| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Franziska Briest, Patricia Grabowsk. The p53 network as therapeutic target in gastroenteropancreatic neuroendocrine neoplasms. Cancer treatment reviews. vol 41. issue 5. 2015-07-21. PMID:25837868. |
in this review we analyze the current knowledge about the p53 network in gep-nens and discuss three possible strategies that include recovering p53 function, enforcing apoptosis by genotoxic stress induction and restoring silenced gene function, based on in vitro, in vivo and clinical data. |
2015-07-21 |
2023-08-13 |
Not clear |
| A Vashishta, M Hetma. Inhibitors of histone deacetylases enhance neurotoxicity of DNA damage. Neuromolecular medicine. vol 16. issue 4. 2015-07-20. PMID:25063076. |
moreover, nonselective hdac inhibition exacerbated neuronal apoptosis that was induced by the overexpressed p53. |
2015-07-20 |
2023-08-13 |
rat |
| Rebecca A Clewell, Bin Sun, Yeyejide Adeleye, Paul Carmichael, Alina Efremenko, Patrick D McMullen, Salil Pendse, O J Trask, Andy White, Melvin E Anderse. Profiling dose-dependent activation of p53-mediated signaling pathways by chemicals with distinct mechanisms of DNA damage. Toxicological sciences : an official journal of the Society of Toxicology. vol 142. issue 1. 2015-07-20. PMID:25078064. |
as part of a larger effort to provide proof-of-concept in vitro-only risk assessments, we have developed a suite of high-throughput assays for key readouts in the p53 dna damage response toxicity pathway: double-strand break dna damage (p-h2ax), permanent chromosomal damage (micronuclei), p53 activation, p53 transcriptional activity, and cell fate (cell cycle arrest, apoptosis, micronuclei). |
2015-07-20 |
2023-08-13 |
human |
| Mistuni Ghosh, Robert O Rya. Curcumin homing to the nucleolus: mechanism for initiation of an apoptotic program. The Journal of nutritional biochemistry. vol 25. issue 11. 2015-07-20. PMID:25172633. |
between 2 and 4 h following curcumin treatment, p53 levels increased with maximum levels reached by 8 h. thus, curcumin homing to the nucleolus induces redistribution of p14(arf) to the nucleoplasm where interaction with mdm2 leads to stabilization of p53, with subsequent initiation of apoptosis. |
2015-07-20 |
2023-08-13 |
mouse |
| Ozlen Bektas, Aysegul Uner, Yahya Buyukasik, Burak Uz, Sureyya Bozkurt, Eylem Eliacik, Ayse Işik, Ibrahim Celalettin Haznedaroglu, Hakan Goker, Haluk Demiroglu, Salih Aksu, Osman Ilhami Ozcebe, Nilgun Sayinal. Clinical and pathological correlations of marrow PUMA and P53 expressions in myelodysplastic syndromes. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. vol 123. issue 5. 2015-07-20. PMID:25846496. |
p53 is a key regulator of apoptosis. |
2015-07-20 |
2023-08-13 |
Not clear |
| Ozlen Bektas, Aysegul Uner, Yahya Buyukasik, Burak Uz, Sureyya Bozkurt, Eylem Eliacik, Ayse Işik, Ibrahim Celalettin Haznedaroglu, Hakan Goker, Haluk Demiroglu, Salih Aksu, Osman Ilhami Ozcebe, Nilgun Sayinal. Clinical and pathological correlations of marrow PUMA and P53 expressions in myelodysplastic syndromes. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. vol 123. issue 5. 2015-07-20. PMID:25846496. |
p53 upregulated modulator of apoptosis (puma) is a critical mediator of p53-dependent and independent apoptosis. |
2015-07-20 |
2023-08-13 |
Not clear |
