| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ji Young Kim, Jin-Yong Chung, Seung Gee Lee, Yoon-Jae Kim, Ji-Eun Park, Jeanho Yun, Young Chul Park, Byeong Gee Kim, Young Hyun Yoo, Jong-Min Ki. p53 interferes with microtubule-stabilizing agent-induced apoptosis in prostate and colorectal cancer cells. International journal of molecular medicine. vol 31. issue 6. 2013-11-12. PMID:23563592. |
in this study, we showed that p53 has a profound inhibitory effect on docetaxel (doc)-induced apoptosis in prostate and colorectal cancer cells and that caspases play a critical role in this process. |
2013-11-12 |
2023-08-12 |
human |
| Ji Young Kim, Jin-Yong Chung, Seung Gee Lee, Yoon-Jae Kim, Ji-Eun Park, Jeanho Yun, Young Chul Park, Byeong Gee Kim, Young Hyun Yoo, Jong-Min Ki. p53 interferes with microtubule-stabilizing agent-induced apoptosis in prostate and colorectal cancer cells. International journal of molecular medicine. vol 31. issue 6. 2013-11-12. PMID:23563592. |
doc induced prostate cancer cell apoptosis at high levels in p53-null pc3 cells, at intermediate levels in p53-mutant du145 cells and at low levels in p53 wild-type lncap cells. |
2013-11-12 |
2023-08-12 |
human |
| Ji Young Kim, Jin-Yong Chung, Seung Gee Lee, Yoon-Jae Kim, Ji-Eun Park, Jeanho Yun, Young Chul Park, Byeong Gee Kim, Young Hyun Yoo, Jong-Min Ki. p53 interferes with microtubule-stabilizing agent-induced apoptosis in prostate and colorectal cancer cells. International journal of molecular medicine. vol 31. issue 6. 2013-11-12. PMID:23563592. |
while transient overexpression of p53 in pc3 cells suppressed doc-induced apoptosis, knockdown of p53 in lncap cells increased apoptosis. |
2013-11-12 |
2023-08-12 |
human |
| Ji Young Kim, Jin-Yong Chung, Seung Gee Lee, Yoon-Jae Kim, Ji-Eun Park, Jeanho Yun, Young Chul Park, Byeong Gee Kim, Young Hyun Yoo, Jong-Min Ki. p53 interferes with microtubule-stabilizing agent-induced apoptosis in prostate and colorectal cancer cells. International journal of molecular medicine. vol 31. issue 6. 2013-11-12. PMID:23563592. |
this finding was further confirmed using an isogenic pair of colorectal cancer cell lines, hct-116 p53-/- and p53+/+, indicating that p53 inhibits induction of apoptosis by doc. |
2013-11-12 |
2023-08-12 |
human |
| Ji Young Kim, Jin-Yong Chung, Seung Gee Lee, Yoon-Jae Kim, Ji-Eun Park, Jeanho Yun, Young Chul Park, Byeong Gee Kim, Young Hyun Yoo, Jong-Min Ki. p53 interferes with microtubule-stabilizing agent-induced apoptosis in prostate and colorectal cancer cells. International journal of molecular medicine. vol 31. issue 6. 2013-11-12. PMID:23563592. |
to our knowledge, this is the first report describing that chemical or genetic knockout of p53 enhances the susceptibility of both prostate and colorectal cancer cells to doc-induced apoptosis. |
2013-11-12 |
2023-08-12 |
human |
| Bo Mi Ku, Dae-Seok Kim, Kyung-Hee Kim, Byong Chul Yoo, Seok-Hyun Kim, Young-Dae Gong, Soo-Youl Ki. Transglutaminase 2 inhibition found to induce p53 mediated apoptosis in renal cell carcinoma. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 27. issue 9. 2013-11-12. PMID:23704086. |
transglutaminase 2 inhibition found to induce p53 mediated apoptosis in renal cell carcinoma. |
2013-11-12 |
2023-08-12 |
mouse |
| Bo Mi Ku, Dae-Seok Kim, Kyung-Hee Kim, Byong Chul Yoo, Seok-Hyun Kim, Young-Dae Gong, Soo-Youl Ki. Transglutaminase 2 inhibition found to induce p53 mediated apoptosis in renal cell carcinoma. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 27. issue 9. 2013-11-12. PMID:23704086. |
