| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Samik Chakraborty, Kaushik Das, Shilpi Saha, Minakshi Mazumdar, Argha Manna, Sreeparna Chakraborty, Shravanti Mukherjee, Poulami Khan, Arghya Adhikary, Suchismita Mohanty, Samit Chattopadhyay, Subhash C Biswas, Gaurisankar Sa, Tanya Da. Nuclear matrix protein SMAR1 represses c-Fos-mediated HPV18 E6 transcription through alteration of chromatin histone deacetylation. The Journal of biological chemistry. vol 289. issue 42. 2014-12-22. PMID:25157104. |
tip60, in turn, acetylates p53, thereby restoring p53-mediated transactivation of proapoptotic genes to ensure apoptosis. |
2014-12-22 |
2023-08-13 |
Not clear |
| Zi-Hui Liu, Ming-Hui Wang, Hong-Jiu Ren, Wei Qu, Li-Mei Sun, Qing-Fu Zhang, Xue-Shan Qiu, En-Hua Wan. Interleukin 7 signaling prevents apoptosis by regulating bcl-2 and bax via the p53 pathway in human non-small cell lung cancer cells. International journal of clinical and experimental pathology. vol 7. issue 3. 2014-12-19. PMID:24695377. |
interleukin 7 signaling prevents apoptosis by regulating bcl-2 and bax via the p53 pathway in human non-small cell lung cancer cells. |
2014-12-19 |
2023-08-13 |
human |
| Zi-Hui Liu, Ming-Hui Wang, Hong-Jiu Ren, Wei Qu, Li-Mei Sun, Qing-Fu Zhang, Xue-Shan Qiu, En-Hua Wan. Interleukin 7 signaling prevents apoptosis by regulating bcl-2 and bax via the p53 pathway in human non-small cell lung cancer cells. International journal of clinical and experimental pathology. vol 7. issue 3. 2014-12-19. PMID:24695377. |
furthermore, the inhibition of p53 significantly abolished the effects of il-7/il-7r on lung cancer cell apoptosis. |
2014-12-19 |
2023-08-13 |
human |
| Zi-Hui Liu, Ming-Hui Wang, Hong-Jiu Ren, Wei Qu, Li-Mei Sun, Qing-Fu Zhang, Xue-Shan Qiu, En-Hua Wan. Interleukin 7 signaling prevents apoptosis by regulating bcl-2 and bax via the p53 pathway in human non-small cell lung cancer cells. International journal of clinical and experimental pathology. vol 7. issue 3. 2014-12-19. PMID:24695377. |
these results strongly suggest that il-7/il-7r prevents apoptosis by upregulating the expression of bcl-2 and by downregulating the expression of bax, potentially via the p53 pathway in a549 and hbe cells. |
2014-12-19 |
2023-08-13 |
human |
| Kejun Zhang, Dong Chen, Xingang Wang, Shaoyan Zhang, Jigang Wang, Yuan Gao, Bomin Ya. RNA interference targeting slug increases cholangiocarcinoma cell sensitivity to cisplatin via upregulating PUMA. International journal of molecular sciences. vol 12. issue 1. 2014-12-18. PMID:21339993. |
slug is an e-cadherin repressor and a suppressor of puma (p53 upregulated modulator of apoptosis) and it has recently been demonstrated that slug plays an important role in controlling apoptosis. |
2014-12-18 |
2023-08-12 |
mouse |
| Kuan-Han Lee, Wen-Yueh Ho, Shu-Jing Wu, Hany A Omar, Po-Jui Huang, Clay C C Wang, Jui-Hsiang Hun. Modulation of cyclins, p53 and mitogen-activated protein kinases signaling in breast cancer cell lines by 4-(3,4,5-trimethoxyphenoxy)benzoic acid. International journal of molecular sciences. vol 15. issue 1. 2014-12-18. PMID:24406729. |
taken together, the current study underscores evidence that tmpba induces apoptosis in breast cancer cells via the modulation of cyclins and p53 expression as well as the modulation of ampk and mitogen-activated protein kinases (mapk) signaling. |
2014-12-18 |
2023-08-12 |
human |
| Zhaohu Lin, Chao Zhang, Meifang Zhang, Danqing Xu, Yanfen Fang, Zheng Zhou, Xiaolong Chen, Ning Qin, Xiongwen Zhan. Targeting cadherin-17 inactivates Ras/Raf/MEK/ERK signaling and inhibits cell proliferation in gastric cancer. PloS one. vol 9. issue 1. 2014-12-18. PMID:24465527. |
