| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Juan J Salazar, Roberto Gallego-Pinazo, Rosa de Hoz, Maria D Pinazo-Durán, Blanca Rojas, Ana I Ramírez, Manuel Serrano, José M Ramíre. "Super p53" mice display retinal astroglial changes. PloS one. vol 8. issue 6. 2014-01-22. PMID:23762373. |
the p53 gene can arrest proliferation and trigger death by apoptosis subsequent to several factors. |
2014-01-22 |
2023-08-12 |
mouse |
| Zoltan Derdak, Kristine A Villegas, Ragheb Harb, Annie M Wu, Aryanna Sousa, Jack R Wand. Inhibition of p53 attenuates steatosis and liver injury in a mouse model of non-alcoholic fatty liver disease. Journal of hepatology. vol 58. issue 4. 2014-01-21. PMID:23211317. |
we tested the efficacy of a p53 inhibitor, pifithrin-α p-nitro (pft) in attenuating steatosis, associated oxidative stress and apoptosis in a murine model of non-alcoholic fatty liver disease (nafld). |
2014-01-21 |
2023-08-12 |
mouse |
| Yoshitaka Sato, Tatsuya Tsurum. Genome guardian p53 and viral infections. Reviews in medical virology. vol 23. issue 4. 2014-01-21. PMID:23255396. |
the genome guardian p53 plays a central part not only in dna damage responses, inducing cell cycle arrest or apoptosis, but also in the innate host immune control of viral infections by orchestrating diverse signaling pathways originating from many different cellular receptors and sensors. |
2014-01-21 |
2023-08-12 |
Not clear |
| Jolanta Dorszewsk. Cell biology of normal brain aging: synaptic plasticity-cell death. Aging clinical and experimental research. vol 25. issue 1. 2014-01-20. PMID:23740630. |
in the aging brain, apoptosis does not seem to be activated in wild-type p53-expressing cells because the elevated levels of the p53 protein are no longer accompanied by decreased levels of the bcl-2 protein and increased levels of the bax protein. |
2014-01-20 |
2023-08-12 |
Not clear |
| Kathleen I Pishas, Susan J Neuhaus, Mark T Clayer, Alaknanda Adwal, Michael P Brown, Andreas Evdokiou, David F Callen, Paul M Neilse. Pre-activation of the p53 pathway through Nutlin-3a sensitises sarcomas to drozitumab therapy. Oncology reports. vol 30. issue 1. 2014-01-17. PMID:23670273. |
silencing of p53 strongly decreased dr5 mrna expression resulting in abrogation of drozitumab-induced apoptosis. |
2014-01-17 |
2023-08-12 |
human |
| Kiyohiro Hashimoto, Takeshi Tod. Mitotic slippage underlies the relationship between p53 dysfunction and the induction of large micronuclei by colcemid. Mutagenesis. vol 28. issue 4. 2014-01-16. PMID:23702691. |
this indicates that p53 dysfunction enhances aneugen-induced chromosome loss or perturbs apoptosis, resulting in the formation of large mn. |
2014-01-16 |
2023-08-12 |
Not clear |
| Wen-Yi Lu, Ming-Feng Zha. [Effect of oxidative stress on bone marrow mesenchymal stem cells]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 34. issue 1. 2014-01-14. PMID:22737723. |
it can induce the senescence and apoptosis of mscs via phosphatidylinositol 3-kinase/protein kinase b (pi3k/akt) and p53 pathways, and inhibit the proliferation and differentiation of mscs through apurinic/apyrimidinic endonuclease/redox factor 1 (ape/ref-1) and extracellular signal-regulated kinase (erk) pathways. |
2014-01-14 |
2023-08-12 |
Not clear |
| Qinsheng Dai, Yuehan Yin, Wei Liu, Libin Wei, Yuxin Zhou, Zhiyu Li, Qidong You, Na Lu, Qinglong Gu. Two p53-related metabolic regulators, TIGAR and SCO2, contribute to oroxylin A-mediated glucose metabolism in human hepatoma HepG2 cells. The international journal of biochemistry & cell biology. vol 45. issue 7. 2014-01-14. PMID:23612020. |
moreover, oroxylin a could increase protein and mrna expression of tp53-induced glycolysis and apoptosis regulator (tigar) and synthesis of cytochrome c oxidase 2 (sco2), which are the key metabolic modulators regulated by p53. |
2014-01-14 |
2023-08-12 |
human |
| Nan Bai, Chunyan Zhang, Ning Liang, Zhuhong Zhang, Antao Chang, Jing Yin, Zongjin Li, Na Luo, Xiaoyue Tan, Na Luo, Yunping Luo, Rong Xiang, Xiru Li, Ralph A Reisfeld, Dwayne Stupack, Dan Lv, Chenghu Li. Yes-associated protein (YAP) increases chemosensitivity of hepatocellular carcinoma cells by modulation of p53. Cancer biology & therapy. vol 14. issue 6. 2014-01-14. PMID:23760493. |
taken together, our current data indicate that yap functions as a tumor suppressor that enhances apoptosis by modulating p53 during chemotherapy. |
2014-01-14 |
2023-08-12 |
human |
| Camila B Piantino, Sabrina T Reis, Nayara I Viana, Iran A Silva, Denis R Morais, Alberto A Antunes, Nelson Dip, Miguel Srougi, Katia R Leit. Prima-1 induces apoptosis in bladder cancer cell lines by activating p53. Clinics (Sao Paulo, Brazil). vol 68. issue 3. 2014-01-13. PMID:23644847. |
prima-1 induces apoptosis in bladder cancer cell lines by activating p53. |
