| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mourad Sanhaji, Frank Louwen, Brigitte Zimmer, Nina-Naomi Kreis, Susanne Roth, Juping Yua. Polo-like kinase 1 inhibitors, mitotic stress and the tumor suppressor p53. Cell cycle (Georgetown, Tex.). vol 12. issue 9. 2013-12-03. PMID:23574746. |
in the present work, we further demonstrate that in the presence of mitotic stress induced by different agents, plk1 inhibitors strongly induced apoptosis in hct116 p53(+/+) cells, whereas hct116 p53(-/-) cells arrested in mitosis with less apoptosis. |
2013-12-03 |
2023-08-12 |
Not clear |
| Mourad Sanhaji, Frank Louwen, Brigitte Zimmer, Nina-Naomi Kreis, Susanne Roth, Juping Yua. Polo-like kinase 1 inhibitors, mitotic stress and the tumor suppressor p53. Cell cycle (Georgetown, Tex.). vol 12. issue 9. 2013-12-03. PMID:23574746. |
depletion of p53 in hct116 p53(+/+) or u2os cells reduced the induction of apoptosis. |
2013-12-03 |
2023-08-12 |
Not clear |
| Gisela Caceres, Kathy McGraw, Bon Ham Yip, Andrea Pellagatti, Joseph Johnson, Ling Zhang, Kenian Liu, Lan Min Zhang, William J Fulp, Ji-Hyun Lee, Najla H Al Ali, Ashley Basiorka, Larry J Smith, F Joseph Daugherty, Neil Littleton, Richard A Wells, Lubomir Sokol, Sheng Wei, Rami S Komrokji, Jacqueline Boultwood, Alan F Lis. TP53 suppression promotes erythropoiesis in del(5q) MDS, suggesting a targeted therapeutic strategy in lenalidomide-resistant patients. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 40. 2013-12-03. PMID:24043769. |
cenersen treatment of ribosomal protein s-14-deficient erythroblasts significantly reduced cellular p53 and p53-up-regulated modulator of apoptosis expression compared with controls, accompanied by a significant reduction in apoptosis and increased cell proliferation. |
2013-12-03 |
2023-08-12 |
Not clear |
| Yongfeng Zhou, Yanying Bi, Chunhui Yang, Jingbo Yang, Yu Jiang, Fanmin Meng, Bo Yu, Muhammad Khan, Tonghui Ma, Hong Yan. Magnolol induces apoptosis in MCF-7 human breast cancer cells through G2/M phase arrest and caspase-independent pathway. Die Pharmazie. vol 68. issue 9. 2013-12-03. PMID:24147344. |
further mechanistic studies revealed that induction of apoptosis is associated with cell cycle arrest at g2/m phase, increased generation of reactive oxygen species (ros), reduced mitochondrial membrane potential (mmp), release of cytochrome c (cyto c) and apoptosis inducing factor (aif) from mitochondria to cytosol, upregulation of bax, p21 and p53, and down-regulation of bcl-2, cyclin b1 and cyclin-dependent kinase 1 (cdk1). |
2013-12-03 |
2023-08-12 |
human |
| B A Falana, O M Ogundele, F I Duru, A A Oshinubi, D T Falod. Role of Se+Zn in regeneration (Ki-67) following Pb toxicity (p53andcad) in the germinal epithelium of adult Wistar rats. Pakistan journal of biological sciences : PJBS. vol 16. issue 2. 2013-12-03. PMID:24199489. |
pb induced toxicity can follow a mitochondria pathway involving cathepsin d (cad) or a cytoplasmic pathway involving p53 (protein 53; a 53 kda nucleolase), the most predominant form of cell death is apoptosis which can result from both pathways. |
2013-12-03 |
2023-08-12 |
rat |
| Xiang Li, Feng Xu, ChunKang Chang, John Byon, Thalia Papayannopoulou, H Joachim Deeg, A Mario Marconde. Transcriptional regulation of miR-10a/b by TWIST-1 in myelodysplastic syndromes. Haematologica. vol 98. issue 3. 2013-11-26. PMID:22983574. |
inhibition of mir10a/10b in clonal cells interfered with proliferation and enhanced sensitivity to apoptosis, which involved nf-κb-dependent p53 activation. |
2013-11-26 |
2023-08-12 |
Not clear |
| Neera Yadav, Ashish Dwivedi, Syed Faiz Mujtaba, Hari Narayan Kushwaha, Shio Kumar Singh, Ratan Singh Ra. Ambient UVA-induced expression of p53 and apoptosis in human skin melanoma A375 cell line by quinine. Photochemistry and photobiology. vol 89. issue 3. 2013-11-26. PMID:23336807. |
