| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohamed A El-Missiry, Azza I Othman, Monera A Al-Abdan, Aml A El-Saye. Melatonin ameliorates oxidative stress, modulates death receptor pathway proteins, and protects the rat cerebrum against bisphenol-A-induced apoptosis. Journal of the neurological sciences. vol 347. issue 1-2. 2015-08-06. PMID:25454643. |
bpa caused an upregulation of p53 and cd95-fas and activation of capsases-3 and 8, resulting in cerebral cell apoptosis. |
2015-08-06 |
2023-08-13 |
rat |
| Radim Jancale. The role of the TP73 gene and its transcripts in neuro-oncology. British journal of neurosurgery. vol 28. issue 5. 2015-08-05. PMID:24742294. |
protein p73 is a member of the p53 protein family that can induce cell cycle arrest or apoptosis by the activation of p53-responsive genes as well as p53-independent pathways. |
2015-08-05 |
2023-08-13 |
Not clear |
| Radim Jancale. The role of the TP73 gene and its transcripts in neuro-oncology. British journal of neurosurgery. vol 28. issue 5. 2015-08-05. PMID:24742294. |
while tap73 isoforms respond to genotoxic stress in a manner similar to tumor suppressor p53, Δtap73 isoforms inhibit apoptosis during normal development and in cancer cell lines. |
2015-08-05 |
2023-08-13 |
Not clear |
| Jung-Hoon Lee, Eunji Kang, Jungmin Lee, Jungmin Kim, Kyoung Hu Lee, Jieun Han, Hye Yoon Kang, Soshin Ahn, Youngmi Oh, Dongkyu Shin, Kyeyeon Hur, Su Young Chae, Paul H Song, Yong-In Kim, Jae Chan Park, Jae Il Le. Protein grafting of p53TAD onto a leucine zipper scaffold generates a potent HDM dual inhibitor. Nature communications. vol 5. 2015-08-04. PMID:24804811. |
a cell-permeable tat-p53lz2 effectively inhibits the cancer cell growth in wild-type but not mutant p53 by arresting cell cycle and inducing apoptosis in vitro. |
2015-08-04 |
2023-08-13 |
Not clear |
| Zhenhuan Ma, Yong Yang, Guokai Yang, Jia Wan, Guojian Li, Ping Lu, Lingjuan D. Iodine-125 induces apoptosis via regulating p53, microvessel density, and vascular endothelial growth factor in colorectal cancer. World journal of surgical oncology. vol 12. 2015-08-04. PMID:25033896. |
iodine-125 induces apoptosis via regulating p53, microvessel density, and vascular endothelial growth factor in colorectal cancer. |
2015-08-04 |
2023-08-13 |
Not clear |
| Ji Young Lee, Su Bean Jee, Won Young Park, Yu Jin Choi, Bokyung Kim, Yoon Hee Kim, Do Youn Jun, Young Ho Ki. Tumor suppressor protein p53 promotes 2-methoxyestradiol-induced activation of Bak and Bax, leading to mitochondria-dependent apoptosis in human colon cancer HCT116 cells. Journal of microbiology and biotechnology. vol 24. issue 12. 2015-08-04. PMID:25179905. |
tumor suppressor protein p53 promotes 2-methoxyestradiol-induced activation of bak and bax, leading to mitochondria-dependent apoptosis in human colon cancer hct116 cells. |
2015-08-04 |
2023-08-13 |
human |
| Allison James, Yubo Wang, Himanshu Raje, Raphyel Rosby, Patrick DiMari. Nucleolar stress with and without p53. Nucleus (Austin, Tex.). vol 5. issue 5. 2015-08-04. PMID:25482194. |
we begin by describing p53 activation upon nucleolar stress resulting in cell cycle arrest or apoptosis. |
2015-08-04 |
2023-08-13 |
human |
| Cen Zhang, Juan Liu, Xiaolong Wang, Rui Wu, Meihua Lin, Saurabh V Laddha, Qifeng Yang, Chang S Chan, Zhaohui Fen. MicroRNA-339-5p inhibits colorectal tumorigenesis through regulation of the MDM2/p53 signaling. Oncotarget. vol 5. issue 19. 2015-08-03. PMID:25193859. |
