| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Reza Izadpanah, Deborah J Schächtele, Andreas B Pfnür, Dong Lin, Douglas P Slakey, Philip J Kadowitz, Eckhard U Al. The impact of statins on biological characteristics of stem cells provides a novel explanation for their pleiotropic beneficial and adverse clinical effects. American journal of physiology. Cell physiology. vol 309. issue 8. 2016-01-25. PMID:26224580. |
on a negative side, statins impaired the osteogenic and chondrogenic differentiation potential of mscs and increased cell senescence and apoptosis, as indicated by upregulation of p16, p53 and caspase 3, 8, and 9. |
2016-01-25 |
2023-08-13 |
Not clear |
| HyeRan Gwak, Guy Haegeman, Benjamin K Tsang, Yong Sang Son. Cancer-specific interruption of glucose metabolism by resveratrol is mediated through inhibition of Akt/GLUT1 axis in ovarian cancer cells. Molecular carcinogenesis. vol 54. issue 12. 2016-01-22. PMID:25307508. |
we have demonstrated that, in contrast to primary normal ovarian epithelial cells, rsv selectively inhibited glucose uptake and induced apoptosis irrespective of p53 status in vitro. |
2016-01-22 |
2023-08-13 |
Not clear |
| Magesh Muthu, Vino T Cheriyan, Arun K Rish. CARP-1/CCAR1: a biphasic regulator of cancer cell growth and apoptosis. Oncotarget. vol 6. issue 9. 2016-01-19. PMID:25894788. |
carp-1/ccar1 (cell division cycle and apoptosis regulator 1), a peri-nuclear phospho-protein, plays a dynamic role in regulating cell growth and apoptosis by serving as a co-activator of steroid/thyroid nuclear receptors, β-catenin, anaphase promoting complex/cyclosome (apc/c) e3 ligase, and tumor suppressor p53. |
2016-01-19 |
2023-08-13 |
Not clear |
| Magesh Muthu, Vino T Cheriyan, Arun K Rish. CARP-1/CCAR1: a biphasic regulator of cancer cell growth and apoptosis. Oncotarget. vol 6. issue 9. 2016-01-19. PMID:25894788. |
cfms promote apoptosis in a manner independent of p53. |
2016-01-19 |
2023-08-13 |
Not clear |
| A R M Ruhul Amin, Abedul Haque, Mohammad Aminur Rahman, Zhuo Georgia Chen, Fadlo Raja Khuri, Dong Moon Shi. Curcumin induces apoptosis of upper aerodigestive tract cancer cells by targeting multiple pathways. PloS one. vol 10. issue 4. 2016-01-19. PMID:25910231. |
inactivation of p73 by dominant negative p73 significantly protected cells from curcumin-induced apoptosis, whereas ablation of p53 by shrna had no effect. |
2016-01-19 |
2023-08-13 |
Not clear |
| Xiaolan Feng, Haocheng Li, Michelle Dean, Holly E Wilson, Elizabeth Kornaga, Emeka K Enwere, Patricia Tang, Alexander Paterson, Susan P Lees-Miller, Anthony M Magliocco, Gwyn Beb. Low ATM protein expression in malignant tumor as well as cancer-associated stroma are independent prognostic factors in a retrospective study of early-stage hormone-negative breast cancer. Breast cancer research : BCR. vol 17. 2016-01-15. PMID:25935535. |
upon dna double-strand breaks, atm phosphorylates key downstream proteins including p53 and brca1/2, thereby orchestrating complex signaling pathways involved in cell cycle arrest, dna repair, senescence and apoptosis. |
2016-01-15 |
2023-08-13 |
Not clear |
| Jianxia Miao, Liangrong Wang, Lei Chen, Tao Yang, Lida Jin, Lina Li. Fentanyl inhibits cell viability in human pancreatic cancer cell line and tumor growth in pancreatic cancer cell-transplanted mice. International journal of clinical and experimental medicine. vol 8. issue 10. 2016-01-15. PMID:26770358. |
