| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lorena Veneziano, Viviana Barra, Laura Lentini, Sergio Spatafora, Aldo Di Leonard. p14(ARF) Prevents Proliferation of Aneuploid Cells by Inducing p53-Dependent Apoptosis. Journal of cellular physiology. vol 231. issue 2. 2016-04-22. PMID:25752701. |
in addition, p14(arf) ectopic expression in mad2-depleted cells induced apoptosis associated with increased p53 protein levels. |
2016-04-22 |
2023-08-13 |
human |
| Man Qiao, Dan Luo, Yi Kuang, Haiyan Feng, Guangping Luo, Peng Lian. Cell cycle specific distribution of killin: evidence for negative regulation of both DNA and RNA synthesis. Cell cycle (Georgetown, Tex.). vol 14. issue 12. 2016-04-19. PMID:25945611. |
p53 tumor-suppressor gene is a master transcription factor which controls cell cycle progression and apoptosis. |
2016-04-19 |
2023-08-13 |
human |
| I Porębska, M Kosacka, E Sobańska, E Wyrodek, R Jankowsk. Comparative Expression of Apoptotic Markers in Lung Adenocarcinoma and Squamous Cell Carcinoma. Advances in experimental medicine and biology. vol 873. 2016-04-19. PMID:26022894. |
the goal of our study was a comparative evaluation of apoptosis regulators: p53, bcl-2, bax, cox-2, and survivin in lung adenocarcinoma (ac) and squamous cell carcinoma (scc). |
2016-04-19 |
2023-08-13 |
Not clear |
| Chun-Yen Liu, Pei-Tsen Wu, Jing-Ping Wang, Po-Wei Fan, Chang-Hung Hsieh, Chun-Li Su, Chien-Chih Chiu, Ching-Fa Yao, Kang Fan. An indolylquinoline derivative promotes apoptosis in human lung cancer cells by impairing mitochondrial functions. Apoptosis : an international journal on programmed cell death. vol 20. issue 11. 2016-04-19. PMID:26349782. |
emmq caused transient elevation of p53 that assists in cytochrome c release, cleavage of downstream parp and procaspase-3 and mitochondria-related apoptosis. |
2016-04-19 |
2023-08-13 |
human |
| Ahmad Naqib Shuid, Nikoo Safi, Amin Haghani, Parvaneh Mehrbod, Mohd Syamsul Reza Haron, Sheau Wei Tan, Abdul Rahman Oma. Apoptosis transcriptional mechanism of feline infectious peritonitis virus infected cells. Apoptosis : an international journal on programmed cell death. vol 20. issue 11. 2016-04-19. PMID:26386572. |
131 genes from apoptosis cluster (80 down-regulated and 51 up-regulated) along with increase of apoptosis, p53, p38 mapk, vegf and chemokines/cytokines signaling pathways were probably involved in apoptosis process. |
2016-04-19 |
2023-08-13 |
Not clear |
| Dimitris Missirlis, Marc Farine, Mark Kastantin, Badriprasad Ananthanarayanan, Thorsten Neumann, Matthew Tirrel. Linker chemistry determines secondary structure of p5314-29 in peptide amphiphile micelles. Bioconjugate chemistry. vol 21. issue 3. 2016-04-18. PMID:20166676. |
peptide p5314-29 may act as an inhibitor of the interaction between tumor suppressor p53 and human double minute-2 (hdm2) proteins by binding hdm2 in a partially helical form, leading to the release of p53 and the induction of apoptosis in certain tumors. |
2016-04-18 |
2023-08-12 |
human |
| Hung-Yun Lin, Gennadi V Glinsky, Shaker A Mousa, Paul J Davi. Thyroid hormone and anti-apoptosis in tumor cells. Oncotarget. vol 6. issue 17. 2016-04-18. PMID:26041883. |
among the mechanisms of anti-apoptosis activated by the hormone are interference with the ser-15 phosphorylation (activation) of p53 and with tnfα/fas-induced apoptosis. |
2016-04-18 |
2023-08-13 |
human |
| Hung-Yun Lin, Gennadi V Glinsky, Shaker A Mousa, Paul J Davi. Thyroid hormone and anti-apoptosis in tumor cells. Oncotarget. vol 6. issue 17. 2016-04-18. PMID:26041883. |
tetraiodothyroacetic acid (tetrac) is a t4 derivative that, in a model of resveratrol-induced p53-dependent apoptosis in glioma cells, blocks the anti-apoptotic action of thyroid hormone, permitting specific serine phosphorylation of p53 and apoptosis to proceed. |
2016-04-18 |
2023-08-13 |
human |
| Josiana A Vaz, Gabriela M Almeida, Isabel C F R Ferreira, Anabela Martins, M Helena Vasconcelo. Clitocybe alexandri extract induces cell cycle arrest and apoptosis in a lung cancer cell line: Identification of phenolic acids with cytotoxic potential. Food chemistry. vol 132. issue 1. 2016-04-18. PMID:26434319. |
