| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Thouraya Ben Safta, Linda Ziani, Loetitia Favre, Lucille Lamendour, Gwendoline Gros, Fathia Mami-Chouaib, Denis Martinvalet, Salem Chouaib, Jerome Thier. Granzyme B-activated p53 interacts with Bcl-2 to promote cytotoxic lymphocyte-mediated apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 194. issue 1. 2016-02-26. PMID:25404359. |
granzyme b-activated p53 interacts with bcl-2 to promote cytotoxic lymphocyte-mediated apoptosis. |
2016-02-26 |
2023-08-13 |
human |
| Thouraya Ben Safta, Linda Ziani, Loetitia Favre, Lucille Lamendour, Gwendoline Gros, Fathia Mami-Chouaib, Denis Martinvalet, Salem Chouaib, Jerome Thier. Granzyme B-activated p53 interacts with Bcl-2 to promote cytotoxic lymphocyte-mediated apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 194. issue 1. 2016-02-26. PMID:25404359. |
we previously showed that gzmb also induces a rapid accumulation of the tumor-suppressor protein p53 within target cells, which seems to be involved in gzmb-induced apoptosis. |
2016-02-26 |
2023-08-13 |
human |
| Thouraya Ben Safta, Linda Ziani, Loetitia Favre, Lucille Lamendour, Gwendoline Gros, Fathia Mami-Chouaib, Denis Martinvalet, Salem Chouaib, Jerome Thier. Granzyme B-activated p53 interacts with Bcl-2 to promote cytotoxic lymphocyte-mediated apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 194. issue 1. 2016-02-26. PMID:25404359. |
together, our results define p53 as a new important player in the gzmb apoptotic signaling pathway and in ctl/nk-induced apoptosis. |
2016-02-26 |
2023-08-13 |
human |
| Edward Chaum, Christina S Winborn, Sujoy Bhattachary. Genomic regulation of senescence and innate immunity signaling in the retinal pigment epithelium. Mammalian genome : official journal of the International Mammalian Genome Society. vol 26. issue 5-6. 2016-02-24. PMID:25963977. |
the tumor suppressor p53 is a major regulator of genes important for cell cycle arrest, senescence, apoptosis, and innate immunity, and has recently been implicated in retinal aging. |
2016-02-24 |
2023-08-13 |
mouse |
| Chao Yu, Zhiguo Zhou, Jun Wang, Jin Sun, Wei Liu, Yanan Sun, Bin Kong, Hong Yang, Shiping Yan. In depth analysis of apoptosis induced by silica coated manganese oxide nanoparticles in vitro. Journal of hazardous materials. vol 283. 2016-02-23. PMID:25464291. |
firstly, reactive oxygen species (ros) is generated induced by mno@sio2 nps, then p53 is activated followed by an increase in the bax and a decrease in the bcl-2, ultimately leading to g2/m phase arrest, increasing the activity of caspase-3 and inducing apoptosis. |
2016-02-23 |
2023-08-13 |
mouse |
| A Aubry, S Galiacy, L Ceccato, C Marchand, C Tricoire, F Lopez, R Bremner, C Racaud-Sultan, B Monsarrat, F Malecaze, M Allouch. Peptides derived from the dependence receptor ALK are proapoptotic for ALK-positive tumors. Cell death & disease. vol 6. 2016-02-23. PMID:25950466. |
furthermore, sirna-mediated knockdown of p53 rescued these cells from p36-induced apoptosis. |
2016-02-23 |
2023-08-13 |
human |
| G G Sun, J Zhang, X B Ma, Y D Wang, Y J Cheng, W N H. Overexpression of Wild-Type p53-Induced Phosphatase 1 Confers Poor Prognosis of Patients with Nasopharyngeal Carcinoma. Pathology oncology research : POR. vol 21. issue 2. 2016-02-22. PMID:25060857. |
