generation of reactive oxygen species (ros), regulated the ros-mediated expression of bax, bcl-2, and p53, and induced the degradation of the poly (adp-ribosyl) polymerase (parp). |
2014-12-30 |
2023-08-13 |
human |
| Sara M Reed, Dawn E Quell. p53 Acetylation: Regulation and Consequences. Cancers. vol 7. issue 1. 2014-12-30. PMID:25545885. |
yet recent in vivo evidence from mouse models questions the importance of p53 acetylation (at least at certain sites) as well as canonical p53 functions (cell cycle arrest, senescence and apoptosis) to tumor suppression. |
2014-12-30 |
2023-08-13 |
mouse |
| Yan-Hong Zhen, Li Wang, Hasan Riaz, Jia-Bin Wu, Yi-Feng Yuan, Li Han, Yan-Ling Wang, Yi Zhao, Yi Dan, Li-Jun Hu. Knockdown of CEBPβ by RNAi in porcine granulosa cells resulted in S phase cell cycle arrest and decreased progesterone and estradiol synthesis. The Journal of steroid biochemistry and molecular biology. vol 143. 2014-12-29. PMID:24607812. |
to uncover the regulatory mechanism of cebpβ knockdown on cell cycle and steroids synthesis, we found that the mrna expression of bcl-2 (anti-apoptosis), star and runx2 (steroid hormone synthesis) was up-regulated, while genes related to apoptosis (caspase-3 and p53), hormonal synthesis (cyp11a1) and cell cycle (cyclina1, cyclinb1, cyclind1) were down-regulated, suggesting that knockdown of cebpβ may inhibit apoptosis, regulate cell cycle and hormone secretions at the transcriptional level in porcine gcs. |
2014-12-29 |
2023-08-12 |
mouse |