| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dawei Yang, Peng Wang, Xiaoping Re. Apoptosis induced by chamaejasmine in human osteosarcoma cells through p53 pathway. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 7. 2015-10-26. PMID:25677904. |
apoptosis induced by chamaejasmine in human osteosarcoma cells through p53 pathway. |
2015-10-26 |
2023-08-13 |
human |
| Nina Reuven, Julia Adler, Ziv Porat, Tilman Polonio-Vallon, Thomas G Hofmann, Yosef Shau. The Tyrosine Kinase c-Abl Promotes Homeodomain-interacting Protein Kinase 2 (HIPK2) Accumulation and Activation in Response to DNA Damage. The Journal of biological chemistry. vol 290. issue 27. 2015-10-26. PMID:25944899. |
under this condition, dna damage-induced hipk2 accumulation, phosphorylation of p53 at ser(46), and apoptosis were attenuated. |
2015-10-26 |
2023-08-13 |
Not clear |
| Bianca Gilbert, Khalil Ahmad, Jessica Roos, Christoph Lehmann, Tomohiro Chiba, Sandra Ulrich-Rückert, Leonie Smeenk, Simon van Heeringen, Thorsten J Maier, Bernd Groner, Dieter Steinhilbe. 5-Lipoxygenase is a direct p53 target gene in humans. Biochimica et biophysica acta. vol 1849. issue 8. 2015-10-26. PMID:26070487. |
p53 can transactivate or repress target genes in response to diverse stress signals, such as transient growth arrest, dna repair, cellular differentiation, senescence and apoptosis. |
2015-10-26 |
2023-08-13 |
human |
| James Whitwell, Robert Smith, Karen Jenner, Heather Lyon, Deborah Wood, Julie Clements, Kelly Aschcroft-Hawley, Bhaskar Gollapudi, David Kirkland, Elisabeth Lorge, Stefan Pfuhler, Jennifer Y Tanir, Veronique Thybau. Relationships between p53 status, apoptosis and induction of micronuclei in different human and mouse cell lines in vitro: Implications for improving existing assays. Mutation research. Genetic toxicology and environmental mutagenesis. vol 789-790. 2015-10-26. PMID:26232254. |
relationships between p53 status, apoptosis and induction of micronuclei in different human and mouse cell lines in vitro: implications for improving existing assays. |
2015-10-26 |
2023-08-13 |
mouse |
| Hao Gong, Xin Yang, Yudan Zhao, Robert B Petersen, Xinran Liu, Yang Liu, Kun Huan. Amyloidogenicity of p53: a hidden link between protein misfolding and cancer. Current protein & peptide science. vol 16. issue 2. 2015-10-23. PMID:25692950. |
the tumor suppressor p53, a transcription factor that regulates the cell cycle and apoptosis, is also amyloidogenic. |
2015-10-23 |
2023-08-13 |
Not clear |
| V Méniel, M Megges, M A Young, A Cole, O J Sansom, A R Clark. Apc and p53 interaction in DNA damage and genomic instability in hepatocytes. Oncogene. vol 34. issue 31. 2015-10-21. PMID:25347740. |
we show that, although apc loss leads to increased proliferation, it also leads to increased apoptosis, the accumulation of p53, p21 and markers of double-strand breaks and dna repair. |
2015-10-21 |
2023-08-13 |
Not clear |
| J Gao, N Li, Y Dong, S Li, L Xu, X Li, Y Li, Z Li, S S Ng, J J Sung, L Shen, J Y. miR-34a-5p suppresses colorectal cancer metastasis and predicts recurrence in patients with stage II/III colorectal cancer. Oncogene. vol 34. issue 31. 2015-10-21. PMID:25362853. |
mir-34a-5p induced cell apoptosis, cell cycle arrest at g1 phase and p53 transcription activity in hct116 cells, but not in the hct116 p53 knockout (p53(-/-)) cells. |