mtt assay, cell apoptosis, cell cycles demonstrated that cne2 cell transfected wip1 sirna had a lower survival fraction, higher cell apoptosis, more percentage of the g0/g1 phases, significant decrease in migration and invasion, and higher p53 and p16 protein expression compared with cne2 cell untransfected wip1 sirna (p < 0.05). |
2016-02-22 |
2023-08-13 |
Not clear |
| G G Sun, J Zhang, X B Ma, Y D Wang, Y J Cheng, W N H. Overexpression of Wild-Type p53-Induced Phosphatase 1 Confers Poor Prognosis of Patients with Nasopharyngeal Carcinoma. Pathology oncology research : POR. vol 21. issue 2. 2016-02-22. PMID:25060857. |
wip1 may involved in the biological processes of nasopharyngeal cancer cell proliferation, apoptosis, and migration and invasion by regulation p53 and p16 protein expression. |
2016-02-22 |
2023-08-13 |
Not clear |
| Ai-Jun Jiang, Guan Jiang, Lian-Tao Li, Jun-Nian Zhen. Curcumin induces apoptosis through mitochondrial pathway and caspases activation in human melanoma cells. Molecular biology reports. vol 42. issue 1. 2016-02-22. PMID:25262359. |
curcumin treatment also altered the expressions of apoptosis associated proteins nf-κb, p38 and p53. |
2016-02-22 |
2023-08-13 |
human |
| Shakti Ranjan Satapathy, Purusottam Mohapatra, Dipon Das, Sumit Siddharth, Chanakya Nath Kund. The Apoptotic Effect of Plant Based Nanosilver in Colon Cancer Cells is a p53 Dependent Process Involving ROS and JNK Cascade. Pathology oncology research : POR. vol 21. issue 2. 2016-02-22. PMID:25359126. |
pd-agnp-mediated apoptosis in crcs is a p53 dependent process involving ros and jnk cascade. |
2016-02-22 |
2023-08-13 |
Not clear |
| Manpreet Kaur Saini, Sankar Nath Sanya. Cell cycle regulation and apoptotic cell death in experimental colon carcinogenesis: intervening with cyclooxygenase-2 inhibitors. Nutrition and cancer. vol 67. issue 4. 2016-02-22. PMID:25825916. |
cell cycle regulators [cyclin d1, cyclin e, cyclin dependent kinase 2 (cdk2), cdk4, and p53], nfκb (p65) pathway, and proliferating cell nuclear antigen (pcna) were evaluated by gene and protein expression, whereas apoptosis was studied by terminal deoxynucleotidyl transferase dutp nick end labeling and apoptotic bleb assay. |
2016-02-22 |
2023-08-13 |
rat |
| Manpreet Kaur Saini, Sankar Nath Sanya. Cell cycle regulation and apoptotic cell death in experimental colon carcinogenesis: intervening with cyclooxygenase-2 inhibitors. Nutrition and cancer. vol 67. issue 4. 2016-02-22. PMID:25825916. |
both drugs mediated apoptosis through p53 activation. |
2016-02-22 |
2023-08-13 |
rat |
| Hu Shan, Rui Yan, Jiayu Diao, Lin Lin, Suqin Wang, Ming Zhang, Rong Zhang, Jin We. Involvement of caspases and their upstream regulators in myocardial apoptosis in a rat model of selenium deficiency-induced dilated cardiomyopathy. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). vol 31. 2016-02-22. PMID:26004897. |
in conclusion, the intrinsic, extrinsic pathways and the upstream regulators such as p53, bax, bcl-2, and bcl-x(l )were all involved in selenium deficiency-induced myocardial apoptosis. |
2016-02-22 |
2023-08-13 |
rat |
| Emanuela Papaianni, Souhayla El Maadidi, Andrea Schejtman, Simon Neumann, Ulrich Maurer, Francesca Marino-Merlo, Antonio Mastino, Christoph Borne. Phylogenetically Distant Viruses Use the Same BH3-Only Protein Puma to Trigger Bax/Bak-Dependent Apoptosis of Infected Mouse and Human Cells. PloS one. vol 10. issue 6. 2016-02-22. PMID:26030884. |
