| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Camila B Piantino, Sabrina T Reis, Nayara I Viana, Iran A Silva, Denis R Morais, Alberto A Antunes, Nelson Dip, Miguel Srougi, Katia R Leit. Prima-1 induces apoptosis in bladder cancer cell lines by activating p53. Clinics (Sao Paulo, Brazil). vol 68. issue 3. 2014-01-13. PMID:23644847. |
prima-1 induces apoptosis in bladder cancer cell lines by activating p53. |
2014-01-13 |
2023-08-12 |
Not clear |
| Diana M González-Gironès, Cristina Moncunill-Massaguer, Daniel Iglesias-Serret, Ana M Cosialls, Alba Pérez-Perarnau, Claudia M Palmeri, Camila Rubio-Patiño, Andreas Villunger, Gabriel Pons, Joan Gi. AICAR induces Bax/Bak-dependent apoptosis through upregulation of the BH3-only proteins Bim and Noxa in mouse embryonic fibroblasts. Apoptosis : an international journal on programmed cell death. vol 18. issue 8. 2014-01-10. PMID:23605481. |
it has been recently described that aicar triggers apoptosis in chronic lymphocytic leukemia (cll) cells, and its mechanism of action is independent of ampk as well as p53. |
2014-01-10 |
2023-08-12 |
mouse |
| Diana M González-Gironès, Cristina Moncunill-Massaguer, Daniel Iglesias-Serret, Ana M Cosialls, Alba Pérez-Perarnau, Claudia M Palmeri, Camila Rubio-Patiño, Andreas Villunger, Gabriel Pons, Joan Gi. AICAR induces Bax/Bak-dependent apoptosis through upregulation of the BH3-only proteins Bim and Noxa in mouse embryonic fibroblasts. Apoptosis : an international journal on programmed cell death. vol 18. issue 8. 2014-01-10. PMID:23605481. |
in addition, aicar acts independently of p53, as mefs lacking p53 also underwent apoptosis normally. |
2014-01-10 |
2023-08-12 |
mouse |
| Pearl Lee, Karen H Vousden, Eric C Cheun. TIGAR, TIGAR, burning bright. Cancer & metabolism. vol 2. issue 1. 2014-01-10. PMID:24383451. |
while the p53 tumor suppressor protein is known to inhibit cell growth by inducing apoptosis, senescence and cell cycle arrest, recent studies have found that p53 is also able to influence cell metabolism. |
2014-01-10 |
2023-08-12 |
Not clear |
| Xiao-Dan Hao, Yue Yang, Xin Song, Xue-Ke Zhao, Li-Dong Wang, Jun-Dong He, Qing-Peng Kong, Nelson Leung Sang Tang, Ya-Ping Zhan. Correlation of telomere length shortening with TP53 somatic mutations, polymorphisms and allelic loss in breast tumors and esophageal cancer. Oncology reports. vol 29. issue 1. 2014-01-09. PMID:23124483. |
p53 plays a key role in cellular senescence and/or apoptosis associated with telomere erosion which positions p53 as a guard against tumorigenesis. |
2014-01-09 |
2023-08-12 |
Not clear |
| Lixin Wang, Lei Wang, Shuping Zhang, Guangbo Qu, Daoqiang Zhang, Shitao Li, Sijin Li. Downregulation of ubiquitin E3 ligase TNF receptor-associated factor 7 leads to stabilization of p53 in breast cancer. Oncology reports. vol 29. issue 1. 2014-01-09. PMID:23128672. |
p53 is a key tumor suppressor and a master regulator of various signaling pathways, such as those related to apoptosis, cell cycle and dna repair. |
2014-01-09 |
2023-08-12 |
Not clear |
| Zhongbo Liu, Mitchell Antalek, Linda Nguyen, Xuesen Li, Xuejiao Tian, Amy Le, Xiaolin Z. The effect of gartanin, a naturally occurring xanthone in mangosteen juice, on the mTOR pathway, autophagy, apoptosis, and the growth of human urinary bladder cancer cell lines. Nutrition and cancer. vol 65 Suppl 1. 2014-01-09. PMID:23682785. |
