| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Scott E Williams, Idoia Garcia, Andrew J Crowther, Shiyi Li, Alyssa Stewart, Hedi Liu, Kendall J Lough, Sean O'Neill, Katherine Veleta, Esteban A Oyarzabal, Joseph R Merrill, Yen-Yu Ian Shih, Timothy R Gersho. Aspm sustains postnatal cerebellar neurogenesis and medulloblastoma growth in mice. Development (Cambridge, England). vol 142. issue 22. 2016-03-04. PMID:26450969. |
co-deletion of aspm and either of the apoptosis regulators bax or trp53 (also known as p53) rescues the survival of neural progenitors and reduces the growth restriction imposed by aspm deletion. |
2016-03-04 |
2023-08-13 |
mouse |
| Carlotta Giorgi, Massimo Bonora, Sonia Missiroli, Claudia Morganti, Giampaolo Morciano, Mariusz R Wieckowski, Paolo Pinto. Alterations in Mitochondrial and Endoplasmic Reticulum Signaling by p53 Mutants. Frontiers in oncology. vol 6. 2016-03-04. PMID:26942128. |
indeed, cytosolic localization of endogenous wild-type or transactivation-deficient p53 is necessary and sufficient for the induction of apoptosis and autophagy. |
2016-03-04 |
2023-08-13 |
Not clear |
| Suwen Yang, Shengrui Wang, Fengchao Sun, Mengmeng Zhang, Fengchang Wu, Fanfan Xu, Zhishan Din. Protective effects of puerarin against tetrabromobisphenol a-induced apoptosis and cardiac developmental toxicity in zebrafish embryo-larvae. Environmental toxicology. vol 30. issue 9. 2016-03-03. PMID:24596333. |
acridine orange staining results revealed that tbbpa exposure caused cardiomyocyte apoptosis and induced the expression of three proapoptotic genes: p53, bax, and caspase9. |
2016-03-03 |
2023-08-12 |
zebrafish |
| Huai-Cai Zeng, Qing-Zhi He, Yuan-Yuan Li, Cheng-Qiu Wu, Yi-Mou Wu, Shun-Qing X. Prenatal exposure to PFOS caused mitochondia-mediated apoptosis in heart of weaned rat. Environmental toxicology. vol 30. issue 9. 2016-03-03. PMID:24616003. |
apoptosis, as well as expression of apoptosis related genes associated with mitochondrial-mediated apoptosis pathway, including p53, bcl-2, bax, cytochrome c, caspase-9, and caspase-3 were analyzed in heart tissues from weaned (postnatal day 21, pnd 21) offspring. |
2016-03-03 |
2023-08-12 |
rat |
| E Baldini, C Tuccilli, N Prinzi, S Sorrenti, A Antonelli, P Fallahi, C Mian, S Barollo, A Catania, S Morrone, F Tartaglia, D Mascagni, C Coccaro, M Pepe, A Filippini, M D'Armiento, S Uliss. Selective inhibitors of aurora kinases inhibit proliferation, reduce cell viability and impair cell cycle progression in papillary thyroid carcinoma cells. Journal of biological regulators and homeostatic agents. vol 29. issue 4. 2016-03-03. PMID:26753639. |
apoptosis was induced in all the cells by both inhibitors independently from the p53 status. |
2016-03-03 |
2023-08-13 |
human |
| Hem C Jha, Karren Yang, Darine W El-Naccache, Zhiguo Sun, Erle S Robertso. EBNA3C regulates p53 through induction of Aurora kinase B. Oncotarget. vol 6. issue 8. 2016-03-02. PMID:25691063. |
in multicellular organisms p53 maintains genomic integrity through activation of dna repair, and apoptosis. |
2016-03-02 |
2023-08-13 |
human |
| Bodo C Melni. MiR-21: an environmental driver of malignant melanoma? Journal of translational medicine. vol 13. 2016-03-02. PMID:26116372. |
mir-21 is an oncomir that affects critical target genes of malignant melanoma, resulting in sustained proliferation (pten, pi3k, sprouty, pdcd4, foxo1, tipe2, p53, cyclin d1), evasion from apoptosis (foxo1, fbxo11, apaf1, timp3, tipe2), genetic instability (msh2, fbxo11, htert), increased oxidative stress (foxo1), angiogenesis (pten, hif1α, timp3), invasion and metastasis (apaf1, pten, pdcd4, timp3). |
2016-03-02 |
2023-08-13 |
Not clear |
