| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Carlos Giovanni Silva-García, Rosa Estela Navarr. The C. elegans TIA-1/TIAR homolog TIAR-1 is required to induce germ cell apoptosis. Genesis (New York, N.Y. : 2000). vol 51. issue 10. 2014-04-25. PMID:23913578. |
dna damage-induced apoptosis also requires the nematode p53 homolog cep-1. |
2014-04-25 |
2023-08-12 |
caenorhabditis_elegans |
| Seok-Jo Kim, Paul Cheresh, David Williams, Yuan Cheng, Karen Ridge, Paul T Schumacker, Sigmund Weitzman, Vilhelm A Bohr, David W Kam. Mitochondria-targeted Ogg1 and aconitase-2 prevent oxidant-induced mitochondrial DNA damage in alveolar epithelial cells. The Journal of biological chemistry. vol 289. issue 9. 2014-04-25. PMID:24429287. |
amosite asbestos (5-25 μg/cm(2)) or h2o2 (100-250 μm)) for 24 h. overexpression of wild-type mt-hogg1 or mt-long α/β 317-323 hogg1 mutant incapable of dna repair (mt-hogg1-mut) each blocked a549 cell oxidant-induced mtdna damage, mitochondrial p53 translocation, and intrinsic apoptosis as assessed by dna fragmentation and cleaved caspase-9. |
2014-04-25 |
2023-08-12 |
mouse |
| Seok-Jo Kim, Paul Cheresh, David Williams, Yuan Cheng, Karen Ridge, Paul T Schumacker, Sigmund Weitzman, Vilhelm A Bohr, David W Kam. Mitochondria-targeted Ogg1 and aconitase-2 prevent oxidant-induced mitochondrial DNA damage in alveolar epithelial cells. The Journal of biological chemistry. vol 289. issue 9. 2014-04-25. PMID:24429287. |
notably, overexpression of aco-2 reduced oxidant-induced mtdna lesions, mitochondrial p53 translocation, and apoptosis, whereas sirna for aco-2 (siaco-2) enhanced mtdna damage, mitochondrial p53 translocation, and apoptosis. |
2014-04-25 |
2023-08-12 |
mouse |
| Seok-Jo Kim, Paul Cheresh, David Williams, Yuan Cheng, Karen Ridge, Paul T Schumacker, Sigmund Weitzman, Vilhelm A Bohr, David W Kam. Mitochondria-targeted Ogg1 and aconitase-2 prevent oxidant-induced mitochondrial DNA damage in alveolar epithelial cells. The Journal of biological chemistry. vol 289. issue 9. 2014-04-25. PMID:24429287. |
collectively, these data demonstrate a novel role for mt-hogg1 and aco-2 in preserving aec mtdna integrity, thereby preventing oxidant-induced mitochondrial dysfunction, p53 mitochondrial translocation, and intrinsic apoptosis. |
2014-04-25 |
2023-08-12 |
mouse |
| W Cai, Q Li, Z Yang, X Miao, Y Wen, S Huang, J Ouyan. Expression of p53 upregulated modulator of apoptosis (PUMA) and C-myb in gallbladder adenocarcinoma and their pathological significance. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. vol 15. issue 10. 2014-04-24. PMID:23475628. |
expression of p53 upregulated modulator of apoptosis (puma) and c-myb in gallbladder adenocarcinoma and their pathological significance. |
2014-04-24 |
2023-08-12 |
human |
| Huanli Xu, Jinmei Yu, Yan Sun, Xiaona Xu, Li Li, Ming Xue, Guanhua D. Scutellaria barbata D. Don extract synergizes the antitumor effects of low dose 5-fluorouracil through induction of apoptosis and metabolism. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 20. issue 10. 2014-04-24. PMID:23694749. |
tumor growth inhibition both in vitro and in vivo, cell apoptosis, apoptosis related protein expressions (p53, bid, bax, bcl-2), caspase-3 activities and 5-fu related enzymes were assessed. |
2014-04-24 |
2023-08-12 |
Not clear |
