| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alessia Formigari, Elisa Gregianin, Paola Irat. The effect of zinc and the role of p53 in copper-induced cellular stress responses. Journal of applied toxicology : JAT. vol 33. issue 7. 2013-10-24. PMID:23401182. |
copper (cu) accumulation causes apoptosis that seems to be mediated by dna damage and subsequent p53 activation. |
2013-10-24 |
2023-08-12 |
rat |
| Xin Zho. p73 G4C14-to-A4T14 polymorphisms are positively correlated with triple-negative breast cancer in southwestern China. Medical oncology (Northwood, London, England). vol 30. issue 2. 2013-10-24. PMID:23443851. |
p73 gene shares structural and functional similarities to p53 and plays an important role in modulating cell cycle arrest and apoptosis. |
2013-10-24 |
2023-08-12 |
human |
| Luis A Carvajal, James J Manfred. Another fork in the road--life or death decisions by the tumour suppressor p53. EMBO reports. vol 14. issue 5. 2013-10-24. PMID:23588418. |
gaining a clear understanding of the mechanisms controlling cell fate determination by p53 could lead to the identification of molecular targets for therapy, which could selectively sensitize cancer cells to apoptosis. |
2013-10-24 |
2023-08-12 |
Not clear |
| Yashodhar P Bhandary, Shwetha K Shetty, Amarnath S Marudamuthu, Hong-Long Ji, Pierre F Neuenschwander, Vijay Boggaram, Gilbert F Morris, Jian Fu, Steven Idell, Sreerama Shett. Regulation of lung injury and fibrosis by p53-mediated changes in urokinase and plasminogen activator inhibitor-1. The American journal of pathology. vol 183. issue 1. 2013-10-24. PMID:23665346. |
transgenic mice expressing transcriptionally inactive dominant negative p53 in atii cells showed augmented apoptosis, whereas those deficient in p53 resisted blm-induced atii cell apoptosis. |
2013-10-24 |
2023-08-12 |
mouse |
| S Santag, W Jäger, C B Karsten, S Kati, M Pietrek, D Steinemann, G Sarek, P M Ojala, T F Schul. Recruitment of the tumour suppressor protein p73 by Kaposi's Sarcoma Herpesvirus latent nuclear antigen contributes to the survival of primary effusion lymphoma cells. Oncogene. vol 32. issue 32. 2013-10-23. PMID:22964633. |
the small-molecule retra, which activates p73 in the context of mutant p53, leads to the induction of apoptosis in p53-mutant pel cell lines. |
2013-10-23 |
2023-08-12 |
Not clear |
| S Sinha, R Ghildiyal, V S Mehta, E Se. ATM-NFκB axis-driven TIGAR regulates sensitivity of glioma cells to radiomimetics in the presence of TNFα. Cell death & disease. vol 4. 2013-10-23. PMID:23640457. |
ncs-induced p53 expression was accompanied by increase in tp53-induced glycolysis and apoptosis regulator (tigar) levels and atm phosphorylation. |
2013-10-23 |
2023-08-12 |
Not clear |
| S Sinha, R Ghildiyal, V S Mehta, E Se. ATM-NFκB axis-driven TIGAR regulates sensitivity of glioma cells to radiomimetics in the presence of TNFα. Cell death & disease. vol 4. 2013-10-23. PMID:23640457. |
transfection with tigar mutant (i) decreased apoptosis and γh2ax foci formation (ii) decreased p53 (iii) elevated ros and (iv) increased akt/erk activation in cells cotreated with ncs and tnfα. |
2013-10-23 |
2023-08-12 |
Not clear |
| Yuichiro Nakata, Kosuke Nishi, Sogo Nishimoto, Takuya Sugahar. Phenylhydroquinone induces loss of thymocytes through cell cycle arrest and apoptosis elevation in p53-dependent pathway. The Journal of toxicological sciences. vol 38. issue 3. 2013-10-23. PMID:23665931. |
phosphorylation of p53 at ser15 was upregulated by activation of not only atr but also erk1/2 and p38, leading to increase of apoptosis. |
2013-10-23 |
2023-08-12 |
mouse |
| Ha Ryong Kim, Mi Hyun Jung, Soo Yeun Lee, Seung Min Oh, Kyu Hyuck Chun. Marijuana smoke condensate induces p53-mediated apoptosis in human lung epithelial cells. The Journal of toxicological sciences. vol 38. issue 3. 2013-10-23. PMID:23665932. |
because p53, a tumor suppressor gene, has an important pathophysiologic role in the regulation of lung epithelial cell dna damage responses, we hypothesized that p53 may be involved in the oxidative stress-mediated apoptosis induced by marijuana smoking. |
2013-10-23 |
2023-08-12 |
human |
| Ha Ryong Kim, Mi Hyun Jung, Soo Yeun Lee, Seung Min Oh, Kyu Hyuck Chun. Marijuana smoke condensate induces p53-mediated apoptosis in human lung epithelial cells. The Journal of toxicological sciences. vol 38. issue 3. 2013-10-23. PMID:23665932. |
the results indicate that p53 plays a role in msc-induced apoptosis. |
2013-10-23 |
2023-08-12 |
human |