| Huai Wang, Lijun Tang, Yajie Tang, Zhanpeng Yua. SAR analysis and biological studies of synthesized podophyllum derivates obtained by N linkage modification at C-4 position. Bioorganic & medicinal chemistry. vol 22. issue 21. 2015-07-16. PMID:25282651. |
both compounds resulted in g2/m phase arrest and apoptosis, purportedly by increasing the expression of p53, followed by bax up-regulation, bcl-2 down-regulation, and caspase-3 activation. |
2015-07-16 |
2023-08-13 |
Not clear |
| Qian Hao, William C Ch. Battle against cancer: an everlasting saga of p53. International journal of molecular sciences. vol 15. issue 12. 2015-07-16. PMID:25470027. |
in response to various stress signals, p53 can be activated and transcriptionally induces a myriad of target genes, including both protein-encoding and non-coding genes, controlling cell cycle progression, dna repair, senescence, apoptosis, autophagy and metabolism of tumor cells. |
2015-07-16 |
2023-08-13 |
human |
| Fangfang Jiang, Wei Zhao, Lijie Zhou, Zifeng Liu, Wenqing Li, Dongsheng Y. MiR-222 targeted PUMA to improve sensitization of UM1 cells to cisplatin. International journal of molecular sciences. vol 15. issue 12. 2015-07-16. PMID:25474084. |
the present study explored the role and mechanism of mir-222 in increasing the expression of p53 up-regulated modulator of apoptosis (puma) and enhancing the sensitivity of oscc to cisplatin (cddp). |
2015-07-16 |
2023-08-13 |
human |
| Nuno Bernardes, Ana Sofia Ribeiro, Sofia Abreu, André F Vieira, Laura Carreto, Manuel Santos, Raquel Seruca, Joana Paredes, Arsenio M Fialh. High-throughput molecular profiling of a P-cadherin overexpressing breast cancer model reveals new targets for the anti-cancer bacterial protein azurin. The international journal of biochemistry & cell biology. vol 50. 2015-07-15. PMID:24509127. |
azurin up-regulated apoptosis mediated by p53 protein, endocytosis and vesicle-mediated transport. |
2015-07-15 |
2023-08-12 |
Not clear |
| Alan S Ma. p53 in cell invasion, podosomes, and invadopodia. Cell adhesion & migration. vol 8. issue 3. 2015-07-15. PMID:24714032. |
the tumor suppressor p53, better known for its roles in the regulation of cell cycle and apoptosis, has ignited much interest in its function as a suppressor of cell migration and invasion. |
2015-07-15 |
2023-08-13 |
Not clear |
| Marveh Rahmati, Mohammad Amin Moosavi, Nosratollah Zargham. Nucleostemin knocking-down causes cell cycle arrest and apoptosis in human T-cell acute lymphoblastic leukemia MOLT-4 cells via p53 and p21Waf1/Cip1 up-regulation. Hematology (Amsterdam, Netherlands). vol 19. issue 8. 2015-07-14. PMID:24628257. |
nucleostemin knocking-down causes cell cycle arrest and apoptosis in human t-cell acute lymphoblastic leukemia molt-4 cells via p53 and p21waf1/cip1 up-regulation. |
2015-07-14 |
2023-08-12 |
human |
| Lingyu Wang, Jingwei Zhu, Ming Fang, Tuaner Zhang, Hua Xie, Nan Wang, Nan Shen, Hui Guo, Bo Fu, Hongli Li. Inhibition of p53 deSUMOylation exacerbates puromycin aminonucleoside-induced apoptosis in podocytes. International journal of molecular sciences. vol 15. issue 11. 2015-07-14. PMID:25411797. |
inhibition of p53 desumoylation exacerbates puromycin aminonucleoside-induced apoptosis in podocytes. |
2015-07-14 |
2023-08-13 |
Not clear |
| Lingyu Wang, Jingwei Zhu, Ming Fang, Tuaner Zhang, Hua Xie, Nan Wang, Nan Shen, Hui Guo, Bo Fu, Hongli Li. Inhibition of p53 deSUMOylation exacerbates puromycin aminonucleoside-induced apoptosis in podocytes. International journal of molecular sciences. vol 15. issue 11. 2015-07-14. PMID:25411797. |
