| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lina S Schneider, Karin von Schwarzenberg, Thorsten Lehr, Melanie Ulrich, Rebekka Kubisch-Dohmen, Johanna Liebl, Dirk Trauner, Dirk Menche, Angelika M Vollma. Vacuolar-ATPase Inhibition Blocks Iron Metabolism to Mediate Therapeutic Effects in Breast Cancer. Cancer research. vol 75. issue 14. 2015-10-06. PMID:26018087. |
as a consequence of disturbed iron metabolism, archazolid caused s-phase arrest, double-stranded dna breaks, and p53 stabilization, leading to apoptosis. |
2015-10-06 |
2023-08-13 |
Not clear |
| N E Fedorova, S S Emelianova, G R Vinogradskaya, E V Chichev, A V Murzakova, A A Kirichenko, V N Verbenko, A A Kushc. [EFFECT OF ANTI-CANCER DRUG DOXORUBICINE ON CYTOMEGALOVIRUS INFECTED HUMAN FIBROBLASTS]. Tsitologiia. vol 57. issue 4. 2015-10-06. PMID:26349243. |
it has been suggested that dox induces death of cancer cells via p53-dependent apoptosis, however, the information regarding the role of p73 protein, a member of p53 tumor suppressor family, is scanty. |
2015-10-06 |
2023-08-13 |
human |
| Yu Leng Phua, Jessica Y S Chu, April K Marrone, Andrew J Bodnar, Sunder Sims-Lucas, Jacqueline H. Renal stromal miRNAs are required for normal nephrogenesis and glomerular mesangial survival. Physiological reports. vol 3. issue 10. 2015-10-06. PMID:26438731. |
although the initial lineage specification of foxd1(+) stroma was not perturbed, both the glomerular mesangium and renal interstitium exhibited ectopic apoptosis, which was associated with increased expression of bcl2l11 (bim) and p53 effector genes (bax, trp53inp1, jun, cdkn1a, mmp2, and arid3a). |
2015-10-06 |
2023-08-13 |
mouse |
| Se-Lim Kim, Yu-Chuan Liu, Young Ran Park, Seung Young Seo, Seong Hun Kim, In Hee Kim, Seung Ok Lee, Soo Teik Lee, Dae-Ghon Kim, Sang-Wook Ki. Parthenolide enhances sensitivity of colorectal cancer cells to TRAIL by inducing death receptor 5 and promotes TRAIL-induced apoptosis. International journal of oncology. vol 46. issue 3. 2015-10-05. PMID:25502339. |
apoptosis through the mitochondrial pathway was confirmed by detecting regulation of bcl-2 family members, p53 cytochrome c release, and caspase cascades. |
2015-10-05 |
2023-08-13 |
human |
| Bin Fu, Yibing Wang, Xiali Zhang, Bin Lang, Xiaocheng Zhou, Xiaoyuan Xu, Tao Zeng, Weipeng Liu, Xu Zhang, Ju Guo, Gongxian Wan. MiR-221-induced PUMA silencing mediates immune evasion of bladder cancer cells. International journal of oncology. vol 46. issue 3. 2015-10-05. PMID:25585941. |
as a result, the repression of mir‑221 on p53 upregulated modulator of apoptosis (puma) was abolished, resulting in increased expression of the pro-apoptotic bax and reduced expression of the anti-apoptotic bcl-2, which promotes apoptosis of bladder cancer cells. |
2015-10-05 |
2023-08-13 |
Not clear |
| Ajda Çoker-Gürkan, Elif Damla Arisan, Pınar Obakan, Narçin Palavan-Unsa. Lack of functional p53 renders DENSpm-induced autophagy and apoptosis in time dependent manner in colon cancer cells. Amino acids. vol 47. issue 1. 2015-10-02. PMID:25311224. |
lack of functional p53 renders denspm-induced autophagy and apoptosis in time dependent manner in colon cancer cells. |
2015-10-02 |
2023-08-13 |
Not clear |
| Ajda Çoker-Gürkan, Elif Damla Arisan, Pınar Obakan, Narçin Palavan-Unsa. Lack of functional p53 renders DENSpm-induced autophagy and apoptosis in time dependent manner in colon cancer cells. Amino acids. vol 47. issue 1. 2015-10-02. PMID:25311224. |