2015-10-21 |
2023-08-13 |
Not clear |
| S Rybárová, I Hodorová, J Vecanová, J Muri, J Mihali. [Interaction between p53 and MDM2 in human lung cancer cells]. Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti. vol 27. issue 1. 2015-10-20. PMID:24635435. |
the oncoprotein p53 protein induces cell growth arrest (apoptosis) in response to endo or exogenous stimuli. |
2015-10-20 |
2023-08-12 |
human |
| Tianhui Niu, Yan Tian, Qu Ren, Lizhao Wei, Xiaoxin Li, Qing Ca. Red light interferes in UVA-induced photoaging of human skin fibroblast cells. Photochemistry and photobiology. vol 90. issue 6. 2015-10-20. PMID:25039464. |
red light irradiation retarded the cumulative low-dose uva irradiation-induced skin photoaging, decreased the expression of senescence-associated β-galactosidase, upregulated sirt1 expression, decreased matrix metalloproteinase mmp-1 and the acetylation of p53 expression, reduced the horizon of cell apoptosis and enhanced cell viability. |
2015-10-20 |
2023-08-13 |
human |
| Xing-Qi Li, Zhi-Gang Ouyang, Sheng-Hua Zhang, Hong Liu, Yue Shang, Yi Li, Yong-Su Zhe. Synergy of enediyne antibiotic lidamycin and temozolomide in suppressing glioma growth with potentiated apoptosis induction. Journal of neuro-oncology. vol 119. issue 1. 2015-10-19. PMID:24842385. |
as determined by western blot, apoptosis signal pathways in c6 cells and u87 cells were markedly affected by the synergistic alteration of p53, bax, procaspase 3, and bcd-2 expression. |
2015-10-19 |
2023-08-13 |
human |
| Xiao-Ling Xu, Wei-Hui Zheng, Kai-Yi Tao, Xian-Xing Li, Wei-Zhen Xu, Yin Wang, Shuang-Mei Zhu, Wei-Min Ma. p53 is an independent prognostic factor in operable esophageal squamous cell carcinoma: a large-scale study with a long follow-up. Medical oncology (Northwood, London, England). vol 31. issue 11. 2015-10-19. PMID:25270283. |
the p53 protein is involved in many biological functions in cancer, such as cell cycle arrest, dna repair, apoptosis, senescence, dna metabolism, angiogenesis, and cellular differentiation. |
2015-10-19 |
2023-08-13 |
Not clear |
| Bo-Yong Wang, Jun Cao, Ji-Wei Chen, Quan-Yan Li. Triptolide induces apoptosis of gastric cancer cells via inhibiting the overexpression of MDM2. Medical oncology (Northwood, London, England). vol 31. issue 11. 2015-10-19. PMID:25280518. |
the expression of mdm2, p53 protein, and target proteins including p21, puma, and x-linked inhibitor of apoptosis protein (xiap) was detected. |
2015-10-19 |
2023-08-13 |
Not clear |
| Jingjing Wang, Zhuang Yang, Jiaolin Wen, Feng Ma, Fang Wang, Kun Yu, Minghai Tang, Wenshuang Wu, Yinfeng Dong, Xia Cheng, Chunlai Nie, Lijuan Che. SKLB-M8 induces apoptosis through the AKT/mTOR signaling pathway in melanoma models and inhibits angiogenesis with decrease of ERK1/2 phosphorylation. Journal of pharmacological sciences. vol 126. issue 3. 2015-10-19. PMID:25341684. |
flow cytometory analysis showed that sklb-m8 induced g2/m arrest in three melanoma cell lines, and western blotting demonstrated that sklb-m8 down-regulated the expression of cdc2, up-regulated p53 in a2058 and chl-1 cells, and triggered cell apoptosis through down-regulating akt and phosphorylated mtor (p-mtor). |
2015-10-19 |
2023-08-13 |
mouse |
