| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W Wen, C Peng, M O Kim, C Ho Jeong, F Zhu, K Yao, T Zykova, W Ma, A Carper, A Langfald, A M Bode, Z Don. Knockdown of RNF2 induces apoptosis by regulating MDM2 and p53 stability. Oncogene. vol 33. issue 4. 2014-03-11. PMID:23318437. |
knockdown of rnf2 induces apoptosis by regulating mdm2 and p53 stability. |
2014-03-11 |
2023-08-12 |
Not clear |
| W Wen, C Peng, M O Kim, C Ho Jeong, F Zhu, K Yao, T Zykova, W Ma, A Carper, A Langfald, A M Bode, Z Don. Knockdown of RNF2 induces apoptosis by regulating MDM2 and p53 stability. Oncogene. vol 33. issue 4. 2014-03-11. PMID:23318437. |
knockdown of rnf2 in hct116 p53(+/+) cells resulted in significantly more apoptosis than was observed in rnf2 knockdown hct116 p53(-/-) cells, indicating that rnf2 knockdown-induced apoptosis is partially dependent on p53. |
2014-03-11 |
2023-08-12 |
Not clear |
| Marcelo Hernández-Salazar, Ramón G Guevara-González, Andrés Cruz-Hernández, Lorenzo Guevara-Olvera, Luis Arturo Bello-Pérez, Eduardo Castaño-Tostado, Guadalupe Loarca-Piñ. Flaxseed (Linum usitatissimum L.) and its total non-digestible fraction influence the expression of genes involved in azoxymethane-induced colon cancer in rats. Plant foods for human nutrition (Dordrecht, Netherlands). vol 68. issue 3. 2014-03-10. PMID:23907590. |
both treatments (flaxseed and tndf) influence the overexpression of genes involved in cell cycle arrest and mitochondrial apoptosis: p53, p21, bcl-2, bax and caspase-3. |
2014-03-10 |
2023-08-12 |
rat |
| K Stephen Suh, Takemi Tanaka, Sreeja Sarojini, Ginah Nightingale, Rajendra Gharbaran, Andrew Pecora, Andre Go. The role of the ubiquitin proteasome system in lymphoma. Critical reviews in oncology/hematology. vol 87. issue 3. 2014-03-06. PMID:23541070. |
these drugs largely interfere with the e1 and e2 regions of the 26s proteasome, blocking proteasomal activity and promoting apoptosis by enhancing activities of the extrinsic (death receptors, trail, fas) and intrinsic (caspases, bax, bcl2, p53, nuclear factor-kappa b, p27) cell death programs. |
2014-03-06 |
2023-08-12 |
Not clear |
| C Berger, Y Qian, X Che. The p53-estrogen receptor loop in cancer. Current molecular medicine. vol 13. issue 8. 2014-03-06. PMID:23865427. |
tumor suppressor p53 maintains genome stability by regulating diverse cellular functions including cell cycle arrest, apoptosis, senescence and metabolic homeostasis. |
2014-03-06 |
2023-08-12 |
human |
| Paul B Essers, Tamara C Pereboom, Yvonne J Goos, Judith T Paridaen, Alyson W Macinne. A comparative study of nucleostemin family members in zebrafish reveals specific roles in ribosome biogenesis. Developmental biology. vol 385. issue 2. 2014-03-06. PMID:24211311. |
however, the loss of gnl3l still results in p53 stabilization, apoptosis, and lethality similarly to ns and gnl2 loss. |
2014-03-06 |
2023-08-12 |
zebrafish |
| Ji Ho Yun, Saet Byoul Lee, Kyungsu Kang, Eun Ha Lee, Hee Ju Lee, Sang Hoon Jung, Chu Won Nh. Bifunctional chemopreventive effects of Adenocaulon himalaicum through induction of detoxification enzymes and apoptosis. Journal of medicinal food. vol 16. issue 8. 2014-03-05. PMID:23957354. |
we also found that the ahe and ahb induced apoptosis, as evidenced by phosphatidylserine externalization, an increase in the sub-g0/g1 content, chromatin condensation, poly(adp-ribose) polymerase cleavage, and p53 induction. |
2014-03-05 |
2023-08-12 |
human |
| Weimin Chen, Huihui Wang, Shasha Tao, Yi Zheng, Wei Wu, Fangru Lian, Melba Jaramillo, Deyu Fang, Donna D Zhan. Tumor protein translationally controlled 1 is a p53 target gene that promotes cell survival. Cell cycle (Georgetown, Tex.). vol 12. issue 14. 2014-03-05. PMID:24067374. |
