| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maki Tokumoto, Masahiko Sato. [Cadmium induces p53-dependent apoptosis through the inhibition of Ube2d family gene expression]. Nihon eiseigaku zasshi. Japanese journal of hygiene. vol 67. issue 4. 2013-12-17. PMID:23095357. |
in vivo studies showed that chronic cd exposure also suppressed ube2d family gene expression and induced p53 accumulation and apoptosis in the renal tubules of the mouse kidney. |
2013-12-17 |
2023-08-12 |
mouse |
| Maki Tokumoto, Masahiko Sato. [Cadmium induces p53-dependent apoptosis through the inhibition of Ube2d family gene expression]. Nihon eiseigaku zasshi. Japanese journal of hygiene. vol 67. issue 4. 2013-12-17. PMID:23095357. |
these findings suggest that cd causes p53-dependent apoptosis due to the inhibition of p53 degradation through the down-regulation of ube2d family genes in nrk-52e cells and mouse kidney. |
2013-12-17 |
2023-08-12 |
mouse |
| Jin-Sun Ryu, Sang Jo Kang, Hyeon-Sook Ko. The 53BP1 homolog in C. elegans influences DNA repair and promotes apoptosis in response to ionizing radiation. PloS one. vol 8. issue 5. 2013-12-17. PMID:23667696. |
however, they attenuated apoptosis induced by dsbs, but not when cep-1 (a p53 ortholog) was absent, suggesting that hsr-9 functions in the same pathway as cep-1. |
2013-12-17 |
2023-08-12 |
caenorhabditis_elegans |
| Honit Piplani, Vivek Vaish, Chandan Rana, Sankar N Sanya. Up-regulation of p53 and mitochondrial signaling pathway in apoptosis by a combination of COX-2 inhibitor, Celecoxib and Dolastatin 15, a marine mollusk linear peptide in experimental colon carcinogenesis. Molecular carcinogenesis. vol 52. issue 11. 2013-12-16. PMID:22623379. |
up-regulation of p53 and mitochondrial signaling pathway in apoptosis by a combination of cox-2 inhibitor, celecoxib and dolastatin 15, a marine mollusk linear peptide in experimental colon carcinogenesis. |
2013-12-16 |
2023-08-12 |
rat |
| Liz J Valente, Daniel H D Gray, Ewa M Michalak, Josefina Pinon-Hofbauer, Alex Egle, Clare L Scott, Ana Janic, Andreas Strasse. p53 efficiently suppresses tumor development in the complete absence of its cell-cycle inhibitory and proapoptotic effectors p21, Puma, and Noxa. Cell reports. vol 3. issue 5. 2013-12-16. PMID:23665218. |
activation of apoptosis through transcriptional induction of puma and noxa has long been considered to constitute the critical (if not sole) process by which p53 suppresses tumor development, although g1/s boundary cell-cycle arrest via induction of the cdk inhibitor p21 has also been thought to contribute. |
2013-12-16 |
2023-08-12 |
mouse |
| Oleg Timofeev, Katharina Schlereth, Michael Wanzel, Attila Braun, Bernhard Nieswandt, Axel Pagenstecher, Andreas Rosenwald, Hans-Peter Elsässer, Thorsten Stiew. p53 DNA binding cooperativity is essential for apoptosis and tumor suppression in vivo. Cell reports. vol 3. issue 5. 2013-12-16. PMID:23665223. |
p53 dna binding cooperativity is essential for apoptosis and tumor suppression in vivo. |
2013-12-16 |
2023-08-12 |
mouse |
| Oleg Timofeev, Katharina Schlereth, Michael Wanzel, Attila Braun, Bernhard Nieswandt, Axel Pagenstecher, Andreas Rosenwald, Hans-Peter Elsässer, Thorsten Stiew. p53 DNA binding cooperativity is essential for apoptosis and tumor suppression in vivo. Cell reports. vol 3. issue 5. 2013-12-16. PMID:23665223. |
