| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marjory Alana Marcello, Elaine Cristina Morari, Lucas Leite Cunha, Aline Carolina De Nadai Silva, Dirce Maria Carraro, André Lopes Carvalho, Fernando Augusto Soares, José Vassallo, Laura Sterian War. P53 and expression of immunological markers may identify early stage thyroid tumors. Clinical & developmental immunology. vol 2013. 2014-06-09. PMID:24171036. |
besides its major role in cell proliferation, dna repair, and apoptosis, functional p53 protein is involved in the induction of antitumor cytotoxic-t-cell activity against carcinoma cells. |
2014-06-09 |
2023-08-12 |
Not clear |
| Mothanna Sadiq Al-Qubaisi, Abdullah Rasedee, Moayad Husein Flaifel, Sahrim Hj Ahmad, Samer Hussein-Al-Ali, Mohd Zobir Hussein, Zulkarnain Zainal, Fatah H Alhassan, Yun H Taufiq-Yap, Eltayeb E M Eid, Ismail Adam Arbab, Bandar A Al-Asbahi, Thomas J Webster, Mohamed Ezzat El Zowalat. Induction of apoptosis in cancer cells by NiZn ferrite nanoparticles through mitochondrial cytochrome C release. International journal of nanomedicine. vol 8. 2014-06-09. PMID:24204141. |
our results indicate that nizn ferrite nanoparticles promote apoptosis in cancer cells via caspase-3 and caspase-9, downregulation of bcl-2, and upregulation of bax and p53, with cytochrome c translocation. |
2014-06-09 |
2023-08-12 |
Not clear |
| Kathryn T Bieging, Stephano Spano Mello, Laura D Attard. Unravelling mechanisms of p53-mediated tumour suppression. Nature reviews. Cancer. vol 14. issue 5. 2014-06-09. PMID:24739573. |
p53 is a crucial tumour suppressor that responds to diverse stress signals by orchestrating specific cellular responses, including transient cell cycle arrest, cellular senescence and apoptosis, which are all processes associated with tumour suppression. |
2014-06-09 |
2023-08-13 |
Not clear |
| Jitender Monga, Saurabh Pandit, Chetan Singh Chauhan, Manu Sharm. Cytotoxicity and apoptosis induction in human breast adenocarcinoma MCF-7 cells by (+)-cyanidan-3-ol. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 65. issue 7-8. 2014-06-07. PMID:23706674. |
the induction of apoptosis is correlated with the increased mrna expressions of p53, bax, and caspase-3, -7, -8 and -9 and decreased mrna expressions of bcl-2. |
2014-06-07 |
2023-08-12 |
human |
| Jiang Yin, Guopei Zheng, Xiaoting Jia, Zhijie Zhang, Weijia Zhang, Ying Song, Yan Xiong, Zhimin H. A Bmi1-miRNAs cross-talk modulates chemotherapy response to 5-fluorouracil in breast cancer cells. PloS one. vol 8. issue 9. 2014-06-07. PMID:24039897. |
thus, our study suggests a cross-talk between bmi1 and mir-200c mediated by p53, and bmi1 interference would improve chemotherapy efficiency in breast cancer via susceptive apoptosis induction and cancer stem cell enrichment inhibition. |
2014-06-07 |
2023-08-12 |
Not clear |
| Benjamin J Wilkins, Kristin Lorent, Randolph P Matthews, Michael Pac. p53-mediated biliary defects caused by knockdown of cirh1a, the zebrafish homolog of the gene responsible for North American Indian Childhood Cirrhosis. PloS one. vol 8. issue 10. 2014-06-05. PMID:24147052. |
previous yeast and in vitro studies have shown that defects in ribosome biogenesis cause stabilization and nuclear accumulation of p53, which in turn causes p53-mediated cell cycle arrest and/or apoptosis. |
2014-06-05 |
2023-08-12 |
human |
| Joseph Weinstock, Jian Wu, Ping Cao, William D Kingsbury, Jeffrey L McDermott, Matthew P Kodrasov, Devin M McKelvey, K G Suresh Kumar, Seth J Goldenberg, Michael R Mattern, Benjamin Nicholso. Selective Dual Inhibitors of the Cancer-Related Deubiquitylating Proteases USP7 and USP47. ACS medicinal chemistry letters. vol 3. issue 10. 2014-06-05. PMID:24900381. |
