| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xi Chen, Chunyan Liao, Qiqi Chu, Guixuan Zhou, Xiang Lin, Xiaobo Li, Haijie Lu, Benhua Xu, Zhicao Yu. Dissecting the molecular mechanism of ionizing radiation-induced tissue damage in the feather follicle. PloS one. vol 9. issue 2. 2015-01-27. PMID:24586618. |
molecular and cellular analysis revealed p53 activation, dna damage and repair, cell cycle arrest and apoptosis in the pathobiology. |
2015-01-27 |
2023-08-12 |
Not clear |
| Martina Magni, Vincenzo Ruscica, Giacomo Buscemi, Ja-Eun Kim, Benjamin Tamilselvan Nachimuthu, Enrico Fontanella, Domenico Delia, Laura Zannin. Chk2 and REGγ-dependent DBC1 regulation in DNA damage induced apoptosis. Nucleic acids research. vol 42. issue 21. 2015-01-27. PMID:25361978. |
upon dna damage, dbc1 is phosphorylated by atm/atr on thr454 and this modification increases its inhibitory interaction with sirt1, leading to p53 acetylation and p53-dependent apoptosis. |
2015-01-27 |
2023-08-13 |
human |
| Martina Magni, Vincenzo Ruscica, Giacomo Buscemi, Ja-Eun Kim, Benjamin Tamilselvan Nachimuthu, Enrico Fontanella, Domenico Delia, Laura Zannin. Chk2 and REGγ-dependent DBC1 regulation in DNA damage induced apoptosis. Nucleic acids research. vol 42. issue 21. 2015-01-27. PMID:25361978. |
indeed we found that inactivation of chk2 reduces dbc1-sirt1 binding, thus preventing p53 acetylation and dbc1-induced apoptosis. |
2015-01-27 |
2023-08-13 |
human |
| Li-li Liu, Jiu-li Zhang, Zi-wei Zhang, Hai-dong Yao, Gang Sun, Shi-wen X. Protective roles of selenium on nitric oxide-mediated apoptosis of immune organs induced by cadmium in chickens. Biological trace element research. vol 159. issue 1-3. 2015-01-26. PMID:24839000. |
then, the production of nitric oxide, messenger rna (mrna level), and the activity of inducible nitric oxide synthase, ultrastructural changes, tunel assay, and flow cytometric analysis of apoptosis and bcl-2 and p53 mrna levels in the immune organs were examined. |
2015-01-26 |
2023-08-13 |
chicken |
| Sun-Young Lee, Hyun Chul Choi, Yun-Jeong Choe, Seok Joon Shin, Sug Hyung Lee, Ho-Shik Ki. Nutlin-3 induces BCL2A1 expression by activating ELK1 through the mitochondrial p53-ROS-ERK1/2 pathway. International journal of oncology. vol 45. issue 2. 2015-01-26. PMID:24867259. |
nutlin-3 which occupies the p53 binding pocket in hdm2, has been reported to activate apoptosis through both the transcriptional activity-dependent and -independent programs of p53. |
2015-01-26 |
2023-08-13 |
Not clear |
| Sun-Young Lee, Hyun Chul Choi, Yun-Jeong Choe, Seok Joon Shin, Sug Hyung Lee, Ho-Shik Ki. Nutlin-3 induces BCL2A1 expression by activating ELK1 through the mitochondrial p53-ROS-ERK1/2 pathway. International journal of oncology. vol 45. issue 2. 2015-01-26. PMID:24867259. |
transcription-independent apoptosis by nutlin-3 is triggered by p53 which is translocated to mitochondria. |
2015-01-26 |
2023-08-13 |
Not clear |
| Vitaliy O Kaminskyy, Boris Zhivotovsk. Free radicals in cross talk between autophagy and apoptosis. Antioxidants & redox signaling. vol 21. issue 1. 2015-01-23. PMID:24359220. |
although high levels of ros/rns mainly causes cell death, low levels of free radicals directly modulate the activities of transcriptional factors, nuclear factor kappa-light-chain-enhancer of activated b cells (nf-κb), p53, and nuclear factor (erythroid-derived) 2-like (nrf2), and regulate numerous protein kinase cascades that participate in the regulation of the cross talk between autophagy and apoptosis. |
2015-01-23 |
2023-08-12 |
Not clear |
