| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yassine Chtourou, Bakhta Aouey, Mohammed Kebieche, Hamadi Fetou. Protective role of naringin against cisplatin induced oxidative stress, inflammatory response and apoptosis in rat striatum via suppressing ROS-mediated NF-κB and P53 signaling pathways. Chemico-biological interactions. vol 239. 2015-11-24. PMID:26120027. |
moreover, nar inhibited p53, nfkb and tnf-α pathways mediated inflammation and apoptosis, and improved the histological changes induced by cis. |
2015-11-24 |
2023-08-13 |
rat |
| Janet Mendonca, Anup Sharma, Hae-Soo Kim, Hans Hammers, Alan Meeker, Angelo De Marzo, Michael Carducci, Michael Kauffman, Sharon Shacham, Sushant Kachha. Selective inhibitors of nuclear export (SINE) as novel therapeutics for prostate cancer. Oncotarget. vol 5. issue 15. 2015-11-20. PMID:25026284. |
targeting xpo 1 can lead to nuclear retention of cargo proteins such as p53, foxo, and brca1 leading to cell cycle arrest and apoptosis. |
2015-11-20 |
2023-08-13 |
Not clear |
| Janet Mendonca, Anup Sharma, Hae-Soo Kim, Hans Hammers, Alan Meeker, Angelo De Marzo, Michael Carducci, Michael Kauffman, Sharon Shacham, Sushant Kachha. Selective inhibitors of nuclear export (SINE) as novel therapeutics for prostate cancer. Oncotarget. vol 5. issue 15. 2015-11-20. PMID:25026284. |
treatment of prostate cancer cells with sine inhibitors lead to xpo 1 inhibition, as evaluated by revgfp export assay, leading to nuclear retention of p53 and foxo proteins, consequently, triggering apoptosis. |
2015-11-20 |
2023-08-13 |
Not clear |
| E G Novoselova, S M Lunin, M O Khrenov, S B Parfenyuk, T V Novoselova, B S Shenkman, E E Fesenk. Changes in immune cell signalling, apoptosis and stress response functions in mice returned from the BION-M1 mission in space. Immunobiology. vol 220. issue 4. 2015-11-20. PMID:25468559. |
to assess the apoptosis in thymus lymphocytes, caspase-3 and levels of p53 protein along with its phosphorylated form were measured in thymic lymphocytes. |
2015-11-20 |
2023-08-13 |
mouse |
| Liang Xie, Xinchun Pi, Zhongjing Wang, Jun He, Monte S Willis, Cam Patterso. Depletion of PHD3 protects heart from ischemia/reperfusion injury by inhibiting cardiomyocyte apoptosis. Journal of molecular and cellular cardiology. vol 80. 2015-11-20. PMID:25633836. |
consistently, a prolyl hydroxylase inhibitor or depletion of phd3 significantly inhibits the activation of chk1 and p53 in cardiomyocytes and the subsequent apoptosis induced by doxorubicin, hydrogen peroxide or hypoxia/reoxygenation. |
2015-11-20 |
2023-08-13 |
mouse |
| Santi Tofan. Electromagnetic energy as a bridge between atomic and cellular levels in the genetics approach to cancer treatment. Current topics in medicinal chemistry. vol 15. issue 6. 2015-11-20. PMID:25714380. |
the use of a static mf amplitude modulated by 50 hz mf, with a time average total intensity of 5.5 mt, has been shown to influence tumor cell functions such as cell proliferation, apoptosis, p53 expression, inhibition of tumor growth and prolongation of survival in animals, evidence that mf can be more effective than chemotherapy (cyclophosphamide) in inhibiting metastatic spread and growth, having synergistic activity with chemotherapy (cis-platin), and no observable side effects or toxicity in animals or in humans. |
2015-11-20 |
2023-08-13 |
Not clear |
| Jeonghoon Han, Eun-Ji Won, Min-Chul Lee, Jung Soo Seo, Su-Jae Lee, Jae-Seong Le. Developmental retardation, reduced fecundity, and modulated expression of the defensome in the intertidal copepod Tigriopus japonicus exposed to BDE-47 and PFOS. Aquatic toxicology (Amsterdam, Netherlands). vol 165. 2015-11-20. PMID:26037098. |