compound 1, a selective inhibitor of usp7 and usp47 with moderate potency, demonstrates inhibition of usp7 in cells and induces elevated p53 and apoptosis in cancer cell lines. |
2014-06-05 |
2023-08-13 |
human |
| Binh Vu, Peter Wovkulich, Giacomo Pizzolato, Allen Lovey, Qingjie Ding, Nan Jiang, Jin-Jun Liu, Chunlin Zhao, Kelli Glenn, Yang Wen, Christian Tovar, Kathryn Packman, Lyubomir Vassilev, Bradford Grave. Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development. ACS medicinal chemistry letters. vol 4. issue 5. 2014-06-05. PMID:24900694. |
in cancer cells expressing wild-type p53, rg7112 stabilizes p53 and activates the p53 pathway, leading to cell cycle arrest, apoptosis, and inhibition or regression of human tumor xenografts. |
2014-06-05 |
2023-08-13 |
human |
| Hisham Bazzi, Kathryn V Anderso. Acentriolar mitosis activates a p53-dependent apoptosis pathway in the mouse embryo. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 15. 2014-06-04. PMID:24706806. |
unlike mutants that lack cilia, sas4(-/-) embryos show widespread apoptosis associated with global elevated expression of p53. |
2014-06-04 |
2023-08-13 |
mouse |
| Wei Liu, Xiangyi Lu, Guangyang He, Xiang Gao, Maonian Xu, Jingkai Zhang, Meiling Li, Lifeng Wang, Zhenjing Li, Likui Wang, Cheng Lu. Protective roles of Gadd45 and MDM2 in blueberry anthocyanins mediated DNA repair of fragmented and non-fragmented DNA damage in UV-irradiated HepG2 cells. International journal of molecular sciences. vol 14. issue 11. 2014-06-03. PMID:24177565. |
the proteins, p21 and p53, retain cellular integrity, suppressing the oncogenic transformation by interruption of the g1 phase of the cellular cycle, giving time for repairing the damage to dna, or apoptosis induction if the damage is too severe to be repaired, while mdm2 and gadd45 concomitantly ensure the presence of p53 and p21. |
2014-06-03 |
2023-08-12 |
Not clear |
| Madeeha Aqil, Kim M Elseth, Benjamin J Vesper, Zane Deliu, Bulent Aydogan, Jiaping Xue, James A Radosevic. Part I-mechanism of adaptation: high nitric oxide adapted A549 cells show enhanced DNA damage response and activation of antiapoptotic pathways. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 3. 2014-06-03. PMID:24241898. |
activation of p53 results in inhibition of apoptosis through induced mcl1 expression. |
2014-06-03 |
2023-08-12 |
human |
| Edward C Lauterbac. Neuroprotective effects of psychotropic drugs in Huntington's disease. International journal of molecular sciences. vol 14. issue 11. 2014-06-03. PMID:24248060. |
in hd preclinical models, while no psychotropic has convincingly affected huntingtin gene, hd modifying gene, or huntingtin protein expression, psychotropic neuroprotective effects include upregulated huntingtin autophagy (lithium), histone acetylation (lithium, valproate, lamotrigine), mir-222 (lithium-plus-valproate), mitochondrial protection (haloperidol, trifluoperazine, imipramine, desipramine, nortriptyline, maprotiline, trazodone, sertraline, venlafaxine, melatonin), neurogenesis (lithium, valproate, fluoxetine, sertraline), and bdnf (lithium, valproate, sertraline) and downregulated ap-1 dna binding (lithium), p53 (lithium), huntingtin aggregation (antipsychotics, lithium), and apoptosis (trifluoperazine, loxapine, lithium, desipramine, nortriptyline, maprotiline, cyproheptadine, melatonin). |
2014-06-03 |
2023-08-12 |
mouse |
| Li Ding, Yong Huang, Qian Du, Feng Dong, Xiaomin Zhao, Wenlong Zhang, Xingang Xu, Dewen Ton. TGEV nucleocapsid protein induces cell cycle arrest and apoptosis through activation of p53 signaling. Biochemical and biophysical research communications. vol 445. issue 2. 2014-06-03. PMID:24548406. |
tgev nucleocapsid protein induces cell cycle arrest and apoptosis through activation of p53 signaling. |