| Sohier Yahia, Abd Elazeez Shabaan, Mona Gouida, Doaa El-Ghanam, Heba Eldegla, Amal El-Bakary, Hesham Abdel-Had. Influence of hyperbilirubinemia and phototherapy on markers of genotoxicity and apoptosis in full-term infants. European journal of pediatrics. vol 174. issue 4. 2016-03-01. PMID:25209224. |
all enrolled infants were subjected to assessment of dna damage and apoptosis in peripheral blood lymphocytes, using the comet assay and p53 by flow cytometry, consecutively. |
2016-03-01 |
2023-08-13 |
Not clear |
| Mona Sobhani, Jahangir Abdi, Saha N Manujendra, Christine Chen, Hong Chan. PRIMA-1Met induces apoptosis in Waldenström's Macroglobulinemia cells independent of p53. Cancer biology & therapy. vol 16. issue 5. 2016-03-01. PMID:25803193. |
prima-1met induces apoptosis in waldenström's macroglobulinemia cells independent of p53. |
2016-03-01 |
2023-08-13 |
Not clear |
| Shaorong Han, Xiaoyan Lv, Yanming Wang, Hai Gong, Cong Zhang, Anna Tong, Baoyi Zhang, Hui Ya. Effect and mechanism of peroxisome proliferator-activated receptor-γ on the drug resistance of the U-87 MG/CDDP human malignant glioma cell line. Molecular medicine reports. vol 12. issue 2. 2016-03-01. PMID:25891367. |
flow cytometry revealed that the intracellular content of rhodamine-123 was increased, expression of p-glycoprotein was downregulated, cell cycle was arrested in g0/g1 phase, apoptosis and oxidative stress was increased, levels of intracellular thymidylate synthase, glutathione and transforming growth factor-β1 were decreased, expression levels of multidrug resistance related gene (mdr), multidrug resistance-associated protein and glutothionine s-transferase-π were downregulated, expression levels of cell proliferation and apoptosis associated genes, including survivin and b-cell lymphoma-2, were downregulated, p53, p21 and caspase-3/8 were significantly upregulated, phosphorylation of extracellular signal-regulated kinase and small mothers against decapentaplegic 2 were downregulated, and the transcriptional activities of twist and nuclear factor (erythroid-derived 2)-like 2 were significantly reduced. |
2016-03-01 |
2023-08-13 |
human |
| Hamed Karimian, Mehran Fadaeinasab, Soheil Zorofchian Moghadamtousi, Maryam Hajrezaei, Mahboubeh Razavi, Sher Zaman Safi, Mahmood Ameen Abdulla, Hapipah Mohd Ali, Mohamad Ibrahim Noordi. Chemopreventive Activity of Ferulago angulate against Breast Tumor in Rats and the Apoptotic Effect of Polycerasoidin in MCF7 Cells: A Bioassay-Guided Approach. PloS one. vol 10. issue 5. 2016-03-01. PMID:25996383. |
falhe administration induced apoptosis in breast tumor cells, and this was confirmed by high expression levels of bax, p53 and caspase 3. |
2016-03-01 |
2023-08-13 |
rat |
| Beng Hooi Phang, Rashidah Othman, Gaelle Bougeard, Ren Hui Chia, Thierry Frebourg, Choong Leong Tang, Peh Yean Cheah, Kanaga Sabapath. Amino-terminal p53 mutations lead to expression of apoptosis proficient p47 and prognosticate better survival, but predispose to tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 46. 2016-03-01. PMID:26578795. |
amino-terminal p53 mutations lead to expression of apoptosis proficient p47 and prognosticate better survival, but predispose to tumorigenesis. |
2016-03-01 |
2023-08-13 |
Not clear |
| Beng Hooi Phang, Rashidah Othman, Gaelle Bougeard, Ren Hui Chia, Thierry Frebourg, Choong Leong Tang, Peh Yean Cheah, Kanaga Sabapath. Amino-terminal p53 mutations lead to expression of apoptosis proficient p47 and prognosticate better survival, but predispose to tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 46. 2016-03-01. PMID:26578795. |
these data from atp53 mutations collectively demonstrate that p53's apoptosis proficiency is dispensable for tumor suppression, but could prognosticate better survival. |