| Ashraf Dar, Etsuko Shibata, Anindya Dutt. Deubiquitination of Tip60 by USP7 determines the activity of the p53-dependent apoptotic pathway. Molecular and cellular biology. vol 33. issue 16. 2013-10-23. PMID:23775119. |
tip60 acetylates the p53 tumor suppressor at lysine 120 (k120), a modification essential for p53-dependent induction of puma and apoptosis. |
2013-10-23 |
2023-08-12 |
Not clear |
| M Ruscica, M Arvigo, L Steffani, D Ferone, P Magn. Somatostatin, somatostatin analogs and somatostatin receptor dynamics in the biology of cancer progression. Current molecular medicine. vol 13. issue 4. 2013-10-22. PMID:22934849. |
these compounds may control tumor development, cell proliferation and metastatization by direct actions, including cell division arrest in g0/g1 phase (i.e., induction of cyclin-dependent kinase inhibitor p27(kip1) or p21(cip1)), induction of apoptosis (i.e., induction of p53 and bax) and suppression of cell invasion. |
2013-10-22 |
2023-08-12 |
Not clear |
| Chandrashekhar D Kamat, Ron B Shmueli, Nick Connis, Charles M Rudin, Jordan J Green, Christine L Han. Poly(β-amino ester) nanoparticle delivery of TP53 has activity against small cell lung cancer in vitro and in vivo. Molecular cancer therapeutics. vol 12. issue 4. 2013-10-22. PMID:23364678. |
nanoparticle delivery of tp53 resulted in expression of exogenous p53, induction of p21, induction of apoptosis, and accumulation of cells in sub-g1 consistent with functional p53 activity. |
2013-10-22 |
2023-08-12 |
mouse |
| D Chen, Y Chen, D Forrest, R Bremne. E2f2 induces cone photoreceptor apoptosis independent of E2f1 and E2f3. Cell death and differentiation. vol 20. issue 7. 2013-10-22. PMID:23558950. |
moreover, whereas e2f1-dependent apoptosis was p53 and p73-independent, e2f2 caused p53-dependent cone death. |
2013-10-22 |
2023-08-12 |
mouse |
| Sumaira Amir, Ai-Hong Ma, Xu-Bao Shi, Lingru Xue, Hsing-Jien Kung, Ralph W Devere Whit. Oncomir miR-125b suppresses p14(ARF) to modulate p53-dependent and p53-independent apoptosis in prostate cancer. PloS one. vol 8. issue 4. 2013-10-22. PMID:23585871. |
our results highlight that mir-125b modulates the p53 network by hindering the down-regulation of mdm2, thereby affecting p53 and its target genes p21 and puma to a degree sufficient to inhibit apoptosis. |
2013-10-22 |
2023-08-12 |
human |
| P Sridevi, M K Nhiayi, J Y J Wan. Genetic disruption of Abl nuclear import reduces renal apoptosis in a mouse model of cisplatin-induced nephrotoxicity. Cell death and differentiation. vol 20. issue 7. 2013-10-22. PMID:23660976. |
however, the accumulation of p53 and pumaα could not be sustained in the abl(μ/μ) kidneys, leading to reductions in renal apoptosis and tubule damage. |
2013-10-22 |
2023-08-12 |
mouse |
| P Sridevi, M K Nhiayi, J Y J Wan. Genetic disruption of Abl nuclear import reduces renal apoptosis in a mouse model of cisplatin-induced nephrotoxicity. Cell death and differentiation. vol 20. issue 7. 2013-10-22. PMID:23660976. |
the residual apoptosis in the abl(μ/μ) mice was not further reduced in the abl(μ/μ); p53(-/-) double-mutant mice, suggesting that nuclear abl and p53 are epistatic to each other in this apoptosis response. |
2013-10-22 |
2023-08-12 |
mouse |
| P Sridevi, M K Nhiayi, J Y J Wan. Genetic disruption of Abl nuclear import reduces renal apoptosis in a mouse model of cisplatin-induced nephrotoxicity. Cell death and differentiation. vol 20. issue 7. 2013-10-22. PMID:23660976. |
these results provide in vivo evidence for the pro-apoptotic function of abl, and show that its nuclear localization and tyrosine kinase activity are both required for the sustained expression of p53 and pumaα in cisplatin-induced renal apoptosis. |
2013-10-22 |
2023-08-12 |
mouse |
| Ni Zhang, Xiang Wei, Lijun X. miR-150 promotes the proliferation of lung cancer cells by targeting P53. FEBS letters. vol 587. issue 15. 2013-10-22. PMID:23747308. |
inhibition of mir-150 effectively delays cell proliferation and promotes apoptosis, accompanied by increased p53 protein expression. |
2013-10-22 |
2023-08-12 |
Not clear |
| Jian Xu, Wei Jin, Xinmin Wu, Xiaohong Wu, Aihong Li, Kaifu Ke, Jianhua Cao, Xiaojuan Liu, Xiang Tan, Hongran Fu, Yilu Gao, Zhiwei Ga. Up-regulation of Che-1 relates to neuronal apoptosis after traumatic brain injury in adult rats. Cellular and molecular neurobiology. vol 33. issue 1. 2013-10-21. PMID:23007641. |
based on our data, we suggested that che-1 might play an important role in neuronal apoptosis following tbi; and might provide a basis for the further study on its role in regulating the expression of p53 and cell cycle re-entry in traumatic brain injury. |
2013-10-21 |
2023-08-12 |
rat |