| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Takuya Kumazawa, Kazuho Nishimura, Naohiro Katagiri, Sayaka Hashimoto, Yuki Hayashi, Keiji Kimur. Gradual reduction in rRNA transcription triggers p53 acetylation and apoptosis via MYBBP1A. Scientific reports. vol 5. 2016-03-24. PMID:26044764. |
we propose that the nucleolus functions as a stress sensor to modulate p53 protein levels and its acetylation status, determining cell fate between cell cycle arrest and apoptosis by regulating mybbp1a translocation. |
2016-03-24 |
2023-08-13 |
Not clear |
| Mustafa Ozan Gursoy, Suleyman Karakoyun, Macit Kalcik, Mahmut Yesin, Sabahattin Gunduz, Mehmet Ali Astarcioğlu, Ali Emrah Oğuz, Mehmet Ozka. Evaluation of p53 Polymorphism in Patients with Pannus-Derived Prosthetic Dysfunction. The Journal of heart valve disease. vol 24. issue 5. 2016-03-24. PMID:26897840. |
the p53 gene plays a critical role in apoptosis and cell proliferation. |
2016-03-24 |
2023-08-13 |
Not clear |
| Widodo, Muhammad Sasmito Djati, Muhaimin Rifa'. Role of MicroRNAs in carcinogenesis that potential for biomarker of endometrial cancer. Annals of medicine and surgery (2012). vol 7. 2016-03-23. PMID:27006767. |
these genes cluster into several functional groups involving a process of angiogenesis, apoptosis, cell cycle, cell proliferation and p53 pathways. |
2016-03-23 |
2023-08-13 |
Not clear |
| M A Voicekhovskaya, N I Chalisova, E A Kontsevaya, G A Ryzha. Effect of bioregulatory tripeptides on the culture of skin cells from young and old rats. Bulletin of experimental biology and medicine. vol 152. issue 3. 2016-03-22. PMID:22803085. |
immunocytochemical study of the proapoptotic p53 protein expression showed that cell proliferation increased due to less pronounced apoptosis. |
2016-03-22 |
2023-08-12 |
rat |
| Lenka Pálková, Jan Vondráček, Lenka Trilecová, Miroslav Ciganek, Kateřina Pěnčíková, Jiří Neča, Alena Milcová, Jan Topinka, Miroslav Machal. The aryl hydrocarbon receptor-mediated and genotoxic effects of fractionated extract of standard reference diesel exhaust particle material in pulmonary, liver and prostate cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 29. issue 3. 2016-03-21. PMID:25500124. |
we focused on the aryl hydrocarbon receptor (ahr)-mediated activity, modulation of cell proliferation, formation of dna adducts, oxidative dna damage, and induction of dna damage responses, including evaluation of apoptosis, and phosphorylation of p53 tumor suppressor and checkpoint kinases (chk). |
2016-03-21 |
2023-08-13 |
human |
| Lenka Pálková, Jan Vondráček, Lenka Trilecová, Miroslav Ciganek, Kateřina Pěnčíková, Jiří Neča, Alena Milcová, Jan Topinka, Miroslav Machal. The aryl hydrocarbon receptor-mediated and genotoxic effects of fractionated extract of standard reference diesel exhaust particle material in pulmonary, liver and prostate cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 29. issue 3. 2016-03-21. PMID:25500124. |
in contrast to pahs, polar compounds contributed more significantly to overall formation of dna adducts associated with phosphorylation of p53, chk1 or chk2, and partly with apoptosis. |
2016-03-21 |
2023-08-13 |
human |
| Songshu Xiao, Yanhong Zhou, Wei Yi, Guijuan Luo, Bin Jiang, Qi Tian, Yueran Li, Min Xu. Fra-1 is downregulated in cervical cancer tissues and promotes cervical cancer cell apoptosis by p53 signaling pathway in vitro. International journal of oncology. vol 46. issue 4. 2016-03-21. PMID:25651840. |
