| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bing Liu, Divesh Bhatt, Zoltán N Oltvai, Joel S Greenberger, Ivet Baha. Significance of p53 dynamics in regulating apoptosis in response to ionizing radiation, and polypharmacological strategies. Scientific reports. vol 4. 2015-10-16. PMID:25175563. |
significance of p53 dynamics in regulating apoptosis in response to ionizing radiation, and polypharmacological strategies. |
2015-10-16 |
2023-08-13 |
Not clear |
| Bing Liu, Divesh Bhatt, Zoltán N Oltvai, Joel S Greenberger, Ivet Baha. Significance of p53 dynamics in regulating apoptosis in response to ionizing radiation, and polypharmacological strategies. Scientific reports. vol 4. 2015-10-16. PMID:25175563. |
here we build a stochastic model of p53 induced apoptosis comprised of coupled modules of nuclear p53 activation, mitochondrial cytochrome c release and cytosolic caspase activation that also takes into account cellular heterogeneity. |
2015-10-16 |
2023-08-13 |
Not clear |
| Bing Liu, Divesh Bhatt, Zoltán N Oltvai, Joel S Greenberger, Ivet Baha. Significance of p53 dynamics in regulating apoptosis in response to ionizing radiation, and polypharmacological strategies. Scientific reports. vol 4. 2015-10-16. PMID:25175563. |
our simulations show that the strength of p53 transcriptional activity and its coupling (or timing with respect) to mitochondrial pore opening are major determinants of cell fate: for systems where apoptosis is elicited via a p53-transcription-independent mechanism, direct activation of bax by p53 becomes critical to ir-induced-damage initiation. |
2015-10-16 |
2023-08-13 |
Not clear |
| Sonal Sawhney, Kylie Hood, Alisha Shaw, Antony W Braithwaite, Richard Stubbs, Noelyn A Hung, Janice A Royds, Tania L Slatte. Alpha-enolase is upregulated on the cell surface and responds to plasminogen activation in mice expressing a ∆133p53α mimic. PloS one. vol 10. issue 2. 2015-10-16. PMID:25643152. |
it acts as a tumor suppressor by inducing transcriptional activation of p53 target genes, with roles in apoptosis, cell cycle arrest and metabolism. |
2015-10-16 |
2023-08-13 |
mouse |
| Wei Wang, Subhasree Nag, Xu Zhang, Ming-Hai Wang, Hui Wang, Jianwei Zhou, Ruiwen Zhan. Ribosomal proteins and human diseases: pathogenesis, molecular mechanisms, and therapeutic implications. Medicinal research reviews. vol 35. issue 2. 2015-10-15. PMID:25164622. |
perturbation of ribosome biogenesis results in ribosomal stress, which triggers activation of the p53 signaling pathway through rps-mdm2 interactions, resulting in p53-dependent cell cycle arrest and apoptosis. |
2015-10-15 |
2023-08-13 |
human |
| Joel A Yb. Novel clathrin activity: developments in health and disease. Biomolecular concepts. vol 5. issue 2. 2015-10-15. PMID:25372751. |
clathrin is argued to help transactivate tumor suppressor p53 that controls specific genes in dna repair and apoptosis. |
2015-10-15 |
2023-08-13 |
human |
| Xin Zhang, Ramona Schulz, Shelley Edmunds, Elke Krüger, Elke Markert, Jochen Gaedcke, Estelle Cormet-Boyaka, Michael Ghadimi, Tim Beissbarth, Arnold J Levine, Ute M Moll, Matthias Dobbelstei. MicroRNA-101 Suppresses Tumor Cell Proliferation by Acting as an Endogenous Proteasome Inhibitor via Targeting the Proteasome Assembly Factor POMP. Molecular cell. vol 59. issue 2. 2015-10-14. PMID:26145175. |
here we show that the microrna-101 (mir-101) targets the proteasome maturation protein pomp, leading to impaired proteasome assembly and activity, and resulting in accumulation of p53 and cyclin-dependent kinase inhibitors, cell cycle arrest, and apoptosis. |
