| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhibing Ai, Chengyan Li, Longti Li, Guohou H. Resveratrol inhibits β-amyloid-induced neuronal apoptosis via regulation of p53 acetylation in PC12 cells. Molecular medicine reports. vol 11. issue 4. 2015-09-16. PMID:25483559. |
resveratrol inhibits β-amyloid-induced neuronal apoptosis via regulation of p53 acetylation in pc12 cells. |
2015-09-16 |
2023-08-13 |
Not clear |
| Zhibing Ai, Chengyan Li, Longti Li, Guohou H. Resveratrol inhibits β-amyloid-induced neuronal apoptosis via regulation of p53 acetylation in PC12 cells. Molecular medicine reports. vol 11. issue 4. 2015-09-16. PMID:25483559. |
it was demonstrated that resveratrol exerted neuronal protection through inhibition of cell apoptosis, which was associated with an increased acetylation level of p53. |
2015-09-16 |
2023-08-13 |
Not clear |
| Zhibing Ai, Chengyan Li, Longti Li, Guohou H. Resveratrol inhibits β-amyloid-induced neuronal apoptosis via regulation of p53 acetylation in PC12 cells. Molecular medicine reports. vol 11. issue 4. 2015-09-16. PMID:25483559. |
in conclusion, it was revealed that resveratrol inhibited aβ(25‑35)‑induced cell apoptosis via the acetylation of p53 in pc12 cells. |
2015-09-16 |
2023-08-13 |
Not clear |
| Siddhartha Kumar Mishra, Swati Tripathi, Archana Shukla, Seung Hyun Oh, Hwan Mook Ki. Andrographolide and analogues in cancer prevention. Frontiers in bioscience (Elite edition). vol 7. 2015-09-16. PMID:25553378. |
andrographolide induced both intrinsic and extrinsic apoptosis pathway in different cancer cells via expression of different anti-apoptotic protein like bax, p53, and activated caspases. |
2015-09-16 |
2023-08-13 |
human |
| Alyaa M Mousa, Ameera S Al-Fadhli, Muddanna S Rao, Narayana Kilarkaj. Gestational lead exposure induces developmental abnormalities and up-regulates apoptosis of fetal cerebellar cells in rats. Drug and chemical toxicology. vol 38. issue 1. 2015-09-15. PMID:24724870. |
an increase in bax and caspase 3, and a decrease in bcl-2 (p < 0.05), but not in p53, showed apoptosis of the neurons. |
2015-09-15 |
2023-08-13 |
rat |
| Thekkuttuparambil Ananthanarayanan Ajit. Strategies used in the clinical trials of gene therapy for cancer. Journal of experimental therapeutics & oncology. vol 11. issue 1. 2015-09-15. PMID:26259388. |
introducing a wild type p53 gene, enhancing the immune system to protect against the cancer cells, enhancing the apoptosis of cancer cells and inhibiting the process of angiogenesis in the tumor are some of the clinical trials that are achieved through the gene therapy. |
2015-09-15 |
2023-08-13 |
Not clear |
| P M Kondratovskii, A I Dubikov, A Yu Doroshevskaya, M G Eliseikin. PUMA protein in p53 regulatory molecule pattern determines the prognosis for patients with lymphoproliferative diseases. Bulletin of experimental biology and medicine. vol 156. issue 6. 2015-09-14. PMID:24824714. |
the pool of apoptosis regulator proteins (p53, puma, p21, and mdm2) in the bone marrow, lymph node, and other tumor substrate cells were studied by immunocytochemical analysis in patients with chronic lymphoproliferative diseases. |
2015-09-14 |
2023-08-13 |
Not clear |
| Hai-Jian Wu, Jia-Li Pu, Paul R Krafft, Jian-Min Zhang, Sheng Che. The molecular mechanisms between autophagy and apoptosis: potential role in central nervous system disorders. Cellular and molecular neurobiology. vol 35. issue 1. 2015-09-14. PMID:25257832. |
the crosstalk between autophagy and apoptosis was partially uncovered and several key molecules, including bcl-2 family members, beclin 1, and p53 were identified. |
2015-09-14 |
2023-08-13 |
Not clear |
| Anne Benard, Connie M Janssen, Peter J van den Elsen, Marja C J A van Eggermond, Dave S B Hoon, Cornelis J H van de Velde, Peter J K Kuppe. Chromatin status of apoptosis genes correlates with sensitivity to chemo-, immune- and radiation therapy in colorectal cancer cell lines. Apoptosis : an international journal on programmed cell death. vol 19. issue 12. 2015-09-14. PMID:25292014. |
using chromatin immunoprecipitation (chip), we measured the presence of transcription-activating histone modifications h3ac and h3k4me3 and silencing modifications h3k9me3 and h3k27me3 at the gene promoter regions of key apoptosis genes bax, bcl2, caspase-9, fas (cd95) and p53. |
2015-09-14 |
2023-08-13 |
Not clear |
| Anne Benard, Connie M Janssen, Peter J van den Elsen, Marja C J A van Eggermond, Dave S B Hoon, Cornelis J H van de Velde, Peter J K Kuppe. Chromatin status of apoptosis genes correlates with sensitivity to chemo-, immune- and radiation therapy in colorectal cancer cell lines. Apoptosis : an international journal on programmed cell death. vol 19. issue 12. 2015-09-14. PMID:25292014. |
the chromatin status of the apoptosis genes reflected the activation status of the intrinsic (bax, bcl2, caspase-9 and p53) and extrinsic (fas) pathways. |
