| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E B Peixoto, A Papadimitriou, D A T Teixeira, C Montemurro, D A Duarte, K C Silva, P P Joazeiro, J M Lopes de Faria, J B Lopes de Fari. Reduced LRP6 expression and increase in the interaction of GSK3β with p53 contribute to podocyte apoptosis in diabetes mellitus and are prevented by green tea. The Journal of nutritional biochemistry. vol 26. issue 4. 2016-02-11. PMID:25655048. |
reduced lrp6 expression and increase in the interaction of gsk3β with p53 contribute to podocyte apoptosis in diabetes mellitus and are prevented by green tea. |
2016-02-11 |
2023-08-13 |
mouse |
| E B Peixoto, A Papadimitriou, D A T Teixeira, C Montemurro, D A Duarte, K C Silva, P P Joazeiro, J M Lopes de Faria, J B Lopes de Fari. Reduced LRP6 expression and increase in the interaction of GSK3β with p53 contribute to podocyte apoptosis in diabetes mellitus and are prevented by green tea. The Journal of nutritional biochemistry. vol 26. issue 4. 2016-02-11. PMID:25655048. |
glycogen synthase kinase 3 (gsk3) interaction with p53 (gsk3-p53) promotes apoptosis in carcinoma cells. |
2016-02-11 |
2023-08-13 |
mouse |
| E B Peixoto, A Papadimitriou, D A T Teixeira, C Montemurro, D A Duarte, K C Silva, P P Joazeiro, J M Lopes de Faria, J B Lopes de Fari. Reduced LRP6 expression and increase in the interaction of GSK3β with p53 contribute to podocyte apoptosis in diabetes mellitus and are prevented by green tea. The Journal of nutritional biochemistry. vol 26. issue 4. 2016-02-11. PMID:25655048. |
in immortalized mouse podocytes (imps), high glucose (hg), silencing rna (sirna) or blocking lrp6 (dkk-1) reduced p-lrp6 expression, leading to high gsk3β-p53, p53 expression, apoptosis and increased albumin influx. |
2016-02-11 |
2023-08-13 |
mouse |
| Andrzej Szkaradkiewicz, Tomasz M Karpiński, Jan Majewski, Kamila Malinowska, Olga Goślińska-Kuźniarek, Krzysztof Link. The Participation of p53 and bcl-2 Proteins in Gastric Carcinomas Associated with Helicobacterpylori and/or Epstein-Barr Virus (EBV). Polish journal of microbiology. vol 64. issue 3. 2016-02-11. PMID:26638529. |
the obtained results allow the conclusion, that h. pylori (caga+)-associated development of the gastric adenocarcinoma is determined by abnormalities in the p53 protein function and overexpression of anti-apoptotic bcl-2 protein, whereas ebv-associated adenocarcinomas seem to be related with apoptosis resistance associated with bcl-2 overexpression. |
2016-02-11 |
2023-08-13 |
Not clear |
| Hyun-Lim Kim, Hana Ra, Ki-Ryeong Kim, Jeong-Min Lee, Hana Im, Yang-Hee Ki. Poly(ADP-ribosyl)ation of p53 contributes to TPEN-induced neuronal apoptosis. Molecules and cells. vol 38. issue 4. 2016-02-10. PMID:25813624. |
poly(adp-ribosyl)ation of p53 contributes to tpen-induced neuronal apoptosis. |
2016-02-10 |
2023-08-13 |
mouse |
| Hyun-Lim Kim, Hana Ra, Ki-Ryeong Kim, Jeong-Min Lee, Hana Im, Yang-Hee Ki. Poly(ADP-ribosyl)ation of p53 contributes to TPEN-induced neuronal apoptosis. Molecules and cells. vol 38. issue 4. 2016-02-10. PMID:25813624. |
here, we examined the requirement for poly(adp-ribose) polymerase (parp)-1 as an upstream regulator of p53 in zinc depletion-induced neuronal apoptosis. |
2016-02-10 |
2023-08-13 |
mouse |
| Zhe Cheng, Shan Zhu, Liang Wang, Fan Liu, Huimin Tian, Theerakamol Pengsakul, Yanhai Wan. Identification and characterisation of Emp53, the homologue of human tumor suppressor p53, from Echinococcus multilocularis: its role in apoptosis and the oxidative stress response. International journal for parasitology. vol 45. issue 8. 2016-02-10. PMID:25858091. |