antibody array and western blotting assay demonstrated that knockdown of cdh17 in ags cells down-regulated integrin β series proteins, further inactivated the ras/raf/mek/erk pathway and led to p53 and p21 accumulation, which resulted in proliferation inhibition, cell-cycle arrest and apoptosis induction. |
2014-12-18 |
2023-08-12 |
mouse |
| b' J V\\xc3\\xa1vrov\\xc3\\xa1, M Rez\\xc3\\xa1\\xc4\\x8dov\\xc3\\xa. Importance of proapoptotic protein PUMA in cell radioresistance. Folia biologica. vol 60. issue 2. 2014-12-18. PMID:24785107.' |
protein p53 plays an essential role in the induction of apoptosis by ionizing radiation in haemopoietic cells, the damage of which is the main reason for the development of bone marrow post-irradiation syndrome. |
2014-12-18 |
2023-08-13 |
mouse |
| b' J V\\xc3\\xa1vrov\\xc3\\xa1, M Rez\\xc3\\xa1\\xc4\\x8dov\\xc3\\xa. Importance of proapoptotic protein PUMA in cell radioresistance. Folia biologica. vol 60. issue 2. 2014-12-18. PMID:24785107.' |
in proliferating cells, knockout of p53 inhibits apoptosis on the one hand, but on the other disables the cellular division arrest moderated by p21cip1/waf1. |
2014-12-18 |
2023-08-13 |
mouse |
| Guofang Zeng, Jie Liu, Hege Chen, Bin Liu, Qingyu Zhang, Mingyi Li, Runzhi Zh. Dihydromyricetin induces cell cycle arrest and apoptosis in melanoma SK-MEL-28 cells. Oncology reports. vol 31. issue 6. 2014-12-17. PMID:24789439. |
tunel assay was used to evaluate dhm-mediated apoptosis, and western blotting was applied to examine expression levels of p53, p21, cdc25a, cdc2, p-cdc2, bax, ikk-α, nf-κb p65, p38 and p-p38 proteins. |
2014-12-17 |
2023-08-13 |
human |
| Pinar Obakan, Elif Damla Arisan, Ajda Coker-Gurkan, Narcin Palavan-Unsa. Epibrassinolide-induced apoptosis regardless of p53 expression via activating polyamine catabolic machinery, a common target for androgen sensitive and insensitive prostate cancer cells. The Prostate. vol 74. issue 16. 2014-12-17. PMID:25214240. |
epibrassinolide-induced apoptosis regardless of p53 expression via activating polyamine catabolic machinery, a common target for androgen sensitive and insensitive prostate cancer cells. |
2014-12-17 |
2023-08-13 |
Not clear |
| JinYan Chen, MengRu Sun, XingHua Wang, Jing Lu, Yan Wei, Yan Tan, Ying Liu, Jürgen Götz, RongQiao He, Qian Hu. The herbal compound geniposide rescues formaldehyde-induced apoptosis in N2a neuroblastoma cells. Science China. Life sciences. vol 57. issue 4. 2014-12-16. PMID:24658849. |
fa-exposed murine n2a neuroblastoma cells were incubated with tljn, its main ingredient gp, as well as pns, to measure cell viability and morphology, the rate of apoptosis and expression of genes encoding akt, foxo3, bcl2 and p53. |
2014-12-16 |
2023-08-12 |
mouse |
| Michael C Cavalier, Adam D Pierce, Paul T Wilder, Milad J Alasady, Kira G Hartman, David B Neau, Timothy L Foley, Ajit Jadhav, David J Maloney, Anton Simeonov, Eric A Toth, David J Webe. Covalent small molecule inhibitors of Ca(2+)-bound S100B. Biochemistry. vol 53. issue 42. 2014-12-16. PMID:25268459. |
likewise, inhibiting s100b with small interfering rna (sirna(s100b)) is sufficient to restore wild-type p53 levels and its downstream gene products and induce the arrest of cell growth and uv-dependent apoptosis in malignant melanoma. |
2014-12-16 |
2023-08-13 |
Not clear |
