| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lili Ma, Rong Ma, Yiping Wang, Xiaoyue Zhu, Junliang Zhang, Hoi Ching Chan, Xianfeng Chen, Wenjun Zhang, Sung-Kay Chiu, Guangyu Zh. Chalcoplatin, a dual-targeting and p53 activator-containing anticancer platinum(IV) prodrug with unique mode of action. Chemical communications (Cambridge, England). vol 51. issue 29. 2015-12-15. PMID:25644651. |
chalcoplatin significantly induced p53 activation as well as the subsequent apoptosis pathways. |
2015-12-15 |
2023-08-13 |
human |
| Shahla Karim Baloch, Lin Ma, Guo-Hua Xu, Li-Fei Bai, Hua Zhao, Cheng-Yi Tang, Yan-Jun Pang, Rong-Wu Yang, Xiao-Ming Wang, Gui-Hua Lu, Yong-Hua Yan. A potent anticancer agent of shikonin derivative targeting tubulin. Chirality. vol 27. issue 3. 2015-12-15. PMID:25663187. |
compound was simulated to have good binding site with tubulin and arrested the cell cycle at g2/m phase, which also induces apoptosis in hepg2 cells, in which p53 and members of bcl-2 protein family were both involved in the progress of apoptosis revealed by western blot. |
2015-12-15 |
2023-08-13 |
human |
| P Ghosh, S Singha Roy, A Basu, A Bhattacharjee, S Bhattachary. Sensitization of cisplatin therapy by a naphthalimide based organoselenium compound through modulation of antioxidant enzymes and p53 mediated apoptosis. Free radical research. vol 49. issue 4. 2015-12-15. PMID:25730340. |
sensitization of cisplatin therapy by a naphthalimide based organoselenium compound through modulation of antioxidant enzymes and p53 mediated apoptosis. |
2015-12-15 |
2023-08-13 |
mouse |
| Víctor Rodríguez-Sureda, Ángel Vilches, Olga Sánchez, Laura Audí, Carmen Domíngue. Intracellular oxidant activity, antioxidant enzyme defense system, and cell senescence in fibroblasts with trisomy 21. Oxidative medicine and cellular longevity. vol 2015. 2015-12-15. PMID:25852816. |
cell senescence was found to appear prematurely in ds cells as shown by sa-β-gal assay and p21 assessment, though not apoptosis, as neither p53 nor the proapoptotic proteins cytochrome c and caspase 9 were altered in t21f. |
2015-12-15 |
2023-08-13 |
Not clear |
| Min-Bin Chen, Qin Jiang, Yuan-yuan Liu, Yan Zhang, Bang-shun He, Mu-Xin Wei, Jian-Wei Lu, Yong Ji, Pei-Hua L. C6 ceramide dramatically increases vincristine sensitivity both in vivo and in vitro, involving AMP-activated protein kinase-p53 signaling. Carcinogenesis. vol 36. issue 9. 2015-12-15. PMID:26116623. |
in vitro, c6 and vincristine coadministration induced substantial necrosis and apoptosis in multiple human cancer cell lines, which were accompanied by a profound amp-activated protein kinase (ampk) activation, subsequent p53 activation, mtorc1 inactivation and bcl-2/hif-1α downregulation. |
2015-12-15 |
2023-08-13 |
human |
| Ingrid Jakobsen Falk, Kerstin Willander, Roza Chaireti, Johan Lund, Hareth Nahi, Monica Hermanson, Henrik Gréen, Kourosh Lotfi, Peter Söderkvis. TP53 mutations and MDM2(SNP309) identify subgroups of AML patients with impaired outcome. European journal of haematology. vol 94. issue 4. 2015-12-14. PMID:25156865. |
altered expression of mouse double minute 2 (mdm2), a negative regulator of p53, may also attenuate normal p53 signaling, thereby enhancing tumor transformation and resistance to apoptosis. |