in addition, gartanin downregulated the expression of bcl-2 and activated the p53 pathway leading to apoptosis induction. |
2014-01-09 |
2023-08-12 |
mouse |
| Zhe Zhou, Ji-Xiang Cao, Shu-Yan Li, Guo-Shun An, Ju-Hua Ni, Hong-Ti Ji. p53 Suppresses E2F1-dependent PLK1 expression upon DNA damage by forming p53-E2F1-DNA complex. Experimental cell research. vol 319. issue 20. 2014-01-09. PMID:24076372. |
in addition, we showed that suppression of plk1 by p53 promoted apoptosis. |
2014-01-09 |
2023-08-12 |
Not clear |
| Sayem Miah, Shahram Nour Mohammad Zadeh, Xi-Ming Yuan, Wei L. Expression of Egr1 and p53 in human carotid plaques and apoptosis induced by 7-oxysterol or p53. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 65. issue 5. 2014-01-07. PMID:22999639. |
expression of egr1 and p53 in human carotid plaques and apoptosis induced by 7-oxysterol or p53. |
2014-01-07 |
2023-08-12 |
human |
| Sayem Miah, Shahram Nour Mohammad Zadeh, Xi-Ming Yuan, Wei L. Expression of Egr1 and p53 in human carotid plaques and apoptosis induced by 7-oxysterol or p53. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 65. issue 5. 2014-01-07. PMID:22999639. |
however, it is unknown whether p53 and egr1 are interactively involved in apoptosis in atherosclerosis. |
2014-01-07 |
2023-08-12 |
human |
| Sayem Miah, Shahram Nour Mohammad Zadeh, Xi-Ming Yuan, Wei L. Expression of Egr1 and p53 in human carotid plaques and apoptosis induced by 7-oxysterol or p53. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 65. issue 5. 2014-01-07. PMID:22999639. |
in u937 cells, 7β-hydroxycholesterol and 7-ketocholesterol induced production of reactive oxygen species (ros), transient up-regulation of egr1 followed by late induction of p53 and apoptosis. |
2014-01-07 |
2023-08-12 |
human |
| Xiaoguang Li, Tao Chen, Sheng Lin, Jing Zhao, Peizhan Chen, Qian Ba, He Guo, Yanling Liu, Jingquan Li, Ruiai Chu, Lei Shan, Weidong Zhang, Hui Wan. Valeriana jatamansi constituent IVHD-valtrate as a novel therapeutic agent to human ovarian cancer: in vitro and in vivo activities and mechanisms. Current cancer drug targets. vol 13. issue 4. 2014-01-07. PMID:23597199. |
the detailed in vitro and in vivo study on the molecular mechanisms of this compound demonstrated that ivhd-valtrate exposure modulated the expression of numerous molecules involved in cell cycle progression and apoptosis regardless of p53 status, leading to increase the level of p53, rb, p21, p27 and decrease mdm2, e2f1, cyclin b1, cdc25c and cdc2. |
2014-01-07 |
2023-08-12 |
human |
| Zhen-Bo Wang, Xian-Zhong Peng, Shao-Shui Chen, Fang-Ling Ning, Chun-Juan Du, Kai Wang, Wei Ma, Yu-Feng Chen. High p53 and MAP1 light chain 3A co-expression predicts poor prognosis in patients with esophageal squamous cell carcinoma. Molecular medicine reports. vol 8. issue 1. 2014-01-07. PMID:23632916. |
p53 and microtubule-associated protein 1 light chain 3a (lc3a) are regulators of apoptosis and autophagy and are expressed at high levels in a number of human tumors. |
2014-01-07 |
2023-08-12 |
human |