our data underscore the relevance of dna binding cooperativity for p53-dependent apoptosis and tumor suppression and highlight cooperativity mutations as a class of p53 mutations that result in a selective loss of apoptotic functions due to an altered quaternary structure of the p53 tetramer. |
2013-12-16 |
2023-08-12 |
mouse |
| Zdenek Andrysik, Jihye Kim, Aik Choon Tan, Joaquín M Espinos. A genetic screen identifies TCF3/E2A and TRIAP1 as pathway-specific regulators of the cellular response to p53 activation. Cell reports. vol 3. issue 5. 2013-12-16. PMID:23684607. |
the p53 transcription factor participates in diverse cellular responses to stress, including cell-cycle arrest, apoptosis, senescence, and autophagy. |
2013-12-16 |
2023-08-12 |
human |
| Zdenek Andrysik, Jihye Kim, Aik Choon Tan, Joaquín M Espinos. A genetic screen identifies TCF3/E2A and TRIAP1 as pathway-specific regulators of the cellular response to p53 activation. Cell reports. vol 3. issue 5. 2013-12-16. PMID:23684607. |
we performed a genome-wide genetic screen in human cells to identify pathway-specific coregulators of the p53 target gene cdkn1a (p21), an inhibitor of cell-cycle progression, versus bbc3 (puma), a key mediator of apoptosis. |
2013-12-16 |
2023-08-12 |
human |
| Zdenek Andrysik, Jihye Kim, Aik Choon Tan, Joaquín M Espinos. A genetic screen identifies TCF3/E2A and TRIAP1 as pathway-specific regulators of the cellular response to p53 activation. Cell reports. vol 3. issue 5. 2013-12-16. PMID:23684607. |
accordingly, tcf3/e2a depletion impairs the cell-cycle-arrest response and promotes apoptosis upon p53 activation by chemotherapeutic agents. |
2013-12-16 |
2023-08-12 |
human |
| Jie Xu, Xiaolin Zhou, Jilin Wang, Zhaoli Li, Xuan Kong, Jin Qian, Ye Hu, Jing-Yuan Fan. RhoGAPs attenuate cell proliferation by direct interaction with p53 tetramerization domain. Cell reports. vol 3. issue 5. 2013-12-16. PMID:23684608. |
here, we show that the rhogap arhgap11a induces cell-cycle arrest and apoptosis by binding to the tumor suppressor p53. |
2013-12-16 |
2023-08-12 |
Not clear |
| Jie Xu, Xiaolin Zhou, Jilin Wang, Zhaoli Li, Xuan Kong, Jin Qian, Ye Hu, Jing-Yuan Fan. RhoGAPs attenuate cell proliferation by direct interaction with p53 tetramerization domain. Cell reports. vol 3. issue 5. 2013-12-16. PMID:23684608. |
the interaction stabilizes the tetrameric conformation of p53 and enhances its dna-binding activity, thereby inducing cell-cycle arrest and apoptosis. |
2013-12-16 |
2023-08-12 |
Not clear |
| Hestia Mellert, Joaquín M Espinos. Tumor suppression by p53: is apoptosis important or not? Cell reports. vol 3. issue 5. 2013-12-16. PMID:23726020. |
tumor suppression by p53: is apoptosis important or not? |
2013-12-16 |
2023-08-12 |
Not clear |
| Praveen Kumar Jaiswal, Vibha Singh, Rama Devi Mitta. Polymorphism at P21 codon 31 and dinucleotide polymorphism of P73 gene and susceptibility to bladder cancer in individuals from North India. Indian journal of human genetics. vol 19. issue 3. 2013-12-16. PMID:24339541. |
p73, a novel p53 homolog and plays an important role in modulating cell cycle control, apoptosis and cell growth while p21, functions to negatively control the cell cycle. |
2013-12-16 |
2023-08-12 |
Not clear |