tumor suppressor p53 maintains genome stability by differentially activating target genes that control diverse cellular responses, such as the antioxidant response, cell cycle arrest and apoptosis. |
2014-03-05 |
2023-08-12 |
mouse |
| H-H Choi, H-K Choi, S Y Jung, J Hyle, B-J Kim, K Yoon, E-J Cho, H-D Youn, J M Lahti, J Qin, S-T Ki. CHK2 kinase promotes pre-mRNA splicing via phosphorylating CDK11(p110). Oncogene. vol 33. issue 1. 2014-03-03. PMID:23178491. |
upon ir, chk2 is activated by ataxia telangiectasia mutated kinase and regulates the s-phase and g1-s checkpoints, apoptosis and dna repair by phosphorylating downstream target proteins, such as p53 and brca1. |
2014-03-03 |
2023-08-12 |
Not clear |
| Venkateshwar Madka, Yuting Zhang, Qian Li, Altaf Mohammed, Puneet Sindhwani, Stan Lightfoot, Xue-Re Wu, Levy Kopelovich, Chinthalapally V Ra. p53-stabilizing agent CP-31398 prevents growth and invasion of urothelial cancer of the bladder in transgenic UPII-SV40T mice. Neoplasia (New York, N.Y.). vol 15. issue 8. 2014-03-03. PMID:23908596. |
molecular analysis of the bladder tumors showed an increase in apoptosis markers (p53, p21, bax, and annexin v) with a decrease in vascular endothelial growth factor in transgenic mice fed cp-31398. |
2014-03-03 |
2023-08-12 |
mouse |
| Chao Ji, Yan-li Yang, Zhi Yang, Ying Tu, Lei Cheng, Bin Chen, Ji-ping Xia, Wei-ling Sun, Zhong-lan Su, Li He, Zhi-gang B. Perifosine sensitizes UVB-induced apoptosis in skin cells: new implication of skin cancer prevention? Cellular signalling. vol 24. issue 9. 2014-02-28. PMID:22584119. |
perifosine inhibited uvb-induced pro-survival akt/mammalian target of rapamycin (mtor) and erk activation, while facilitating pro-apoptotic amp-activated protein kinas (ampk), c-jun-nh(2)-kinase (jnk), and p53 activation; these signaling changes together promoted a striking increase in skin cell apoptosis and a significantly reduced amount of dna damages. |
2014-02-28 |
2023-08-12 |
Not clear |
| Andreas K Hock, Karen H Vousde. The role of ubiquitin modification in the regulation of p53. Biochimica et biophysica acta. vol 1843. issue 1. 2014-02-28. PMID:23742843. |
the p53 tumor suppressor protein is involved in regulating a wide variety of stress responses, from senescence and apoptosis to more recently discovered roles in allowing adaptation to metabolic and oxidative stress. |
2014-02-28 |
2023-08-12 |
Not clear |
| Kirsten Janke, Ulf Brockmeier, Katja Kuhlmann, Martin Eisenacher, Jan Nolde, Helmut E Meyer, Heimo Mairbäurl, Eric Metze. Factor inhibiting HIF-1 (FIH-1) modulates protein interactions of apoptosis-stimulating p53 binding protein 2 (ASPP2). Journal of cell science. vol 126. issue Pt 12. 2014-02-27. PMID:23606740. |
however, fih-1 depletion did lead to impaired binding of par-3 to aspp2 while the interaction between aspp2 and p53, apoptosis and proliferation of the cancer cells were not affected. |
2014-02-27 |
2023-08-12 |
Not clear |
| Luis A Flores-López, Margarita Díaz-Flores, Rebeca García-Macedo, Alejandro Ávalos-Rodríguez, Marcela Vergara-Onofre, Miguel Cruz, Alejandra Contreras-Ramos, Mina Konigsberg, Clara Ortega-Camarill. High glucose induces mitochondrial p53 phosphorylation by p38 MAPK in pancreatic RINm5F cells. Molecular biology reports. vol 40. issue 8. 2014-02-25. PMID:23657598. |
the addition of a specific p38 mapk inhibitor (sb203580) to the culture medium during high glucose treatment blocked p53 mobilisation to the mitochondria and phosphorylation; thus, the release of cytochrome c and the apoptosis rate in rinm5f cells decreased. |
