| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E V Kuzenko, A N Romaniuk, A M Politun, R A Moskalenk. [Pathogenesis of periodontal cell DNA damage during periodontitis]. Georgian medical news. issue 217. 2013-12-31. PMID:23676490. |
p53 in apoptosis may include inability to repair. |
2013-12-31 |
2023-08-12 |
Not clear |
| Goutam Mondal, Sugata Barui, Arabinda Chaudhur. The relationship between the cyclic-RGDfK ligand and αvβ3 integrin receptor. Biomaterials. vol 34. issue 26. 2013-12-31. PMID:23702147. |
we demonstrate that intravenous administration of the electrostatic complex of the cationic liposomes of an amphiphiles with cyclic rgdfk head-group and the anti-cancer p53 gene leads to significant tumor growth inhibition in a syngeneic mouse tumor model presumably through inducing apoptosis of tumor neovasculatures. |
2013-12-31 |
2023-08-12 |
mouse |
| Soyeon Shin, Kaipeng Jing, Soyeon Jeong, Nayeong Kim, Kyoung-Sub Song, Jun-Young Heo, Ji-Hoon Park, Kang-Sik Seo, Jeongsu Han, Jong-Il Park, Gi-Ryang Kweon, Seung-Kiel Park, Tong Wu, Byung-Doo Hwang, Kyu Li. The omega-3 polyunsaturated fatty acid DHA induces simultaneous apoptosis and autophagy via mitochondrial ROS-mediated Akt-mTOR signaling in prostate cancer cells expressing mutant p53. BioMed research international. vol 2013. 2013-12-31. PMID:23841076. |
the omega-3 polyunsaturated fatty acid dha induces simultaneous apoptosis and autophagy via mitochondrial ros-mediated akt-mtor signaling in prostate cancer cells expressing mutant p53. |
2013-12-31 |
2023-08-12 |
Not clear |
| Soyeon Shin, Kaipeng Jing, Soyeon Jeong, Nayeong Kim, Kyoung-Sub Song, Jun-Young Heo, Ji-Hoon Park, Kang-Sik Seo, Jeongsu Han, Jong-Il Park, Gi-Ryang Kweon, Seung-Kiel Park, Tong Wu, Byung-Doo Hwang, Kyu Li. The omega-3 polyunsaturated fatty acid DHA induces simultaneous apoptosis and autophagy via mitochondrial ROS-mediated Akt-mTOR signaling in prostate cancer cells expressing mutant p53. BioMed research international. vol 2013. 2013-12-31. PMID:23841076. |
results show that, in addition to apoptosis, dha increased the expression levels of lipidated form lc3b and potently stimulated the autophagic flux, suggesting that dha induces both autophagy and apoptosis in cancer cells expressing mutant p53. |
2013-12-31 |
2023-08-12 |
Not clear |
| Soyeon Shin, Kaipeng Jing, Soyeon Jeong, Nayeong Kim, Kyoung-Sub Song, Jun-Young Heo, Ji-Hoon Park, Kang-Sik Seo, Jeongsu Han, Jong-Il Park, Gi-Ryang Kweon, Seung-Kiel Park, Tong Wu, Byung-Doo Hwang, Kyu Li. The omega-3 polyunsaturated fatty acid DHA induces simultaneous apoptosis and autophagy via mitochondrial ROS-mediated Akt-mTOR signaling in prostate cancer cells expressing mutant p53. BioMed research international. vol 2013. 2013-12-31. PMID:23841076. |
similarly, pretreatment with the antioxidant n-acetyl-cysteine (nac) markedly inhibited both the autophagy and the apoptosis triggered by dha, indicating that mitochondrial ros mediate the cytotoxicity of dha in mutant p53 cells. |
2013-12-31 |
2023-08-12 |
Not clear |
| Soyeon Shin, Kaipeng Jing, Soyeon Jeong, Nayeong Kim, Kyoung-Sub Song, Jun-Young Heo, Ji-Hoon Park, Kang-Sik Seo, Jeongsu Han, Jong-Il Park, Gi-Ryang Kweon, Seung-Kiel Park, Tong Wu, Byung-Doo Hwang, Kyu Li. The omega-3 polyunsaturated fatty acid DHA induces simultaneous apoptosis and autophagy via mitochondrial ROS-mediated Akt-mTOR signaling in prostate cancer cells expressing mutant p53. BioMed research international. vol 2013. 2013-12-31. PMID:23841076. |
collectively, these findings present a novel mechanism of ros-regulated apoptosis and autophagy that involves akt-mtor signaling in prostate cancer cells with mutant p53 exposed to dha. |