| Katherine Karakoula, Thomas S Jacques, Kim P Phipps, William Harkness, Dominic Thompson, Brian N Harding, John L Darling, Tracy J War. Epigenetic genome-wide analysis identifies BEX1 as a candidate tumour suppressor gene in paediatric intracranial ependymoma. Cancer letters. vol 346. issue 1. 2014-04-24. PMID:24333734. |
we identified 55 candidate epigenetically silenced genes, which are involved in the regulation of apoptosis, wnt signalling, p53 and cell differentiation. |
2014-04-24 |
2023-08-12 |
Not clear |
| Duarte M S Ferreira, Marta B Afonso, Pedro M Rodrigues, André L Simão, Diane M Pereira, Pedro M Borralho, Cecília M P Rodrigues, Rui E Castr. c-Jun N-terminal kinase 1/c-Jun activation of the p53/microRNA 34a/sirtuin 1 pathway contributes to apoptosis induced by deoxycholic acid in rat liver. Molecular and cellular biology. vol 34. issue 6. 2014-04-24. PMID:24421392. |
jnk1 and c-jun were shown to be major targets of dca, upstream of p53, in engaging the mir-34a pathway and apoptosis. |
2014-04-24 |
2023-08-12 |
rat |
| Monique Anchelin, Francisca Alcaraz-Pérez, Carlos M Martínez, Manuel Bernabé-García, Victoriano Mulero, María L Cayuel. Premature aging in telomerase-deficient zebrafish. Disease models & mechanisms. vol 6. issue 5. 2014-04-22. PMID:23744274. |
furthermore, p53 was induced by telomere attrition, leading to growth arrest and apoptosis. |
2014-04-22 |
2023-08-12 |
mouse |
| Bo Hong, Varun V Prabhu, Shengliang Zhang, A Pieter J van den Heuvel, David T Dicker, Levy Kopelovich, Wafik S El-Deir. Prodigiosin rescues deficient p53 signaling and antitumor effects via upregulating p73 and disrupting its interaction with mutant p53. Cancer research. vol 74. issue 4. 2014-04-22. PMID:24247721. |
prodigiosin and its structural analogue (compound r) induced the expression of p53 target genes accompanied by cell-cycle arrest and apoptosis in p53-deficient cancer cells. |
2014-04-22 |
2023-08-12 |
human |
| Gesine Hoffmann, Frank Breitenbücher, Martin Schuler, Ann E Ehrenhofer-Murra. A novel sirtuin 2 (SIRT2) inhibitor with p53-dependent pro-apoptotic activity in non-small cell lung cancer. The Journal of biological chemistry. vol 289. issue 8. 2014-04-22. PMID:24379401. |
because deacetylation of p53 regulates its effect on apoptosis, pharmacological inhibition of sirt2-dependent p53 deacetylation is of great therapeutic interest for the treatment of cancer. |
2014-04-22 |
2023-08-12 |
Not clear |
| Yuhuang Li, Xiao-Xin Sun, Johannes Elferich, Ujwal Shinde, Larry L David, Mu-Shui Da. Monoubiquitination is critical for ovarian tumor domain-containing ubiquitin aldehyde binding protein 1 (Otub1) to suppress UbcH5 enzyme and stabilize p53 protein. The Journal of biological chemistry. vol 289. issue 8. 2014-04-22. PMID:24403071. |
consistently, this mutant is unable to stabilize p53, induce apoptosis, and suppress cell proliferation. |
2014-04-22 |
2023-08-12 |
Not clear |
| Sylvia A Hilliard, Xiao Yao, Samir S El-Dah. Mdm2 is required for maintenance of the nephrogenic niche. Developmental biology. vol 387. issue 1. 2014-04-22. PMID:24440154. |
this is accompanied by aberrant accumulation of phospho-γh2ax and p53, and elevated apoptosis together with reduced cell proliferation. |
2014-04-22 |
2023-08-12 |
mouse |
| Xinghua Chen, Zhilong Ren, Wei Liang, Dongqing Zha, Yipeng Liu, Cheng Chen, Pravin C Singhal, Guohua Din. c-Abl mediates angiotensin II-induced apoptosis in podocytes. Journal of molecular histology. vol 44. issue 5. 2014-04-21. PMID:23515840. |
