| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qing Yang, Jun Chang, Jiao Song, Meng-Ting Qian, Jian-Ming Yu, Xun Su. Synthesis and in vitro antitumor activity of novel iridium(III) complexes with enantiopure C2-symmetrical vicinal diamine ligands. Bioorganic & medicinal chemistry letters. vol 23. issue 16. 2014-01-30. PMID:23849808. |
as indicated by the activation of caspase-3, the cleavage of parp, and the upregulation of p53, the preliminary mechanism studies revealed that the mode of cell death initiated by (r,r)-5a in a2780 cells was predominantly p53-mediated apoptosis. |
2014-01-30 |
2023-08-12 |
human |
| D Drakulić, N Veličković, M Stanojlović, I Grković, N Mitrović, I Lavrnja, A Horva. Low-dose dexamethasone treatment promotes the pro-survival signalling pathway in the adult rat prefrontal cortex. Journal of neuroendocrinology. vol 25. issue 7. 2014-01-28. PMID:23551329. |
the present study aimed to determine whether low-dose subchronic dex treatment (100 μg/kg for eight consecutive days) exerts long-term effects on apoptosis in the adult rat prefrontal cortex (pfc) by examining the expression of cell death-promoting molecules [poly(adp-ribose) polymerase (parp), p53, procaspase 3, cleaved caspase 3, bax] and cell-survival molecules (akt, bcl-2). |
2014-01-28 |
2023-08-12 |
rat |
| Yanyu Huang, Lizhen He, Wen Liu, Cundong Fan, Wenjie Zheng, Yum-Shing Wong, Tianfeng Che. Selective cellular uptake and induction of apoptosis of cancer-targeted selenium nanoparticles. Biomaterials. vol 34. issue 29. 2014-01-27. PMID:23800743. |
internalized tf-senps triggers intracellular ros overproduction, thus activates p53 and mapks pathways to promote cell apoptosis. |
2014-01-27 |
2023-08-12 |
mouse |
| So Jin Bing, Danbee Ha, Min Ju Kim, Eunjin Park, Ginnae Ahn, Dae Seung Kim, Ryeo Kyeong Ko, Jae Woo Park, Nam Ho Lee, Youngheun Je. Geraniin down regulates gamma radiation-induced apoptosis by suppressing DNA damage. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 57. 2014-01-24. PMID:23541438. |
also, geraniin inhibited apoptosis in radiosensitive splenocytes by reducing the expression level and immunoreactivity of proapoptotic p53 and bax and increasing those of anti-apoptotic bcl-2. |
2014-01-24 |
2023-08-12 |
mouse |
| Weilin Wang, Qiang Sun, Zehui Wu, Dongkai Zhou, Jianfeng Wei, Haiyang Xie, Lin Zhou, Shusen Zhen. Mitochondrial dysfunction-related genes in hepatocellular carcinoma. Frontiers in bioscience (Landmark edition). vol 18. 2014-01-24. PMID:23747873. |
the p53 family plays a key role in the mitochondrial apoptosis pathway and acts as part of the molecular mechanisms underlying mitochondrial dysfunction in hcc. |
2014-01-24 |
2023-08-12 |
Not clear |
| Weilin Wang, Qiang Sun, Zehui Wu, Dongkai Zhou, Jianfeng Wei, Haiyang Xie, Lin Zhou, Shusen Zhen. Mitochondrial dysfunction-related genes in hepatocellular carcinoma. Frontiers in bioscience (Landmark edition). vol 18. 2014-01-24. PMID:23747873. |
the novel genes found in the mitochondrial apoptosis signaling pathways, such as mfn2, play a role in the p53 network. |
2014-01-24 |
2023-08-12 |
Not clear |
| Naveen Kumar Vishvakarma, Anjani Kumar, Vivek Singh, Sukh Mahendra Sing. Hyperglycemia of tumor microenvironment modulates stage-dependent tumor progression and multidrug resistance: implication of cell survival regulatory molecules and altered glucose transport. Molecular carcinogenesis. vol 52. issue 12. 2014-01-23. PMID:22566271. |
