| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Geethu Emily Thomas, Jamuna S Sreeja, K K Gireesh, Hindol Gupta, Tapas K Mann. +TIP EB1 downregulates paclitaxel‑induced proliferation inhibition and apoptosis in breast cancer cells through inhibition of paclitaxel binding on microtubules. International journal of oncology. vol 46. issue 1. 2015-08-11. PMID:25310526. |
p53 and bax were upregulated and bcl2 was downregulated in the eb1‑depleted ptx‑treated mcf‑7 cells, indicating that the apoptosis occurs via a p53‑dependent pathway. |
2015-08-11 |
2023-08-13 |
Not clear |
| Mi Ae Kang, Mi-Sook Kim, Ji Young Kim, Young-Joo Shin, Jie-Young Song, Jae-Hoon Jeon. A novel pyrido-thieno-pyrimidine derivative activates p53 through induction of phosphorylation and acetylation in colorectal cancer cells. International journal of oncology. vol 46. issue 1. 2015-08-11. PMID:25338966. |
the tumor suppressor p53 plays a key role in regulation of the cell cycle, apoptosis and senescence in response to various stresses. |
2015-08-11 |
2023-08-13 |
Not clear |
| Ahmad Fatemi, Ahmad Kazemi, Meysam Kashiri, Majid Saf. Elevation of cAMP Levels Inhibits Doxorubicin-Induced Apoptosis in Pre- B ALL NALM- 6 Cells Through Induction of BAD Phosphorylation and Inhibition of P53 Accumulation. International journal of molecular and cellular medicine. vol 4. issue 2. 2015-08-11. PMID:26261798. |
elevation of camp levels inhibits doxorubicin-induced apoptosis in pre- b all nalm- 6 cells through induction of bad phosphorylation and inhibition of p53 accumulation. |
2015-08-11 |
2023-08-13 |
Not clear |
| Ahmad Fatemi, Ahmad Kazemi, Meysam Kashiri, Majid Saf. Elevation of cAMP Levels Inhibits Doxorubicin-Induced Apoptosis in Pre- B ALL NALM- 6 Cells Through Induction of BAD Phosphorylation and Inhibition of P53 Accumulation. International journal of molecular and cellular medicine. vol 4. issue 2. 2015-08-11. PMID:26261798. |
considering the critical role of bcl-2-associated death promoter (bad) and p53 proteins in dna damage -induced apoptosis, the aim of this study was to assess the effect of camp-elevating agents on these proteins in doxorubicin-treated pre-b acute lymphoblastic leukemia (pre-b all) nalm-6 cells.the pre-b all cell line nalm-6 was cultured and treated with doxorubicin in combination with or without camp-elevating agents forskolin and 3-isobutyl-1-methylxanthine (ibmx). |
2015-08-11 |
2023-08-13 |
Not clear |
| Ahmad Fatemi, Ahmad Kazemi, Meysam Kashiri, Majid Saf. Elevation of cAMP Levels Inhibits Doxorubicin-Induced Apoptosis in Pre- B ALL NALM- 6 Cells Through Induction of BAD Phosphorylation and Inhibition of P53 Accumulation. International journal of molecular and cellular medicine. vol 4. issue 2. 2015-08-11. PMID:26261798. |
our study suggests that elevated camp levels inhibit doxorubicin-induced apoptosis in pre-b all cells through induction of bad phosphorylation and abrogation of p53 accumulation. |
2015-08-11 |
2023-08-13 |
Not clear |
| John Towe. Mitochondrial maintenance failure in aging and role of sexual dimorphism. Archives of biochemistry and biophysics. vol 576. 2015-08-10. PMID:25447815. |
studies in mammals and invertebrates implicate autophagy, apoptosis, akt, parp, p53 and foxo in mediating sex-specific differences in stress resistance and aging. |
2015-08-10 |
2023-08-13 |
caenorhabditis_elegans |
| D B Chen, H J Yan. Comparison of gene regulatory networks of benign and malignant breast cancer samples with normal samples. Genetics and molecular research : GMR. vol 13. issue 4. 2015-08-10. PMID:25501155. |