2014-06-03 |
2023-08-12 |
Not clear |
| Li Ding, Yong Huang, Qian Du, Feng Dong, Xiaomin Zhao, Wenlong Zhang, Xingang Xu, Dewen Ton. TGEV nucleocapsid protein induces cell cycle arrest and apoptosis through activation of p53 signaling. Biochemical and biophysical research communications. vol 445. issue 2. 2014-06-03. PMID:24548406. |
our previous studies showed that tgev infection could induce cell cycle arrest and apoptosis via activation of p53 signaling in cultured host cells. |
2014-06-03 |
2023-08-12 |
Not clear |
| Li Ding, Yong Huang, Qian Du, Feng Dong, Xiaomin Zhao, Wenlong Zhang, Xingang Xu, Dewen Ton. TGEV nucleocapsid protein induces cell cycle arrest and apoptosis through activation of p53 signaling. Biochemical and biophysical research communications. vol 445. issue 2. 2014-06-03. PMID:24548406. |
further studies showed that p53 inhibitor attenuated tgev n protein induced cell cycle arrest at s and g2/m phases and apoptosis through reversing the expression changes of cdc2, cdk2 and cyclin b1 and the translocation changes of bax and cytochrome c induced by tgev n protein. |
2014-06-03 |
2023-08-12 |
Not clear |
| Li Ding, Yong Huang, Qian Du, Feng Dong, Xiaomin Zhao, Wenlong Zhang, Xingang Xu, Dewen Ton. TGEV nucleocapsid protein induces cell cycle arrest and apoptosis through activation of p53 signaling. Biochemical and biophysical research communications. vol 445. issue 2. 2014-06-03. PMID:24548406. |
taken together, these results demonstrated that tgev n protein might play an important role in tgev infection-induced p53 activation and cell cycle arrest at the s and g2/m phases and apoptosis occurrence. |
2014-06-03 |
2023-08-12 |
Not clear |
| Margaret Finlay, Zhengqiang Yuan, Iain M Morgan, M Saveria Campo, Lubna Nasi. Equine sarcoids: Bovine Papillomavirus type 1 transformed fibroblasts are sensitive to cisplatin and UVB induced apoptosis and show aberrant expression of p53. Veterinary research. vol 43. 2014-06-02. PMID:23210796. |
equine sarcoids: bovine papillomavirus type 1 transformed fibroblasts are sensitive to cisplatin and uvb induced apoptosis and show aberrant expression of p53. |
2014-06-02 |
2023-08-12 |
cattle |
| Young-Ae Kim, Mi-Young Kim, Hye Yon Yu, Siddhartha Kumar Mishra, Jae-Hyeok Lee, Kyeong Sook Choi, Jae-Ho Kim, Yang Kevin Xiang, Yi-Sook Jun. Gadd45β is transcriptionally activated by p53 via p38α-mediated phosphorylation during myocardial ischemic injury. Journal of molecular medicine (Berlin, Germany). vol 91. issue 11. 2014-06-02. PMID:23948959. |
the well-known transcription factor p53 is known to cause apoptosis in cardiomyocytes under ischemia. |
2014-06-02 |
2023-08-12 |
rat |
| Young-Ae Kim, Mi-Young Kim, Hye Yon Yu, Siddhartha Kumar Mishra, Jae-Hyeok Lee, Kyeong Sook Choi, Jae-Ho Kim, Yang Kevin Xiang, Yi-Sook Jun. Gadd45β is transcriptionally activated by p53 via p38α-mediated phosphorylation during myocardial ischemic injury. Journal of molecular medicine (Berlin, Germany). vol 91. issue 11. 2014-06-02. PMID:23948959. |
based on the common role of gadd45β and p53 in ischemia-induced apoptosis, we investigated whether p53 is involved in the mechanisms responsible for gadd45β expression in both in vitro and in vivo models of ischemic heart injury. |
2014-06-02 |
2023-08-12 |
rat |
| Gerald M Pao, Quan Zhu, Carlos G Perez-Garcia, Shen-Ju Chou, Hoonkyo Suh, Fred H Gage, Dennis D M O'Leary, Inder M Verm. Role of BRCA1 in brain development. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 13. 2014-06-02. PMID:24639535. |
major phenotypes are caused by excess apoptosis, as these could be significantly suppressed by the concomitant deletion of p53. |
2014-06-02 |
2023-08-12 |
Not clear |