| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria Ferraiuolo, Silvia Di Agostino, Giovanni Blandino, Sabrina Stran. Oncogenic Intra-p53 Family Member Interactions in Human Cancers. Frontiers in oncology. vol 6. 2016-04-12. PMID:27066457. |
p53, p73, and p63 are tumor suppressor genes that promote differentiation, senescence, and apoptosis. |
2016-04-12 |
2023-08-13 |
human |
| Amlanjyoti Dhar, Shampa Mallick, Piya Ghosh, Atanu Maiti, Israr Ahmed, Seemana Bhattacharya, Tapashi Mandal, Asit Manna, Koushik Roy, Sandeep Singh, Dipak Kumar Nayak, Paul T Wilder, Joseph Markowitz, David Weber, Mrinal K Ghosh, Samit Chattopadhyay, Rajdeep Guha, Aditya Konar, Santu Bandyopadhyay, Siddhartha Ro. Simultaneous inhibition of key growth pathways in melanoma cells and tumor regression by a designed bidentate constrained helical peptide. Biopolymers. vol 102. issue 4. 2016-04-11. PMID:24839139. |
the apoptosis induced by the bidentate constrained helix is caused by direct migration of p53 to mitochondria. |
2016-04-11 |
2023-08-13 |
mouse |
| Nour S Ereka. Apoptotic Mediators are Upregulated in the Skeletal Muscle of Chronic/Progressive Mouse Model of Parkinson's Disease. Anatomical record (Hoboken, N.J. : 2007). vol 298. issue 8. 2016-04-11. PMID:25704481. |
thus, our present data suggest that pd induction increased the expression of the apoptotic mediators p53 and active caspase-3 in gastrocnemius muscle, indicating the induction of apoptosis, which was correlative with gastrocnemius muscle atrophy subsequent to the induction of pd. |
2016-04-11 |
2023-08-13 |
mouse |
| Jinjin Zhang, Pan Xu, Youlei Wang, Meirong Wang, Hongbo Li, Shengcui Lin, Cuiping Mao, Bingsi Wang, Xiaodong Song, Changjun L. Astaxanthin prevents pulmonary fibrosis by promoting myofibroblast apoptosis dependent on Drp1-mediated mitochondrial fission. Journal of cellular and molecular medicine. vol 19. issue 9. 2016-04-11. PMID:26119034. |
drp1-associated genes, such as bcl-2-associated x protein, cytochrome c, tumour suppressor gene p53 and p53-up-regulated modulator of apoptosis, were highly up-regulated in the astaxanthin group compared with those in the sham group. |
2016-04-11 |
2023-08-13 |
Not clear |
| C-G Sun, J Zhuang, W-J Teng, Z Wang, S-S D. PUMA gene transfection can enhance the sensitivity of epirubicin-induced apoptosis of MCF-7 breast cancer cells. Genetics and molecular research : GMR. vol 14. issue 2. 2016-04-11. PMID:26125773. |
we explored whether p53 upregulated modulator of apoptosis (puma) gene transfection could enhance the sensitivity of epirubicin-induced apoptosis of mcf-7 breast cancer cells. |
2016-04-11 |
2023-08-13 |
Not clear |
| Chun-Chi Wu, Keh-Feng Huang, Tsung-Ying Yang, Ya-Ling Li, Chi-Luan Wen, Shih-Lan Hsu, Tzu-Hsiu Che. The Topoisomerase 1 Inhibitor Austrobailignan-1 Isolated from Koelreuteria henryi Induces a G2/M-Phase Arrest and Cell Death Independently of p53 in Non-Small Cell Lung Cancer Cells. PloS one. vol 10. issue 7. 2016-04-11. PMID:26147394. |
overall, our results suggest that austrobailignan-1 is a novel dna damaging agent and displays a topoisomerase i inhibitory activity, causes dna strand breaks, and consequently induces dna damage response signaling for cell cycle g2/m arrest and apoptosis in a p53 independent manner. |
2016-04-11 |
2023-08-13 |
human |
| Dongjian Song, Lifang Yue, Gang Wu, Shanshan Ma, Heying Yang, Qiuliang Liu, Da Zhang, Ziqiang Xia, Jia Jia, Jiaxiang Wan. Evaluation of promoter hypomethylation and expression of p73 as a diagnostic and prognostic biomarker in Wilms' tumour. Journal of clinical pathology. vol 69. issue 1. 2016-04-11. PMID:26184366. |