a total of 2380 breast cancer-related genes and 215 transcription factors were screened by exploring databases; the genes were mainly enriched in their functions, such as cell apoptosis and proliferation, and pathways, such as p53 signaling and apoptosis, which were related with carcinogenesis. |
2015-08-10 |
2023-08-13 |
Not clear |
| Wei-Xia Duan, Min-Di He, Lin Mao, Feng-Hua Qian, Yu-Ming Li, Hui-Feng Pi, Chuan Liu, Chun-Hai Chen, Yong-Hui Lu, Zheng-Wang Cao, Lei Zhang, Zheng-Ping Yu, Zhou Zho. NiO nanoparticles induce apoptosis through repressing SIRT1 in human bronchial epithelial cells. Toxicology and applied pharmacology. vol 286. issue 2. 2015-08-10. PMID:25840356. |
however, overexpression of sirt1 through resveratrol treatment or transfection clearly attenuated the nionps-induced apoptosis and activation of p53 and bax. |
2015-08-10 |
2023-08-13 |
human |
| Wei-Xia Duan, Min-Di He, Lin Mao, Feng-Hua Qian, Yu-Ming Li, Hui-Feng Pi, Chuan Liu, Chun-Hai Chen, Yong-Hui Lu, Zheng-Wang Cao, Lei Zhang, Zheng-Ping Yu, Zhou Zho. NiO nanoparticles induce apoptosis through repressing SIRT1 in human bronchial epithelial cells. Toxicology and applied pharmacology. vol 286. issue 2. 2015-08-10. PMID:25840356. |
our results suggest that the repression of sirt1 may underlie the nionps-induced apoptosis via p53 hyperacetylation and subsequent bax activation. |
2015-08-10 |
2023-08-13 |
human |
| Tali H Reingewertz, Anat Iosub-Amir, Daniel A Bonsor, Guy Mayer, Hadar Amartely, Assaf Friedler, Eric J Sundber. An Intrinsically Disordered Region in the Proapoptotic ASPP2 Protein Binds to the Helicobacter pylori Oncoprotein CagA. Biochemistry. vol 54. issue 21. 2015-08-10. PMID:25963096. |
once inside host cells, caga interacts with aspp2, which specifically stimulates p53-mediated apoptosis and reverses its pro-apoptotic function to promote aspp2-dependent degradation of p53. |
2015-08-10 |
2023-08-13 |
Not clear |
| Colins O Eno, Guoping Zhao, Avinashnarayan Venkatanarayan, Bing Wang, Elsa R Flores, Chi L. Noxa couples lysosomal membrane permeabilization and apoptosis during oxidative stress. Free radical biology & medicine. vol 65. 2015-08-07. PMID:23770082. |
importantly, lmp-induced noxa expression increase was mediated by p53 and seems to be a unique feature of apoptosis caused by oxidative stress. |
2015-08-07 |
2023-08-12 |
Not clear |
| Rodrigo Portes Ureshino, Yi-Te Hsu, Lúcia Garcez do Carmo, César Henrique Yokomizo, Iseli Lourenço Nantes, Soraya Soubhi Smail. Inhibition of cytoplasmic p53 differentially modulates Ca(2+) signaling and cellular viability in young and aged striata. Experimental gerontology. vol 58. 2015-08-06. PMID:25084214. |
the p53 protein, a transcription factor with many gene targets, can also trigger apoptosis in the cytoplasm. |
2015-08-06 |
2023-08-13 |
rat |
| Zhenhong Hu, Qunli Zeng, Bo Zhang, Haichao Liu, Wei Wan. Promotion of p53 expression and reactive oxidative stress production is involved in zerumbone-induced cisplatin sensitization of non-small cell lung cancer cells. Biochimie. vol 107 Pt B. 2015-08-06. PMID:25220870. |
combinational treatment with zerumbone and cisplatin significantly accelerated apoptosis and promoted p53 expression and ros production in nsclc cells, compared with each alone. |
2015-08-06 |
2023-08-13 |
Not clear |
