| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hae Na Lee, Sung-Min Ahn, Ho Hee Jan. Cold-inducible RNA-binding protein, CIRP, inhibits DNA damage-induced apoptosis by regulating p53. Biochemical and biophysical research communications. vol 464. issue 3. 2015-11-10. PMID:26188505. |
cold-inducible rna-binding protein, cirp, inhibits dna damage-induced apoptosis by regulating p53. |
2015-11-10 |
2023-08-13 |
Not clear |
| David W Mee. Regulation of the p53 response and its relationship to cancer. The Biochemical journal. vol 469. issue 3. 2015-11-10. PMID:26205489. |
p53 has been studied intensively as a major tumour suppressor that detects oncogenic events in cancer cells and eliminates them through senescence (a permanent non-proliferative state) or apoptosis. |
2015-11-10 |
2023-08-13 |
Not clear |
| Liang Chen, Farooq Rashid, Abdullah Shah, Hassaan M Awan, Mingming Wu, An Liu, Jun Wang, Tao Zhu, Zhaofeng Luo, Ge Sha. The isolation of an RNA aptamer targeting to p53 protein with single amino acid mutation. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 32. 2015-11-10. PMID:26216949. |
p53, known as a tumor suppressor, is a dna binding protein that regulates cell cycle, activates dna repair proteins, and triggers apoptosis in multicellular animals. |
2015-11-10 |
2023-08-13 |
mouse |
| Ewelina Wawryk-Gawda, Patrycja Chylińska-Wrzos, Marta Lis-Sochocka, Kamila Bulak, Barbara Jodłowska-Jędryc. Intrinsic apoptosis pathway in fallopian tube epithelial cells induced by cladribine. TheScientificWorldJournal. vol 2014. 2015-11-09. PMID:25431797. |
moreover, the available data confirms that cladribine, with the participation of the p53 protein, as well as the proapoptotic proteins from the bcl-2 family, also induces the activation of the intrinsic apoptosis pathway. |
2015-11-09 |
2023-08-13 |
rat |
| Yingxi Xu, Rong Liao, Na Li, Rong Xiang, Peiqing Su. Phosphorylation of Tip60 by p38α regulates p53-mediated PUMA induction and apoptosis in response to DNA damage. Oncotarget. vol 5. issue 24. 2015-11-09. PMID:25544752. |
acetylation of p53 at k120 by tip60 promotes p53-mediated apoptosis after dna damage. |
2015-11-09 |
2023-08-13 |
Not clear |
| Yingxi Xu, Rong Liao, Na Li, Rong Xiang, Peiqing Su. Phosphorylation of Tip60 by p38α regulates p53-mediated PUMA induction and apoptosis in response to DNA damage. Oncotarget. vol 5. issue 24. 2015-11-09. PMID:25544752. |
in addition, both p38α and tip60 are essential for p53-k120 acetylation, binding of p53 to puma promoter, puma expression and apoptosis induced by dna damage. |
2015-11-09 |
2023-08-13 |
Not clear |
| Bingqing Zhang, Sonam Mehrotra, Wei Lun Ng, Brian R Calv. Low levels of p53 protein and chromatin silencing of p53 target genes repress apoptosis in Drosophila endocycling cells. PLoS genetics. vol 10. issue 9. 2015-11-06. PMID:25211335. |
low levels of p53 protein and chromatin silencing of p53 target genes repress apoptosis in drosophila endocycling cells. |
2015-11-06 |
2023-08-13 |
drosophila_melanogaster |
| Crystal Woodard, Gangling Liao, C Rory Goodwin, Jianfei Hu, Zhi Xie, Thaila F Dos Reis, Rob Newman, Heesool Rho, Jiang Qian, Heng Zhu, S Diane Haywar. A Screen for Extracellular Signal-Regulated Kinase-Primed Glycogen Synthase Kinase 3 Substrates Identifies the p53 Inhibitor iASPP. Journal of virology. vol 89. issue 18. 2015-11-06. PMID:26109723. |
iaspp interferes with apoptosis induced by p53 family members. |
2015-11-06 |
2023-08-13 |
Not clear |
| David Engelmann, Brigitte M Pütze. Emerging from the shade of p53 mutants: N-terminally truncated variants of the p53 family in EMT signaling and cancer progression. Science signaling. vol 7. issue 345. 2015-11-05. PMID:25270260. |
the prevailing view has been that n-terminally truncated p53 family isoforms (Δnp53, Δnp63, and dnp73) predominantly counteract cell cycle arrest and apoptosis. |
2015-11-05 |
2023-08-13 |
Not clear |
| Ruth Clark, Jihye Lee, Seong-Ho Le. Synergistic anticancer activity of capsaicin and 3,3'-diindolylmethane in human colorectal cancer. Journal of agricultural and food chemistry. vol 63. issue 17. 2015-11-05. PMID:25876645. |
the present study suggests capsaicin and dim work synergistically to inhibit cell proliferation and induce apoptosis in colorectal cancer through modulating transcriptional activity of nf-κb, p53, and target genes associated with apoptosis. |
2015-11-05 |
2023-08-13 |
human |
| Y L Wang, H He, Z J Liu, Z G Cao, X Y Wang, K Yang, Y Fang, M Han, C Zhang, F Y Hu. Effects of TNF-α on Cementoblast Differentiation, Mineralization, and Apoptosis. Journal of dental research. vol 94. issue 9. 2015-11-05. PMID:26088424. |