the down-regulation of tgase 2 was found to stabilize p53 expression, thereby inducing a 3- to 10-fold increase in apoptosis for 786-o, a498, caki-1, and achn cell lines by dapi staining. |
2013-11-12 |
2023-08-12 |
mouse |
| Anthony Massip, Tania Arcondéguy, Christian Touriol, Céline Basset, Hervé Prats, Eric Lacazett. E2F1 activates p53 transcription through its distal site and participates in apoptosis induction in HPV-positive cells. FEBS letters. vol 587. issue 19. 2013-11-12. PMID:23954287. |
e2f1 activates p53 transcription through its distal site and participates in apoptosis induction in hpv-positive cells. |
2013-11-12 |
2023-08-12 |
human |
| Xinyue Zhang, Yunlong He, Kyoung-Hwa Lee, Wendy Dubois, Ziqing Li, Xiaolin Wu, Alexander Kovalchuk, Weimin Zhang, Jing Huan. Rap2b, a novel p53 target, regulates p53-mediated pro-survival function. Cell cycle (Georgetown, Tex.). vol 12. issue 8. 2013-11-11. PMID:23535297. |
the tumor suppressor p53 is a critical regulator of apoptosis and cell cycle arrest/pro-survival. |
2013-11-11 |
2023-08-12 |
Not clear |
| Xinyue Zhang, Yunlong He, Kyoung-Hwa Lee, Wendy Dubois, Ziqing Li, Xiaolin Wu, Alexander Kovalchuk, Weimin Zhang, Jing Huan. Rap2b, a novel p53 target, regulates p53-mediated pro-survival function. Cell cycle (Georgetown, Tex.). vol 12. issue 8. 2013-11-11. PMID:23535297. |
upon dna damage, p53 evokes both cell cycle arrest/pro-survival and apoptosis transcriptional programs. |
2013-11-11 |
2023-08-12 |
Not clear |
| Xinyue Zhang, Yunlong He, Kyoung-Hwa Lee, Wendy Dubois, Ziqing Li, Xiaolin Wu, Alexander Kovalchuk, Weimin Zhang, Jing Huan. Rap2b, a novel p53 target, regulates p53-mediated pro-survival function. Cell cycle (Georgetown, Tex.). vol 12. issue 8. 2013-11-11. PMID:23535297. |
together, our results identify rap2b as a new player in the pro-survival program conducted by p53 and raise the possibility that targeting rap2b could sensitize tumor cells to apoptosis in response to dna damage. |
2013-11-11 |
2023-08-12 |
Not clear |
| Rive Sarfstein, Yael Friedman, Zohar Attias-Geva, Ami Fishman, Ilan Bruchim, Haim Werne. Metformin downregulates the insulin/IGF-I signaling pathway and inhibits different uterine serous carcinoma (USC) cells proliferation and migration in p53-dependent or -independent manners. PloS one. vol 8. issue 4. 2013-11-11. PMID:23620761. |
our results show that metformin interacts with the igf pathway, and induces apoptosis and inhibition of proliferation and migration of usc cell lines with both wild type and mutant p53. |
2013-11-11 |
2023-08-12 |
human |
| Jared J Gartner, Stephen C J Parker, Todd D Prickett, Ken Dutton-Regester, Michael L Stitzel, Jimmy C Lin, Sean Davis, Vijaya L Simhadri, Sujata Jha, Nobuko Katagiri, Valer Gotea, Jamie K Teer, Xiaomu Wei, Mario A Morken, Umesh K Bhanot, Guo Chen, Laura L Elnitski, Michael A Davies, Jeffrey E Gershenwald, Hannah Carter, Rachel Karchin, William Robinson, Steven Robinson, Steven A Rosenberg, Francis S Collins, Giovanni Parmigiani, Anton A Komar, Chava Kimchi-Sarfaty, Nicholas K Hayward, Elliott H Margulies, Yardena Samuel. Whole-genome sequencing identifies a recurrent functional synonymous mutation in melanoma. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 33. 2013-11-11. PMID:23901115. |