hyperglycemic tumor microenvironment modulates the tumorigenic ability, survival, apoptosis, and glucose utilization of tumor cells in late tumor-bearing stage accompanied by an altered tumor acidosis and expression of cell survival regulatory molecules: hif-1α, p53, bcl2, caspase-activated dnase, il-4, il-6, il-10, ifn-γ, tgf-β, and vegf. |
2014-01-23 |
2023-08-12 |
Not clear |
| Jaiprakash R Patil, Guddadarangavvanahally K Jayaprakasha, Jinhee Kim, Kotamballi N Chidambara Murthy, Mahadev B Chetti, Sang-Yong Nam, Bhimanagouda S Pati. 5-Geranyloxy-7-methoxycoumarin inhibits colon cancer (SW480) cells growth by inducing apoptosis. Planta medica. vol 79. issue 3-4. 2014-01-23. PMID:23345169. |
in addition, 5-geranyloxy-7-methoxycoumarin arrested cells at the g0/g1 phase, and induction of apoptosis was demonstrated through the activation of tumour suppressor gene p53, caspase8/3, regulation of bcl2, and inhibition of p38 mapk phosphorylation. |
2014-01-23 |
2023-08-12 |
human |
| Baosheng Chen, Mark S Longtine, D Michael Nelso. Punicalagin, a polyphenol in pomegranate juice, downregulates p53 and attenuates hypoxia-induced apoptosis in cultured human placental syncytiotrophoblasts. American journal of physiology. Endocrinology and metabolism. vol 305. issue 10. 2014-01-23. PMID:24085032. |
punicalagin, a polyphenol in pomegranate juice, downregulates p53 and attenuates hypoxia-induced apoptosis in cultured human placental syncytiotrophoblasts. |
2014-01-23 |
2023-08-12 |
mouse |
| Baosheng Chen, Mark S Longtine, D Michael Nelso. Punicalagin, a polyphenol in pomegranate juice, downregulates p53 and attenuates hypoxia-induced apoptosis in cultured human placental syncytiotrophoblasts. American journal of physiology. Endocrinology and metabolism. vol 305. issue 10. 2014-01-23. PMID:24085032. |
p53 is involved in the oxidative stress-induced apoptosis in trophoblasts. |
2014-01-23 |
2023-08-12 |
mouse |
| Ai-hong Li, Ai-song Guo, Xin Chen, Xiao-lei Su. [Che-1 participates in the regulation of rat cortical neuronal apoptosis and axonal regeneration after traumatic brain injury via p53]. Zhonghua yi xue za zhi. vol 93. issue 21. 2014-01-23. PMID:24125679. |
[che-1 participates in the regulation of rat cortical neuronal apoptosis and axonal regeneration after traumatic brain injury via p53]. |
2014-01-23 |
2023-08-12 |
rat |
| Juan J Salazar, Roberto Gallego-Pinazo, Rosa de Hoz, Maria D Pinazo-Durán, Blanca Rojas, Ana I Ramírez, Manuel Serrano, José M Ramíre. "Super p53" mice display retinal astroglial changes. PloS one. vol 8. issue 6. 2014-01-22. PMID:23762373. |
the p53 gene can arrest proliferation and trigger death by apoptosis subsequent to several factors. |
2014-01-22 |
2023-08-12 |
mouse |
| Zoltan Derdak, Kristine A Villegas, Ragheb Harb, Annie M Wu, Aryanna Sousa, Jack R Wand. Inhibition of p53 attenuates steatosis and liver injury in a mouse model of non-alcoholic fatty liver disease. Journal of hepatology. vol 58. issue 4. 2014-01-21. PMID:23211317. |
we tested the efficacy of a p53 inhibitor, pifithrin-α p-nitro (pft) in attenuating steatosis, associated oxidative stress and apoptosis in a murine model of non-alcoholic fatty liver disease (nafld). |
2014-01-21 |
2023-08-12 |
mouse |
| Yoshitaka Sato, Tatsuya Tsurum. Genome guardian p53 and viral infections. Reviews in medical virology. vol 23. issue 4. 2014-01-21. PMID:23255396. |