| Ya Feng, Te Liu, Su-Yan Dong, Yan-Jie Guo, Joseph Jankovic, Huaxi Xu, Yun-Cheng W. Rotenone affects p53 transcriptional activity and apoptosis via targeting SIRT1 and H3K9 acetylation in SH-SY5Y cells. Journal of neurochemistry. vol 134. issue 4. 2015-10-19. PMID:25991017. |
rotenone affects p53 transcriptional activity and apoptosis via targeting sirt1 and h3k9 acetylation in sh-sy5y cells. |
2015-10-19 |
2023-08-13 |
Not clear |
| Ya Feng, Te Liu, Su-Yan Dong, Yan-Jie Guo, Joseph Jankovic, Huaxi Xu, Yun-Cheng W. Rotenone affects p53 transcriptional activity and apoptosis via targeting SIRT1 and H3K9 acetylation in SH-SY5Y cells. Journal of neurochemistry. vol 134. issue 4. 2015-10-19. PMID:25991017. |
in this study, we found that rotenone treatment decreased cell viability, induced apoptosis, reduced sirt1 level, and promoted p53 expression. |
2015-10-19 |
2023-08-13 |
Not clear |
| Ya Feng, Te Liu, Su-Yan Dong, Yan-Jie Guo, Joseph Jankovic, Huaxi Xu, Yun-Cheng W. Rotenone affects p53 transcriptional activity and apoptosis via targeting SIRT1 and H3K9 acetylation in SH-SY5Y cells. Journal of neurochemistry. vol 134. issue 4. 2015-10-19. PMID:25991017. |
in conclusion, our data indicate that rotenone promotes p53 transcription and apoptosis through targeting sirt1 and h3k9. |
2015-10-19 |
2023-08-13 |
Not clear |
| Weiwei Yi, Xuelian Hu, Zhiyang Chen, Leiming Liu, Yuan Tian, Hui Chen, Yu-Sheng Cong, Fan Yang, Lianfeng Zhang, Karl Lenhard Rudolph, Zhixin Zhang, Yong Zhao, Zhenyu J. Phosphatase Wip1 controls antigen-independent B-cell development in a p53-dependent manner. Blood. vol 126. issue 5. 2015-10-19. PMID:26012568. |
further experiments revealed that wip1 deficiency led to a sustained activation of p53 in b cells, which led to increased level of apoptosis in the pre-b-cell compartment. |
2015-10-19 |
2023-08-13 |
mouse |
| Elizabeth A Slee, Xin L. Requirement for phosphorylation of P53 at Ser312 in suppression of chemical carcinogenesis. Scientific reports. vol 3. 2015-10-16. PMID:24173284. |
phosphorylation on ser312 aids p53's interaction with e2f1, and enhances p53-mediated apoptosis. |
2015-10-16 |
2023-08-12 |
mouse |
| Simona Daniele, Sabrina Taliani, Eleonora Da Pozzo, Chiara Giacomelli, Barbara Costa, Maria Letizia Trincavelli, Leonardo Rossi, Valeria La Pietra, Elisabetta Barresi, Alfonso Carotenuto, Antonio Limatola, Anna Lamberti, Luciana Marinelli, Ettore Novellino, Federico Da Settimo, Claudia Martin. Apoptosis therapy in cancer: the first single-molecule co-activating p53 and the translocator protein in glioblastoma. Scientific reports. vol 4. 2015-10-16. PMID:24756113. |
apoptosis therapy in cancer: the first single-molecule co-activating p53 and the translocator protein in glioblastoma. |
2015-10-16 |
2023-08-13 |
Not clear |
| Simona Daniele, Sabrina Taliani, Eleonora Da Pozzo, Chiara Giacomelli, Barbara Costa, Maria Letizia Trincavelli, Leonardo Rossi, Valeria La Pietra, Elisabetta Barresi, Alfonso Carotenuto, Antonio Limatola, Anna Lamberti, Luciana Marinelli, Ettore Novellino, Federico Da Settimo, Claudia Martin. Apoptosis therapy in cancer: the first single-molecule co-activating p53 and the translocator protein in glioblastoma. Scientific reports. vol 4. 2015-10-16. PMID:24756113. |
in glioblastoma multiforme (gbm), p53 and translocator protein (tspo), both acting as apoptosis inducers, represent two attractive intracellular targets. |
2015-10-16 |
2023-08-13 |
Not clear |