| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Huizhen Guo, Songzhi Kong, Weimin Chen, Zhenhua Dai, Tongxiang Lin, Jiyan Su, Shanshan Li, Qingfeng Xie, Ziren Su, Yang Xu, Xiaoping La. Apigenin mediated protection of OGD-evoked neuron-like injury in differentiated PC12 cells. Neurochemical research. vol 39. issue 11. 2015-07-29. PMID:25208641. |
cells were pretreated with apigenin for 6 h, and then subjected to ogd for 12 h followed by reperfusion for 24 h. the results showed that ogd/r significantly decreased cell viability, mitochondrial membrane potential, mrna levels of antioxidant and detoxifying enzymes and nrf2 protein expression, while elevated the release of ldh, cell apoptosis, intracellular ros level, p53 protein expression and upregulated its downstream genes in pc12 cells. |
2015-07-29 |
2023-08-13 |
Not clear |
| Abedul Haque, Mohammad A Rahman, James R Fuchs, Zhuo Georgia Chen, Fadlo R Khuri, Dong M Shin, A R M Ruhul Ami. FLLL12 induces apoptosis in lung cancer cells through a p53/p73-independent but death receptor 5-dependent pathway. Cancer letters. vol 363. issue 2. 2015-07-29. PMID:25917567. |
we further showed that the apoptosis is independent of p53 and p73. |
2015-07-29 |
2023-08-13 |
Not clear |
| Yun-Bao Guo, Xin-Jie Bao, Song-Bai Xu, Xing-Dong Zhang, Hai-Yan Li. Honokiol induces cell cycle arrest and apoptosis via p53 activation in H4 human neuroglioma cells. International journal of clinical and experimental medicine. vol 8. issue 5. 2015-07-29. PMID:26221255. |
honokiol induces cell cycle arrest and apoptosis via p53 activation in h4 human neuroglioma cells. |
2015-07-29 |
2023-08-13 |
human |
| Yun-Bao Guo, Xin-Jie Bao, Song-Bai Xu, Xing-Dong Zhang, Hai-Yan Li. Honokiol induces cell cycle arrest and apoptosis via p53 activation in H4 human neuroglioma cells. International journal of clinical and experimental medicine. vol 8. issue 5. 2015-07-29. PMID:26221255. |
to investigate the signal pathway of honokiol-induced apoptosis in h4 human neuroglioma cells and to evaluate whether p53 signaling and cell cycle arrest were involved in honokiol-treated h4 human neuroglioma cells. |
2015-07-29 |
2023-08-13 |
human |
| Chuck C-K Cha. Mechanisms of p53 degradation. Clinica chimica acta; international journal of clinical chemistry. vol 438. 2015-07-28. PMID:25172038. |
ubiquitination by e3 ligases may induce cellular relocation of p53 and determine the outcome of p53-mediated stress response, including cell proliferation, apoptosis and efficacy of cancer therapy. |
2015-07-28 |
2023-08-13 |
Not clear |
| Hui Wang, Changqing Lu, Qing Li, Jun Xie, Tongbing Chen, Yan Tan, Changping Wu, Jingting Jian. The role of Kif4A in doxorubicin-induced apoptosis in breast cancer cells. Molecules and cells. vol 37. issue 11. 2015-07-28. PMID:25377255. |
using two human breast cancer cell lines mcf-7 (with wild-type p53) and mda-mb-231 (with mutant p53), we quantitated the expression levels of kinesin super-family protein 4a (kif4a) and poly (adp-ribose) polymerase-1 (parp-1) by western blot after doxorubicin treatment and examined the apoptosis by flow cytometry after treatment with doxorubicin and parp-1 inhibitor, 3-aminobenzamide (3-aba). |
2015-07-28 |
2023-08-13 |
human |
| Alex R D Delbridge, Joseph T Opferman, Stephanie Grabow, Andreas Strasse. Antagonism between MCL-1 and PUMA governs stem/progenitor cell survival during hematopoietic recovery from stress. Blood. vol 125. issue 21. 2015-07-28. PMID:25847014. |
we identified inhibition of proapoptotic p53 upregulated modulator of apoptosis (puma) as the key role of mcl-1 in both settings, with mcl-1(+/-);puma(-/-) mice completely protected from the deleterious effects of loss of 1 mcl-1 allele. |
2015-07-28 |
2023-08-13 |
mouse |