2015-12-14 |
2023-08-13 |
mouse |
| Daniel Speide. The role of DNA damage responses in p53 biology. Archives of toxicology. vol 89. issue 4. 2015-12-14. PMID:25618545. |
p53 is upregulated and activated by genotoxic stress and induces a transcriptional programme with effectors promoting apoptosis, cell cycle arrest, senescence and dna repair. |
2015-12-14 |
2023-08-13 |
mouse |
| Daniel Speide. The role of DNA damage responses in p53 biology. Archives of toxicology. vol 89. issue 4. 2015-12-14. PMID:25618545. |
however, this interpretation has been challenged by a number of recent in vivo studies, demonstrating that mice which are defective in inducing p53-dependent apoptosis, cell cycle arrest and senescence suppress thymic lymphoma as well as wild-type p53 expressing animals. |
2015-12-14 |
2023-08-13 |
mouse |
| Chun-Ju Liu, Xia-Li Zhang, Da-Ya Luo, Wei-Feng Zhu, Hui-Fang Wan, Jun-Ping Yang, Xiao-Jun Yang, Fu-Sheng Wa. Exogenous p53 upregulated modulator of apoptosis (PUMA) decreases growth of lung cancer A549 cells. Asian Pacific journal of cancer prevention : APJCP. vol 16. issue 2. 2015-12-14. PMID:25684518. |
exogenous p53 upregulated modulator of apoptosis (puma) decreases growth of lung cancer a549 cells. |
2015-12-14 |
2023-08-13 |
mouse |
| Chun-Ju Liu, Xia-Li Zhang, Da-Ya Luo, Wei-Feng Zhu, Hui-Fang Wan, Jun-Ping Yang, Xiao-Jun Yang, Fu-Sheng Wa. Exogenous p53 upregulated modulator of apoptosis (PUMA) decreases growth of lung cancer A549 cells. Asian Pacific journal of cancer prevention : APJCP. vol 16. issue 2. 2015-12-14. PMID:25684518. |
to investigate the influence of exogenous p53 upregulated modulator of apoptosis (puma) expression on cell proliferation and apoptosis in human non-small cell lung cancer a549 cells and transplanted tumor cell growth in nude mice. |
2015-12-14 |
2023-08-13 |
mouse |
| Rumana Akhter, Priyankar Sanphui, Hrishita Das, Pampa Saha, Subhas Chandra Biswa. The regulation of p53 up-regulated modulator of apoptosis by JNK/c-Jun pathway in β-amyloid-induced neuron death. Journal of neurochemistry. vol 134. issue 6. 2015-12-14. PMID:25891762. |
the regulation of p53 up-regulated modulator of apoptosis by jnk/c-jun pathway in β-amyloid-induced neuron death. |
2015-12-14 |
2023-08-13 |
mouse |
| Rumana Akhter, Priyankar Sanphui, Hrishita Das, Pampa Saha, Subhas Chandra Biswa. The regulation of p53 up-regulated modulator of apoptosis by JNK/c-Jun pathway in β-amyloid-induced neuron death. Journal of neurochemistry. vol 134. issue 6. 2015-12-14. PMID:25891762. |
our study shows that pro-apoptotic proteins, bim (bcl-2 interacting mediator of cell death) and puma (p53 up-regulated modulator of apoptosis) are targets of c-jun in aβ-treated neurons. |
2015-12-14 |
2023-08-13 |
mouse |
| Rumana Akhter, Priyankar Sanphui, Hrishita Das, Pampa Saha, Subhas Chandra Biswa. The regulation of p53 up-regulated modulator of apoptosis by JNK/c-Jun pathway in β-amyloid-induced neuron death. Journal of neurochemistry. vol 134. issue 6. 2015-12-14. PMID:25891762. |
our study shows that two important pro-apoptotic proteins, bim (bcl-2 interacting mediator of cell death) and puma (p53 up-regulated modulator of apoptosis) are targets of c-jun in aβ-treated neurons. |