the p53 protein plays a major role in the pathogenesis of podocyte apoptosis, and p53 can be sumoylated. |
2015-07-14 |
2023-08-13 |
Not clear |
| Lingyu Wang, Jingwei Zhu, Ming Fang, Tuaner Zhang, Hua Xie, Nan Wang, Nan Shen, Hui Guo, Bo Fu, Hongli Li. Inhibition of p53 deSUMOylation exacerbates puromycin aminonucleoside-induced apoptosis in podocytes. International journal of molecular sciences. vol 15. issue 11. 2015-07-14. PMID:25411797. |
therefore, in the present study, we evaluated the effect of p53 desumoylation, which is regulated by sentrin/sumo-specific protease 1 (senp1), on podocyte apoptosis. |
2015-07-14 |
2023-08-13 |
Not clear |
| Lingyu Wang, Jingwei Zhu, Ming Fang, Tuaner Zhang, Hua Xie, Nan Wang, Nan Shen, Hui Guo, Bo Fu, Hongli Li. Inhibition of p53 deSUMOylation exacerbates puromycin aminonucleoside-induced apoptosis in podocytes. International journal of molecular sciences. vol 15. issue 11. 2015-07-14. PMID:25411797. |
thus, senp1 may be essential for preventing podocyte apoptosis, at least partly through regulating the functions of p53 protein via desumoylation. |
2015-07-14 |
2023-08-13 |
Not clear |
| Arzu Z Karabay, Fugen Aktan, Asuman Sunguroğlu, Zeliha Buyukbingo. Methylsulfonylmethane modulates apoptosis of LPS/IFN-γ-activated RAW 264.7 macrophage-like cells by targeting p53, Bax, Bcl-2, cytochrome c and PARP proteins. Immunopharmacology and immunotoxicology. vol 36. issue 6. 2015-07-13. PMID:25211405. |
methylsulfonylmethane modulates apoptosis of lps/ifn-γ-activated raw 264.7 macrophage-like cells by targeting p53, bax, bcl-2, cytochrome c and parp proteins. |
2015-07-13 |
2023-08-13 |
Not clear |
| Batzaya Davaadelger, Hong Shen, Carl G Mak. Novel roles for p53 in the genesis and targeting of tetraploid cancer cells. PloS one. vol 9. issue 11. 2015-07-13. PMID:25380055. |
importantly, the tetraploid clones selected after nutlin treatment expressed approximately twice as much p53 and mdm2 mrna as diploid precursors, expressed approximately twice as many p53-mdm2 protein complexes (by co-immunoprecipitation), and were more susceptible to p53-dependent apoptosis and growth arrest induced by nutlin. |
2015-07-13 |
2023-08-13 |
Not clear |
| Batzaya Davaadelger, Hong Shen, Carl G Mak. Novel roles for p53 in the genesis and targeting of tetraploid cancer cells. PloS one. vol 9. issue 11. 2015-07-13. PMID:25380055. |
specifically, we propose that 1) transient p53 activation can promote a tetraploid-g1 arrest and, as a result, may inadvertently promote formation of therapy-resistant tetraploid cells, and 2) therapy-resistant tetraploid cells, by virtue of having higher p53 gene copy number and expressing twice as many p53-mdm2 complexes, are more sensitive to apoptosis and/or growth arrest by anti-cancer mdm2 antagonists (e.g. |
2015-07-13 |
2023-08-13 |
Not clear |
| Shohei Shinozaki, Kyungho Chang, Michihiro Sakai, Nobuyuki Shimizu, Marina Yamada, Tomokazu Tanaka, Harumasa Nakazawa, Fumito Ichinose, Yoshitsugu Yamada, Akihito Ishigami, Hideki Ito, Yasuyoshi Ouchi, Marlene E Starr, Hiroshi Saito, Kentaro Shimokado, Jonathan S Stamler, Masao Kanek. Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65. Science signaling. vol 7. issue 351. 2015-07-13. PMID:25389371. |
sirt1 limits apoptosis and inflammation by deacetylating p53 and p65 (also known as rela), a subunit of nf-κb. |
2015-07-13 |
2023-08-13 |
Not clear |