identification and characterisation of emp53, the homologue of human tumor suppressor p53, from echinococcus multilocularis: its role in apoptosis and the oxidative stress response. |
2016-02-10 |
2023-08-13 |
human |
| Liyan Yang, Qiannan Liang, Ke Shen, Li Ma, Na An, Weiping Deng, Zhewei Fei, Jianwen Li. A novel class I histone deacetylase inhibitor, I-7ab, induces apoptosis and arrests cell cycle progression in human colorectal cancer cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 71. 2016-02-10. PMID:25960218. |
further analyses revealed potential role of p53 and p21 in i-7ab-induced apoptosis and cell cycle arrest. |
2016-02-10 |
2023-08-13 |
human |
| Melanie A Blevins, Jennifer Kouznetsova, Aaron B Krueger, Rebecca King, Lesley Mathews Griner, Xin Hu, Noel Southall, Juan J Marugan, Qinghong Zhang, Marc Ferrer, Rui Zha. Small Molecule, NSC95397, Inhibits the CtBP1-Protein Partner Interaction and CtBP1-Mediated Transcriptional Repression. Journal of biomolecular screening. vol 20. issue 5. 2016-02-09. PMID:25477201. |
knockdown of ctbp also increases apoptosis independent of p53 in cell culture. |
2016-02-09 |
2023-08-13 |
human |
| Changwei Lin, Xiaorong Li, Yi Zhang, Yihang Guo, Jianyu Zhou, Kai Gao, Jing Dai, Gui Hu, Lv Lv, Juan Du, Yi Zhan. The microRNA feedback regulation of p63 in cancer progression. Oncotarget. vol 6. issue 11. 2016-02-08. PMID:25726529. |
the transcription factor p63 is a member of the p53 gene family that plays a complex role in cancer due to its involvement in epithelial differentiation, cell cycle arrest and apoptosis. |
2016-02-08 |
2023-08-13 |
Not clear |
| Jone A Stanley, Joe A Arosh, Robert C Burghardt, Sakhila K Ban. A fetal whole ovarian culture model for the evaluation of CrVI-induced developmental toxicity during germ cell nest breakdown. Toxicology and applied pharmacology. vol 289. issue 1. 2016-02-08. PMID:26348139. |
results showed that crvi increased germ cell/oocyte apoptosis by increasing caspase 3, bax, p53 and puma; decreasing bcl2, bmp15, gdf9 and ckit; and altering cell cycle regulatory genes and proteins. |
2016-02-08 |
2023-08-13 |
human |
| Mutsumi Matsuu-Matsuyama, Kazuko Shichijo, Kumio Okaichi, Tomomi Kurashige, Hisayoshi Kondo, Shiro Miura, Masahiro Nakashim. Effect of age on the sensitivity of the rat thyroid gland to ionizing radiation. Journal of radiation research. vol 56. issue 3. 2016-02-05. PMID:25691451. |
amounts of proteins involved in dna damage response (p53, p53 phosphorylated at serine 15, p21), apoptosis (cleaved caspase-3), and autophagy (lc3, p62) were determined via western blotting. |
2016-02-05 |
2023-08-13 |
rat |
| Mutsumi Matsuu-Matsuyama, Kazuko Shichijo, Kumio Okaichi, Tomomi Kurashige, Hisayoshi Kondo, Shiro Miura, Masahiro Nakashim. Effect of age on the sensitivity of the rat thyroid gland to ionizing radiation. Journal of radiation research. vol 56. issue 3. 2016-02-05. PMID:25691451. |
no increase in apoptosis or in the levels of p53, p21 or cleaved caspase-3 was detected for any ages. |
2016-02-05 |
2023-08-13 |
rat |
| Mutsumi Matsuu-Matsuyama, Kazuko Shichijo, Kumio Okaichi, Tomomi Kurashige, Hisayoshi Kondo, Shiro Miura, Masahiro Nakashim. Effect of age on the sensitivity of the rat thyroid gland to ionizing radiation. Journal of radiation research. vol 56. issue 3. 2016-02-05. PMID:25691451. |
