| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fan An, Wei-Jie Zhao, Li Tang, Rong-Guo Qi. Concentration-dependent differential effects of an epothilone analog on cell cycle and p53 signaling. Oncology reports. vol 34. issue 3. 2016-05-09. PMID:26177745. |
p53 also acts in the cytoplasm to trigger apoptosis. |
2016-05-09 |
2023-08-13 |
Not clear |
| Fan An, Wei-Jie Zhao, Li Tang, Rong-Guo Qi. Concentration-dependent differential effects of an epothilone analog on cell cycle and p53 signaling. Oncology reports. vol 34. issue 3. 2016-05-09. PMID:26177745. |
however, at high concentrations of utd1, p53 was accumulated in the cytoplasm which contributed to induction of apoptosis. |
2016-05-09 |
2023-08-13 |
Not clear |
| Özdemirhan Serçin, Jean-Christophe Larsimont, Andrea E Karambelas, Veronique Marthiens, Virginie Moers, Bram Boeckx, Marie Le Mercier, Diether Lambrechts, Renata Basto, Cédric Blanpai. Transient PLK4 overexpression accelerates tumorigenesis in p53-deficient epidermis. Nature cell biology. vol 18. issue 1. 2016-05-09. PMID:26595384. |
plk4oe in the developing epidermis induced centrosome amplification and multipolar divisions, leading to p53 stabilization and apoptosis of epidermal progenitors. |
2016-05-09 |
2023-08-13 |
mouse |
| Özdemirhan Serçin, Jean-Christophe Larsimont, Andrea E Karambelas, Veronique Marthiens, Virginie Moers, Bram Boeckx, Marie Le Mercier, Diether Lambrechts, Renata Basto, Cédric Blanpai. Transient PLK4 overexpression accelerates tumorigenesis in p53-deficient epidermis. Nature cell biology. vol 18. issue 1. 2016-05-09. PMID:26595384. |
concomitant plk4oe and p53 deletion (plk4oe/p53cko) rescued the differentiation defects, but did not prevent the apoptosis of plk4oe cells. |
2016-05-09 |
2023-08-13 |
mouse |
| Chao Dong, Fengmei Zhang, Yue Luo, Hui Wang, Xipeng Zhao, Gongshe Guo, Simon N Powell, Zhihui Fen. p53 suppresses hyper-recombination by modulating BRCA1 function. DNA repair. vol 33. 2016-05-06. PMID:26162908. |
both p53 and brca1 are tumor suppressors and are involved in a number of cellular processes including cell cycle arrest, apoptosis, transcriptional regulation, and dna damage repair. |
2016-05-06 |
2023-08-13 |
Not clear |
| Erin K Crane, Suet-Yan Kwan, Daisy I Izaguirre, Yvonne T M Tsang, Lisa K Mullany, Zhifei Zu, JoAnne S Richards, David M Gershenson, Kwong-Kwok Won. Nutlin-3a: A Potential Therapeutic Opportunity for TP53 Wild-Type Ovarian Carcinomas. PloS one. vol 10. issue 8. 2016-05-06. PMID:26248031. |
we therefore sought to investigate nutlin-3a--a therapeutic which inhibits mdm2, activates wild-type p53, and induces apoptosis--as a therapeutic compound for tp53 wild-type ovarian carcinomas. |
2016-05-06 |
2023-08-13 |
Not clear |
| Utpal K Karmakar, Naoki Ishikawa, Kazufumi Toume, Midori A Arai, Samir K Sadhu, Firoj Ahmed, Masami Ishibash. Sesquiterpenes with TRAIL-resistance overcoming activity from Xanthium strumarium. Bioorganic & medicinal chemistry. vol 23. issue 15. 2016-05-04. PMID:26081757. |
compounds 1 and 5 enhanced the levels of apoptosis inducing proteins dr4, dr5, p53, chop, bax, cleaved caspase-3, cleaved caspase-8, and cleaved caspase-9 and also decreased the levels of cell survival protein bcl-2 in trail-resistant ags cells in a dose-dependent manner. |