| A Gentil Dit Maurin, C Lemercier, V Collin-Faure, P N Marche, E Jouvin-Marche, S M Candéia. Developmental regulation of p53-dependent radiation-induced thymocyte apoptosis in mice. Clinical and experimental immunology. vol 179. issue 1. 2015-01-23. PMID:24635132. |
finally, we found no correlation between p53 activation and thymocyte sensitivity to radiation-induced apoptosis. |
2015-01-23 |
2023-08-12 |
mouse |
| Wen-Hsiung Cha. Photodynamic treatment induces an apoptotic pathway involving calcium, nitric oxide, p53, p21-activated kinase 2, and c-Jun N-terminal kinase and inactivates survival signal in human umbilical vein endothelial cells. International journal of molecular sciences. vol 12. issue 2. 2015-01-22. PMID:21541041. |
inhibition of p53 mrna expression using small interfering rna (sirna) additionally blocked activation of pak2 and apoptosis induced by pdt. |
2015-01-22 |
2023-08-12 |
human |
| Barbara Costa, Sara Bendinelli, Pamela Gabelloni, Eleonora Da Pozzo, Simona Daniele, Fabrizio Scatena, Renato Vanacore, Pietro Campiglia, Alessia Bertamino, Isabel Gomez-Monterrey, Daniela Sorriento, Carmine Del Giudice, Guido Iaccarino, Ettore Novellino, Claudia Martin. Human glioblastoma multiforme: p53 reactivation by a novel MDM2 inhibitor. PloS one. vol 8. issue 8. 2015-01-22. PMID:23977270. |
we report that a new small-molecule inhibitor of mdm2 with a spirooxoindolepyrrolidine core structure, named isa27, effectively reactivated p53 function and inhibited human gbm cell growth in vitro by inducing cell cycle arrest and apoptosis. |
2015-01-22 |
2023-08-12 |
mouse |
| Barbara Costa, Sara Bendinelli, Pamela Gabelloni, Eleonora Da Pozzo, Simona Daniele, Fabrizio Scatena, Renato Vanacore, Pietro Campiglia, Alessia Bertamino, Isabel Gomez-Monterrey, Daniela Sorriento, Carmine Del Giudice, Guido Iaccarino, Ettore Novellino, Claudia Martin. Human glioblastoma multiforme: p53 reactivation by a novel MDM2 inhibitor. PloS one. vol 8. issue 8. 2015-01-22. PMID:23977270. |
in immunoincompetent balb/c nude mice bearing a human gbm xenograft, the administration of isa27 in vivo activated p53, inhibited cell proliferation and induced apoptosis in tumor tissue. |
2015-01-22 |
2023-08-12 |
mouse |
| M E Fiori, C Barbini, T L Haas, N Marroncelli, M Patrizii, M Biffoni, R De Mari. Antitumor effect of miR-197 targeting in p53 wild-type lung cancer. Cell death and differentiation. vol 21. issue 5. 2015-01-22. PMID:24488097. |
we further identified the two bh3-only proteins noxa and bmf as new mir-197 targets responsible for induction of apoptosis in p53 wild-type cells, delineating mir-197 as a key survival factor in nsclc. |
2015-01-22 |
2023-08-12 |
mouse |
| Mo-Li Wu, Hong Li, Li-Jun Yu, Xiao-Yan Chen, Qing-You Kong, Xue Song, Xiao-Hong Shu, Jia Li. Short-term resveratrol exposure causes in vitro and in vivo growth inhibition and apoptosis of bladder cancer cells. PloS one. vol 9. issue 2. 2015-01-22. PMID:24587049. |
the results revealed that 2 h 150 µm or 200 µm resveratrol treatment leaded to remarkable s phase arrest and apoptosis at 72 h time-point, accompanied with attenuated phosphorylation, nuclear translocation and transcription of stat3, down-regulation of stat3 downstream genes (survivin, cyclind1, c-myc and vegf) and nuclear translocations of sirt1 and p53. |
2015-01-22 |
2023-08-12 |
mouse |
| Ali Abdullah Alshatwi, Gowhar Shafi, Tarique Noorul Hasan, Naveed Ahmed Syed, Kholoud Khalid Khoj. Fenugreek induced apoptosis in breast cancer MCF-7 cells mediated independently by fas receptor change. Asian Pacific journal of cancer prevention : APJCP. vol 14. issue 10. 2015-01-21. PMID:24289578. |