further proofs indicated that the factors related to cell apoptosis (bcl-2, p53 and caspase-3), cell cycle (p21, cyclin d1 and cdk4) and epithelial-mesenchymal transition (e-cadherin, vimentin and α-sma) showed the corresponding expression changes. |
2016-01-15 |
2023-08-13 |
mouse |
| Zelal Adiguzel, Nazli Arda, Omer Kacar, Muge Serhatli, Serpil Gezer Tas, Ahmet Tarik Baykal, Kemal Baysal, Ceyda Acila. Evaluation of apoptotic molecular pathways for smooth muscle cells isolated from thoracic aortic aneurysms in response to oxidized sterols. Molecular biology reports. vol 41. issue 12. 2016-01-13. PMID:25266234. |
efficient silencing of other targets including apoptotic proteins (p53, bax), and survival proteins (akt1, akt2) showed that apoptosis can occur through p53, and bax independent pathways. |
2016-01-13 |
2023-08-13 |
Not clear |
| Jinlong Zhang, Zhiming Cui, Guijuan Feng, Guofeng Bao, Guanhua Xu, Yuyu Sun, Lingling Wang, Jiajia Chen, Huricha Jin, Jian Liu, Longfei Yang, Weidong L. RBM5 and p53 expression after rat spinal cord injury: implications for neuronal apoptosis. The international journal of biochemistry & cell biology. vol 60. 2016-01-13. PMID:25578565. |
rbm5 and p53 expression after rat spinal cord injury: implications for neuronal apoptosis. |
2016-01-13 |
2023-08-13 |
rat |
| Jinlong Zhang, Zhiming Cui, Guijuan Feng, Guofeng Bao, Guanhua Xu, Yuyu Sun, Lingling Wang, Jiajia Chen, Huricha Jin, Jian Liu, Longfei Yang, Weidong L. RBM5 and p53 expression after rat spinal cord injury: implications for neuronal apoptosis. The international journal of biochemistry & cell biology. vol 60. 2016-01-13. PMID:25578565. |
rbm5 (rna-binding motif protein 5), a nuclear rna binding protein, is known to trigger apoptosis and induce cell cycle arrest by regulating the activity of the tumor suppressor protein p53. |
2016-01-13 |
2023-08-13 |
rat |
| Jinlong Zhang, Zhiming Cui, Guijuan Feng, Guofeng Bao, Guanhua Xu, Yuyu Sun, Lingling Wang, Jiajia Chen, Huricha Jin, Jian Liu, Longfei Yang, Weidong L. RBM5 and p53 expression after rat spinal cord injury: implications for neuronal apoptosis. The international journal of biochemistry & cell biology. vol 60. 2016-01-13. PMID:25578565. |
taken together, our findings indicate that rbm5 promotes neuronal apoptosis through modulating p53 signaling pathway following sci. |
2016-01-13 |
2023-08-13 |
rat |
| Se-Jin Kim, Channy Park, Joon No Lee, Hyewon Lim, Gi-Yeon Hong, Sung K Moon, David J Lim, Seong-Kyu Choe, Raekil Par. Erdosteine protects HEI-OC1 auditory cells from cisplatin toxicity through suppression of inflammatory cytokines and induction of Nrf2 target proteins. Toxicology and applied pharmacology. vol 288. issue 2. 2016-01-13. PMID:26193055. |
in addition, pretreatment with erdosteine clearly suppressed the phosphorylation of p53 (ser15) and expression of p53-upregulated modulator of apoptosis. |
2016-01-13 |
2023-08-13 |
Not clear |
| Hyewon Suh, Ko-woon Choi, Chul-Hoon Le. CR389, a benzoimidazolyl pyridinone analog, induces cell cycle arrest and apoptosis via p53 activation in human ovarian cancer PA-1 cells. Journal of microbiology and biotechnology. vol 25. issue 3. 2016-01-12. PMID:25639717. |
cr389, a benzoimidazolyl pyridinone analog, induces cell cycle arrest and apoptosis via p53 activation in human ovarian cancer pa-1 cells. |
2016-01-12 |
2023-08-13 |
human |