| Zhenhong Hu, Qunli Zeng, Bo Zhang, Haichao Liu, Wei Wan. Promotion of p53 expression and reactive oxidative stress production is involved in zerumbone-induced cisplatin sensitization of non-small cell lung cancer cells. Biochimie. vol 107 Pt B. 2015-08-06. PMID:25220870. |
these findings demonstrate that zerumbone induces mitochondrial apoptosis and enhances the susceptibility to cisplatin in nsclc cells, which are, at least partially, mediated through activation of p53 signaling and promotion of ros generation. |
2015-08-06 |
2023-08-13 |
Not clear |
| Wenqiang Cao, Xiaoling Li, Shanyuan Zheng, Wenjie Zheng, Yum-Shing Wong, Tianfeng Che. Selenocysteine derivative overcomes TRAIL resistance in melanoma cells: evidence for ROS-dependent synergism and signaling crosstalk. Oncotarget. vol 5. issue 17. 2015-08-06. PMID:25277183. |
herein, we reported that 3,3'-diselenodipropionic acid (dsea), a selenocysteine derivative, could synergistically enhance the growth inhibitory effect of trail on a375 melanoma cells though induction of ros-dependent apoptosis with involvement of pten-mediated akt inactivation and dna damage-mediated p53 phosphorylation, which subsequently activated mitochondrial and death receptor apoptotic pathways. |
2015-08-06 |
2023-08-13 |
Not clear |
| Wenqiang Cao, Xiaoling Li, Shanyuan Zheng, Wenjie Zheng, Yum-Shing Wong, Tianfeng Che. Selenocysteine derivative overcomes TRAIL resistance in melanoma cells: evidence for ROS-dependent synergism and signaling crosstalk. Oncotarget. vol 5. issue 17. 2015-08-06. PMID:25277183. |
moreover, silencing of p53 down-regulated the expression levels of p53-inducible genes, and effectively blocked the cell apoptosis. |
2015-08-06 |
2023-08-13 |
Not clear |
| Wenqiang Cao, Xiaoling Li, Shanyuan Zheng, Wenjie Zheng, Yum-Shing Wong, Tianfeng Che. Selenocysteine derivative overcomes TRAIL resistance in melanoma cells: evidence for ROS-dependent synergism and signaling crosstalk. Oncotarget. vol 5. issue 17. 2015-08-06. PMID:25277183. |
in contrast, antioxidants effectively reversed the cell apoptosis through regulation of akt and p53 signaling pathways. |
2015-08-06 |
2023-08-13 |
Not clear |
| Masashi Idogawa, Tomoko Ohashi, Jun Sugisaka, Yasushi Sasaki, Hiromu Suzuki, Takashi Tokin. Array-based genome-wide RNAi screening to identify shRNAs that enhance p53-related apoptosis in human cancer cells. Oncotarget. vol 5. issue 17. 2015-08-06. PMID:25277188. |
p53 transduction is a potentially effective cancer therapy but does not result in a good therapeutic response in all human cancers due to resistance to apoptosis. |
2015-08-06 |
2023-08-13 |
human |
| Masashi Idogawa, Tomoko Ohashi, Jun Sugisaka, Yasushi Sasaki, Hiromu Suzuki, Takashi Tokin. Array-based genome-wide RNAi screening to identify shRNAs that enhance p53-related apoptosis in human cancer cells. Oncotarget. vol 5. issue 17. 2015-08-06. PMID:25277188. |
shrna-58335 enhanced p53-related apoptosis in vitro and augmented the inhibitory effect of adenoviral p53 transduction on tumor growth in vivo. |
2015-08-06 |
2023-08-13 |
human |
| Masashi Idogawa, Tomoko Ohashi, Jun Sugisaka, Yasushi Sasaki, Hiromu Suzuki, Takashi Tokin. Array-based genome-wide RNAi screening to identify shRNAs that enhance p53-related apoptosis in human cancer cells. Oncotarget. vol 5. issue 17. 2015-08-06. PMID:25277188. |
we found that shrna-58335 evokes the apoptotic response following p53 transduction or functional restoration of p53 with a small molecule drug in cancer cells resistant to p53-induced apoptosis. |
2015-08-06 |
2023-08-13 |
human |