protein made from mutant bcl2l12 transcript bound p53, inhibited uv-induced apoptosis more efficiently than wt bcl2l12, and reduced endogenous p53 target gene transcription. |
2013-11-11 |
2023-08-12 |
human |
| Toshinori Ozaki, Akira Nakagawar. Role of p53 in Cell Death and Human Cancers. Cancers. vol 3. issue 1. 2013-11-11. PMID:24212651. |
activated p53 promotes cell cycle arrest to allow dna repair and/or apoptosis to prevent the propagation of cells with serious dna damage through the transactivation of its target genes implicated in the induction of cell cycle arrest and/or apoptosis. |
2013-11-11 |
2023-08-12 |
human |
| Janina Seznec, Ulrike Nauman. Microarray analysis in a cell death resistant glioma cell line to identify signaling pathways and novel genes controlling resistance and malignancy. Cancers. vol 3. issue 3. 2013-11-11. PMID:24212935. |
since the tumor suppressor p53 functions as a transcription factor regulating the expression of genes involved in growth inhibition, dna repair and apoptosis, we previously assessed whether specific differences in the modulation of gene expression are responsible for the anti-tumor properties of a dominant positive p53, chimeric tumor suppressor (cts)-1. |
2013-11-11 |
2023-08-12 |
Not clear |
| Seiji Takashima, Michiko Hirose, Narumi Ogonuki, Miki Ebisuya, Kimiko Inoue, Mito Kanatsu-Shinohara, Takashi Tanaka, Eisuke Nishida, Atsuo Ogura, Takashi Shinohar. Regulation of pluripotency in male germline stem cells by Dmrt1. Genes & development. vol 27. issue 18. 2013-11-08. PMID:24029916. |
dmrt1 depletion caused apoptosis of gs cells, but a combination of dmrt1 and p53 depletion also induced pluripotency. |
2013-11-08 |
2023-08-12 |
Not clear |
| Amanda M Goh, David P Lan. How p53 wields the scales of fate: arrest or death? Transcription. vol 3. issue 5. 2013-11-07. PMID:22885979. |
understanding how the tumor suppressor p53 induces cell cycle arrest or apoptosis is critical for developing chemotherapeutic strategies. |
2013-11-07 |
2023-08-12 |
mouse |
| Vivian Gama, Mohanish Deshmuk. Adenosine: essential for life but licensed to kill. Molecular cell. vol 50. issue 3. 2013-11-07. PMID:23664374. |
in this issue of molecular cell,long and crighton (2013) report a cell death priming mechanism activated by p53 that senses extracellular adenosine accumulated following chemotherapy or hypoxia, providing a novel connection between adenosine signaling and apoptosis. |
2013-11-07 |
2023-08-12 |
Not clear |
| Ying Wang, Shao-Lin Xu, Ya-Zhen Wu, Mei-Sheng Zhao, Wen-Jing Xu, Hai-Yan Yang, Yu-Xin L. Simvastatin induces caspase-dependent apoptosis and activates P53 in OCM-1 cells. Experimental eye research. vol 113. 2013-11-07. PMID:23727160. |
simvastatin induces caspase-dependent apoptosis and activates p53 in ocm-1 cells. |
2013-11-07 |
2023-08-12 |
Not clear |
| Ying Wang, Shao-Lin Xu, Ya-Zhen Wu, Mei-Sheng Zhao, Wen-Jing Xu, Hai-Yan Yang, Yu-Xin L. Simvastatin induces caspase-dependent apoptosis and activates P53 in OCM-1 cells. Experimental eye research. vol 113. 2013-11-07. PMID:23727160. |
in addition, simvastatin resulted in an increase in levels of reactive oxygen species (ros) in ocm-1 cells and simvastatin significantly triggered apoptosis in ocm-1 cells, which was characterized by increased chromatin condensation, activation of caspase-9 and cleaved-caspase-3, increased expression mitochondrion-related apoptosis protein of p53, bax and decreased expression of bcl2 and iaspp. |
2013-11-07 |
2023-08-12 |
Not clear |