2015-09-14 |
2023-08-13 |
Not clear |
| Xichen Bao, Haitao Wu, Xihua Zhu, Xiangpeng Guo, Andrew P Hutchins, Zhiwei Luo, Hong Song, Yongqiang Chen, Keyu Lai, Menghui Yin, Lingxiao Xu, Liang Zhou, Jiekai Chen, Dongye Wang, Baoming Qin, Jon Frampton, Hung-Fat Tse, Duanqing Pei, Huating Wang, Biliang Zhang, Miguel A Esteba. The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters. Cell research. vol 25. issue 1. 2015-09-14. PMID:25512341. |
notably, lincrna-p21 is induced by p53 but does not promote apoptosis or cell senescence in reprogramming. |
2015-09-14 |
2023-08-13 |
Not clear |
| Mandana Behbahan. Evaluation of in vitro anticancer activity of Ocimum basilicum, Alhagi maurorum, Calendula officinalis and their parasite Cuscuta campestris. PloS one. vol 9. issue 12. 2015-09-14. PMID:25548920. |
the induction of apoptosis was measured by the expression levels of p53, bcl-2, bax and caspase-3 genes using quantitative real time pcr. |
2015-09-14 |
2023-08-13 |
human |
| Xiao-Lan Li, Jianbiao Zhou, Zhi-Rong Chen, Wee-Joo Chn. P53 mutations in colorectal cancer - molecular pathogenesis and pharmacological reactivation. World journal of gastroenterology. vol 21. issue 1. 2015-09-14. PMID:25574081. |
tumor suppressor p53 protein is a transcription factor inducing cell cycle arrest, senescence, and apoptosis under cellular stress. |
2015-09-14 |
2023-08-13 |
Not clear |
| Amr Amin, Khuloud Bajbouj, Adrian Koch, Muktheshwar Gandesiri, Regine Schneider-Stoc. Defective autophagosome formation in p53-null colorectal cancer reinforces crocin-induced apoptosis. International journal of molecular sciences. vol 16. issue 1. 2015-09-14. PMID:25584615. |
baf-exposed hct116 p53(-/-) cells did not, however, show any enhancement of apoptosis induction despite an increase in the dna damage-sensor accumulation, γh2ax indicating that crocin induced an autophagy-independent classical programmed cell death. |
2015-09-14 |
2023-08-13 |
Not clear |
| Gandhari Maity-Kumar, Dietmar R Thal, Bernd Baumann, Karin Scharffetter-Kochanek, Thomas Wirt. Neuronal redox imbalance results in altered energy homeostasis and early postnatal lethality. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 29. issue 7. 2015-09-14. PMID:25829510. |
jnk activation and stabilization of p53, as a result of reactive oxygen species accumulation, are most likely the inducers of neuronal apoptosis in sod2(nko) mice. |
2015-09-14 |
2023-08-13 |
mouse |
| Shangshi Shi, Jianya Zhao, Lingling Yang, Xiaoke Nie, Jingling Han, Xia Ma, Chunhua Wan, Junkang Jian. KHSRP participates in manganese-induced neurotoxicity in rat striatum and PC12 cells. Journal of molecular neuroscience : MN. vol 55. issue 2. 2015-09-11. PMID:25027559. |
importantly, interference with khsrp apparently decreased the level of p53 and attenuated mn-induced neuronal apoptosis. |
2015-09-11 |
2023-08-13 |
rat |
| O Fortunato, M Boeri, M Moro, C Verri, M Mensah, D Conte, L Caleca, L Roz, U Pastorino, G Sozz. Mir-660 is downregulated in lung cancer patients and its replacement inhibits lung tumorigenesis by targeting MDM2-p53 interaction. Cell death & disease. vol 5. 2015-09-11. PMID:25501825. |
transient and stable overexpression of mir-660 using mirna mimics reduced migration, invasion, and proliferation properties and increased apoptosis in p53 wild-type lung cancer cells (nci-h460, lt73, and a549). |
2015-09-11 |
2023-08-13 |
mouse |
| Y L Shi, S Feng, W Chen, Z C Hua, J J Bian, W Yi. Mitochondrial inhibitor sensitizes non-small-cell lung carcinoma cells to TRAIL-induced apoptosis by reactive oxygen species and Bcl-X(L)/p53-mediated amplification mechanisms. Cell death & disease. vol 5. 2015-09-11. PMID:25522273. |
as puma expression was regulated by p53, the puma, bcl-x(l) and p53 in rotenone-treated cells form a positive feedback amplification loop to increase the apoptosis sensitivity. |
2015-09-11 |
2023-08-13 |
Not clear |
| Chun'an Bian, Zhongyou Li, Youtao Xu, Jie Wang, Lin Xu, Hongbing She. [Clinical significance of mutant p53 protein expression in lung adenocarcinoma]. Zhongguo fei ai za zhi = Chinese journal of lung cancer. vol 18. issue 1. 2015-09-11. PMID:25603869. |
the mutation of p53 may cause loss of tumor suppressor functions and gain of functions favoring cellular proliferation and apoptosis inhibition. |
2015-09-11 |
2023-08-13 |
Not clear |
| Ying Shi, Yue Han, Fang Xie, Anna Wang, Xiaokun Feng, Ning Li, Hongliang Guo, Dexi Che. ASPP2 enhances oxaliplatin (L-OHP)-induced colorectal cancer cell apoptosis in a p53-independent manner by inhibiting cell autophagy. Journal of cellular and molecular medicine. vol 19. issue 3. 2015-09-10. PMID:25534115. |
aspp2 (apoptosis stimulated protein of p53-2) is a p53 binding protein that specially stimulates pro-apoptosis function of p53. |
2015-09-10 |
2023-08-13 |
mouse |