through the down-regulation of mdm2, microrna-339-5p increases p53 protein levels and functions, including p53 transcriptional activity and p53-mediated apoptosis and senescence in response to stress. |
2015-08-03 |
2023-08-13 |
Not clear |
| Dongfang Hu, Taixiang Zhang, Zhendong Zhang, Guangwen Wang, Fangkun Wang, Yajin Qu, Yujuan Niu, Sidang Li. Toxicity to the hematopoietic and lymphoid organs of piglets treated with a therapeutic dose of florfenicol. Veterinary immunology and immunopathology. vol 162. issue 3-4. 2015-08-03. PMID:25467888. |
the levels of classical swine fever virus (csfv) antibody against the vaccine, the concentrations of hsp70 and il-6 in serum and hsp70 in tissues, and the mrna expression levels of b-cell lymphoma 2 (bcl-2) and tumor suppressor p53 were detected, the hematology of the piglets were analyzed, and the histopathology and the status of apoptosis of the hematopoietic and lymphoid organs was examined. |
2015-08-03 |
2023-08-13 |
Not clear |
| Sharda Kumari, Susheel N Chaurasia, Manasa K Nayak, Ram L Mallick, Debabrata Das. Sirtuin Inhibition Induces Apoptosis-like Changes in Platelets and Thrombocytopenia. The Journal of biological chemistry. vol 290. issue 19. 2015-08-03. PMID:25829495. |
expression of acetylated p53 and the conformationally active form of bax were found to be significantly higher in both sirtinol- and ex-527-treated platelets, implicating the p53-bax axis in apoptosis induced by sirtuin inhibitors. |
2015-08-03 |
2023-08-13 |
mouse |
| S K Mungamuri, S Wang, J J Manfredi, W Gu, S A Aaronso. Ash2L enables P53-dependent apoptosis by favoring stable transcription pre-initiation complex formation on its pro-apoptotic target promoters. Oncogene. vol 34. issue 19. 2015-07-31. PMID:25023704. |
overexpression of ash2l enhanced p53-dependent apoptosis in response to chemotherapy, associated with increased p53 pro-apoptotic gene promoter occupancy and target gene expression. |
2015-07-31 |
2023-08-13 |
Not clear |
| Junlan Zhu, Jingjie Zhang, Haishan Huang, Jingxia Li, Yonghui Yu, Honglei Jin, Yang Li, Xu Deng, Jimin Gao, Qinshi Zhao, Chuanshu Huan. Crucial role of c-Jun phosphorylation at Ser63/73 mediated by PHLPP protein degradation in the cheliensisin a inhibition of cell transformation. Cancer prevention research (Philadelphia, Pa.). vol 7. issue 12. 2015-07-30. PMID:25281487. |
in the current study, we found that chel a treatment could increase c-jun protein phosphorylation and activation, whereas the inhibition of c-jun phosphorylation, by ectopic expression of a dominant-negative mutant of c-jun, tam67, reversed the chel a inhibition of egf-induced cell transformation and impaired chel a induction of p53 protein and apoptosis. |
2015-07-30 |
2023-08-13 |
Not clear |
| Qun Liu, Rui Sui, Ruirui Li, Jinwei Miao, Jian Li. Biological characteristics of Taxol‑resistant ovarian cancer cells and reversal of Taxol resistance by adenovirus expressing p53. Molecular medicine reports. vol 11. issue 2. 2015-07-30. PMID:25351378. |
to examine the mechanism, the expression of p53 upregulated modulator of apoptosis (puma) was compared between skov3/tax and skov3 cells by western blot analysis. |
2015-07-30 |
2023-08-13 |
Not clear |