ambient uva-induced expression of p53 and apoptosis in human skin melanoma a375 cell line by quinine. |
2013-11-26 |
2023-08-12 |
human |
| Yuqin Hao, Weixing Huang, Mingmei Liao, Yude Zhu, Hong Liu, Chunguang Hao, Guodong Liu, Guohui Zhang, Hongxia Feng, Xiaohong Ning, Henggui Li, Zhehai L. The inhibition of resveratrol to human skin squamous cell carcinoma A431 xenografts in nude mice. Fitoterapia. vol 86. 2013-11-26. PMID:23428654. |
the results demonstrate res inhibitory effect and indicate that the inhibition mechanism of res is to upgrade the protein and mrna expression of p53 and to downgrade the protein and mrna expression of svv, thus inducing the apoptosis of tumor cells. |
2013-11-26 |
2023-08-12 |
mouse |
| Salomé Paillas, Vincent Boudousq, Bérengère Piron, Nathalie Kersual, Manuel Bardiès, Nicolas Chouin, Caroline Bascoul-Mollevi, François-Xavier Arnaud, André Pèlegrin, Isabelle Navarro-Teulon, Jean-Pierre Pouge. Apoptosis and p53 are not involved in the anti-tumor efficacy of ¹²⁵I-labeled monoclonal antibodies targeting the cell membrane. Nuclear medicine and biology. vol 40. issue 4. 2013-11-26. PMID:23522976. |
apoptosis and p53 are not involved in the anti-tumor efficacy of ¹²⁵i-labeled monoclonal antibodies targeting the cell membrane. |
2013-11-26 |
2023-08-12 |
Not clear |
| Salomé Paillas, Vincent Boudousq, Bérengère Piron, Nathalie Kersual, Manuel Bardiès, Nicolas Chouin, Caroline Bascoul-Mollevi, François-Xavier Arnaud, André Pèlegrin, Isabelle Navarro-Teulon, Jean-Pierre Pouge. Apoptosis and p53 are not involved in the anti-tumor efficacy of ¹²⁵I-labeled monoclonal antibodies targeting the cell membrane. Nuclear medicine and biology. vol 40. issue 4. 2013-11-26. PMID:23522976. |
here, we investigated the role of apoptosis, autophagy and mitotic catastrophe in (125)i-mab toxicity in p53(-/-) and p53(+/+) cancer cells. |
2013-11-26 |
2023-08-12 |
Not clear |
| Wei Du, Yong Yi, Haibo Zhang, Johann Bergholz, Junfeng Wu, Haoqiang Ying, Yujun Zhang, Zhi-Xiong Jim Xia. Rapamycin inhibits IGF-1-mediated up-regulation of MDM2 and sensitizes cancer cells to chemotherapy. PloS one. vol 8. issue 4. 2013-11-26. PMID:23638184. |
the murine double minute 2 (mdm2) protein is a key regulator of cell proliferation and apoptosis that acts primarily by inhibiting the p53 tumor suppressor. |
2013-11-26 |
2023-08-12 |
Not clear |
| Arantza Fariña Sarasqueta, Giusi Forte, Wim E Corver, Noel F de Miranda, Dina Ruano, Ronald van Eijk, Jan Oosting, Rob A E M Tollenaar, Tom van Wezel, Hans Morrea. Integral analysis of p53 and its value as prognostic factor in sporadic colon cancer. BMC cancer. vol 13. 2013-11-26. PMID:23739040. |
p53 (encoded by tp53) is involved in dna damage repair, cell cycle regulation, apoptosis, aging and cellular senescence. |
2013-11-26 |
2023-08-12 |
mouse |
| Lee Farrand, Sanguine Byun, Ji Young Kim, Akechai Im-Aram, Jihoon Lee, Semi Lim, Ki Won Lee, Jeong-Yong Suh, Hyong Joo Lee, Benjamin K Tsan. Piceatannol enhances cisplatin sensitivity in ovarian cancer via modulation of p53, X-linked inhibitor of apoptosis protein (XIAP), and mitochondrial fission. The Journal of biological chemistry. vol 288. issue 33. 2013-11-26. PMID:23833193. |
piceatannol enhances cisplatin sensitivity in ovarian cancer via modulation of p53, x-linked inhibitor of apoptosis protein (xiap), and mitochondrial fission. |
2013-11-26 |
2023-08-12 |
mouse |
| Tiffany Yin, Seong-Jun Cho, Xinbin Che. RNPC1, an RNA-binding protein and a p53 target, regulates macrophage inhibitory cytokine-1 (MIC-1) expression through mRNA stability. The Journal of biological chemistry. vol 288. issue 33. 2013-11-26. PMID:23836903. |