in summary, no apoptosis or p53 accumulation was noted, despite the expression of some pro-apoptotic genes in immature and adult thyroids. |
2016-02-05 |
2023-08-13 |
rat |
| Koichi Okamoto, Aziz Zaanan, Hisato Kawakami, Shengbing Huang, Frank A Sinicrop. Reversal of Mutant KRAS-Mediated Apoptosis Resistance by Concurrent Noxa/Bik Induction and Bcl-2/Bcl-xL Antagonism in Colon Cancer Cells. Molecular cancer research : MCR. vol 13. issue 4. 2016-02-04. PMID:25548100. |
concurrent bcl-xl antagonism by the bh3 mimetic abt-263 combined with carfilzomib synergistically enhanced apoptosis that was dependent on bax or p53, and was attenuated by noxa or bik shrna. |
2016-02-04 |
2023-08-13 |
human |
| Shuo Chen, Xi Chen, Yin-Ling Xiu, Kai-Xuan Sun, Yang Zha. Inhibition of Ovarian Epithelial Carcinoma Tumorigenesis and Progression by microRNA 106b Mediated through the RhoC Pathway. PloS one. vol 10. issue 5. 2016-02-04. PMID:25933027. |
mir-106b transfection reduced cell proliferation; promoted g1 or s arrest and apoptosis (p < 0.05); suppressed cell migration and invasion (p < 0.05); reduced ras homolog gene family member c (rhoc), p70 ribosomal s6 kinase (p70s6k), bcl-xl, matrix metallopeptidase 2 (mmp2), mmp9 mrna and protein expression; and induced p53 expression (p < 0.05). |
2016-02-04 |
2023-08-13 |
mouse |
| Zheng Lu, Shengbo Cao, Hongbo Zhou, Ling Hua, Shishuo Zhang, Jiyue Ca. Mechanism of Arctigenin-Induced Specific Cytotoxicity against Human Hepatocellular Carcinoma Cell Lines: Hep G2 and SMMC7721. PloS one. vol 10. issue 5. 2016-02-04. PMID:25933104. |
additionally, arg induced apoptosis was accompanied by a deactivation of pi3k/p-akt pathway, an accumulation of p53 protein and an inhibition of nf-κb nuclear translocation especially in hep g2 cells, which might be the reason that hep g2 was more sensitive than smmc7721 cells to arg treatment. |
2016-02-04 |
2023-08-13 |
human |
| Xiaoguang Tian, Guang Zeng, Xi Li, Zizhong Wu, Lei Wan. Cantharidin inhibits cell proliferation and promotes apoptosis in tongue squamous cell carcinoma through suppression of miR-214 and regulation of p53 and Bcl-2/Bax. Oncology reports. vol 33. issue 6. 2016-02-04. PMID:25962755. |
cantharidin inhibits cell proliferation and promotes apoptosis in tongue squamous cell carcinoma through suppression of mir-214 and regulation of p53 and bcl-2/bax. |
2016-02-04 |
2023-08-13 |
human |
| Xiaoguang Tian, Guang Zeng, Xi Li, Zizhong Wu, Lei Wan. Cantharidin inhibits cell proliferation and promotes apoptosis in tongue squamous cell carcinoma through suppression of miR-214 and regulation of p53 and Bcl-2/Bax. Oncology reports. vol 33. issue 6. 2016-02-04. PMID:25962755. |
however, the overexpression of mir-214 reduced the anticancer effect of cantharidin on the proliferation and apoptosis of tscc tca8113 cells, inhibited p53 protein expression, and increased the bcl-2/bax signaling pathway. |
2016-02-04 |
2023-08-13 |
human |
| Wei Cui, Zhijun Huang, Hongjuan He, Ning Gu, Geng Qin, Jie Lv, Tao Zheng, Kenkichi Sugimoto, Qiong W. MiR-1188 at the imprinted Dlk1-Dio3 domain acts as a tumor suppressor in hepatoma cells. Molecular biology of the cell. vol 26. issue 8. 2016-02-03. PMID:25694452. |
moreover, overexpressed mir-1188 promotes apoptosis, enhances caspase-3 activity, and also up-regulates the expression of bax and p53. |
2016-02-03 |
2023-08-13 |
mouse |