the genome guardian p53 plays a central part not only in dna damage responses, inducing cell cycle arrest or apoptosis, but also in the innate host immune control of viral infections by orchestrating diverse signaling pathways originating from many different cellular receptors and sensors. |
2014-01-21 |
2023-08-12 |
Not clear |
| Jolanta Dorszewsk. Cell biology of normal brain aging: synaptic plasticity-cell death. Aging clinical and experimental research. vol 25. issue 1. 2014-01-20. PMID:23740630. |
in the aging brain, apoptosis does not seem to be activated in wild-type p53-expressing cells because the elevated levels of the p53 protein are no longer accompanied by decreased levels of the bcl-2 protein and increased levels of the bax protein. |
2014-01-20 |
2023-08-12 |
Not clear |
| Kathleen I Pishas, Susan J Neuhaus, Mark T Clayer, Alaknanda Adwal, Michael P Brown, Andreas Evdokiou, David F Callen, Paul M Neilse. Pre-activation of the p53 pathway through Nutlin-3a sensitises sarcomas to drozitumab therapy. Oncology reports. vol 30. issue 1. 2014-01-17. PMID:23670273. |
silencing of p53 strongly decreased dr5 mrna expression resulting in abrogation of drozitumab-induced apoptosis. |
2014-01-17 |
2023-08-12 |
human |
| Kiyohiro Hashimoto, Takeshi Tod. Mitotic slippage underlies the relationship between p53 dysfunction and the induction of large micronuclei by colcemid. Mutagenesis. vol 28. issue 4. 2014-01-16. PMID:23702691. |
this indicates that p53 dysfunction enhances aneugen-induced chromosome loss or perturbs apoptosis, resulting in the formation of large mn. |
2014-01-16 |
2023-08-12 |
Not clear |
| Wen-Yi Lu, Ming-Feng Zha. [Effect of oxidative stress on bone marrow mesenchymal stem cells]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 34. issue 1. 2014-01-14. PMID:22737723. |
it can induce the senescence and apoptosis of mscs via phosphatidylinositol 3-kinase/protein kinase b (pi3k/akt) and p53 pathways, and inhibit the proliferation and differentiation of mscs through apurinic/apyrimidinic endonuclease/redox factor 1 (ape/ref-1) and extracellular signal-regulated kinase (erk) pathways. |
2014-01-14 |
2023-08-12 |
Not clear |
| Qinsheng Dai, Yuehan Yin, Wei Liu, Libin Wei, Yuxin Zhou, Zhiyu Li, Qidong You, Na Lu, Qinglong Gu. Two p53-related metabolic regulators, TIGAR and SCO2, contribute to oroxylin A-mediated glucose metabolism in human hepatoma HepG2 cells. The international journal of biochemistry & cell biology. vol 45. issue 7. 2014-01-14. PMID:23612020. |
moreover, oroxylin a could increase protein and mrna expression of tp53-induced glycolysis and apoptosis regulator (tigar) and synthesis of cytochrome c oxidase 2 (sco2), which are the key metabolic modulators regulated by p53. |
2014-01-14 |
2023-08-12 |
human |
| Nan Bai, Chunyan Zhang, Ning Liang, Zhuhong Zhang, Antao Chang, Jing Yin, Zongjin Li, Na Luo, Xiaoyue Tan, Na Luo, Yunping Luo, Rong Xiang, Xiru Li, Ralph A Reisfeld, Dwayne Stupack, Dan Lv, Chenghu Li. Yes-associated protein (YAP) increases chemosensitivity of hepatocellular carcinoma cells by modulation of p53. Cancer biology & therapy. vol 14. issue 6. 2014-01-14. PMID:23760493. |
taken together, our current data indicate that yap functions as a tumor suppressor that enhances apoptosis by modulating p53 during chemotherapy. |
2014-01-14 |
2023-08-12 |
human |