| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chaoming Zhang, Congcong Wang, Shusheng Tang, Yu Sun, Dongxu Zhao, Shen Zhang, Sijun Deng, Yan Zhou, Xilong Xia. TNFR1/TNF-α and mitochondria interrelated signaling pathway mediates quinocetone-induced apoptosis in HepG2 cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 62. 2014-08-15. PMID:24161692. |
taken together, quinocetone induced apoptosis in hepg2 cells via activation of caspase, interaction of tnf-α and tnfr1 and modulation of the protein levels of bid, bax and bcl-2, involving the participation of p53, p38 and jnk. |
2014-08-15 |
2023-08-12 |
Not clear |
| Xuzhen Tang, Gang Hu, Chunhua Xu, Kedong Ouyang, Weirong Fang, Wenlong Huang, Jingjing Zhang, Fu Li, Ke Wang, Xiaoran Qin, Yunman L. HZ08 reverse the aneuploidy-induced cisplatin-resistance in Gastric cancer by modulating the p53 pathway. European journal of pharmacology. vol 720. issue 1-3. 2014-08-15. PMID:24183976. |
aneu-mkn45 developed a resistance to cisplatin which could be reversed by hz08; flow cytometry and western-blot indicates that hz08-combination could induce apoptosis and increase the expression of apoptosis-related biomarkers on aneu-mkn45; in vivo study also reflect the same correlation between aneuploidy and cisplatin-resistance, which could be antagonized by hz08 combination; when investigating the involved pathway, in anue-mkn45, the expression of molecules in p53 pathway was decreased; hz08 could increase the expression of p53 down-stream molecules as well as elevate the activity of p53, while inhibiting mdm2, the major negative regulator of p53; p53 inhibitor pifithrin-α could completely abrogate hz08's synergism effects, and mimic cisplatin-resistance on dip-mkn45.lower p53 pathway expression that attenuates cisplatin-induced apoptosis might be at least partly the reason of cisplatin-resistance occurred in aneuploid mkn45 both in vitro and in vivo; combination of hz08 could sensitize cisplatin-induced apoptosis through the activation of the p53 pathway, therefore represented a synergism effect on aneuploid mkn45 cells. |
2014-08-15 |
2023-08-12 |
human |
| Takunori Ueno, Shinji Endo, Rie Saito, Mitsuaki Hirose, Sachiko Hirai, Hideo Suzuki, Kenji Yamato, Ichinosuke Hyod. The sirtuin inhibitor tenovin-6 upregulates death receptor 5 and enhances cytotoxic effects of 5-fluorouracil and oxaliplatin in colon cancer cells. Oncology research. vol 21. issue 3. 2014-08-15. PMID:24512730. |
tenovin-6 induced apoptosis in all five colon cancer cell lines investigated (two cell lines with wild-type p53 and three with mutant p53) regardless of the p53 mutation status. |
2014-08-15 |
2023-08-12 |
human |
| Zhao Ou, Le Yin, Changqing Chang, Jinrong Peng, Jun Che. Protein interaction between p53 and Δ113p53 is required for the anti-apoptotic function of Δ113p53. Journal of genetics and genomics = Yi chuan xue bao. vol 41. issue 2. 2014-08-13. PMID:24576456. |
interestingly, Δ113p53 does not act on p53 in a dominant-negative manner, but rather interferes with the p53 function by differentially modulating p53-target gene expression to protect cells from apoptosis. |
2014-08-13 |
2023-08-12 |
zebrafish |
| Zhao Ou, Le Yin, Changqing Chang, Jinrong Peng, Jun Che. Protein interaction between p53 and Δ113p53 is required for the anti-apoptotic function of Δ113p53. Journal of genetics and genomics = Yi chuan xue bao. vol 41. issue 2. 2014-08-13. PMID:24576456. |
furthermore, of the six Δ113p53 mutants we generated with different point mutations in the oligomerisation domain, two failed to interact with p53 and lost the ability to modulate p53-target gene expression and inhibit p53-induced cell apoptosis. |
2014-08-13 |
2023-08-12 |
zebrafish |