| Xiao-Hong Zhang, Xian-Xiang Xu, Tao X. Ginsenoside Ro suppresses interleukin-1β-induced apoptosis and inflammation in rat chondrocytes by inhibiting NF-κB. Chinese journal of natural medicines. vol 13. issue 4. 2016-01-12. PMID:25908625. |
apoptosis related proteins bax, bad, bcl-xl, pcna, p53 and phospho-p53, along with inflammation related protein mmp 3, mmp 9 and cox-2, and the expression of phospho-nf-κb p65 were assayed by western blotting analyses. |
2016-01-12 |
2023-08-13 |
rat |
| Xiao-Hong Zhang, Xian-Xiang Xu, Tao X. Ginsenoside Ro suppresses interleukin-1β-induced apoptosis and inflammation in rat chondrocytes by inhibiting NF-κB. Chinese journal of natural medicines. vol 13. issue 4. 2016-01-12. PMID:25908625. |
ro could suppress il-1β-induced apoptosis by inhibiting levels of bax and bad, decreasing p53 phosphorylation and promoting the expression of bcl-xl and pcna. |
2016-01-12 |
2023-08-13 |
rat |
| Cristovao F Lima, Marta Costa, M F Proença, Cristina Pereira-Wilso. Novel structurally similar chromene derivatives with opposing effects on p53 and apoptosis mechanisms in colorectal HCT116 cancer cells. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 72. 2016-01-11. PMID:25746954. |
novel structurally similar chromene derivatives with opposing effects on p53 and apoptosis mechanisms in colorectal hct116 cancer cells. |
2016-01-11 |
2023-08-13 |
human |
| Cristovao F Lima, Marta Costa, M F Proença, Cristina Pereira-Wilso. Novel structurally similar chromene derivatives with opposing effects on p53 and apoptosis mechanisms in colorectal HCT116 cancer cells. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 72. 2016-01-11. PMID:25746954. |
on the other hand, compound 2c increased significantly p53 levels and induced apoptosis in a p53- and caspases-dependent manner, even at concentrations lower than its gi50. |
2016-01-11 |
2023-08-13 |
human |
| Cristovao F Lima, Marta Costa, M F Proença, Cristina Pereira-Wilso. Novel structurally similar chromene derivatives with opposing effects on p53 and apoptosis mechanisms in colorectal HCT116 cancer cells. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 72. 2016-01-11. PMID:25746954. |
in conclusion, two novel and structurally similar chromene derivatives showed cytotoxicity to hct16 cells through opposing effects on p53 levels and apoptosis mechanisms, which may be relevant for further development of drugs acting on distinct molecular targets useful in the treatment of cancers with different genetic profiles and for personalized medicine. |
2016-01-11 |
2023-08-13 |
human |
| Shweta Sharma, Jayanta Sarkar, Chandana Haldar, Sudhir Sinh. Melatonin Reverses Fas, E2F-1 and Endoplasmic Reticulum Stress Mediated Apoptosis and Dysregulation of Autophagy Induced by the Herbicide Atrazine in Murine Splenocytes. PloS one. vol 9. issue 9. 2016-01-08. PMID:25259610. |
mel also attenuated the atr-induced, p53 independent mitochondrial apoptosis through upregulation of e2f-1 and puma and suppression of their downstream target bax. |
2016-01-08 |
2023-08-13 |
mouse |
| Shweta Sharma, Jayanta Sarkar, Chandana Haldar, Sudhir Sinh. Melatonin Reverses Fas, E2F-1 and Endoplasmic Reticulum Stress Mediated Apoptosis and Dysregulation of Autophagy Induced by the Herbicide Atrazine in Murine Splenocytes. PloS one. vol 9. issue 9. 2016-01-08. PMID:25259610. |
the cytoprotective role of mel, on the other hand, was defined by attenuation of er stress, fas-mediated and p53 independent mitochondria-mediated apoptosis as well as autophagy signals. |
2016-01-08 |
2023-08-13 |
mouse |