2015-12-14 |
2023-08-13 |
mouse |
| Jianxin Wang, Feifan Xu, Dandan Zhu, Yinong Duan, Jinling Chen, Xiaolei Sun, Xue He, Pan Li, Wei Sun, Jinrong Fen. Schistosoma japonicum soluble egg antigens facilitate hepatic stellate cell apoptosis by downregulating Akt expression and upregulating p53 and DR5 expression. PLoS neglected tropical diseases. vol 8. issue 8. 2015-12-08. PMID:25144704. |
schistosoma japonicum soluble egg antigens facilitate hepatic stellate cell apoptosis by downregulating akt expression and upregulating p53 and dr5 expression. |
2015-12-08 |
2023-08-13 |
Not clear |
| Jay-Hyun Jo, Tae-Moon Chung, Hyewon Youn, Joo-Yeon Yo. Cytoplasmic parafibromin/hCdc73 targets and destabilizes p53 mRNA to control p53-mediated apoptosis. Nature communications. vol 5. 2015-12-08. PMID:25388829. |
cytoplasmic parafibromin/hcdc73 targets and destabilizes p53 mrna to control p53-mediated apoptosis. |
2015-12-08 |
2023-08-13 |
Not clear |
| Jay-Hyun Jo, Tae-Moon Chung, Hyewon Youn, Joo-Yeon Yo. Cytoplasmic parafibromin/hCdc73 targets and destabilizes p53 mRNA to control p53-mediated apoptosis. Nature communications. vol 5. 2015-12-08. PMID:25388829. |
here we demonstrate that hcdc73 specifically controls messenger rna stability of p53 and p53-mediated apoptosis. |
2015-12-08 |
2023-08-13 |
Not clear |
| Pinki Chowdhury, Gregory E Lin, Kang Liu, Yongcheng Song, Fang-Tsyr Lin, Weei-Chin Li. Targeting TopBP1 at a convergent point of multiple oncogenic pathways for cancer therapy. Nature communications. vol 5. 2015-12-08. PMID:25400145. |
here we perform a molecular docking screening and identify a lead compound, calcein, capable of blocking topbp1 oligomerization and p53 binding, resulting in re-activation of e2f1-dependent apoptosis and blockade of mutp53 gain-of-function. |
2015-12-08 |
2023-08-13 |
Not clear |
| Nonkululeko N Mthembu, Lesetja Raymond Motad. Apoptotic potential role of Agave palmeri and Tulbaghia violacea extracts in cervical cancer cells. Molecular biology reports. vol 41. issue 9. 2015-12-07. PMID:24993114. |
to achieve this, ag and tv crude extracts were utilized to screen for apoptosis induction, inhibition of cell proliferation followed by elucidation of the role of bax, bcl-2, p53, rb, rbbp and mdm2 genes in cervical cancer. |
2015-12-07 |
2023-08-13 |
mouse |
| Xingxing He, Jiazhi Liao, Fang Liu, Junwei Yan, Jingjun Yan, Haitao Shang, Qian Dou, Ying Chang, Jusheng Lin, Yuhu Son. Functional repair of p53 mutation in colorectal cancer cells using trans-splicing. Oncotarget. vol 6. issue 4. 2015-12-04. PMID:25576916. |
repair of mutant p53 transcripts by trans-splicing induced cell-cycle arrest and apoptosis in p53-defective colorectal cancer cells in vitro and in vivo. |
2015-12-04 |
2023-08-13 |
human |
| Catherine Kamtchueng, Marie-Éve Stébenne, Aurélie Delannoy, Emmanuelle Wilhelm, Hélène Léger, Arndt G Benecke, Brendan Bel. Alternative splicing of TAF6: downstream transcriptome impacts and upstream RNA splice control elements. PloS one. vol 9. issue 7. 2015-12-03. PMID:25025302. |
the taf6δ pathway of apoptosis can dictate life versus death decisions independently of the status of p53 tumor suppressor. |
2015-12-03 |
2023-08-13 |
Not clear |