| Donatella Vizza, Anna Perri, Danilo Lofaro, Giuseppina Toteda, Simona Lupinacci, Francesca Leone, Paolo Gigliotti, Teresa Papalia, Renzo Bonofigli. Exposure to nerve growth factor worsens nephrotoxic effect induced by Cyclosporine A in HK-2 cells. PloS one. vol 8. issue 11. 2014-08-12. PMID:24244623. |
in addition we observed that the combined exposure to cyclosporine a + nerve growth factor promoted an up-regulation of p75 (ntr) and its target genes, p53 and bad leading to the activation of intrinsic apoptosis. |
2014-08-12 |
2023-08-12 |
human |
| James E Trosk. Induction of iPS cells and of cancer stem cells: the stem cell or reprogramming hypothesis of cancer? Anatomical record (Hoboken, N.J. : 2007). vol 297. issue 1. 2014-08-12. PMID:24293264. |
again, using the role of glycolysis, known to be associated with the warburg effect in cancer cells, a list of experiments showing that (a) normal stem cells, which have few mitochondria, metabolize via glycolysis; (b) the stem cells are targets for "initiation" or "immortalization" or the blockage of differentiation and apoptosis of the stem cells by "immortalizing viruses"; (c) lactate dehydrogenase a (ldha), when expressed, is associated with glycolysis and therefore, must be expressed in normal adult stem cells, as well as in cancer cells; and (d) p53, depleted or rendered dysfunctional by sv40 large t antigen, is associated with the reduction of mitochondrial function and mass and is associated with the warburg effect. |
2014-08-12 |
2023-08-12 |
human |
| Fei Teng, Guangxi Li, Zhangjing Liu, Liangdeng Zhang, Kuiwu Ya. The Comparative Study on Expression of SIRT1 Signal Transduction by Xuefuzhuyu Capsule. Evidence-based complementary and alternative medicine : eCAM. vol 2014. 2014-08-12. PMID:25114706. |
all the result showed that the target genes of sirt1 pathway including p53, nf-kb, foxo1, foxo3, and foxo4 were significantly downregulated to sirt1, suggesting that apoptosis pathway might transcriptionally be regulated to sirt1. |
2014-08-12 |
2023-08-13 |
rat |
| Paloma Olvera-Caltzontzin, Guadalupe Delgado, Carmen Aceves, Brenda Anguian. Iodine uptake and prostate cancer in the TRAMP mouse model. Molecular medicine (Cambridge, Mass.). vol 19. 2014-08-08. PMID:24306422. |
the weight of the genitourinary tract (gut), the number of acini with lesions, cell proliferation (levels of proliferating cell nuclear antigen [pcna] by immunohistochemistry), p53 and p21 expression (by qpcr) and apoptosis (relative amount of nucleosomes by enzyme-linked immunosorbent assay) were evaluated. |
2014-08-08 |
2023-08-12 |
mouse |
| C Urani, P Melchioretto, M Fabbri, G Bowe, E Maserati, L Gribald. Cadmium Impairs p53 Activity in HepG2 Cells. ISRN toxicology. vol 2014. 2014-08-07. PMID:25101185. |
the present work is designed to gain an insight into the mechanism of p53 impairment at gene and protein level to understand cd-induced resistance to apoptosis. |
2014-08-07 |
2023-08-13 |
Not clear |
| Vivian M Rumjanek, Raphael S Vidal, Raquel C Mai. Multidrug resistance in chronic myeloid leukaemia: how much can we learn from MDR-CML cell lines? Bioscience reports. vol 33. issue 6. 2014-08-05. PMID:24070327. |
this work reviews the role played by the influx transporter oct1 (organic cation transporter 1), by efflux abc transporters, molecules involved in the modulation of apoptosis (p53, bcl-2 family, cd95, iaps (inhibitors of apoptosis protein)], hh and wnt/β-catenin pathways, cytoskeleton abnormalities and other features described in leukaemic cells of clinical samples and cml cell lines. |
2014-08-05 |
2023-08-12 |
Not clear |
| Oliver Couture, Eric Lombardi, Kendra Davis, Emily Hays, Nalini Chanda. Gene expression profiles resulting from stable loss of p53 mirrors its role in tissue differentiation. PloS one. vol 8. issue 11. 2014-08-05. PMID:24312426. |