apoptosis of mcf-7 cells was evidenced by investigating trypan blue exclusion, tunel and caspase 3, 8, 9, p53, fadd, bax and bak by real-time pcr assays inducing activities, in the presence of fme at 65 μg/ml for 24 and 48 hours. |
2015-01-21 |
2023-08-12 |
human |
| Ali Abdullah Alshatwi, Gowhar Shafi, Tarique Noorul Hasan, Naveed Ahmed Syed, Kholoud Khalid Khoj. Fenugreek induced apoptosis in breast cancer MCF-7 cells mediated independently by fas receptor change. Asian Pacific journal of cancer prevention : APJCP. vol 14. issue 10. 2015-01-21. PMID:24289578. |
in summary, these data demonstrate that at least 90% of fme induced apoptosis in breast cell is mediated by fas receptor-independently of either fadd, caspase 8 or 3, as well as p53 interdependently. |
2015-01-21 |
2023-08-12 |
human |
| Hua-Jun Sun, Lin-Yi Meng, Yang Shen, Yi-Zhun Zhu, Hong-Rui Li. S-benzyl-cysteine-mediated cell cycle arrest and apoptosis involving activation of mitochondrial-dependent caspase cascade through the p53 pathway in human gastric cancer SGC-7901 cells. Asian Pacific journal of cancer prevention : APJCP. vol 14. issue 11. 2015-01-21. PMID:24377536. |
s-benzyl-cysteine-mediated cell cycle arrest and apoptosis involving activation of mitochondrial-dependent caspase cascade through the p53 pathway in human gastric cancer sgc-7901 cells. |
2015-01-21 |
2023-08-12 |
human |
| Hua-Jun Sun, Lin-Yi Meng, Yang Shen, Yi-Zhun Zhu, Hong-Rui Li. S-benzyl-cysteine-mediated cell cycle arrest and apoptosis involving activation of mitochondrial-dependent caspase cascade through the p53 pathway in human gastric cancer SGC-7901 cells. Asian Pacific journal of cancer prevention : APJCP. vol 14. issue 11. 2015-01-21. PMID:24377536. |
furthermore, western blotting indicated that sbc-induced apoptosis was accompanied by up-regulation of the expression of p53, bax and the down-regulation of bcl-2. |
2015-01-21 |
2023-08-12 |
human |
| Hua-Jun Sun, Lin-Yi Meng, Yang Shen, Yi-Zhun Zhu, Hong-Rui Li. S-benzyl-cysteine-mediated cell cycle arrest and apoptosis involving activation of mitochondrial-dependent caspase cascade through the p53 pathway in human gastric cancer SGC-7901 cells. Asian Pacific journal of cancer prevention : APJCP. vol 14. issue 11. 2015-01-21. PMID:24377536. |
taken together, this study suggested that sbc exerts cytotoxic activity involving activation of mitochondrial-dependent apoptosis through p53 and bax/bcl-2 pathways in human gastric cancer sgc-7901 cells. |
2015-01-21 |
2023-08-12 |
human |
| Li Yuan, Shuping Wei, Jing Wang, Xuebo Li. Isoorientin induces apoptosis and autophagy simultaneously by reactive oxygen species (ROS)-related p53, PI3K/Akt, JNK, and p38 signaling pathways in HepG2 cancer cells. Journal of agricultural and food chemistry. vol 62. issue 23. 2015-01-21. PMID:24841907. |
isoorientin induces apoptosis and autophagy simultaneously by reactive oxygen species (ros)-related p53, pi3k/akt, jnk, and p38 signaling pathways in hepg2 cancer cells. |
2015-01-21 |
2023-08-13 |
human |
| Li Yuan, Shuping Wei, Jing Wang, Xuebo Li. Isoorientin induces apoptosis and autophagy simultaneously by reactive oxygen species (ROS)-related p53, PI3K/Akt, JNK, and p38 signaling pathways in HepG2 cancer cells. Journal of agricultural and food chemistry. vol 62. issue 23. 2015-01-21. PMID:24841907. |
these results demonstrated for the first time that iso simultaneously induced apoptosis and autophagy by ros-related p53, pi3k/akt, jnk, and p38 signaling pathways. |
2015-01-21 |
2023-08-13 |
human |