in addition to pa depletion, denspm induced apoptosis by activating the mitochondria-mediated pathway in a caspase-dependent manner regardless of p53 expression in colon cancer cells. |
2015-10-02 |
2023-08-13 |
Not clear |
| Gecioni Loch-Neckel, Maíra Assunção Bicca, Paulo César Leal, Alessandra Mascarello, Jarbas Mota Siqueira, João B Calixt. In vitro and in vivo anti-glioma activity of a chalcone-quinoxaline hybrid. European journal of medicinal chemistry. vol 90. 2015-10-02. PMID:25461314. |
collectively, data demonstrate that n9 possess in vitro and in vivo anti-cancer activity, an effect that seems to involve the induction of p53 and p21 proteins, as well as, the activation of mitochondrial apoptosis pathway associated with the inhibition of protein mdm2. |
2015-10-02 |
2023-08-13 |
mouse |
| Simona Panni, Stefano Salvioli, Elena Santonico, Francesca Langone, Francesca Storino, Serena Altilia, Claudio Franceschi, Gianni Cesareni, Luisa Castagnol. The adapter protein CD2AP binds to p53 protein in the cytoplasm and can discriminate its polymorphic variants P72R. Journal of biochemistry. vol 157. issue 2. 2015-10-01. PMID:25261582. |
the tumour-suppressor p53 protein presents a proline-rich region that is crucial for regulating apoptosis by connecting the p53 with a complex protein network. |
2015-10-01 |
2023-08-13 |
Not clear |
| Hossein Neamatzadeh, Reza Soleimanizad, Aref Atefi, Masoud Zare-Shehneh, Saba Gharibi, Abolfazl Shekari, Amir Bahman Rahimzade. Association between p53 codon 72 (Arg72Pro) polymorphism and primary open-angle glaucoma in Iranian patients. Iranian biomedical journal. vol 19. issue 1. 2015-10-01. PMID:25605490. |
the p53 gene is one of the regulatory genes of apoptosis. |
2015-10-01 |
2023-08-13 |
Not clear |
| Yan Li, J Alan Dieh. PRMT5-dependent p53 escape in tumorigenesis. Oncoscience. vol 2. issue 8. 2015-10-01. PMID:26425661. |
recent studies suggest that prmt5, which is frequently elevated in human cancers, cooperates with oncogenic cyclin d1 and leaves marks on p53 by way of arginine methylation, promoting the bypass of wild-type p53, and in doing so, evade apoptosis. |
2015-10-01 |
2023-08-13 |
human |
| Danielle L Anderson, Razmik Mirzayans, Bonnie Andrais, E Albert Siegbahn, B Gino Fallone, Brad Warkenti. Spatial and temporal distribution of γH2AX fluorescence in human cell cultures following synchrotron-generated X-ray microbeams: lack of correlation between persistent γH2AX foci and apoptosis. Journal of synchrotron radiation. vol 21. issue Pt 4. 2015-09-30. PMID:24971978. |
formation of γh2ax foci (a marker of dna double-strand breaks), rates of foci clearance and apoptosis were investigated in cultured normal human fibroblasts and p53 wild-type malignant glioma cells after exposure to high-dose synchrotron-generated microbeams. |
2015-09-30 |
2023-08-13 |
human |
| Sun-Ah Kim, Injung Kim, Sungjoo Kim Yoon, Eun Kyung Lee, Hyo-Jeong Ku. Indirect modulation of sensitivity to 5-fluorouracil by microRNA-96 in human colorectal cancer cells. Archives of pharmacal research. vol 38. issue 2. 2015-09-30. PMID:25502560. |
when the level of mir-96 increased, the expression of the anti-apoptotic regulator xiap and p53 stability regulator ube2n decreased, resulting in increased apoptosis and growth inhibition following 5-fu exposure. |