fra-1 is downregulated in cervical cancer tissues and promotes cervical cancer cell apoptosis by p53 signaling pathway in vitro. |
2016-03-21 |
2023-08-13 |
human |
| Songshu Xiao, Yanhong Zhou, Wei Yi, Guijuan Luo, Bin Jiang, Qi Tian, Yueran Li, Min Xu. Fra-1 is downregulated in cervical cancer tissues and promotes cervical cancer cell apoptosis by p53 signaling pathway in vitro. International journal of oncology. vol 46. issue 4. 2016-03-21. PMID:25651840. |
in summary, our results suggested that fra-1 expression is low in cervical cancer tissues and promotes apoptosis of cervical cancer cells by p53 signaling pathway. |
2016-03-21 |
2023-08-13 |
human |
| Xiaoping Xu, Dongjuan Liu, Ning Ji, Taiwen Li, Longjiang Li, Lu Jiang, Jing Li, Ping Zhang, Xin Zeng, Qianming Che. A novel transcript variant of proteasome activator 28γ: Identification and function in oral cancer cells. International journal of oncology. vol 47. issue 1. 2016-03-21. PMID:25936920. |
in order to explore its function, we overexpressed the variant in hek293 cells and demonstrated that this variant is likely to further regulate cell cycle and apoptosis via regulating p53 and the mouse double minute2 homolog (mdm2). |
2016-03-21 |
2023-08-13 |
mouse |
| Seon Hee Kim, Yong Jung Kang, Bokyung Sung, Dong Hwan Kim, Hyun Sook Lim, Hye Rim Kim, Seong Jin Kim, Jeong-Hyun Yoon, Hyung Ryong Moon, Hae Young Chung, Nam Deuk Ki. MHY-449, a novel dihydrobenzofuro[4,5-b][1,8]naphthyridin-6-one derivative, mediates oxidative stress-induced apoptosis in AGS human gastric cancer cells. Oncology reports. vol 34. issue 1. 2016-03-18. PMID:25998412. |
in addition, it was found that mhy-449-induced apoptosis was accompanied by the upregulation of bax, p21(waf1/cip1), p27(kip1), and p53 and suppression of bcl-2. |
2016-03-18 |
2023-08-13 |
human |
| Hao Xiong, Jiaqi Pang, Haidi Yang, Min Dai, Yimin Liu, Yongkang Ou, Qiuhong Huang, Suijun Chen, Zhigang Zhang, Yaodong Xu, Lan Lai, Yiqing Zhen. Activation of miR-34a/SIRT1/p53 signaling contributes to cochlear hair cell apoptosis: implications for age-related hearing loss. Neurobiology of aging. vol 36. issue 4. 2016-03-17. PMID:25638533. |
mir-34a, p53 acetylation, and apoptosis increased in the cochlea of c57bl/6 mice with aging, whereas an age-related decrease in sirt1 was observed. |
2016-03-17 |
2023-08-13 |
mouse |
| Hao Xiong, Jiaqi Pang, Haidi Yang, Min Dai, Yimin Liu, Yongkang Ou, Qiuhong Huang, Suijun Chen, Zhigang Zhang, Yaodong Xu, Lan Lai, Yiqing Zhen. Activation of miR-34a/SIRT1/p53 signaling contributes to cochlear hair cell apoptosis: implications for age-related hearing loss. Neurobiology of aging. vol 36. issue 4. 2016-03-17. PMID:25638533. |
in the inner ear hei-oc1 cell line, mir-34a overexpression inhibited sirt1, leading to an increase in p53 acetylation and apoptosis. |
2016-03-17 |
2023-08-13 |
mouse |
| Hao Xiong, Jiaqi Pang, Haidi Yang, Min Dai, Yimin Liu, Yongkang Ou, Qiuhong Huang, Suijun Chen, Zhigang Zhang, Yaodong Xu, Lan Lai, Yiqing Zhen. Activation of miR-34a/SIRT1/p53 signaling contributes to cochlear hair cell apoptosis: implications for age-related hearing loss. Neurobiology of aging. vol 36. issue 4. 2016-03-17. PMID:25638533. |
moreover, mir-34a knockdown increased sirt1 expression and diminished p53 acetylation, and apoptosis. |
2016-03-17 |
2023-08-13 |
mouse |
| Guan-Nan Zhang, Charles R Ashby, Yun-Kai Zhang, Zhe-Sheng Chen, Huiqin Gu. The reversal of antineoplastic drug resistance in cancer cells by β-elemene. Chinese journal of cancer. vol 34. issue 11. 2016-03-16. PMID:26370907. |
