| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hui-Qing Zhang, Bo He, Nian Fang, Shan Lu, Yu-Qian Liao, Yi-Ye Wa. Autophagy inhibition sensitizes cisplatin cytotoxicity in human gastric cancer cell line SGC7901. Asian Pacific journal of cancer prevention : APJCP. vol 14. issue 8. 2014-05-15. PMID:24083726. |
after inhibition of autophagy by chloroquine, the rates of cell apoptosis were increased to (30.16±3.54)%, and the level of caspase-3 and p53 protein were increased, and bcl-2 protein was decreased. |
2014-05-15 |
2023-08-12 |
human |
| Theodoros Karantanos, Ryuta Tanimoto, Kohei Edamura, Takahiro Hirayama, Guang Yang, Alexei A Golstov, Jianxiang Wang, Shinji Kurosaka, Sanghee Park, Timothy C Thompso. Systemic GLIPR1-ΔTM protein as a novel therapeutic approach for prostate cancer. International journal of cancer. vol 134. issue 8. 2014-05-15. PMID:24590455. |
glipr1 is a p53 target gene known to be downregulated in prostate cancer, and increased endogenous glipr1 expression has been associated with increased production of reactive oxygen species, increased apoptosis, decreased c-myc protein levels and increased cell cycle arrest. |
2014-05-15 |
2023-08-12 |
mouse |
| Yu Chen, Meng-Ying Qin, Lei Wang, Hui Chao, Liang-Nian Ji, An-Long X. A ruthenium(II) β-carboline complex induced p53-mediated apoptosis in cancer cells. Biochimie. vol 95. issue 11. 2014-05-14. PMID:23911866. |
signaling pathways analysis demonstrated that this complex induced apoptosis via the mitochondrial pathway, as evidenced by the loss of mitochondrial membrane potential (mmp, ΔΨm) and the release of cytochrome c. the resulting accumulation of p53 proteins from phosphorylation at ser-15 and ser-392 correlated with an increase in p21 and caspase activation. |
2014-05-14 |
2023-08-12 |
mouse |
| Yi Guo, Xiangkai Meng, Qian Wang, Yanan Wang, Hong Shan. The ING4 Binding with p53 and Induced p53 Acetylation were Attenuated by Human Papillomavirus 16 E6. PloS one. vol 8. issue 8. 2014-05-14. PMID:23967213. |
the enhancing function of ing4 on p53 mediated apoptosis was diminished when hpv16 e6 existed. |
2014-05-14 |
2023-08-12 |
human |
| Si Chen, Xuefei Li, Dan Lu, Yingxi Xu, Wenjun Mou, Lina Wang, Yanan Chen, Yanhua Liu, Xiru Li, Lu-Yuan Li, Lin Liu, Dwayne Stupack, Ralph A Reisfeld, Rong Xiang, Na L. SOX2 regulates apoptosis through MAP4K4-survivin signaling pathway in human lung cancer cells. Carcinogenesis. vol 35. issue 3. 2014-05-14. PMID:24233838. |
evaluation of the apoptotic pathways revealed an increased expression of key inducers of apoptosis, including tumor necrosis factor-α and p53, with concurrent attenuation of survivin. |
2014-05-14 |
2023-08-12 |
human |
| Lenka Sucha, Milos Hroch, Martina Rezacova, Emil Rudolf, Radim Havelek, Ludek Sispera, Jana Cmielova, Renata Kohlerova, Ales Bezrouk, Pavel Tomsi. The cytotoxic effect of α-tomatine in MCF-7 human adenocarcinoma breast cancer cells depends on its interaction with cholesterol in incubation media and does not involve apoptosis induction. Oncology reports. vol 30. issue 6. 2014-05-13. PMID:24100733. |
regarding the mechanism of action of α-tomatine, we observed no dna damage, no changes in the levels of the proteins p53 and p21(waf1/cip1), and no apoptosis (neither activated caspase-8 and -9, nor sub-g1 peak, or morphological signs). |
2014-05-13 |
2023-08-12 |
human |
| Ravindran Jaganathan, Vijaya Ravinayagam, Sachdanandam Panchanadham, Shanthi Palanivel. Potential therapeutic role of Tridham in human hepatocellular carcinoma cell line through induction of p53 independent apoptosis. BMC complementary and alternative medicine. vol 13. 2014-05-13. PMID:24256980. |
potential therapeutic role of tridham in human hepatocellular carcinoma cell line through induction of p53 independent apoptosis. |
2014-05-13 |
2023-08-12 |
human |
| Weiwei Sheng, Chuanping Chen, Ming Dong, Jianping Zhou, Qingfeng Liu, Qi Dong, Feng L. Overexpression of calreticulin contributes to the development and progression of pancreatic cancer. Journal of cellular physiology. vol 229. issue 7. 2014-05-13. PMID:24264800. |
in addition, crt knockdown significantly decreased pho-erk expression and cell chemoresistance independent of activated p53 and caspase-3-related apoptosis in gemcitabine- or oxaliplatin-treated capan-2 cells. |
2014-05-13 |
2023-08-12 |
Not clear |
| S J Allison, J R P Knight, C Granchi, R Rani, F Minutolo, J Milner, R M Phillip. Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53-independent pathways. Oncogenesis. vol 3. 2014-05-13. PMID:24819061. |
to summarise, this work indicates two distinct mechanisms by which suppressing ldh-a could potentially be used to kill cancer cells selectively, (i) through induction of apoptosis, irrespective of cancer cell p53 status and (ii) as a part of a combinatorial approach with redox-sensitive anticancer drugs via a novel p53/nad(h)-dependent mechanism. |
2014-05-13 |
2023-08-13 |
human |