2015-09-30 |
2023-08-13 |
human |
| Jian Ma, Jingtao Peng, Ren Mo, Shaofei Ma, Jing Wang, Lijuan Zang, Weiguo Li, Jie Fa. Ubiquitin E3 ligase UHRF1 regulates p53 ubiquitination and p53-dependent cell apoptosis in clear cell Renal Cell Carcinoma. Biochemical and biophysical research communications. vol 464. issue 1. 2015-09-30. PMID:26102039. |
ubiquitin e3 ligase uhrf1 regulates p53 ubiquitination and p53-dependent cell apoptosis in clear cell renal cell carcinoma. |
2015-09-30 |
2023-08-13 |
human |
| Jian Ma, Jingtao Peng, Ren Mo, Shaofei Ma, Jing Wang, Lijuan Zang, Weiguo Li, Jie Fa. Ubiquitin E3 ligase UHRF1 regulates p53 ubiquitination and p53-dependent cell apoptosis in clear cell Renal Cell Carcinoma. Biochemical and biophysical research communications. vol 464. issue 1. 2015-09-30. PMID:26102039. |
uhrf1 can promote non-degradative ubiquitination of p53, suppress p53 pathway activation and p53-dependent apoptosis in ccrcc cells. |
2015-09-30 |
2023-08-13 |
human |
| Jian Ma, Jingtao Peng, Ren Mo, Shaofei Ma, Jing Wang, Lijuan Zang, Weiguo Li, Jie Fa. Ubiquitin E3 ligase UHRF1 regulates p53 ubiquitination and p53-dependent cell apoptosis in clear cell Renal Cell Carcinoma. Biochemical and biophysical research communications. vol 464. issue 1. 2015-09-30. PMID:26102039. |
together, our study suggests that uhrf1, which overexpressed ccrcc, may act as a p53 regulator, suppress p53 pathway activation and help ccrcc cells to escape from p53-dependent apoptosis. |
2015-09-30 |
2023-08-13 |
human |
| Hye-Jung Park, Moon-Moo Ki. Flavonoids in Ginkgo biloba fallen leaves induce apoptosis through modulation of p53 activation in melanoma cells. Oncology reports. vol 33. issue 1. 2015-09-28. PMID:25394497. |
flavonoids in ginkgo biloba fallen leaves induce apoptosis through modulation of p53 activation in melanoma cells. |
2015-09-28 |
2023-08-13 |
Not clear |
| Ling Zhang, Leah Nemzow, Hua Chen, Abigail Lubin, Xi Rong, Zhongyi Sun, Thomas K Harris, Feng Gon. The deubiquitinating enzyme USP24 is a regulator of the UV damage response. Cell reports. vol 10. issue 2. 2015-09-25. PMID:25578727. |
we show that usp24 depletion renders cells resistant to apoptosis after uv irradiation, consistent with the requirement of usp24 for p53 stabilization and puma activation in vivo. |
2015-09-25 |
2023-08-13 |
human |
| Chih-Yeu Fang, Chung-Chun Wu, Hui-Yu Hsu, Hsin-Ying Chuang, Sheng-Yen Huang, Ching-Hwa Tsai, Yao Chang, George Sai-Wah Tsao, Chi-Long Chen, Jen-Yang Che. EGCG inhibits proliferation, invasiveness and tumor growth by up-regulation of adhesion molecules, suppression of gelatinases activity, and induction of apoptosis in nasopharyngeal carcinoma cells. International journal of molecular sciences. vol 16. issue 2. 2015-09-25. PMID:25625511. |
treatment with egcg was found to elevate the expression of p53 and p21, and eventually led to apoptosis of npc cells via caspase 3 activation. |
2015-09-25 |
2023-08-13 |
mouse |
| Jung Hwan Yoon, Ho Seok Seo, Won Seok Choi, Olga Kim, Suk Woo Nam, Jung Young Lee, Won Sang Par. Gastrokine 1 induces senescence and apoptosis through regulating telomere length in gastric cancer. Oncotarget. vol 5. issue 22. 2015-09-24. PMID:25344918. |
furthermore, gkn1 triggered senescence, followed by apoptosis via up-regulating the p53, p21, p27, and p16 proteins and down-regulating skp2. |
2015-09-24 |
2023-08-13 |
Not clear |