a member of the p53 family, the p73 gene is essential for the maintenance of genomic stability, dna repair and apoptosis regulation. |
2016-04-11 |
2023-08-13 |
Not clear |
| Masayuki Yamashita, Eriko Nitta, Toshio Sud. [Maintenance of hematopoietic stem cell integrity and regulation of leukemogenesis by p53 and its coactivator Aspp1]. [Rinsho ketsueki] The Japanese journal of clinical hematology. vol 56. issue 12. 2016-04-11. PMID:26725350. |
in this review, we will summarize apoptosis regulation and the roles of p53 in hscs, and introduce our findings showing coordinated regulations of hsc self-renewal, dna damage tolerance and hematological malignancies by aspp1 and p53. |
2016-04-11 |
2023-08-13 |
Not clear |
| Guangtao Yang, Wenjuan Zhang, Qizhi Qin, Jing Wang, Hongyan Zheng, Wei Xiong, Jing Yua. Mono(2-ethylhexyl) phthalate induces apoptosis in p53-silenced L02 cells via activation of both mitochondrial and death receptor pathways. Environmental toxicology. vol 30. issue 10. 2016-04-08. PMID:24706461. |
in this study, immortalized normal human liver cell line l02 was chosen, as an in vitro model of nonmalignant liver, to elucidate the role of p53 in mehp-induced apoptosis. |
2016-04-08 |
2023-08-13 |
human |
| Guangtao Yang, Wenjuan Zhang, Qizhi Qin, Jing Wang, Hongyan Zheng, Wei Xiong, Jing Yua. Mono(2-ethylhexyl) phthalate induces apoptosis in p53-silenced L02 cells via activation of both mitochondrial and death receptor pathways. Environmental toxicology. vol 30. issue 10. 2016-04-08. PMID:24706461. |
the results indicated that mehp caused oxidative dna damage and apoptosis in l02 cells were associated with the p53 signaling pathway. |
2016-04-08 |
2023-08-13 |
human |
| Guangtao Yang, Wenjuan Zhang, Qizhi Qin, Jing Wang, Hongyan Zheng, Wei Xiong, Jing Yua. Mono(2-ethylhexyl) phthalate induces apoptosis in p53-silenced L02 cells via activation of both mitochondrial and death receptor pathways. Environmental toxicology. vol 30. issue 10. 2016-04-08. PMID:24706461. |
p53 was not absolutely necessary for mehp-induced l02 cell apoptosis. |
2016-04-08 |
2023-08-13 |
human |
| D Khan, A Katoch, A Das, A Sharathchandra, R Lal, P Roy, S Das, S Chattopadhyay, S Da. Reversible induction of translational isoforms of p53 in glucose deprivation. Cell death and differentiation. vol 22. issue 7. 2016-04-08. PMID:25721046. |
rnai-mediated-transient smar1 knockdown decreased p53 ires activities in normal conditions and under glucose deprivation, this being reflected in changes in mrnas in the p53 and Δ40p53 target genes involved in cell-cycle arrest, metabolism and apoptosis such as p21, tigar and bax. |
2016-04-08 |
2023-08-13 |
mouse |
| A R D Delbridge, A Strasse. The BCL-2 protein family, BH3-mimetics and cancer therapy. Cell death and differentiation. vol 22. issue 7. 2016-04-08. PMID:25952548. |
these drugs directly activate apoptosis by binding and inhibiting select antiapoptotic bcl-2 family members and thereby bypass the requirement for upstream initiators, such as p53. |
2016-04-08 |
2023-08-13 |
mouse |
| Michelandrea De Cesare, Denis Cominetti, Valentina Doldi, Alessia Lopergolo, Marcello Deraco, Paolo Gandellini, Sharon Friedlander, Yosef Landesman, Michael G Kauffman, Sharon Shacham, Marzia Pennati, Nadia Zaffaron. Anti-tumor activity of selective inhibitors of XPO1/CRM1-mediated nuclear export in diffuse malignant peritoneal mesothelioma: the role of survivin. Oncotarget. vol 6. issue 15. 2016-04-07. PMID:25948791. |