additionally, transcript profiles of genes related to detoxification (e.g., cyps), antioxidant functions (e.g., gst- sigma, catalase, mnsod), apoptosis (e.g., p53, rb), and cellular proliferation (e.g., pcna) were modulated over 72h in response to bde-47 (120μg/l) and pfos (1000μg/l). |
2015-11-20 |
2023-08-13 |
Not clear |
| Fu Li, Zhifei Wang, Yuanfu Huang, Hancong Xu, Lei He, Deng Yan, Xin Zeng, Nongyue H. Delivery of PUMA Apoptosis Gene Using Polyethyleneimine-SMCC-TAT/DNA Nanoparticles: Biophysical Characterization and In Vitro Transfection Into Malignant Melanoma Cells. Journal of biomedical nanotechnology. vol 11. issue 10. 2015-11-20. PMID:26502640. |
a synthesized pei-based gene delivery system, wherein pei was crosslinked with sulfosuccinimidyl-4-(n-maleimidomethyl) cyclohexane-1-carboxylate (sulfo-smcc) conjugating trans-activating transcriptional activator (tat), yielding pei-smcc-tat (pst), a novel non-viral vector for apoptosis-related gene puma (p53 up regulated modulator of apoptosis), was designed and evaluated. |
2015-11-20 |
2023-08-13 |
Not clear |
| Yoshimasa Saito, Toshiaki Nakaoka, Hidetsugu Sait. microRNA-34a as a Therapeutic Agent against Human Cancer. Journal of clinical medicine. vol 4. issue 11. 2015-11-20. PMID:26580663. |
mir-34a was identified as a target of p53 and induces a g1 cell cycle arrest, senescence and apoptosis in response to dna damage. |
2015-11-20 |
2023-08-13 |
human |
| Mary Ann Allen, Zdenek Andrysik, Veronica L Dengler, Hestia S Mellert, Anna Guarnieri, Justin A Freeman, Kelly D Sullivan, Matthew D Galbraith, Xin Luo, W Lee Kraus, Robin D Dowell, Joaquin M Espinos. Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms. eLife. vol 3. 2015-11-17. PMID:24867637. |
this immediate response involves all canonical p53 effector pathways, including apoptosis. |
2015-11-17 |
2023-08-13 |
Not clear |
| Carmela Fimognari, Eleonora Turrini, Piero Sestili, Cinzia Calcabrini, Giovanni Carulli, Giulia Fontanelli, Martina Rousseau, Giorgio Cantelli-Forti, Patrizia Hreli. Antileukemic activity of sulforaphane in primary blasts from patients affected by myelo- and lympho-proliferative disorders and in hypoxic conditions. PloS one. vol 9. issue 7. 2015-11-17. PMID:25019218. |
as to its cytotoxic mechanism, we found that sulforaphane creates an oxidative cellular environment that induces dna damage and bax and p53 gene activation, which in turn helps trigger apoptosis. |
2015-11-17 |
2023-08-13 |
Not clear |
| Yolanda Sánchez, Victor Segura, Oskar Marín-Béjar, Alejandro Athie, Francesco P Marchese, Jovanna González, Luis Bujanda, Shuling Guo, Ander Matheu, Maite Huart. Genome-wide analysis of the human p53 transcriptional network unveils a lncRNA tumour suppressor signature. Nature communications. vol 5. 2015-11-17. PMID:25524025. |
we demonstrate that two of the p53-regulated lncrnas are required for the efficient binding of p53 to some of its target genes, modulating the p53 transcriptional network and contributing to apoptosis induction by dna damage. |
2015-11-17 |
2023-08-13 |
human |
| Xianhong Ou, You Lu, Liufeng Liao, Danni Li, Limin Liu, Huagang Liu, Heng X. Nitidine chloride induces apoptosis in human hepatocellular carcinoma cells through a pathway involving p53, p21, Bax and Bcl-2. Oncology reports. vol 33. issue 3. 2015-11-17. PMID:25530218. |
nitidine chloride induces apoptosis in human hepatocellular carcinoma cells through a pathway involving p53, p21, bax and bcl-2. |