| So Jin Bing, Min Ju Kim, Ginnae Ahn, Jaehak Im, Dae Seung Kim, Danbee Ha, Jinhee Cho, Areum Kim, Youngheun Je. Acidic polysaccharide of Panax ginseng regulates the mitochondria/caspase-dependent apoptotic pathway in radiation-induced damage to the jejunum in mice. Acta histochemica. vol 116. issue 3. 2014-12-15. PMID:24380494. |
therefore, apg attenuated the apoptosis through the intrinsic pathway, which is controlled by p53 and bcl-2 family members. |
2014-12-15 |
2023-08-12 |
mouse |
| Bey Hing Goh, Chim Kei Chan, Muhamad Noor Alfarizal Kamarudin, Habsah Abdul Kadi. Swietenia macrophylla King induces mitochondrial-mediated apoptosis through p53 upregulation in HCT116 colorectal carcinoma cells. Journal of ethnopharmacology. vol 153. issue 2. 2014-12-15. PMID:24613274. |
swietenia macrophylla king induces mitochondrial-mediated apoptosis through p53 upregulation in hct116 colorectal carcinoma cells. |
2014-12-15 |
2023-08-12 |
Not clear |
| Selvaraju Karthik, Renu Sankar, Krishnamoorthy Varunkumar, Vilwanathan Ravikuma. Romidepsin induces cell cycle arrest, apoptosis, histone hyperacetylation and reduces matrix metalloproteinases 2 and 9 expression in bortezomib sensitized non-small cell lung cancer cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 68. issue 3. 2014-12-12. PMID:24485799. |
in this study, we investigate whether combined treatment with romidepsin and bortezomib would induce apoptosis in a549 nsclc cells by activating cell cycle arrest, enhanced generation of p21 and p53, down-regulation of matrix metalloproteinases (mmps) 2,9 also altering the acetylation status of histone proteins. |
2014-12-12 |
2023-08-12 |
Not clear |
| Dong-Hwa Lee, Ji-Hyang Ha, Yul Kim, Mi Jang, Sung Jean Park, Ho Sup Yoon, Eun-Hee Kim, Kwang-Hee Bae, Byoung Chul Park, Sung Goo Park, Gwan-Su Yi, Seung-Wook Ch. A conserved mechanism for binding of p53 DNA-binding domain and anti-apoptotic Bcl-2 family proteins. Molecules and cells. vol 37. issue 3. 2014-12-12. PMID:24646834. |
taken altogether, our results revealed a structural basis for a conserved binding mechanism between p53dbd and the anti-apoptotic bcl-2 family proteins, which shed light on to the molecular understanding of the transcription-independent apoptosis pathway of p53. |
2014-12-12 |
2023-08-12 |
Not clear |
| Yu Guo, Ya-Ping Liao, Ding Zhang, Li-Sha Xu, Na Li, Wei-Jun Guan, Chang-Qing Li. In vitro study of nucleostemin as a potential therapeutic target in human breast carcinoma SKBR-3 cells. Asian Pacific journal of cancer prevention : APJCP. vol 15. issue 5. 2014-12-11. PMID:24716972. |
moreover, rnai-mediated ns down- regulation induced skbr-3 cell g1 phase arrest, inhibited cell proliferation, and promoted p53 pathway-mediated cell apoptosis in skbr-3 cells. |
2014-12-11 |
2023-08-13 |
human |
| Hui-Min Chen, Ding-Guo Zhang, Jin-Xia Wu, Dong-Sheng Pei, Jun-Nian Zhen. Ubiquitination of p53 is involved in troglitazone induced apoptosis in cervical cancer cells. Asian Pacific journal of cancer prevention : APJCP. vol 15. issue 5. 2014-12-11. PMID:24716976. |
ubiquitination of p53 is involved in troglitazone induced apoptosis in cervical cancer cells. |
2014-12-11 |
2023-08-13 |
Not clear |
| Hui-Min Chen, Ding-Guo Zhang, Jin-Xia Wu, Dong-Sheng Pei, Jun-Nian Zhen. Ubiquitination of p53 is involved in troglitazone induced apoptosis in cervical cancer cells. Asian Pacific journal of cancer prevention : APJCP. vol 15. issue 5. 2014-12-11. PMID:24716976. |
furthermore, we also detected the protein expression of p53, p21 and mdm2 to explain the underlying mechanism of ppar-γ on cellular apoptosis. |
2014-12-11 |
2023-08-13 |
Not clear |