2014-02-25 |
2023-08-12 |
Not clear |
| Adeeb Shehzad, Jaetae Lee, Tae-Lin Huh, Young Sup Le. Curcumin induces apoptosis in human colorectal carcinoma (HCT-15) cells by regulating expression of Prp4 and p53. Molecules and cells. vol 35. issue 6. 2014-02-25. PMID:23686430. |
curcumin induces apoptosis in human colorectal carcinoma (hct-15) cells by regulating expression of prp4 and p53. |
2014-02-25 |
2023-08-12 |
human |
| W-K Ji, X-C Tang, M Yi, P-Q Chen, F-Y Liu, X-H Hu, W-F Hu, S-J Fu, J-F Liu, K-L Wu, M-X Wu, X-L Liu, L-X Luo, S Huang, Z-Z Liu, M-B Yu, Y-Z Liu, D W-C L. p53 directly regulates αA- and βA3/A1-crystallin genes to modulate lens differentiation. Current molecular medicine. vol 13. issue 6. 2014-02-25. PMID:23745585. |
it is well established that the tumor suppressor p53 plays major roles in regulating apoptosis and cell cycle progression. |
2014-02-25 |
2023-08-12 |
mouse |
| E M Yazlovitskaya, R Uzhachenko, P A Voziyan, W G Yarbrough, A V Ivanov. A novel radioprotective function for the mitochondrial tumor suppressor protein Fus1. Cell death & disease. vol 4. 2014-02-25. PMID:23788044. |
at the molecular level, dysregulated dynamics of activation of main ir response proteins (p53, nfκb, and gsk-3β), as well as key signaling pathways involved in oxidative stress response (sod2, prdx1, and cytochrome c), apoptosis (bax and parp1), cell cycle (cyclins b1 and d1), and dna repair (γh2ax) were found in fus1(-/-) cells after irradiation. |
2014-02-25 |
2023-08-12 |
mouse |
| Béatrice Dendelé, Xavier Tekpli, Kévin Hardonnière, Jørn A Holme, Laure Debure, Daniel Catheline, Volker M Arlt, Eszter Nagy, David H Phillips, Steinar Ovrebø, Steen Mollerup, Mallory Poët, Martine Chevanne, Vincent Rioux, Marie-Thérèse Dimanche-Boitrel, Odile Sergent, Dominique Lagadic-Gossman. Protective action of n-3 fatty acids on benzo[a]pyrene-induced apoptosis through the plasma membrane remodeling-dependent NHE1 pathway. Chemico-biological interactions. vol 207. 2014-02-25. PMID:24246761. |
we previously showed that the pah prototype, benzo[a]pyrene (b[a]p), triggers apoptosis via dna damage-induced p53 activation (genotoxic pathway) and via remodeling of the membrane cholesterol-rich microdomains called lipid rafts, leading to changes in ph homeostasis (non-genotoxic pathway). |
2014-02-25 |
2023-08-12 |
Not clear |
| Yun Dai, Shuang Chen, Maciej Kmieciak, Liang Zhou, Hui Lin, Xin-Yan Pei, Steven Gran. The novel Chk1 inhibitor MK-8776 sensitizes human leukemia cells to HDAC inhibitors by targeting the intra-S checkpoint and DNA replication and repair. Molecular cancer therapeutics. vol 12. issue 6. 2014-02-24. PMID:23536721. |
mk-8776 synergistically potentiated vorinostat-mediated apoptosis in various p53-wt or -deficient leukemia cell lines, whereas p53 knockdown by short hairpin rna (shrna) sensitized p53-wt cells to lethality of this regimen. |
2014-02-24 |
2023-08-12 |
human |
| D R Cui, L Wang, W Jiang, A H Qi, Q H Zhou, X L Zhan. Propofol prevents cerebral ischemia-triggered autophagy activation and cell death in the rat hippocampus through the NF-κB/p53 signaling pathway. Neuroscience. vol 246. 2014-02-24. PMID:23644056. |
the change in target genes including damage-regulated autophagy modulator (dram), microtubule-associated protein 1 light chain 3 (lc3), beclin 1, cathepsin d, cathepsin b, p53-upregulated modulator of apoptosis (puma), bax and bcl-2 upon p53 inhibition was assessed with the co-administration of the intravenous anesthetic propofol and 3-methyladenine (3-ma), pifithrin-alpha (pft-α) or sn50. |
2014-02-24 |
2023-08-12 |
rat |