2013-12-31 |
2023-08-12 |
Not clear |
| Hiroaki Iwasa, Takumi Kudo, Sainawaer Maimaiti, Mitsunobu Ikeda, Junichi Maruyama, Kentaro Nakagawa, Yutaka Hat. The RASSF6 tumor suppressor protein regulates apoptosis and the cell cycle via MDM2 protein and p53 protein. The Journal of biological chemistry. vol 288. issue 42. 2013-12-31. PMID:24003224. |
the rassf6 tumor suppressor protein regulates apoptosis and the cell cycle via mdm2 protein and p53 protein. |
2013-12-31 |
2023-08-12 |
Not clear |
| Hiroaki Iwasa, Takumi Kudo, Sainawaer Maimaiti, Mitsunobu Ikeda, Junichi Maruyama, Kentaro Nakagawa, Yutaka Hat. The RASSF6 tumor suppressor protein regulates apoptosis and the cell cycle via MDM2 protein and p53 protein. The Journal of biological chemistry. vol 288. issue 42. 2013-12-31. PMID:24003224. |
rassf6-induced apoptosis partially depends on p53. |
2013-12-31 |
2023-08-12 |
Not clear |
| Hiroaki Iwasa, Takumi Kudo, Sainawaer Maimaiti, Mitsunobu Ikeda, Junichi Maruyama, Kentaro Nakagawa, Yutaka Hat. The RASSF6 tumor suppressor protein regulates apoptosis and the cell cycle via MDM2 protein and p53 protein. The Journal of biological chemistry. vol 288. issue 42. 2013-12-31. PMID:24003224. |
these findings indicate that rassf6 stabilizes p53, regulates apoptosis and the cell cycle, and functions as a tumor suppressor. |
2013-12-31 |
2023-08-12 |
Not clear |
| Young Hoon Sung, Young Jin, Yunhwa Kang, Sushil Devkota, Jaehoon Lee, Jae-il Roh, Han-Woong Le. Ei24, a novel E2F target gene, affects p53-independent cell death upon ultraviolet C irradiation. The Journal of biological chemistry. vol 288. issue 43. 2013-12-31. PMID:24014029. |
here, we identified that etoposide-induced 2.4 mrna (ei24)/p53-induced gene 8 (pig8), a p53 target gene involved in apoptosis and autophagy, was up-regulated in rb(-/-) mouse embryonic fibroblasts (mefs). |
2013-12-31 |
2023-08-12 |
mouse |
| Nadja Bitomsky, Elisa Conrad, Christian Moritz, Tilman Polonio-Vallon, Dirk Sombroek, Kathrin Schultheiss, Carolina Glas, Vera Greiner, Christoph Herbel, Fiamma Mantovani, Giannino del Sal, Francesca Peri, Thomas G Hofman. Autophosphorylation and Pin1 binding coordinate DNA damage-induced HIPK2 activation and cell death. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 45. 2013-12-31. PMID:24145406. |
autophosphorylation regulates hipk2 activity and mutation of the phosphorylation-acceptor sites deregulates p53 ser46 phosphorylation and apoptosis in cellulo. |
2013-12-31 |
2023-08-12 |
human |
| J Pedro Menvielle, Najete Safini, Sergio G Tisminetzky, Natasa Skok. Dual role of dextran sulfate 5000 Da as anti-apoptotic and pro-autophagy agent. Molecular biotechnology. vol 54. issue 2. 2013-12-30. PMID:23180219. |
at a molecular level, we show that ds inhibits apoptosis by dna fragmentation delay and decrease of annexin v-labeled cells, causes a g0/g1 cell cycle arrest, decreases p53 expression and increases the pro-survival factor hsc70 expression. |
2013-12-30 |
2023-08-12 |
Not clear |
| Shun X Ren, Jin Shen, Alfred S L Cheng, Lan Lu, Ruby L Y Chan, Zhi J Li, Xiao J Wang, Clover C M Wong, Lin Zhang, Simon S M Ng, Franky L Chan, Francis K L Chan, Jun Yu, Joseph J Y Sung, William K K Wu, Chi H Ch. FK-16 derived from the anticancer peptide LL-37 induces caspase-independent apoptosis and autophagic cell death in colon cancer cells. PloS one. vol 8. issue 5. 2013-12-24. PMID:23700428. |
knockdown of p53, genetic ablation of bax, or overexpression of bcl-2 reversed fk-16-induced apoptosis and autophagy. |
2013-12-24 |
2023-08-12 |
Not clear |