exposure to sine induced dose-dependent inhibition of cell growth, cell cycle arrest at g1-phase and caspase-dependent apoptosis, which were consequent to a decrease of xpo1/crm1 protein levels and the concomitant nuclear accumulation of its cargo proteins p53 and cdkn1a. |
2016-04-07 |
2023-08-13 |
Not clear |
| Miroslav Genov, Birgit Kreiseder, Michael Nagl, Elisabeth Drucker, Martina Wiederstein, Barbara Muellauer, Julia Krebs, Teresa Grohmann, Dagmar Pretsch, Karl Baumann, Markus Bacher, Alexander Pretsch, Christoph Wiesne. Tetrahydroanthraquinone Derivative (±)-4-Deoxyaustrocortilutein Induces Cell Cycle Arrest and Apoptosis in Melanoma Cells via Upregulation of p21 and p53 and Downregulation of NF-kappaB. Journal of Cancer. vol 7. issue 5. 2016-04-07. PMID:27053954. |
tetrahydroanthraquinone derivative (±)-4-deoxyaustrocortilutein induces cell cycle arrest and apoptosis in melanoma cells via upregulation of p21 and p53 and downregulation of nf-kappab. |
2016-04-07 |
2023-08-13 |
Not clear |
| Sanne H Tonino, Chantal E Mulkens, Jacoline van Laar, Ingrid A M Derks, Guangli Suo, Fransien Croon-de Boer, Marinus H J van Oers, Eric Eldering, Jean Y Wang, Arnon P Kate. Induction of TAp73 by platinum-based compounds to overcome drug resistance in p53 dysfunctional chronic lymphocytic leukemia. Leukemia & lymphoma. vol 56. issue 8. 2016-04-06. PMID:25511680. |
in vitro treatment with cddp did not induce death in quiescent cll cells, but did induce apoptosis in cd40-ligand (and cpg) stimulated and proliferating cells, irrespective of p53 function. |
2016-04-06 |
2023-08-13 |
Not clear |
| Sanne H Tonino, Chantal E Mulkens, Jacoline van Laar, Ingrid A M Derks, Guangli Suo, Fransien Croon-de Boer, Marinus H J van Oers, Eric Eldering, Jean Y Wang, Arnon P Kate. Induction of TAp73 by platinum-based compounds to overcome drug resistance in p53 dysfunctional chronic lymphocytic leukemia. Leukemia & lymphoma. vol 56. issue 8. 2016-04-06. PMID:25511680. |
in the p53 dysfunctional prolymphocytic cell-line mec1, cddp treatment resulted in apoptosis, cell cycle arrest and abl1-dependent expression of tap73, cdkn1a, puma and bid. |
2016-04-06 |
2023-08-13 |
Not clear |
| Yan-Lai Tang, Li-Bin Huang, Yun Tian, Li-Na Wang, Xiao-Li Zhang, Zhi-Yong Ke, Wu-Guo Deng, Xue-Qun Lu. Flavokawain B inhibits the growth of acute lymphoblastic leukemia cells via p53 and caspase-dependent mechanisms. Leukemia & lymphoma. vol 56. issue 8. 2016-04-06. PMID:25641429. |
it also induced cellular apoptosis by increasing the expression of p53, bax and puma, and activating the cleavage of caspase-3 and poly adp-ribose polymerase (parp). |
2016-04-06 |
2023-08-13 |
mouse |
| Yan-Lai Tang, Li-Bin Huang, Yun Tian, Li-Na Wang, Xiao-Li Zhang, Zhi-Yong Ke, Wu-Guo Deng, Xue-Qun Lu. Flavokawain B inhibits the growth of acute lymphoblastic leukemia cells via p53 and caspase-dependent mechanisms. Leukemia & lymphoma. vol 56. issue 8. 2016-04-06. PMID:25641429. |
furthermore, the enhancement of p53-dependent apoptosis by flavokawain b could be rescued by pifithrin-α, a pharmacological inhibitor of p53 transcriptional activity. |
2016-04-06 |
2023-08-13 |
mouse |
| C Gianna Hoffman-Luca, Chao-Yie Yang, Jianfeng Lu, Daniel Ziazadeh, Donna McEachern, Laurent Debussche, Shaomeng Wan. Significant Differences in the Development of Acquired Resistance to the MDM2 Inhibitor SAR405838 between In Vitro and In Vivo Drug Treatment. PloS one. vol 10. issue 6. 2016-04-06. PMID:26070072. |
consistently, sar405838 is 3-5 times less effective in all the in vivo derived sublines containing a single heterozygous c176f p53 mutation than in the sjsa-1 parental cell line in assays of cell growth and apoptosis. |
2016-04-06 |
2023-08-13 |
mouse |