| Haishi Qiao, Xiaoqing Chen, Lanfang Xu, Jingjing Wang, Guoyan Zhao, Yayi Hou, Hui Ming Ge, Ren-Xiang Tan, Erguang L. Antitumor effects of naturally occurring oligomeric resveratrol derivatives. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 27. issue 11. 2014-01-07. PMID:23925653. |
using pauciflorol b (paub) as an example, we showed that the compound induced apoptosis p53 dependently, inducing p53 accumulation and p53-modulated gene expression in cells with wild-type p53, but not in those with nonfunctional p53. |
2014-01-07 |
2023-08-12 |
mouse |
| Jing-Ping Wang, Kai-Han Lin, Chun-Yen Liu, Ya-Chu Yu, Pei-Tsun Wu, Chien-Chih Chiu, Chun-Li Su, Kwun-Min Chen, Kang Fan. Teroxirone inhibited growth of human non-small cell lung cancer cells by activating p53. Toxicology and applied pharmacology. vol 273. issue 1. 2014-01-06. PMID:23954467. |
the onset of ultimate apoptosis is dependent on the status of p53. |
2014-01-06 |
2023-08-12 |
mouse |
| A Meijer, F A E Kruyt, A G J van der Zee, H Hollema, P Le, K A ten Hoor, G M M Groothuis, W J Quax, E G E de Vries, S de Jon. Nutlin-3 preferentially sensitises wild-type p53-expressing cancer cells to DR5-selective TRAIL over rhTRAIL. British journal of cancer. vol 109. issue 10. 2014-01-06. PMID:24136147. |
tumour cell-selective activation of apoptosis by recombinant human tnf-related apoptosis-inducing ligand (rhtrail) is enhanced through co-activation of p53 by chemotherapeutic drugs. |
2014-01-06 |
2023-08-12 |
human |
| Chuan-Dong Wei, Yan Li, Hong-Yun Zheng, Yong-Qing Tong, Wen Da. Palmitate induces H9c2 cell apoptosis by increasing reactive oxygen species generation and activation of the ERK1/2 signaling pathway. Molecular medicine reports. vol 7. issue 3. 2014-01-03. PMID:23338747. |
in this model of treatment with palmitate, h9c2 cell apoptosis correlated with increased levels of p53 and bax expression and reduced levels of bcl-2 expression. |
2014-01-03 |
2023-08-12 |
Not clear |
| Fuling Wei, Yongmei Cao, Mengran Zhang, Rui Huang, Jun Cheng, Guoan Xiang, Jinqian Zhan. Immunosuppression induced by apoptosis of mixed lymphocyte culture is associated with p53. Molecular medicine reports. vol 7. issue 3. 2014-01-03. PMID:23358574. |
immunosuppression induced by apoptosis of mixed lymphocyte culture is associated with p53. |
2014-01-03 |
2023-08-12 |
Not clear |
| Fuling Wei, Yongmei Cao, Mengran Zhang, Rui Huang, Jun Cheng, Guoan Xiang, Jinqian Zhan. Immunosuppression induced by apoptosis of mixed lymphocyte culture is associated with p53. Molecular medicine reports. vol 7. issue 3. 2014-01-03. PMID:23358574. |
the suppression of recipient lymphocyte activity was due to apoptosis mediated by p53 and caspase-3, and the optimal ratio of donor and recipient lymphocytes for apoptosis was explored. |
2014-01-03 |
2023-08-12 |
Not clear |
| Fuling Wei, Yongmei Cao, Mengran Zhang, Rui Huang, Jun Cheng, Guoan Xiang, Jinqian Zhan. Immunosuppression induced by apoptosis of mixed lymphocyte culture is associated with p53. Molecular medicine reports. vol 7. issue 3. 2014-01-03. PMID:23358574. |
these data suggest that il-2 is involved in mlc-induced apoptosis of recipient lymphocytes, and that apoptosis may be associated with p53 and caspase-3 pathways. |
2014-01-03 |
2023-08-12 |
Not clear |