2015-10-14 |
2023-08-13 |
human |
| Jianhong Zeng, Ping Dai, Lingyun Ren, Bo Song, Xu Chen, Xiaohua Wang, Jianhong Wang, Tiecheng Zhang, Weiguo Zh. Apoptosis-induced anti-tumor effect of Curcuma kwangsiensis polysaccharides against human nasopharyngeal carcinoma cells. Carbohydrate polymers. vol 89. issue 4. 2015-10-13. PMID:24750915. |
cne-2 cells were treated with various concentrations of c. kwangsiensis polysaccharides, then the proliferation, apoptosis and the protein expression of apoptosis-related regulators p53 and bcl-2 were assessed. |
2015-10-13 |
2023-08-13 |
human |
| Jianhong Zeng, Ping Dai, Lingyun Ren, Bo Song, Xu Chen, Xiaohua Wang, Jianhong Wang, Tiecheng Zhang, Weiguo Zh. Apoptosis-induced anti-tumor effect of Curcuma kwangsiensis polysaccharides against human nasopharyngeal carcinoma cells. Carbohydrate polymers. vol 89. issue 4. 2015-10-13. PMID:24750915. |
the results demonstrated that c. kwangsiensis polysaccharides can significantly inhibit the proliferation of cne-2 cells, which was possibly through the induction of apoptosis mediated by attenuating bcl-2 expression and promoting p53 expression. |
2015-10-13 |
2023-08-13 |
human |
| Muxun Zhao, Yarong Liu, Renee S Hsieh, Nova Wang, Wanyi Tai, Kye-Il Joo, Pin Wang, Zhen Gu, Yi Tan. Clickable protein nanocapsules for targeted delivery of recombinant p53 protein. Journal of the American Chemical Society. vol 136. issue 43. 2015-10-13. PMID:25289975. |
lhrh-conjugated nanocapsules selectively delivered recombinant human tumor suppressor protein p53 and its tumor-selective supervariant into targeted tumor cells, which led to reactivation of p53-mediated apoptosis. |
2015-10-13 |
2023-08-13 |
human |
| Caterina Faggio, Kousi Alzoubi, Salvatrice Calabrò, Florian Lan. Stimulation of suicidal erythrocyte death by PRIMA-1. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 35. issue 2. 2015-10-13. PMID:25614142. |
the anticarcinogenic drug prima-1 (p53 reactivation and induction of massive apoptosis 1) induces suicidal death of tumor cells, an effect in large part attributed to the up-regulation of the proapoptotic transcription factor p53. |
2015-10-13 |
2023-08-13 |
Not clear |
| Susan M Christner, Dana M Clausen, Jan H Beumer, Robert A Parise, Jianxia Guo, Yijun Huang, Alexander S Dömling, Julie L Eisema. In vitro cytotoxicity and in vivo efficacy, pharmacokinetics, and metabolism of pyrazole-based small molecule inhibitors of Mdm2/4-p53 interaction. Cancer chemotherapy and pharmacology. vol 76. issue 2. 2015-10-13. PMID:26050209. |
in p53(+/+) cells, expression of mdm2/4 leads to p53 turnover, inhibition of downstream transcription, decreasing cell cycle arrest, or apoptosis. |
2015-10-13 |
2023-08-13 |
Not clear |
| Jing Suo, Long Zhao, Jian Wang, Zhichuan Zhu, Huafeng Zhang, Rong Ga. Influenza virus aggravates the ox-LDL-induced apoptosis of human endothelial cells via promoting p53 signaling. Journal of medical virology. vol 87. issue 7. 2015-10-09. PMID:25777161. |
influenza virus aggravates the ox-ldl-induced apoptosis of human endothelial cells via promoting p53 signaling. |
2015-10-09 |
2023-08-13 |
human |
| Jing Suo, Long Zhao, Jian Wang, Zhichuan Zhu, Huafeng Zhang, Rong Ga. Influenza virus aggravates the ox-LDL-induced apoptosis of human endothelial cells via promoting p53 signaling. Journal of medical virology. vol 87. issue 7. 2015-10-09. PMID:25777161. |