2014-01-13 |
2023-08-12 |
Not clear |
| Diana M González-Gironès, Cristina Moncunill-Massaguer, Daniel Iglesias-Serret, Ana M Cosialls, Alba Pérez-Perarnau, Claudia M Palmeri, Camila Rubio-Patiño, Andreas Villunger, Gabriel Pons, Joan Gi. AICAR induces Bax/Bak-dependent apoptosis through upregulation of the BH3-only proteins Bim and Noxa in mouse embryonic fibroblasts. Apoptosis : an international journal on programmed cell death. vol 18. issue 8. 2014-01-10. PMID:23605481. |
it has been recently described that aicar triggers apoptosis in chronic lymphocytic leukemia (cll) cells, and its mechanism of action is independent of ampk as well as p53. |
2014-01-10 |
2023-08-12 |
mouse |
| Diana M González-Gironès, Cristina Moncunill-Massaguer, Daniel Iglesias-Serret, Ana M Cosialls, Alba Pérez-Perarnau, Claudia M Palmeri, Camila Rubio-Patiño, Andreas Villunger, Gabriel Pons, Joan Gi. AICAR induces Bax/Bak-dependent apoptosis through upregulation of the BH3-only proteins Bim and Noxa in mouse embryonic fibroblasts. Apoptosis : an international journal on programmed cell death. vol 18. issue 8. 2014-01-10. PMID:23605481. |
in addition, aicar acts independently of p53, as mefs lacking p53 also underwent apoptosis normally. |
2014-01-10 |
2023-08-12 |
mouse |
| Pearl Lee, Karen H Vousden, Eric C Cheun. TIGAR, TIGAR, burning bright. Cancer & metabolism. vol 2. issue 1. 2014-01-10. PMID:24383451. |
while the p53 tumor suppressor protein is known to inhibit cell growth by inducing apoptosis, senescence and cell cycle arrest, recent studies have found that p53 is also able to influence cell metabolism. |
2014-01-10 |
2023-08-12 |
Not clear |
| Xiao-Dan Hao, Yue Yang, Xin Song, Xue-Ke Zhao, Li-Dong Wang, Jun-Dong He, Qing-Peng Kong, Nelson Leung Sang Tang, Ya-Ping Zhan. Correlation of telomere length shortening with TP53 somatic mutations, polymorphisms and allelic loss in breast tumors and esophageal cancer. Oncology reports. vol 29. issue 1. 2014-01-09. PMID:23124483. |
p53 plays a key role in cellular senescence and/or apoptosis associated with telomere erosion which positions p53 as a guard against tumorigenesis. |
2014-01-09 |
2023-08-12 |
Not clear |
| Lixin Wang, Lei Wang, Shuping Zhang, Guangbo Qu, Daoqiang Zhang, Shitao Li, Sijin Li. Downregulation of ubiquitin E3 ligase TNF receptor-associated factor 7 leads to stabilization of p53 in breast cancer. Oncology reports. vol 29. issue 1. 2014-01-09. PMID:23128672. |
p53 is a key tumor suppressor and a master regulator of various signaling pathways, such as those related to apoptosis, cell cycle and dna repair. |
2014-01-09 |
2023-08-12 |
Not clear |
| Zhongbo Liu, Mitchell Antalek, Linda Nguyen, Xuesen Li, Xuejiao Tian, Amy Le, Xiaolin Z. The effect of gartanin, a naturally occurring xanthone in mangosteen juice, on the mTOR pathway, autophagy, apoptosis, and the growth of human urinary bladder cancer cell lines. Nutrition and cancer. vol 65 Suppl 1. 2014-01-09. PMID:23682785. |
in addition, gartanin downregulated the expression of bcl-2 and activated the p53 pathway leading to apoptosis induction. |
2014-01-09 |
2023-08-12 |
mouse |
| Zhe Zhou, Ji-Xiang Cao, Shu-Yan Li, Guo-Shun An, Ju-Hua Ni, Hong-Ti Ji. p53 Suppresses E2F1-dependent PLK1 expression upon DNA damage by forming p53-E2F1-DNA complex. Experimental cell research. vol 319. issue 20. 2014-01-09. PMID:24076372. |
in addition, we showed that suppression of plk1 by p53 promoted apoptosis. |
2014-01-09 |
2023-08-12 |
Not clear |
| Sayem Miah, Shahram Nour Mohammad Zadeh, Xi-Ming Yuan, Wei L. Expression of Egr1 and p53 in human carotid plaques and apoptosis induced by 7-oxysterol or p53. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 65. issue 5. 2014-01-07. PMID:22999639. |
expression of egr1 and p53 in human carotid plaques and apoptosis induced by 7-oxysterol or p53. |
2014-01-07 |
2023-08-12 |
human |
| Sayem Miah, Shahram Nour Mohammad Zadeh, Xi-Ming Yuan, Wei L. Expression of Egr1 and p53 in human carotid plaques and apoptosis induced by 7-oxysterol or p53. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 65. issue 5. 2014-01-07. PMID:22999639. |
however, it is unknown whether p53 and egr1 are interactively involved in apoptosis in atherosclerosis. |
2014-01-07 |
2023-08-12 |
human |
| Sayem Miah, Shahram Nour Mohammad Zadeh, Xi-Ming Yuan, Wei L. Expression of Egr1 and p53 in human carotid plaques and apoptosis induced by 7-oxysterol or p53. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 65. issue 5. 2014-01-07. PMID:22999639. |
in u937 cells, 7β-hydroxycholesterol and 7-ketocholesterol induced production of reactive oxygen species (ros), transient up-regulation of egr1 followed by late induction of p53 and apoptosis. |
2014-01-07 |
2023-08-12 |
human |