2016-03-01 |
2023-08-13 |
Not clear |
| Ya-Qiong Jin, Guo-Shun An, Ju-Hua Ni, Shu-Yan Li, Hong-Ti Ji. ATM-dependent E2F1 accumulation in the nucleolus is an indicator of ribosomal stress in early response to DNA damage. Cell cycle (Georgetown, Tex.). vol 13. issue 10. 2016-02-29. PMID:24675884. |
most genotoxic agents disrupt nucleolar structure and function, which results in the stabilization/activation of p53, inducing cell cycle arrest or apoptosis. |
2016-02-29 |
2023-08-12 |
Not clear |
| Jianping Peng, Xiaoning Li, Dongshan Zhang, Jian-Kang Chen, Yunchao Su, Sylvia B Smith, Zheng Don. Hyperglycemia, p53, and mitochondrial pathway of apoptosis are involved in the susceptibility of diabetic models to ischemic acute kidney injury. Kidney international. vol 87. issue 1. 2016-02-29. PMID:24963915. |
hyperglycemia, p53, and mitochondrial pathway of apoptosis are involved in the susceptibility of diabetic models to ischemic acute kidney injury. |
2016-02-29 |
2023-08-13 |
mouse |
| Jianping Peng, Xiaoning Li, Dongshan Zhang, Jian-Kang Chen, Yunchao Su, Sylvia B Smith, Zheng Don. Hyperglycemia, p53, and mitochondrial pathway of apoptosis are involved in the susceptibility of diabetic models to ischemic acute kidney injury. Kidney international. vol 87. issue 1. 2016-02-29. PMID:24963915. |
in vitro, high glucose-conditioned renal proximal tubular cells showed higher apoptosis and caspase activation following atp depletion and hypoxic injury, accompanied by a heightened mitochondrial accumulation of bax and release of cytochrome c. in response to injury, both glucose-conditioned renal proximal tubular cells and diabetic kidney tissues showed markedly higher p53 induction. |
2016-02-29 |
2023-08-13 |
mouse |
| Jianping Peng, Xiaoning Li, Dongshan Zhang, Jian-Kang Chen, Yunchao Su, Sylvia B Smith, Zheng Don. Hyperglycemia, p53, and mitochondrial pathway of apoptosis are involved in the susceptibility of diabetic models to ischemic acute kidney injury. Kidney international. vol 87. issue 1. 2016-02-29. PMID:24963915. |
thus, our results suggest the involvement of hyperglycemia, p53, and the mitochondrial pathway of apoptosis in the susceptibility of diabetic models to aki. |
2016-02-29 |
2023-08-13 |
mouse |
| P Zhang, S Elabd, S Hammer, V Solozobova, H Yan, F Bartel, S Inoue, T Henrich, J Wittbrodt, F Loosli, G Davidson, C Blattne. TRIM25 has a dual function in the p53/Mdm2 circuit. Oncogene. vol 34. issue 46. 2016-02-29. PMID:25728675. |
the downregulation of trim25 furthermore resulted in massive apoptosis during early embryogenesis of medaka, which was rescued by the concomitant downregulation of p53, demonstrating the functional relevance of the regulation of p53 by trim25 in an organismal context. |
2016-02-29 |
2023-08-13 |
Not clear |
| Agnieszka Sliwinska, Aneta Rogalska, Agnieszka Marczak, Jacek Kasznicki, Jozef Drzewosk. Metformin, but not sitagliptin, enhances WP 631-induced apoptotic HepG2 cell death. Toxicology in vitro : an international journal published in association with BIBRA. vol 29. issue 5. 2016-02-29. PMID:25959860. |
both mtt assay and flow cytometry analysis showed that wp 631 reduced the growth of hepg2 cells by apoptosis induction, accompanied by elevated nf-κb and p53 levels. |
2016-02-29 |
2023-08-13 |
human |
| Ji Chen, Hua Shi, Jin Qi, Dingyi Liu, Zemin Yang, Chenghua L. JNK1 inhibits transcriptional and pro-apoptotic activity of TAp63γ. FEBS letters. vol 589. issue 23. 2016-02-29. PMID:26519559. |
tap63γ is a homologue of tumor suppressor p53 and functions as a transcriptional factor playing key roles in cell cycle and cell apoptosis. |
2016-02-29 |
2023-08-13 |
Not clear |