as expected, several genes with profound changes after transient p53 loss were related to apoptosis and cell cycle regulation. |
2014-08-05 |
2023-08-12 |
mouse |
| Andrei L Garte. Suppression of the Oncogenic Transcription Factor FOXM1 by Proteasome Inhibitors. Scientifica. vol 2014. 2014-08-05. PMID:25093142. |
we generated isogenic human cancer cell lines of different origin with wild-type p53 or p53 knockdown and we demonstrated that proteasome inhibitors induce p53-independent apoptosis in these cells. |
2014-08-05 |
2023-08-13 |
mouse |
| Tomoko Ohashi, Masashi Idogawa, Yasushi Sasaki, Hiromu Suzuki, Takashi Tokin. AKR1B10, a transcriptional target of p53, is downregulated in colorectal cancers associated with poor prognosis. Molecular cancer research : MCR. vol 11. issue 12. 2014-07-29. PMID:24140838. |
p53 modulates various cellular functions, such as apoptosis and cell-cycle arrest via transcriptional regulation. |
2014-07-29 |
2023-08-12 |
Not clear |
| Eveline Barbieri, Katleen De Preter, Mario Capasso, Peter Johansson, Tsz-Kwong Man, Zaowen Chen, Paris Stowers, Gian Paolo Tonini, Frank Speleman, Jason M Shohe. A p53 drug response signature identifies prognostic genes in high-risk neuroblastoma. PloS one. vol 8. issue 11. 2014-07-29. PMID:24348903. |
recently developed small molecule inhibitors of the mdm2-p53 interaction are able to overcome this repression and potently activate p53 dependent apoptosis in malignancies with intact p53 downstream signaling. |
2014-07-29 |
2023-08-12 |
Not clear |
| Sheng-Yung Yu, Chiung-Ho Liao, Ming-Hsien Chien, Tsung-Yu Tsai, Jen-Kun Lin, Meng-Shih Wen. Induction of p21(Waf1/Cip1) by garcinol via downregulation of p38-MAPK signaling in p53-independent H1299 lung cancer. Journal of agricultural and food chemistry. vol 62. issue 9. 2014-07-28. PMID:24533688. |
accordingly, our data suggested that garcinol induced g1 cell cycle arrest and apoptosis in lung cancer cells under different p53 statuses. |
2014-07-28 |
2023-08-12 |
human |
| Duarte M S Ferreira, André L Simão, Cecília M P Rodrigues, Rui E Castr. Revisiting the metabolic syndrome and paving the way for microRNAs in non-alcoholic fatty liver disease. The FEBS journal. vol 281. issue 11. 2014-07-28. PMID:24702768. |
although not yet considered in the diagnosis of nafld, recent reports also reinforce the crucial role of apoptosis in disease progression via activation of either death receptor or mitochondrial pathways and p53. |
2014-07-28 |
2023-08-13 |
Not clear |
| Renaud F Warin, Huadong Chen, Dominique N Soroka, Yingdong Zhu, Shengmin San. Induction of lung cancer cell apoptosis through a p53 pathway by [6]-shogaol and its cysteine-conjugated metabolite M2. Journal of agricultural and food chemistry. vol 62. issue 6. 2014-07-25. PMID:24446736. |
induction of lung cancer cell apoptosis through a p53 pathway by [6]-shogaol and its cysteine-conjugated metabolite m2. |
2014-07-25 |
2023-08-12 |
mouse |
| N Puebla-Osorio, J Kim, S Ojeda, H Zhang, O Tavana, S Li, Y Wang, Q Ma, K S Schluns, C Zh. A novel Ku70 function in colorectal homeostasis separate from nonhomologous end joining. Oncogene. vol 33. issue 21. 2014-07-24. PMID:23752193. |
however, the tumor phenotype is abrogated by the introduction of a hypomorphic mutant p53(r172p), which impaired p53-mediated apoptosis but not cell-cycle arrest. |
2014-07-24 |
2023-08-12 |
mouse |
| N Puebla-Osorio, J Kim, S Ojeda, H Zhang, O Tavana, S Li, Y Wang, Q Ma, K S Schluns, C Zh. A novel Ku70 function in colorectal homeostasis separate from nonhomologous end joining. Oncogene. vol 33. issue 21. 2014-07-24. PMID:23752193. |
to further elucidate the role of nhej and p53-mediated apoptosis in vivo, we bred ku70(-/-) p53(r172p) mice. |
2014-07-24 |
2023-08-12 |
mouse |