| Monika Kusio-Kobialka, Kamila Wolanin, Paulina Podszywalow-Bartnicka, Ewa Sikora, Krzysztof Skowronek, Sharon L McKenna, Massimo Ghizzoni, Frank J Dekker, Katarzyna Piwock. Increased acetylation of lysine 317/320 of p53 caused by BCR-ABL protects from cytoplasmic translocation of p53 and mitochondria-dependent apoptosis in response to DNA damage. Apoptosis : an international journal on programmed cell death. vol 17. issue 9. 2013-12-23. PMID:22696202. |
increased acetylation of lysine 317/320 of p53 caused by bcr-abl protects from cytoplasmic translocation of p53 and mitochondria-dependent apoptosis in response to dna damage. |
2013-12-23 |
2023-08-12 |
Not clear |
| Monika Kusio-Kobialka, Kamila Wolanin, Paulina Podszywalow-Bartnicka, Ewa Sikora, Krzysztof Skowronek, Sharon L McKenna, Massimo Ghizzoni, Frank J Dekker, Katarzyna Piwock. Increased acetylation of lysine 317/320 of p53 caused by BCR-ABL protects from cytoplasmic translocation of p53 and mitochondria-dependent apoptosis in response to DNA damage. Apoptosis : an international journal on programmed cell death. vol 17. issue 9. 2013-12-23. PMID:22696202. |
we have shown that this site plays a crucial role in the regulation of p53 localization and p53-dependent, bax-mediated apoptosis. |
2013-12-23 |
2023-08-12 |
Not clear |
| Monika Kusio-Kobialka, Kamila Wolanin, Paulina Podszywalow-Bartnicka, Ewa Sikora, Krzysztof Skowronek, Sharon L McKenna, Massimo Ghizzoni, Frank J Dekker, Katarzyna Piwock. Increased acetylation of lysine 317/320 of p53 caused by BCR-ABL protects from cytoplasmic translocation of p53 and mitochondria-dependent apoptosis in response to DNA damage. Apoptosis : an international journal on programmed cell death. vol 17. issue 9. 2013-12-23. PMID:22696202. |
it can, in addition to already known mechanisms, explain the resistance to p53-dependent apoptosis observed in cml cells expressing wt p53. |
2013-12-23 |
2023-08-12 |
Not clear |
| Nishant Mohan, Walden Ai, Mrinmay Chakrabarti, Naren L Banik, Swapan K Ra. KLF4 overexpression and apigenin treatment down regulated anti-apoptotic Bcl-2 proteins and matrix metalloproteinases to control growth of human malignant neuroblastoma SK-N-DZ and IMR-32 cells. Molecular oncology. vol 7. issue 3. 2013-12-23. PMID:23317647. |
we also noticed that the combination therapy decreased expression of the anti-apoptotic proteins bcl-2 and mcl-1, increased expression of the pro-apoptotic proteins bax, noxa, and puma, upregulated p53, and caused activation of caspase-3 for cleavage of the inhibitor of caspase-activated dnase (icad) leading to completion of apoptosis machinery. |
2013-12-23 |
2023-08-12 |
human |
| Xiao-Ming Liu, Fei-Fei Yang, Yi-Feng Yuan, Rui Zhai, Li-Jun Hu. SUMOylation of mouse p53b by SUMO-1 promotes its pro-apoptotic function in ovarian granulosa cells. PloS one. vol 8. issue 5. 2013-12-23. PMID:23696846. |
the roles of p53 in apoptosis of mouse granulosa cells and its post-translational modification are still unclear. |
2013-12-23 |
2023-08-12 |
mouse |
| Kazunari Iwamoto, Hiroyuki Hamada, Masahiro Okamot. Mechanism of cell cycle disruption by multiple p53 pulses. Genome informatics. International Conference on Genome Informatics. vol 25. issue 1. 2013-12-17. PMID:22230936. |
when the dna damage is generated, the tumor suppressor gene p53 is activated and selects the cell fate such as the cell cycle arrest, the dna repair and the induction of apoptosis. |
2013-12-17 |
2023-08-12 |
Not clear |
| Maki Tokumoto, Masahiko Sato. [Cadmium induces p53-dependent apoptosis through the inhibition of Ube2d family gene expression]. Nihon eiseigaku zasshi. Japanese journal of hygiene. vol 67. issue 4. 2013-12-17. PMID:23095357. |
cd markedly increased p53 protein level and induced p53 phosphorylation and apoptosis in the cells. |
2013-12-17 |
2023-08-12 |
mouse |