| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Linda Vuong, Daniel E Brobst, Ivana Ivanovic, David M Sherry, Muayyad R Al-Ubaid. p53 selectively regulates developmental apoptosis of rod photoreceptors. PloS one. vol 8. issue 6. 2014-02-05. PMID:23840687. |
p53 selectively regulates developmental apoptosis of rod photoreceptors. |
2014-02-05 |
2023-08-12 |
mouse |
| Linda Vuong, Daniel E Brobst, Ivana Ivanovic, David M Sherry, Muayyad R Al-Ubaid. p53 selectively regulates developmental apoptosis of rod photoreceptors. PloS one. vol 8. issue 6. 2014-02-05. PMID:23840687. |
these findings strongly support a role for p53 in regulating developmental apoptosis in the retina and suggest a potential role, either direct or indirect, for p53 in the degenerative photoreceptor loss associated with human blinding disorders. |
2014-02-05 |
2023-08-12 |
mouse |
| Biyin Cao, Jie Li, Jingyu Zhu, Mingyun Shen, Kunkun Han, Zubin Zhang, Yang Yu, Yali Wang, Depei Wu, Suning Chen, Aining Sun, Xiaowen Tang, Yun Zhao, Chunhua Qiao, Tingjun Hou, Xinliang Ma. The antiparasitic clioquinol induces apoptosis in leukemia and myeloma cells by inhibiting histone deacetylase activity. The Journal of biological chemistry. vol 288. issue 47. 2014-02-04. PMID:24114842. |
by inhibiting hdac activity, cq induced expression of p21, p27, and p53, cell cycle arrest at g1 phase, and cell apoptosis. |
2014-02-04 |
2023-08-12 |
Not clear |
| You Ah Kim, Hojun Kim, Youngwan Se. Antiproliferative effect of flavonoids from the halophyte Vitex rotundifolia on human cancer cells. Natural product communications. vol 8. issue 10. 2014-02-04. PMID:24354186. |
compound 2 not only enhanced most remarkably the expression level of tumor suppressor genes p53 and p21, and pro-apoptotic gene bax at a concentration of 25 microm, but also suppressed the expression level of antiapoptotic gene bcl-2 to 20% at the same concentration, thus shifting the bax/bcl-2 ratio in favor of apoptosis. |
2014-02-04 |
2023-08-12 |
human |
| John Stanislav, Jan Mls, Miroslav Červinka, Emil Rudol. The role of autophagic cell death and apoptosis in irinotecan-treated p53 null colon cancer cells. Anti-cancer agents in medicinal chemistry. vol 13. issue 5. 2014-02-03. PMID:22721392. |
the role of autophagic cell death and apoptosis in irinotecan-treated p53 null colon cancer cells. |
2014-02-03 |
2023-08-12 |
Not clear |
| John Stanislav, Jan Mls, Miroslav Červinka, Emil Rudol. The role of autophagic cell death and apoptosis in irinotecan-treated p53 null colon cancer cells. Anti-cancer agents in medicinal chemistry. vol 13. issue 5. 2014-02-03. PMID:22721392. |
the roles of autophagic cell death and apoptosis induced by topoisomerase inhibitor irinotecan in colon cancer cells with deleted p53 were investigated during 48 h. we report that irinotecan-dependent cytotoxicity and proapoptotic activity were reduced in the present model while autophagy levels significantly increased. |
2014-02-03 |
2023-08-12 |
Not clear |
| John Stanislav, Jan Mls, Miroslav Červinka, Emil Rudol. The role of autophagic cell death and apoptosis in irinotecan-treated p53 null colon cancer cells. Anti-cancer agents in medicinal chemistry. vol 13. issue 5. 2014-02-03. PMID:22721392. |
upon p53 transfection, cell demise rates increased, with cells bearing the features of apoptosis and autophagic cell death. |