| Quanxin Gao, Lili Qi, Tianxing Wu, Jinbo Wan. Ability of Clostridium butyricum to inhibit Escherichia coli-induced apoptosis in chicken embryo intestinal cells. Veterinary microbiology. vol 160. issue 3-4. 2013-12-13. PMID:22771207. |
c. butyricum also showed a significant inhibitory effect on ehec-induced apoptosis by modulating the expression of xiap (x-linked inhibitor of apoptosis protein), bclxl (b-cell lymphoma-extra large), fas, bcl2 (b-cell leukemia/lymphoma-2), bax (bcl-2-associated x protein), p53 (tumor protein 53) and via inhibition of caspase-9 and caspase-3 activation. |
2013-12-13 |
2023-08-12 |
chicken |
| Hong-Yu Bao, Jian-Ning Wang, Yan-Qiu Hou, Ming Song, Liu-Bo Zhang, Qing-Qi Meng, Chang-Geng Rua. [Apoptosis-inducing effect of annexin A2 on multiple myeloma cells and its related mechanisms]. Zhongguo shi yan xue ye xue za zhi. vol 20. issue 6. 2013-12-13. PMID:23257438. |
the results showed that silencing anxa2 gene by sirna resulted in decreased expressions of anxa2 gene and protein, increased apoptosis of u266 and rpmi8226 cell lines (p < 0.05), at the same time resulted in down-regulation of apoptosis-related gene expressions including p65nf-κb, il-2, il-6 (p < 0.05), and up-regulation of p53 gene expression (p < 0.05). |
2013-12-13 |
2023-08-12 |
human |
| Florian Lang, Else K Hoffman. Role of ion transport in control of apoptotic cell death. Comprehensive Physiology. vol 2. issue 3. 2013-12-13. PMID:23723032. |
signaling involved in the modification of cell-volume regulatory ion transport during apoptosis include mitogen-activated kinases p38, jnk, erk1/2, mekk1, mkk4, the small g proteins cdc42, and/or rac and the transcription factor p53. |
2013-12-13 |
2023-08-12 |
Not clear |
| Sun-Whan Park, Myung-Guk Han, Chan Park, Young Ran Ju, Byung-Yoon Ahn, Jungsang Ryo. Hantaan virus nucleocapsid protein stimulates MDM2-dependent p53 degradation. The Journal of general virology. vol 94. issue Pt 11. 2013-12-13. PMID:23994832. |
to address these conflicting data, expression of the p53 protein, one of the key molecules involved in apoptosis, was assessed in the presence of the n protein in a549 and hela cells. |
2013-12-13 |
2023-08-12 |
Not clear |
| A-Rang Im, Young-Hwa Kim, Md Romij Uddin, Seong Wook Chae, Hye Won Lee, Woo Suk Jung, Yun Hee Kim, Bong Ju Kang, Yeong Shik Kim, Mi-Young Le. Protection from antimycin A-induced mitochondrial dysfunction by Nelumbo nucifera seed extracts. Environmental toxicology and pharmacology. vol 36. issue 1. 2013-12-12. PMID:23542413. |
we found that the extracts reduced cellular apoptosis; preserved the mitochondrial membrane potential; protected mitochondrial atp production; inhibited p53, bax, and caspase 3 activities; and induced bcl-2 production. |
2013-12-12 |
2023-08-12 |
rat |
| Silvia Licciulli, Jacqueline L Avila, Linda Hanlon, Scott Troutman, Matteo Cesaroni, Smitha Kota, Brian Keith, M Celeste Simon, Ellen Puré, Fred Radtke, Anthony J Capobianco, Joseph L Kissi. Notch1 is required for Kras-induced lung adenocarcinoma and controls tumor cell survival via p53. Cancer research. vol 73. issue 19. 2013-12-12. PMID:23943799. |
we found that notch1 function is required for tumor initiation via suppression of p53-mediated apoptosis through the regulation of p53 stability. |
2013-12-12 |
2023-08-12 |
Not clear |