| Ahmad Kazemi, Majid Safa, Atefeh Shahbaz. RITA enhances chemosensivity of pre-B ALL cells to doxorubicin by inducing p53-dependent apoptosis. Hematology (Amsterdam, Netherlands). vol 16. issue 4. 2014-05-12. PMID:21756539. |
here, we used small-molecule reactivation of p53 and induction of tumor cell apoptosis (rita) to sensitize leukemic nalm-6 cells to doxorubicin by upregulating p53 protein. |
2014-05-12 |
2023-08-12 |
Not clear |
| Ahmad Kazemi, Majid Safa, Atefeh Shahbaz. RITA enhances chemosensivity of pre-B ALL cells to doxorubicin by inducing p53-dependent apoptosis. Hematology (Amsterdam, Netherlands). vol 16. issue 4. 2014-05-12. PMID:21756539. |
using p53 inhibitors pft-alpha and pft-mu it was shown that p53-mediated apoptosis induced by rita can be regulated by both p53-transcription-dependent and -independent pathways. |
2014-05-12 |
2023-08-12 |
Not clear |
| Gillian D McFeat, Sarah L Allinson, Trevor J McMilla. Characterisation of the p53-mediated cellular responses evoked in primary mouse cells following exposure to ultraviolet radiation. PloS one. vol 8. issue 9. 2014-05-12. PMID:24098727. |
in response to a variety of dna damaging agents including uv light, wild-type p53 plays a role in mediating cell-cycle arrest, facilitating apoptosis and stimulating repair processes, all of which prevent the propagation of potentially mutagenic defects. |
2014-05-12 |
2023-08-12 |
mouse |
| Gillian D McFeat, Sarah L Allinson, Trevor J McMilla. Characterisation of the p53-mediated cellular responses evoked in primary mouse cells following exposure to ultraviolet radiation. PloS one. vol 8. issue 9. 2014-05-12. PMID:24098727. |
despite this, uva exposure of wild-type cells induced a p53 dependent g1 cell cycle arrest followed by a wave of p53 dependent apoptosis, peaking 12 hours post-insult. |
2014-05-12 |
2023-08-12 |
mouse |
| P Mabet. Decreased secretion of vascular endothelial growth factor is associated with increased apoptosis in vascular tumor derived endothelial cells. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 64. issue 4. 2014-05-12. PMID:24101393. |
apoptosis was associated with an increase in the expression of p53 and a decrease in the expression of the antiapoptotic protein bcl-2. |
2014-05-12 |
2023-08-12 |
Not clear |
| Hiroshi Tazawa, Shunsuke Kagawa, Toshiyoshi Fujiwar. Advances in adenovirus-mediated p53 cancer gene therapy. Expert opinion on biological therapy. vol 13. issue 11. 2014-05-12. PMID:24107178. |
the tumor suppressor p53 gene regulates diverse cellular processes, such as cell-cycle arrest, senescence, apoptosis and autophagy, and it is frequently inactivated by genetic alterations in ∼ 50% of all types of human cancers. |
2014-05-12 |
2023-08-12 |
human |
| Jieming Ye, Zhenhua Liu, Jipeng Wei, Lingli Lu, Yanjun Huang, Lili Luo, Huifang Xi. Protective effect of SIRT1 on toxicity of microglial-derived factors induced by LPS to PC12 cells via the p53-caspase-3-dependent apoptotic pathway. Neuroscience letters. vol 553. 2014-05-08. PMID:23973301. |
further, we found that factors derived from activated microglia significantly decreased the level of deacetylation of p53 by reducing the expression of sirt1, an effect that increased the apoptosis of pc12 and reduced cell viability. |
2014-05-08 |
2023-08-12 |
Not clear |
| Maidong Li, Shuwen Han, Gang Zhang, Ying Wang, Zhaoning J. Antiproliferative activity and apoptosis-inducing mechanism of L-securinine on human breast cancer MCF-7 cells. Die Pharmazie. vol 69. issue 3. 2014-05-08. PMID:24716413. |
real-time quantitative pcr was conducted to evaluate expression levels of apoptosis related genes p53, bax, bcl-2, mtor, p70s6k. |
2014-05-08 |
2023-08-13 |
human |
| Shakti Ranjan Satapathy, Purusottam Mohapatra, Ranjan Preet, Dipon Das, Biplab Sarkar, Tathagata Choudhuri, Michael D Wyatt, Chanakya Nath Kund. Silver-based nanoparticles induce apoptosis in human colon cancer cells mediated through p53. Nanomedicine (London, England). vol 8. issue 8. 2014-05-06. PMID:23514434. |
silver-based nanoparticles induce apoptosis in human colon cancer cells mediated through p53. |
2014-05-06 |
2023-08-12 |
human |
| Xueting Wang, Yu Chen, Xintong Zuo, Naiqing Ding, Huijuan Zeng, Xiang Zou, Xiaodong Ha. Microcystin (-LR) induced testicular cell apoptosis via up-regulating apoptosis-related genes in vivo. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 60. 2014-05-05. PMID:23891578. |
the purpose of the study was to find out whether the expression and phosphorylation of p53, bcl-2 protein family proteins, cyt c, and caspases were involved in the induction of testicular cell apoptosis by mc-lr in mice. |
2014-05-05 |
2023-08-12 |
mouse |
| Xueting Wang, Yu Chen, Xintong Zuo, Naiqing Ding, Huijuan Zeng, Xiang Zou, Xiaodong Ha. Microcystin (-LR) induced testicular cell apoptosis via up-regulating apoptosis-related genes in vivo. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 60. 2014-05-05. PMID:23891578. |
in conclusion, p53, bcl-2, bax, caspase 3 and caspase 8 are involved in the regulation of mc-lr-induced apoptosis of testicular cells. |
2014-05-05 |
2023-08-12 |
mouse |