2014-02-03 |
2023-08-12 |
Not clear |
| Xiaoyun Zhang, Ying Jiang, Jun Yan. [p53-independent signaling pathway in DNA damage-induced cell apoptosis]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences. vol 42. issue 2. 2014-01-30. PMID:23585010. |
p53 is considered as the "master regulator" in dna damage-induced cell apoptosis. |
2014-01-30 |
2023-08-12 |
human |
| Alvaro Blanch, Fiona Robinson, Ian R Watson, Lynn S Cheng, Meredith S Irwi. Eukaryotic translation elongation factor 1-alpha 1 inhibits p53 and p73 dependent apoptosis and chemotherapy sensitivity. PloS one. vol 8. issue 6. 2014-01-30. PMID:23799104. |
eukaryotic translation elongation factor 1-alpha 1 inhibits p53 and p73 dependent apoptosis and chemotherapy sensitivity. |
2014-01-30 |
2023-08-12 |
Not clear |
| Qing Yang, Jun Chang, Jiao Song, Meng-Ting Qian, Jian-Ming Yu, Xun Su. Synthesis and in vitro antitumor activity of novel iridium(III) complexes with enantiopure C2-symmetrical vicinal diamine ligands. Bioorganic & medicinal chemistry letters. vol 23. issue 16. 2014-01-30. PMID:23849808. |
as indicated by the activation of caspase-3, the cleavage of parp, and the upregulation of p53, the preliminary mechanism studies revealed that the mode of cell death initiated by (r,r)-5a in a2780 cells was predominantly p53-mediated apoptosis. |
2014-01-30 |
2023-08-12 |
human |
| D Drakulić, N Veličković, M Stanojlović, I Grković, N Mitrović, I Lavrnja, A Horva. Low-dose dexamethasone treatment promotes the pro-survival signalling pathway in the adult rat prefrontal cortex. Journal of neuroendocrinology. vol 25. issue 7. 2014-01-28. PMID:23551329. |
the present study aimed to determine whether low-dose subchronic dex treatment (100 μg/kg for eight consecutive days) exerts long-term effects on apoptosis in the adult rat prefrontal cortex (pfc) by examining the expression of cell death-promoting molecules [poly(adp-ribose) polymerase (parp), p53, procaspase 3, cleaved caspase 3, bax] and cell-survival molecules (akt, bcl-2). |
2014-01-28 |
2023-08-12 |
rat |
| Yanyu Huang, Lizhen He, Wen Liu, Cundong Fan, Wenjie Zheng, Yum-Shing Wong, Tianfeng Che. Selective cellular uptake and induction of apoptosis of cancer-targeted selenium nanoparticles. Biomaterials. vol 34. issue 29. 2014-01-27. PMID:23800743. |
internalized tf-senps triggers intracellular ros overproduction, thus activates p53 and mapks pathways to promote cell apoptosis. |
2014-01-27 |
2023-08-12 |
mouse |
| So Jin Bing, Danbee Ha, Min Ju Kim, Eunjin Park, Ginnae Ahn, Dae Seung Kim, Ryeo Kyeong Ko, Jae Woo Park, Nam Ho Lee, Youngheun Je. Geraniin down regulates gamma radiation-induced apoptosis by suppressing DNA damage. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 57. 2014-01-24. PMID:23541438. |
also, geraniin inhibited apoptosis in radiosensitive splenocytes by reducing the expression level and immunoreactivity of proapoptotic p53 and bax and increasing those of anti-apoptotic bcl-2. |
2014-01-24 |
2023-08-12 |
mouse |
| Weilin Wang, Qiang Sun, Zehui Wu, Dongkai Zhou, Jianfeng Wei, Haiyang Xie, Lin Zhou, Shusen Zhen. Mitochondrial dysfunction-related genes in hepatocellular carcinoma. Frontiers in bioscience (Landmark edition). vol 18. 2014-01-24. PMID:23747873. |