| Claudia Bruedigam, Frederik O Bagger, Florian H Heidel, Catherine Paine Kuhn, Solene Guignes, Axia Song, Rebecca Austin, Therese Vu, Erwin Lee, Sarbjit Riyat, Andrew S Moore, Richard B Lock, Lars Bullinger, Geoffrey R Hill, Scott A Armstrong, David A Williams, Steven W Lan. Telomerase inhibition effectively targets mouse and human AML stem cells and delays relapse following chemotherapy. Cell stem cell. vol 15. issue 6. 2015-07-30. PMID:25479751. |
genetic deletion of the telomerase subunit terc in a retroviral mouse aml model induces cell-cycle arrest and apoptosis of lscs, and depletion of telomerase-deficient lscs is partially rescued by p53 knockdown. |
2015-07-30 |
2023-08-13 |
mouse |
| N Oi, J Yuan, M Malakhova, K Luo, Y Li, J Ryu, L Zhang, A M Bode, Z Xu, Y Li, Z Lou, Z Don. Resveratrol induces apoptosis by directly targeting Ras-GTPase-activating protein SH3 domain-binding protein 1. Oncogene. vol 34. issue 20. 2015-07-29. PMID:24998844. |
resveratrol (trans-3,5,4'-truhydroxystilbene) possesses a strong anticancer activity exhibited as the induction of apoptosis through p53 activation. |
2015-07-29 |
2023-08-13 |
Not clear |
| N Oi, J Yuan, M Malakhova, K Luo, Y Li, J Ryu, L Zhang, A M Bode, Z Xu, Y Li, Z Lou, Z Don. Resveratrol induces apoptosis by directly targeting Ras-GTPase-activating protein SH3 domain-binding protein 1. Oncogene. vol 34. issue 20. 2015-07-29. PMID:24998844. |
depletion of g3bp1 significantly diminishes resveratrol-induced p53 expression and apoptosis. |
2015-07-29 |
2023-08-13 |
Not clear |
| N Oi, J Yuan, M Malakhova, K Luo, Y Li, J Ryu, L Zhang, A M Bode, Z Xu, Y Li, Z Lou, Z Don. Resveratrol induces apoptosis by directly targeting Ras-GTPase-activating protein SH3 domain-binding protein 1. Oncogene. vol 34. issue 20. 2015-07-29. PMID:24998844. |
these findings disclose a novel mechanism of resveratrol-induced p53 activation and resveratrol-induced apoptosis by direct targeting of g3bp1. |
2015-07-29 |
2023-08-13 |
Not clear |
| H J Lee, J M Kim, K H Kim, J I Heo, S J Kwak, J A Ha. Genotoxic stress/p53-induced DNAJB9 inhibits the pro-apoptotic function of p53. Cell death and differentiation. vol 22. issue 1. 2015-07-29. PMID:25146923. |
in addition, depletion of dnajb9 by using sirnas greatly increased genotoxic stress/p53-induced apoptosis, suggesting that dnajb9 inhibits the pro-apoptotic function of p53. |
2015-07-29 |
2023-08-13 |
Not clear |
| E Ayroldi, M G Petrillo, A Bastianelli, M C Marchetti, S Ronchetti, G Nocentini, L Ricciotti, L Cannarile, C Riccard. L-GILZ binds p53 and MDM2 and suppresses tumor growth through p53 activation in human cancer cells. Cell death and differentiation. vol 22. issue 1. 2015-07-29. PMID:25168242. |
the transcription factor p53 regulates the expression of genes crucial for biological processes such as cell proliferation, metabolism, cell repair, senescence and apoptosis. |
2015-07-29 |
2023-08-13 |
mouse |
| E Ayroldi, M G Petrillo, A Bastianelli, M C Marchetti, S Ronchetti, G Nocentini, L Ricciotti, L Cannarile, C Riccard. L-GILZ binds p53 and MDM2 and suppresses tumor growth through p53 activation in human cancer cells. Cell death and differentiation. vol 22. issue 1. 2015-07-29. PMID:25168242. |
consistent with this finding, l-gilz induced p21 and p53 upregulated modulator of apoptosis (puma) expression only in p53(+/+) cells, while l-gilz silencing reversed the anti-proliferative activity of dexamethasone as well as expression of p53, p21 and puma. |
2015-07-29 |
2023-08-13 |
mouse |