2016-05-04 |
2023-08-13 |
Not clear |
| Ni Wang, Yanxian Feng, Lilan Zeng, Zhennan Zhao, Tianfeng Che. Functionalized Multiwalled Carbon Nanotubes as Carriers of Ruthenium Complexes to Antagonize Cancer Multidrug Resistance and Radioresistance. ACS applied materials & interfaces. vol 7. issue 27. 2016-05-04. PMID:26107995. |
interestingly, rupop@mwcnts significantly enhanced the anticancer efficacy of clinically used x-ray against r-hepg2 cells through induction of apoptosis and g0/g1 cell cycle arrest, with the involvement of ros overproduction, which activated several downstream signaling pathways, including dna damage-mediated p53 phosphorylation, activation of p38, and inactivation of akt and erk. |
2016-05-04 |
2023-08-13 |
Not clear |
| Jihye Lee, Guillaume Adelmant, Jarrod A Marto, Dong-Hyun Le. Dephosphorylation of DBC1 by Protein Phosphatase 4 Is Important for p53-Mediated Cellular Functions. Molecules and cells. vol 38. issue 8. 2016-05-04. PMID:26194823. |
recent studies demonstrated that dbc is phosphorylated at thr454 by atm/atr kinases in response to dna damage, which is a critical event for p53 activation and apoptosis. |
2016-05-04 |
2023-08-13 |
Not clear |
| Jihye Lee, Guillaume Adelmant, Jarrod A Marto, Dong-Hyun Le. Dephosphorylation of DBC1 by Protein Phosphatase 4 Is Important for p53-Mediated Cellular Functions. Molecules and cells. vol 38. issue 8. 2016-05-04. PMID:26194823. |
pp4c efficiently dephosphorylates pthr454 on dbc1 in vitro, and the depletion of pp4c/pp4r2 in cells alters the kinetics of dbc1 phosphorylation and p53 activation, and increases apoptosis in response to dna damage, which are compatible with the expression of the phosphomimetic dbc-1 mutant (t454e). |
2016-05-04 |
2023-08-13 |
Not clear |
| Bidya Dhar Sahu, Jerald Mahesh Kumar, Ramakrishna Sistl. Baicalein, a Bioflavonoid, Prevents Cisplatin-Induced Acute Kidney Injury by Up-Regulating Antioxidant Defenses and Down-Regulating the MAPKs and NF-κB Pathways. PloS one. vol 10. issue 7. 2016-05-04. PMID:26222683. |
moreover, baicalein preserved mitochondrial respiratory enzyme activities and inhibited cisplatin-induced apoptosis by suppressing p53 expression, bax/bcl-2 imbalance, cytochrome c release and activation of caspase-9, caspase-3 and parp. |
2016-05-04 |
2023-08-13 |
Not clear |
| Balu Kamaraj, Annemie Bogaert. Structure and Function of p53-DNA Complexes with Inactivation and Rescue Mutations: A Molecular Dynamics Simulation Study. PloS one. vol 10. issue 8. 2016-05-04. PMID:26244575. |
these drugs should be designed so that they can help to inhibit the abnormal function of the p53 protein and to reactivate the p53 function (cell apoptosis) to treat human cancer. |
2016-05-04 |
2023-08-13 |
human |
| Mehdi Nikbakht Dastjerdi, Ebrahim Momeni Mehdiabady, Farhad Golshan Iranpour, Hamid Bahramia. Effect of Thymoquinone on P53 Gene Expression and Consequence Apoptosis in Breast Cancer Cell Line. International journal of preventive medicine. vol 7. 2016-05-04. PMID:27141285. |
effect of thymoquinone on p53 gene expression and consequence apoptosis in breast cancer cell line. |
2016-05-04 |
2023-08-13 |