moreover, none of the classical puma transcription factors such as p53, p73 or p65 nfκb were involved in hsv-1-induced apoptosis. |
2016-02-22 |
2023-08-13 |
mouse |
| Antonio R Lucena-Araujo, Haesook T Kim, Carolina Thomé, Rafael H Jacomo, Raul A Melo, Rosane Bittencourt, Ricardo Pasquini, Katia Pagnano, Ana Beatriz F Glória, Maria de Lourdes Chauffaille, Melina Athayde, Carlos S Chiattone, Ingrid Mito, Rodrigo Bendlin, Carmino Souza, Cristina Bortolheiro, Juan L Coelho-Silva, Stanley L Schrier, Martin S Tallman, David Grimwade, Arnold Ganser, Nancy Berliner, Raul C Ribeiro, Francesco Lo-Coco, Bob Löwenberg, Miguel A Sanz, Eduardo M Reg. High ΔNp73/TAp73 ratio is associated with poor prognosis in acute promyelocytic leukemia. Blood. vol 126. issue 20. 2016-02-22. PMID:26429976. |
the tp73 gene transcript is alternatively spliced and translated into the transcriptionally active (tap73) or inactive (Δnp73) isoforms, with opposite effects on the expression of p53 target genes and on apoptosis induction. |
2016-02-22 |
2023-08-13 |
human |
| Jianzhang Wu, Zhijian Cai, Xiaoyan Wei, Minxiao Chen, Shilong Ying, Lingyi Shi, Ren-Ai Xu, Fan He, Guang Liang, Xiuhua Zhan. Anti-Lung Cancer Activity of the Curcumin Analog JZ534 In Vitro. BioMed research international. vol 2015. 2016-02-21. PMID:25977922. |
meanwhile, jz534 induced cell apoptosis and upregulated the expression of apoptosis-related proteins, including cleaved caspase-3, bax, and p53. |
2016-02-21 |
2023-08-13 |
Not clear |
| Harun Patel, Yogesh Sonawane, Rakesh Jagtap, Kiran Dhangar, Neeta Thapliyal, Sanjay Surana, Malleshappa Noolvi, Mahamadhanif S Shaikh, Rajesh A Rane, Rajshekhar Karpoormat. Structural insight of glitazone for hepato-toxicity: Resolving mystery by PASS. Bioorganic & medicinal chemistry letters. vol 25. issue 9. 2016-02-19. PMID:25851939. |
the results suggest that chromane containing glitazones are apoptic agonist (activating p53 by intrinsic pathway leading to the apoptosis) and those which do not contain the chromane are devoid of this. |
2016-02-19 |
2023-08-13 |
Not clear |
| A Desantis, T Bruno, V Catena, F De Nicola, F Goeman, S Iezzi, C Sorino, M P Gentileschi, S Germoni, V Monteleone, M Pellegrino, M Kann, P D De Meo, M Pallocca, K Höpker, F Moretti, E Mattei, H C Reinhardt, A Floridi, C Passananti, T Benzing, G Blandino, M Fanciull. Che-1 modulates the decision between cell cycle arrest and apoptosis by its binding to p53. Cell death & disease. vol 6. 2016-02-18. PMID:25996291. |
che-1 modulates the decision between cell cycle arrest and apoptosis by its binding to p53. |
2016-02-18 |
2023-08-13 |
mouse |
| H Nailwal, S Sharma, A K Mayank, S K La. The nucleoprotein of influenza A virus induces p53 signaling and apoptosis via attenuation of host ubiquitin ligase RNF43. Cell death & disease. vol 6. 2016-02-18. PMID:25996295. |
the nucleoprotein of influenza a virus induces p53 signaling and apoptosis via attenuation of host ubiquitin ligase rnf43. |
2016-02-18 |
2023-08-13 |
Not clear |
| H Nailwal, S Sharma, A K Mayank, S K La. The nucleoprotein of influenza A virus induces p53 signaling and apoptosis via attenuation of host ubiquitin ligase RNF43. Cell death & disease. vol 6. 2016-02-18. PMID:25996295. |
collectively, these results conclude that np targets rnf43 to modulate p53 ubiquitination levels and hence causes p53 stabilization which is conducive to an enhanced apoptosis level in the host cells. |
2016-02-18 |
2023-08-13 |
Not clear |