macrophage inhibitory cytokine-1 (mic-1), a secreted cytokine, is a direct target of p53 and known to play a role in cell proliferation, apoptosis, cell metastasis, and angiogenesis through autocrine and paracrine signaling. |
2013-11-26 |
2023-08-12 |
Not clear |
| Sivaraman Natarajan, Yaochen Li, Emily E Miller, David J Shih, Michael D Taylor, Timothy M Stearns, Roderick T Bronson, Susan L Ackerman, Jeong K Yoon, Kyuson Yu. Notch1-induced brain tumor models the sonic hedgehog subgroup of human medulloblastoma. Cancer research. vol 73. issue 17. 2013-11-26. PMID:23852537. |
when apoptosis was blocked by genetic deletion of p53, 30% to 40% of n1icd;gfap-cre;p53(+/-) and n1icd;gfap-cre;p53(-/-) mice developed spontaneous medulloblastomas. |
2013-11-26 |
2023-08-12 |
mouse |
| Hyun-Woo Suh, Sohyun Yun, Haeyoung Song, Haiyoung Jung, Young-Jun Park, Tae-Don Kim, Suk Ran Yoon, Inpyo Cho. TXNIP interacts with hEcd to increase p53 stability and activity. Biochemical and biophysical research communications. vol 438. issue 2. 2013-11-26. PMID:23880345. |
the p53 protein plays a central role in cell cycle arrest and apoptosis in response to diverse stress stimuli. |
2013-11-26 |
2023-08-12 |
human |
| Norma Adán, Jessica Guzmán-Morales, Maria G Ledesma-Colunga, Sonia I Perales-Canales, Andrés Quintanar-Stéphano, Fernando López-Barrera, Isabel Méndez, Bibiana Moreno-Carranza, Jakob Triebel, Nadine Binart, Gonzalo Martínez de la Escalera, Stéphanie Thebault, Carmen Clap. Prolactin promotes cartilage survival and attenuates inflammation in inflammatory arthritis. The Journal of clinical investigation. vol 123. issue 9. 2013-11-26. PMID:23908112. |
here, we demonstrate that prl inhibits the apoptosis of cultured chondrocytes in response to a mixture of proinflammatory cytokines (tnf-α, il-1β, and ifn-γ) by preventing the induction of p53 and decreasing the bax/bcl-2 ratio through a no-independent, jak2/stat3-dependent pathway. |
2013-11-26 |
2023-08-12 |
mouse |
| Hirotoshi Kawashima, Hiroaki Takatori, Kotaro Suzuki, Arifumi Iwata, Masaya Yokota, Akira Suto, Tohru Minamino, Koichi Hirose, Hiroshi Nakajim. Tumor suppressor p53 inhibits systemic autoimmune diseases by inducing regulatory T cells. Journal of immunology (Baltimore, Md. : 1950). vol 191. issue 7. 2013-11-26. PMID:24006461. |
the tumor suppressor p53 plays a central role in tumor suppression by inducing apoptosis, cell cycle arrest, senescence, and dna repair. |
2013-11-26 |
2023-08-12 |
mouse |
| Yang Wang, Norman Sharpless, Sandy Chan. p16(INK4a) protects against dysfunctional telomere-induced ATR-dependent DNA damage responses. The Journal of clinical investigation. vol 123. issue 10. 2013-11-26. PMID:24091330. |
p16(ink4a) deletion enhanced the activation of the atr-dependent ddr in pot1bΔ/Δ hematopoietic cells, leading to p53 stabilization, increased p21-dependent cell cycle arrest, and elevated p53-dependent apoptosis. |
2013-11-26 |
2023-08-12 |
mouse |
| Roland Houben, Christina Dreher, Sabrina Angermeyer, Andreas Borst, Jochen Utikal, Sebastian Haferkamp, Wiebke K Peitsch, David Schrama, Sonja Hesbache. Mechanisms of p53 restriction in Merkel cell carcinoma cells are independent of the Merkel cell polyoma virus T antigens. The Journal of investigative dermatology. vol 133. issue 10. 2013-11-25. PMID:23563200. |
in contrast, inhibition of the ubiquitin ligase hdm-2 (human double minute 2) by nutlin-3a leads to p53 activation and p53-dependent apoptosis or cell cycle arrest in five out of seven p53 wild-type mcc lines, highlighting p53 as a potential target for future therapies of this aggressive tumor. |
2013-11-25 |
2023-08-12 |
human |