Not clear |
| Mehdi Nikbakht Dastjerdi, Ebrahim Momeni Mehdiabady, Farhad Golshan Iranpour, Hamid Bahramia. Effect of Thymoquinone on P53 Gene Expression and Consequence Apoptosis in Breast Cancer Cell Line. International journal of preventive medicine. vol 7. 2016-05-04. PMID:27141285. |
previous studies have shown that tq induces apoptosis in breast cancer cells but it is unclear the role of p53 in the apoptotic pathway. |
2016-05-04 |
2023-08-13 |
Not clear |
| Mehdi Nikbakht Dastjerdi, Ebrahim Momeni Mehdiabady, Farhad Golshan Iranpour, Hamid Bahramia. Effect of Thymoquinone on P53 Gene Expression and Consequence Apoptosis in Breast Cancer Cell Line. International journal of preventive medicine. vol 7. 2016-05-04. PMID:27141285. |
hereby, this study reports the potency of tq on expression of tumor suppressor gene p53 and apoptosis induction in breast cancer cell line michigan cancer foundation-7 (mcf-7). |
2016-05-04 |
2023-08-13 |
Not clear |
| Yoshihiro Shirai, Hiroaki Shiba, Ryota Iwase, Koichiro Haruki, Yuki Fujiwara, Kenei Furukawa, Tadashi Uwagawa, Toya Ohashi, Katsuhiko Yanag. Dual inhibition of nuclear factor kappa-B and Mdm2 enhance the antitumor effect of radiation therapy for pancreatic cancer. Cancer letters. vol 370. issue 2. 2016-05-03. PMID:26546875. |
ionizing radiation induces cell cycle arrest and cell apoptosis through enhancement several signals such as p53, p21(waf1/cip1), and caspase. |
2016-05-03 |
2023-08-13 |
Not clear |
| A Kale, W Li, C-H Lee, N E Bake. Apoptotic mechanisms during competition of ribosomal protein mutant cells: roles of the initiator caspases Dronc and Dream/Strica. Cell death and differentiation. vol 22. issue 8. 2016-05-02. PMID:25613379. |
competitive apoptosis was found to depend on the pro-apoptotic reaper, grim and head involution defective genes but was independent of p53. |
2016-05-02 |
2023-08-13 |
human |
| A Kale, W Li, C-H Lee, N E Bake. Apoptotic mechanisms during competition of ribosomal protein mutant cells: roles of the initiator caspases Dronc and Dream/Strica. Cell death and differentiation. vol 22. issue 8. 2016-05-02. PMID:25613379. |
independence of p53 and unusual dependence on dream/strica distinguish competitive cell death from noncompetitive apoptosis of rp/rp cells and from many other examples of cell death. |
2016-05-02 |
2023-08-13 |
human |
| Wenwen Zhang, Jiayan Luo, Fengxia Chen, Fang Yang, Wei Song, Aiyu Zhu, Xiaoxiang Gua. BRCA1 regulates PIG3-mediated apoptosis in a p53-dependent manner. Oncotarget. vol 6. issue 10. 2016-05-02. PMID:25797244. |
meanwhile, the p53 inducible gene 3 (pig3) is a downstream target of p53 and is involved in p53-initiated apoptosis. |
2016-05-02 |
2023-08-13 |
Not clear |
| Jian Jun Chen, Shi Xi Liu, Mian Zhi Chen, Zi Yi Zha. Has‑miR‑125a and 125b are induced by treatment with cisplatin in nasopharyngeal carcinoma and inhibit apoptosis in a p53‑dependent manner by targeting p53 mRNA. Molecular medicine reports. vol 12. issue 3. 2016-05-02. PMID:26017674. |
has‑mir‑125a and 125b are induced by treatment with cisplatin in nasopharyngeal carcinoma and inhibit apoptosis in a p53‑dependent manner by targeting p53 mrna. |
2016-05-02 |
2023-08-13 |
Not clear |