the use of a specific inhibitor and sirna transfection confirmed that the effects of tnf-α on differentiation and apoptosis in cementoblasts were partially abrogated by inhibiting p53 activity. |
2015-11-05 |
2023-08-13 |
Not clear |
| Y L Wang, H He, Z J Liu, Z G Cao, X Y Wang, K Yang, Y Fang, M Han, C Zhang, F Y Hu. Effects of TNF-α on Cementoblast Differentiation, Mineralization, and Apoptosis. Journal of dental research. vol 94. issue 9. 2015-11-05. PMID:26088424. |
taken together, these results suggested that the differentiation inhibition and apoptosis in cementoblasts induced by tnf-α were partially dependent on p53 activity. |
2015-11-05 |
2023-08-13 |
Not clear |
| Chen-Feng Qi, Yong-Soo Kim, Shao Xiang, Ziedulla Abdullaev, Ted A Torrey, Siegfried Janz, Alexander L Kovalchuk, Jiafang Sun, Delin Chen, William C Cho, Wei Gu, Herbert C Mors. Characterization of ARF-BP1/HUWE1 interactions with CTCF, MYC, ARF and p53 in MYC-driven B cell neoplasms. International journal of molecular sciences. vol 13. issue 5. 2015-11-03. PMID:22754359. |
myc provides a constitutive proliferative signal but can also initiate arf-dependent activation of p53 and apoptosis. |
2015-11-03 |
2023-08-12 |
Not clear |
| Chen-Feng Qi, Yong-Soo Kim, Shao Xiang, Ziedulla Abdullaev, Ted A Torrey, Siegfried Janz, Alexander L Kovalchuk, Jiafang Sun, Delin Chen, William C Cho, Wei Gu, Herbert C Mors. Characterization of ARF-BP1/HUWE1 interactions with CTCF, MYC, ARF and p53 in MYC-driven B cell neoplasms. International journal of molecular sciences. vol 13. issue 5. 2015-11-03. PMID:22754359. |
downregulation of arf-bp1 resulted in elevated steady state levels of p53, growth arrest and apoptosis. |
2015-11-03 |
2023-08-12 |
Not clear |
| Jianchao Li, Yonghong Zhang, Yutao Gao, Yuqian Cui, Hua Liu, Mi Li, Yongjie Tia. Downregulation of HNF1 homeobox B is associated with drug resistance in ovarian cancer. Oncology reports. vol 32. issue 3. 2015-11-03. PMID:24968817. |
pathway enrichment analysis of 36 genes which co-occurred with hnf1b, ovarian cancer and drug resistance indicated that the hnf1b may perform its drug resistance-related functions through 4 pathways including erbb signaling, focal adhesion, apoptosis and p53 signaling. |
2015-11-03 |
2023-08-13 |
Not clear |
| Hongbin Wang, Li Wei, Changli Li, Jing Zhou, Zhigao L. CDK5RAP1 deficiency induces cell cycle arrest and apoptosis in human breast cancer cell line by the ROS/JNK signaling pathway. Oncology reports. vol 33. issue 3. 2015-11-03. PMID:25607831. |
pretreatment with n-acetyl-cysteine (nac), the inhibitor of ros, or with sp600125, the inhibitor of jnk, prevented the apoptosis and the high expression of p-jnk, p53, caspase-9 and caspase-3 in cdk5rap1-deficient mcf-7 cells. |
2015-11-03 |
2023-08-13 |
human |
| Nurmaa Dashzeveg, Kiyotsugu Yoshid. Cell death decision by p53 via control of the mitochondrial membrane. Cancer letters. vol 367. issue 2. 2015-11-03. PMID:26231733. |
recent evidence has revealed that p53 not only regulates apoptosis but also regulates necrotic/necroptotic cell death via the mitochondria. |
2015-11-03 |
2023-08-13 |
human |
| Nurmaa Dashzeveg, Kiyotsugu Yoshid. Cell death decision by p53 via control of the mitochondrial membrane. Cancer letters. vol 367. issue 2. 2015-11-03. PMID:26231733. |
the regulation of apoptosis by p53 is tightly connected to the mitochondrial outer membrane permeabilization and the induction of and interaction with bcl-2 family members. |
2015-11-03 |
2023-08-13 |
human |
| Laura Perucho, Ana Artero-Castro, Sergi Guerrero, Santiago Ramón y Cajal, Matilde E LLeonart, Zhao-Qi Wan. RPLP1, a crucial ribosomal protein for embryonic development of the nervous system. PloS one. vol 9. issue 6. 2015-11-02. PMID:24959908. |
the rplp1 knockout neocortex exhibited progenitor cell proliferation arrest and apoptosis due to the dysregulation of key cell cycle and apoptosis regulators (cyclin a, cyclin e, p21cip1, p27kip1, p53). |
2015-11-02 |
2023-08-13 |
mouse |
| Sang-Min Jang, Joo-Hee An, Chul-Hong Kim, Jung-Woong Kim, Kyung-Hee Cho. Transcription factor FOXA2-centered transcriptional regulation network in non-small cell lung cancer. Biochemical and biophysical research communications. vol 463. issue 4. 2015-11-02. PMID:26093302. |
although various therapeutic approaches are used for lung cancer treatment, these mainly target the tumor suppressor p53 transcription factor, which is involved in apoptosis and cell cycle arrest. |
2015-11-02 |
2023-08-13 |
Not clear |