2015-11-17 |
2023-08-13 |
mouse |
| Xianhong Ou, You Lu, Liufeng Liao, Danni Li, Limin Liu, Huagang Liu, Heng X. Nitidine chloride induces apoptosis in human hepatocellular carcinoma cells through a pathway involving p53, p21, Bax and Bcl-2. Oncology reports. vol 33. issue 3. 2015-11-17. PMID:25530218. |
these data elucidate a pathway of apoptosis in smmc‑7721 cells that involves g2/m arrest, upregulation of p53, bax, caspase-3 and p21, and downregulation of bcl-2. |
2015-11-17 |
2023-08-13 |
mouse |
| Ruitao Zhang, Huirong Shi, Fang Ren, Huina Liu, Minghui Zhang, Youxing Deng, Xia L. Misregulation of polo-like protein kinase 1, P53 and P21WAF1 in epithelial ovarian cancer suggests poor prognosis. Oncology reports. vol 33. issue 3. 2015-11-17. PMID:25592872. |
after plk1 or p53 knockdown, proliferation of the sk-ov-3 cells was inhibited, the apoptosis rate was increased, and cell invasion was suppressed in vitro, and the survival time was prolonged in the animals. |
2015-11-17 |
2023-08-13 |
human |
| Y-G Liu, X-L Zheng, F-M Li. The mechanism and inhibitory effect of recombinant human P53 adenovirus injection combined with paclitaxel on human cervical cancer cell HeLa. European review for medical and pharmacological sciences. vol 19. issue 6. 2015-11-16. PMID:25855930. |
to investigate the effect of recombinant human p53 adenovirus injection combined with paclitaxel on human cervical cancer hela cell proliferation, apoptosis and expression of vascular endothelial growth factor (vegf). |
2015-11-16 |
2023-08-13 |
human |
| Daqian Wan, Chaoyin Jiang, Xin Hua, Ting Wang, Yimin Cha. Cell cycle arrest and apoptosis induced by aspidin PB through the p53/p21 and mitochondria-dependent pathways in human osteosarcoma cells. Anti-cancer drugs. vol 26. issue 9. 2015-11-16. PMID:26181229. |
we also explored the role of sirna targeted to p53; it led to a dose-dependent attenuation of aspidin pb-induced apoptosis signaling. |
2015-11-16 |
2023-08-13 |
human |
| Bidya Dhar Sahu, Madhusudana Kuncha, Shyam Sunder Rachamalla, Ramakrishna Sistl. Lagerstroemia speciosa L. attenuates apoptosis in isoproterenol-induced cardiotoxic mice by inhibiting oxidative stress: possible role of Nrf2/HO-1. Cardiovascular toxicology. vol 15. issue 1. 2015-11-12. PMID:24853613. |
cardiac tissue was examined for lipid peroxidation, protein carbonyl content, antioxidant (gsh, gr, gpx, gst, sod, cat, nqo1, and ho-1), and apoptosis (cleaved caspase-3, bax, bcl-2, p53, and dna fragmentation) status. |
2015-11-12 |
2023-08-13 |
mouse |
| Bishi Wang, Luxin Qiao, Ying Shi, Xiaokun Feng, Dexi Chen, Hongliang Gu. [ASPP2 inhibits oxaliplatin-induced autophagy and promotes apoptosis of colon cancer cells]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 31. issue 7. 2015-11-12. PMID:26146058. |
to investigate the role of apoptosis stimulating p53 binding protein 2 (aspp2)-induced p53-dependent and p53-independent autophagy inhibition in apoptosis-promoting function of oxaliplatin (oxa). |
2015-11-12 |
2023-08-13 |
Not clear |
| Erica J Peterson, Vijay R Menon, Laura Gatti, Ralph Kipping, Dilhara Dewasinghe, Paola Perego, Lawrence F Povirk, Nicholas P Farrel. Nucleolar targeting by platinum: p53-independent apoptosis follows rRNA inhibition, cell-cycle arrest, and DNA compaction. Molecular pharmaceutics. vol 12. issue 1. 2015-11-10. PMID:25407898. |
the combination of dna compaction and apoptosis by triplatinnc treatment conferred striking activity in platinum-resistant and/or p53 mutant or null cell lines. |
2015-11-10 |
2023-08-13 |
human |