the p53 family plays a key role in the mitochondrial apoptosis pathway and acts as part of the molecular mechanisms underlying mitochondrial dysfunction in hcc. |
2014-01-24 |
2023-08-12 |
Not clear |
| Weilin Wang, Qiang Sun, Zehui Wu, Dongkai Zhou, Jianfeng Wei, Haiyang Xie, Lin Zhou, Shusen Zhen. Mitochondrial dysfunction-related genes in hepatocellular carcinoma. Frontiers in bioscience (Landmark edition). vol 18. 2014-01-24. PMID:23747873. |
the novel genes found in the mitochondrial apoptosis signaling pathways, such as mfn2, play a role in the p53 network. |
2014-01-24 |
2023-08-12 |
Not clear |
| Naveen Kumar Vishvakarma, Anjani Kumar, Vivek Singh, Sukh Mahendra Sing. Hyperglycemia of tumor microenvironment modulates stage-dependent tumor progression and multidrug resistance: implication of cell survival regulatory molecules and altered glucose transport. Molecular carcinogenesis. vol 52. issue 12. 2014-01-23. PMID:22566271. |
hyperglycemic tumor microenvironment modulates the tumorigenic ability, survival, apoptosis, and glucose utilization of tumor cells in late tumor-bearing stage accompanied by an altered tumor acidosis and expression of cell survival regulatory molecules: hif-1α, p53, bcl2, caspase-activated dnase, il-4, il-6, il-10, ifn-γ, tgf-β, and vegf. |
2014-01-23 |
2023-08-12 |
Not clear |
| Jaiprakash R Patil, Guddadarangavvanahally K Jayaprakasha, Jinhee Kim, Kotamballi N Chidambara Murthy, Mahadev B Chetti, Sang-Yong Nam, Bhimanagouda S Pati. 5-Geranyloxy-7-methoxycoumarin inhibits colon cancer (SW480) cells growth by inducing apoptosis. Planta medica. vol 79. issue 3-4. 2014-01-23. PMID:23345169. |
in addition, 5-geranyloxy-7-methoxycoumarin arrested cells at the g0/g1 phase, and induction of apoptosis was demonstrated through the activation of tumour suppressor gene p53, caspase8/3, regulation of bcl2, and inhibition of p38 mapk phosphorylation. |
2014-01-23 |
2023-08-12 |
human |
| Baosheng Chen, Mark S Longtine, D Michael Nelso. Punicalagin, a polyphenol in pomegranate juice, downregulates p53 and attenuates hypoxia-induced apoptosis in cultured human placental syncytiotrophoblasts. American journal of physiology. Endocrinology and metabolism. vol 305. issue 10. 2014-01-23. PMID:24085032. |
punicalagin, a polyphenol in pomegranate juice, downregulates p53 and attenuates hypoxia-induced apoptosis in cultured human placental syncytiotrophoblasts. |
2014-01-23 |
2023-08-12 |
mouse |
| Baosheng Chen, Mark S Longtine, D Michael Nelso. Punicalagin, a polyphenol in pomegranate juice, downregulates p53 and attenuates hypoxia-induced apoptosis in cultured human placental syncytiotrophoblasts. American journal of physiology. Endocrinology and metabolism. vol 305. issue 10. 2014-01-23. PMID:24085032. |
p53 is involved in the oxidative stress-induced apoptosis in trophoblasts. |
2014-01-23 |
2023-08-12 |
mouse |
| Ai-hong Li, Ai-song Guo, Xin Chen, Xiao-lei Su. [Che-1 participates in the regulation of rat cortical neuronal apoptosis and axonal regeneration after traumatic brain injury via p53]. Zhonghua yi xue za zhi. vol 93. issue 21. 2014-01-23. PMID:24125679. |
[che-1 participates in the regulation of rat cortical neuronal apoptosis and axonal regeneration after traumatic brain injury via p53]. |
2014-01-23 |
2023-08-12 |
rat |