therefore, present study confirmed that influenza virus aggravated the ox-ldl-induced apoptosis of human endothelial eahy926 cells via promoting p53 signaling. |
2015-10-09 |
2023-08-13 |
human |
| Dong Joon Kim, Young Soo Park, Min Gu Kang, Yeon-Mi You, Yuri Jung, Han Koo, Jung-Ae Kim, Mi-Ju Kim, Seung-Mo Hong, Kyong Bun Lee, Ja-June Jang, Kyung Chan Park, Young Il Yeo. Pyruvate kinase isoenzyme M2 is a therapeutic target of gemcitabine-resistant pancreatic cancer cells. Experimental cell research. vol 336. issue 1. 2015-10-08. PMID:26112218. |
knocking-down of pkm2 significantly enhanced gemcitabine-induced cell apoptosis through the activation of caspase 3/7 and parp cleavage, and this inhibitory activity was associated with p38-mediated activation of p53 phosphorylation at serine 46. |
2015-10-08 |
2023-08-13 |
Not clear |
| Meirong Zang, Zengjun Li, Lanting Liu, Fei Li, Xin Li, Yun Dai, Wei Li, Ulrike Kuckelkorn, Thorsten R Doeppner, Dirk M Hermann, Wen Zhou, Lugui Qiu, Fengyan Ji. Anti-tumor activity of the proteasome inhibitor BSc2118 against human multiple myeloma. Cancer letters. vol 366. issue 2. 2015-10-08. PMID:26116344. |
bsc2118 suppressed tumor cell growth through induction of g2/m phase arrest and induced apoptosis via activation of the apoptotic signaling cascade, in association with up-regulation of p53 and p21. |
2015-10-08 |
2023-08-13 |
mouse |
| Niklas Gebauer, Veronica Bernard, Wolfgang Gebauer, Christoph Thorns, Alfred C Feller, Hartmut Mer. TP53 mutations are frequent events in double-hit B-cell lymphomas with MYC and BCL2 but not MYC and BCL6 translocations. Leukemia & lymphoma. vol 56. issue 1. 2015-10-07. PMID:24679006. |
our findings indicate a significant difference between these two types of dhl at a molecular level with pathogenetic implications, as arguably, tp53 mutations inhibiting p53 mediated promotion of apoptosis pose a synergistic advantage in clonal evolution of cells with malignantly enforced overexpression of bcl2. |
2015-10-07 |
2023-08-12 |
Not clear |
| Mixia Ouyang, Yuan Hu, Fei Zen. [Expressions of ASPP2, iASPP and p53 in cervical cancinoma and the significance]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 40. issue 3. 2015-10-07. PMID:25832528. |
to explore the role of apoptosis stimulating proteins of p53 2 (aspp2) and inhibitory member of the aspp family (iaspp) in the occurrence of cervical cancer and the relation between these two proteins and p53. |
2015-10-07 |
2023-08-13 |
Not clear |
| LingHu Lang, Shunqin Zhu, Haoxing Zhang, Panpan Yang, Haixia Fan, Shanlin Li, Zhihua Liao, Xiaozhong Lan, Hongjuan Cui, Min Che. A natural phenylpropionate derivative from Mirabilis himalaica inhibits cell proliferation and induces apoptosis in HepG2 cells. Bioorganic & medicinal chemistry letters. vol 24. issue 23. 2015-10-06. PMID:25455489. |
mechanistically, compound 1 was able to induce the apoptosis in hepg2 cells through mitochondrial apoptosis pathway in which bcl-2 and p53 were required. |
2015-10-06 |
2023-08-13 |
human |
| Hong-Feng Zhang, Di Wu, Jian-Kuo Du, Yan Zhang, Yun-Ming S. Inhibitory effects of phenolic alkaloids of Menispermum dauricum on gastric cancer in vivo. Asian Pacific journal of cancer prevention : APJCP. vol 15. issue 24. 2015-10-06. PMID:25605184. |
pamd could suppress gastric tumor growth in vivo, possibly through inhibiting oncogenic k-ras, and induce cell apoptosis possibly by targeting the cell apoptosis-related genes of p53, bcl-2, bax, caspase-3. |
2015-10-06 |
2023-08-13 |
mouse |