| Javed Ahmad, Hisham A Alhadlaq, Maqsood A Siddiqui, Quaiser Saquib, Abdulaziz A Al-Khedhairy, Javed Musarrat, Maqusood Ahame. Concentration-dependent induction of reactive oxygen species, cell cycle arrest and apoptosis in human liver cells after nickel nanoparticles exposure. Environmental toxicology. vol 30. issue 2. 2015-07-27. PMID:23776134. |
upregulation of cell cycle checkpoint gene p53 and bax/bcl-2 ratio with a concomitant loss in mitochondrial membrane potential suggested that ni nps induced apoptosis in hepg2 cells was mediated through mitochondrial pathway. |
2015-07-27 |
2023-08-12 |
human |
| Jianyuan Wu, Qingdi Quentin Li, Huiping Zhou, Yinying Lu, Jueli M Li, Yao Ma, Li Wang, Tingting Fu, Xingjiang Gong, Michael Weintraub, Shuangchan Wu, Hong Din. Selective tumor cell killing by triptolide in p53 wild-type and p53 mutant ovarian carcinomas. Medical oncology (Northwood, London, England). vol 31. issue 7. 2015-07-24. PMID:24880464. |
this study shows that triptolide selectively kills ovarian cancer cells with different p53 status predominantly through regulating the coordinate and dynamic cellular processes of proliferation and apoptosis, thereby making it a promising chemotherapeutic agent against a broad spectrum of ovarian carcinomas. |
2015-07-24 |
2023-08-13 |
human |
| Zhaojian Gong, Shanshan Zhang, Zhaoyang Zeng, Hanjiang Wu, Qian Yang, Fang Xiong, Lei Shi, Jianbo Yang, Wenling Zhang, Yanhong Zhou, Yong Zeng, Xiayu Li, Bo Xiang, Shuping Peng, Ming Zhou, Xiaoling Li, Ming Tan, Yong Li, Wei Xiong, Guiyuan L. LOC401317, a p53-regulated long non-coding RNA, inhibits cell proliferation and induces apoptosis in the nasopharyngeal carcinoma cell line HNE2. PloS one. vol 9. issue 11. 2015-07-23. PMID:25422887. |
further studies indicated that loc401317 is directly regulated by p53 and that ectopic expression of loc401317 inhibits hne2 cell proliferation in vitro and in vivo by inducing cell cycle arrest and apoptosis. |
2015-07-23 |
2023-08-13 |
human |
| Feili Wu, Yao Zheng, Jiancao Gao, Shu Chen, Zaizhao Wan. Induction of oxidative stress and the transcription of genes related to apoptosis in rare minnow (Gobiocypris rarus) larvae with Aroclor 1254 exposure. Ecotoxicology and environmental safety. vol 110. 2015-07-22. PMID:25265027. |
the gene expression patterns reveal that waterborne aroclor 1254-induced apoptosis is probably through dna damage (p53 and p53 upregulated modulator of apoptosis (puma)), disrupting mitochondrial membrane integrity (b-cell lymphoma 2 (bcl-2) and bcl-2-associated x (bax)) and c-jin n-terminal kinase (jnk)-mediated apoptotic pathway (thioredoxin 1 (trx1) and c-jun n-terminal kinase (jnk)). |
2015-07-22 |
2023-08-13 |
cat |
| Su-Jin Park, Jina Ryu, In-Hye Kim, Youn-Hee Choi, Taek-Jeong Na. Activation of the mTOR signaling pathway in breast cancer MCF‑7 cells by a peptide derived from Porphyra yezoensis. Oncology reports. vol 33. issue 1. 2015-07-22. PMID:25333576. |
generally, regulation of apoptosis requires participation of the p53 and bcl-2 family by the mammalian target of rapamycin (mtor) pathway, which is activated in a variety of malignant cancers. |
2015-07-22 |
2023-08-13 |
Not clear |
| Eun Joo Bae, Bai Hui Chen, Bing Chun Yan, Bich Na Shin, Jeong Hwi Cho, In Hye Kim, Ji Hyeon Ahn, Jae Chul Lee, Hyun-Jin Tae, Seongkweon Hong, Dong Won Kim, Jun Hwi Cho, Yun Lyul Lee, Moo-Ho Won, Joon Ha Par. Delayed hippocampal neuronal death in young gerbil following transient global cerebral ischemia is related to higher and longer-term expression of p63 in the ischemic hippocampus. Neural regeneration research. vol 10. issue 6. 2015-07-22. PMID:26199612. |
the tumor suppressor p63 is one of p53 family members and plays a vital role as a regulator of neuronal apoptosis in the development of the nervous system. |