in addition, cancer cells can become resistant to drugs via mechanisms that attenuate apoptosis and cell cycle arrest such as alterations in the p53, check point kinase, nuclear factor kappa b, and the p38 mitogen-activated protein kinase pathway. |
2016-03-16 |
2023-08-13 |
Not clear |
| M P Kirillina, K S Loskutova, E L Lushnikova, L M Nepomnyaschi. IMMUNOHISTOCHEMICAL ANALYSIS OF MAMMARY EPITHELIAL CELLS AT TUMORAL GROWTH IN REPUBLIC OF SAKHA (YAKUTIA). Wiadomosci lekarskie (Warsaw, Poland : 1960). vol 68. issue 4. 2016-03-16. PMID:26887131. |
the analysis of results histological examination of surgical material of breast cancer from 294 women with subsequent immunohistochemical determination of estrogen (er)--and progesterone (pgr)--receptors, proliferative activity (ki-67), expression of the mutant suppressor gene (p53) and gene-inhibitor apoptosis (bcl-2) was carried out. |
2016-03-16 |
2023-08-13 |
Not clear |
| I Ozbay, C Kucur, A Değer, I Ital, Cayci M Kasim, F Ogha. Cytotoxic Effects of Intranasal Midazolam on Nasal Mucosal Tissue. The Journal of craniofacial surgery. vol 26. issue 6. 2016-03-15. PMID:26221857. |
all materials were evaluated according to ki67 and p53 staining to evaluate proliferation and apoptosis, respectively, and hemotoxylin and eosin staining was performed for histopathology evaluation. |
2016-03-15 |
2023-08-13 |
rat |
| Jin-Yong Lee, Maki Tokumoto, Yuta Hattori, Yasuyuki Fujiwara, Akinori Shimada, Masahiko Sato. Different Regulation of p53 Expression by Cadmium Exposure in Kidney, Liver, Intestine, Vasculature, and Brain Astrocytes. Toxicological research. vol 32. issue 1. 2016-03-15. PMID:26977261. |
results showed that in the kidney of mice exposed to 300 ppm cd for 12 months, there was overaccumulation of p53 proteins in addition to the induction of apoptosis, which was triggered specifically in the proximal tubules. |
2016-03-15 |
2023-08-13 |
mouse |
| Jin-Yong Lee, Maki Tokumoto, Yuta Hattori, Yasuyuki Fujiwara, Akinori Shimada, Masahiko Sato. Different Regulation of p53 Expression by Cadmium Exposure in Kidney, Liver, Intestine, Vasculature, and Brain Astrocytes. Toxicological research. vol 32. issue 1. 2016-03-15. PMID:26977261. |
interestingly, the site of apoptosis was the same as that of p53 accumulation in the proximal tubules. |
2016-03-15 |
2023-08-13 |
mouse |
| Jin-Yong Lee, Maki Tokumoto, Yuta Hattori, Yasuyuki Fujiwara, Akinori Shimada, Masahiko Sato. Different Regulation of p53 Expression by Cadmium Exposure in Kidney, Liver, Intestine, Vasculature, and Brain Astrocytes. Toxicological research. vol 32. issue 1. 2016-03-15. PMID:26977261. |
in the liver of mice chronically exposed to cd, gene expression of the ube2d family tended to be slightly decreased, together with slight apoptosis without the accumulation of p53 protein. |
2016-03-15 |
2023-08-13 |
mouse |
| Jin-Yong Lee, Maki Tokumoto, Yuta Hattori, Yasuyuki Fujiwara, Akinori Shimada, Masahiko Sato. Different Regulation of p53 Expression by Cadmium Exposure in Kidney, Liver, Intestine, Vasculature, and Brain Astrocytes. Toxicological research. vol 32. issue 1. 2016-03-15. PMID:26977261. |
these results suggest that cd-induced apoptosis through p53 protein is associated with renal toxicity but not hepatic toxicity, and the modification of p53 protein by cd may vary depending on cell type. |
2016-03-15 |
2023-08-13 |
mouse |