ang ii also induced an increase of nuclear p53 protein and nuclear c-abl-p53 complexes in podocytes and podocyte apoptosis. |
2014-04-21 |
2023-08-12 |
mouse |
| Weilin Hu, Yumei Ge, David M Ojcius, Dexter Sun, Haiyan Dong, X Frank Yang, Jie Ya. p53 signalling controls cell cycle arrest and caspase-independent apoptosis in macrophages infected with pathogenic Leptospira species. Cellular microbiology. vol 15. issue 10. 2014-04-21. PMID:23521874. |
p53 signalling controls cell cycle arrest and caspase-independent apoptosis in macrophages infected with pathogenic leptospira species. |
2014-04-21 |
2023-08-12 |
mouse |
| Weilin Hu, Yumei Ge, David M Ojcius, Dexter Sun, Haiyan Dong, X Frank Yang, Jie Ya. p53 signalling controls cell cycle arrest and caspase-independent apoptosis in macrophages infected with pathogenic Leptospira species. Cellular microbiology. vol 15. issue 10. 2014-04-21. PMID:23521874. |
the intranuclear translocation of p53, increased expression of p53-dependent p21(cip) (1/) (waf) (1) and pro-apoptotic bcl-2 family proteins (bax, noxa and puma), release of aif and endog from mitochondria, and membrane translocation of fas occurred during leptospire-induced macrophage apoptosis. |
2014-04-21 |
2023-08-12 |
mouse |
| Li Ding, Xiaomin Zhao, Yong Huang, Qian Du, Feng Dong, Hongling Zhang, Xiangjun Song, Wenlong Zhang, Dewen Ton. Regulation of ROS in transmissible gastroenteritis virus-activated apoptotic signaling. Biochemical and biophysical research communications. vol 442. issue 1-2. 2014-04-21. PMID:24225120. |
furthermore, the two scavengers significantly inhibited the activation of p38 mapk and p53 and further blocked apoptosis occurrence through suppressing the tgev-induced bcl-2 reduction, bax redistribution, cytochrome c release and caspase-3 activation. |
2014-04-21 |
2023-08-12 |
Not clear |
| Debao Li, Jinlong Zhang, Wei Huang, Huricha Jin, Aiguo Shen, Longfei Yang, Jian Liu, Jianbo Fan, Qingzhong Zhou, Hai Wen, Yong Hu, Zhiming Cu. Up-regulation of Smurf1 after spinal cord injury in adult rats. Journal of molecular histology. vol 44. issue 4. 2014-04-18. PMID:23595775. |
recently, a report indicates that smurf1 can inhibit apoptosis by regulating p53 negatively, which depends on the effect of smurf1 stabilizing the mdm2-mdmx complex. |
2014-04-18 |
2023-08-12 |
rat |
| A I Arsen'ev, A A Barchuk, E A Zhelbunova, D E Matsko, A S Barchuk, E V Levchenko, K É Gagua, K A Kostitsyn, S A Tarkov, A O Nefedo. [Morphological, immunohistochemical and spectral characteristics of dysplasia, preinvasive and invasive forms of lung cancer]. Vestnik khirurgii imeni I. I. Grekova. vol 172. issue 5. 2014-04-18. PMID:24640742. |
the tendency of angiogenesis (cd31 and cd34), proliferative activity (ki-67), level of apoptosis (p53), egfr expression were estimated. |
2014-04-18 |
2023-08-12 |
Not clear |
| Ajay Kr Singh, Krishna Misr. Human papilloma virus 16 E6 protein as a target for curcuminoids, curcumin conjugates and congeners for chemoprevention of oral and cervical cancers. Interdisciplinary sciences, computational life sciences. vol 5. issue 2. 2014-04-16. PMID:23740392. |
in silico studies indicate that curcumin and its natural analogs have effective binding with different active sites on hpv 16 e6 protein, ideal target for restoring the tumor suppressor function of p53 and thus allowing the apoptosis of infected cells. |
2014-04-16 |
2023-08-12 |
human |