2015-07-22 |
2023-08-13 |
Not clear |
| Da Hee Lee, Yoon Jeong Nam, Yun Jeong Kim, Min Won Lee, Chung Soo Le. Rotundarpene prevents TRAIL-induced apoptosis in human keratinocytes by suppressing the caspase-8- and Bid-pathways and the mitochondrial pathway. Naunyn-Schmiedeberg's archives of pharmacology. vol 387. issue 12. 2015-07-21. PMID:25273175. |
trail triggers apoptosis by inducing a decrease in the cytosolic levels of bid, bcl-2, bcl-xl, and survivin proteins, increase in the cytosolic levels of bax, and increase in the mitochondrial levels of vdac1, loss of the mitochondrial transmembrane potential, release of cytochrome c, activation of caspases (-8, -9, and -3), cleavage of parp-1, and an increase in the tumor suppressor p53 levels. |
2015-07-21 |
2023-08-13 |
human |
| Renu Pandey, Vatsala Misra, Sri Prakash Misra, Manisha Dwivedi, Alok Misr. Helicobacter pylori infection and a P53 codon 72 single nucleotide polymorphism: a reason for an unexplained Asian enigma. Asian Pacific journal of cancer prevention : APJCP. vol 15. issue 21. 2015-07-21. PMID:25422197. |
p53, the most commonly mutated tumor suppressor gene in all types of human cancer, is involved in cell cycle arrest and control of apoptosis. |
2015-07-21 |
2023-08-13 |
human |
| Renu Pandey, Vatsala Misra, Sri Prakash Misra, Manisha Dwivedi, Alok Misr. Helicobacter pylori infection and a P53 codon 72 single nucleotide polymorphism: a reason for an unexplained Asian enigma. Asian Pacific journal of cancer prevention : APJCP. vol 15. issue 21. 2015-07-21. PMID:25422197. |
the present study aimed to find any correlation between h. pylori infection and progression of carcinogenesis, by studying apoptosis and the p53 gene in gastric biopsies from north indian population. |
2015-07-21 |
2023-08-13 |
human |
| Shin-Yi Liu, Ming-Fu Chiang, Yu-Jen Che. Role of WW domain proteins WWOX in development, prognosis, and treatment response of glioma. Experimental biology and medicine (Maywood, N.J.). vol 240. issue 3. 2015-07-21. PMID:25432984. |
resistance of gbm to clinical treatment is a result of genomic alternation and deregulated signaling pathways, such as p53 mutation and apoptosis signaling blockage, providing cancer cells more opportunities for survival rather than cell death. |
2015-07-21 |
2023-08-13 |
Not clear |
| Shin-Yi Liu, Ming-Fu Chiang, Yu-Jen Che. Role of WW domain proteins WWOX in development, prognosis, and treatment response of glioma. Experimental biology and medicine (Maywood, N.J.). vol 240. issue 3. 2015-07-21. PMID:25432984. |
it has been found that the reintroduction of wwox induced p53-mutant gbm cells to undergo apoptosis, but not in p53 wild-type gbm cells, indicating wwox is likely to reopen apoptosis pathways in a p53-independent manner in gbm. |
2015-07-21 |
2023-08-13 |
Not clear |
| Richard G Carroll, Emilie Hollville, Seamus J Marti. Parkin sensitizes toward apoptosis induced by mitochondrial depolarization through promoting degradation of Mcl-1. Cell reports. vol 9. issue 4. 2015-07-21. PMID:25456142. |
these data suggest that similar to other sensors of cell stress, such as p53, parkin has cytoprotective (mitophagy) or cytotoxic modes (apoptosis), depending on the degree of mitochondrial damage. |
2015-07-21 |
2023-08-13 |
Not clear |
| Hong Seok Shim, Min Wei, Sebastian Brandhorst, Valter D Long. Starvation promotes REV1 SUMOylation and p53-dependent sensitization of melanoma and breast cancer cells. Cancer research. vol 75. issue 6. 2015-07-21. PMID:25614517. |
under starvation, rev1 is modified by sumo2/3, resulting in the relief of rev1's inhibition of p53 and enhancing p53's effects on proapoptotic gene expression and apoptosis in breast cancer and melanoma cells. |
2015-07-21 |
2023-08-13 |
Not clear |