overall, evidence was found for alterations in cell cycle and apoptosis, involving p53 and caspase-3. |
2016-04-18 |
2023-08-13 |
Not clear |
| Valeria Guglielmi, Gaetano Vattemi, Roberto Chignola, Anna Chiarini, Matteo Marini, Ilaria Dal Prà, Marzia Di Chio, Cristiano Chiamulera, Ubaldo Armato, Giuliano Tomeller. Evidence for caspase-dependent programmed cell death along with repair processes in affected skeletal muscle fibres in patients with mitochondrial disorders. Clinical science (London, England : 1979). vol 130. issue 3. 2016-04-18. PMID:26527739. |
the significant increase in caspase 2, caspase 3 and caspase 6 activity strongly suggest that the cell death programme is caspase-dependent and the activation of caspase 2 together with puma (p53 up-regulated modulator of apoptosis) up-regulation point to a role for oxidative stress in triggering the intrinsic pathway. |
2016-04-18 |
2023-08-13 |
Not clear |
| Seulki Lee, Hwan Hee Lee, Jisung Kim, Joohee Jung, Aree Moon, Choon-Sik Jeong, Hyojeung Kang, Hyosun Ch. Anti-tumor effect of Cordyceps militaris in HCV-infected human hepatocarcinoma 7.5 cells. Journal of microbiology (Seoul, Korea). vol 53. issue 7. 2016-04-15. PMID:26115996. |
to examine the molecular mechanisms of the inhibitory effect on huh7.5 cells, the effect of cme on cell apoptosis was measured using flow cytometry and the expressions of p53, bim, bax, parp, (cleaved) caspase-9, and (cleaved) caspase- 3 in huh 7.5 cells were detected by western blot assays. |
2016-04-15 |
2023-08-13 |
human |
| Bing Zhu, Yinghua Li, Zhengfang Lin, Mingqi Zhao, Tiantian Xu, Changbing Wang, Ning Den. Silver Nanoparticles Induce HePG-2 Cells Apoptosis Through ROS-Mediated Signaling Pathways. Nanoscale research letters. vol 11. issue 1. 2016-04-14. PMID:27075340. |
furthermore, agnp-induced apoptosis was found dependent on the overproduction of reactive oxygen species (ros) and affecting of mapks and akt signaling and dna damage-mediated p53 phosphorylation to advance hepg-2 cells apoptosis. |
2016-04-14 |
2023-08-13 |
human |
| Md Jahoor Alam, Sanjay Kumar, Vikram Singh, R K Brojen Sing. Bifurcation in Cell Cycle Dynamics Regulated by p53. PloS one. vol 10. issue 6. 2016-04-13. PMID:26090895. |
we predict that there could be a critical Δtc induced by p53 via irc, where, if Δt〈Δtc the cell cycle may come back to normal state, otherwise it will go to cell cycle arrest (apoptosis). |
2016-04-13 |
2023-08-13 |
Not clear |
| Cong Wang, Liping Jiang, Saiqi Wang, Hongge Shi, Junwei Wang, Ran Wang, Yongmei Li, Yinhui Dou, Ying Liu, Guiqin Hou, Yu Ke, Hongmin Li. The Antitumor Activity of the Novel Compound Jesridonin on Human Esophageal Carcinoma Cells. PloS one. vol 10. issue 6. 2016-04-13. PMID:26103161. |
apoptosis via mitochondrial and death receptor pathways were confirmed by detecting the regulation of mdm2, p53, and bcl-2 family members and by activation of caspase-3/-8/-9. |
2016-04-13 |
2023-08-13 |
mouse |
| Yifu Sun, Peng Xia, Haipeng Zhang, Biao Liu, Ying Sh. P53 is required for Doxorubicin-induced apoptosis via the TGF-beta signaling pathway in osteosarcoma-derived cells. American journal of cancer research. vol 6. issue 1. 2016-04-13. PMID:27073729. |
p53 is required for doxorubicin-induced apoptosis via the tgf-beta signaling pathway in osteosarcoma-derived cells. |
2016-04-13 |
2023-08-13 |
Not clear |
| Yifu Sun, Peng Xia, Haipeng Zhang, Biao Liu, Ying Sh. P53 is required for Doxorubicin-induced apoptosis via the TGF-beta signaling pathway in osteosarcoma-derived cells. American journal of cancer research. vol 6. issue 1. 2016-04-13. PMID:27073729. |
in cell viability assays, doxorubicin effectively induced apoptosis in u2os cells via the p53 signaling pathway, evidenced by elevated puma and p21 protein levels and activated caspase 3 cleavage. |
2016-04-13 |
2023-08-13 |
Not clear |
| Yifu Sun, Peng Xia, Haipeng Zhang, Biao Liu, Ying Sh. P53 is required for Doxorubicin-induced apoptosis via the TGF-beta signaling pathway in osteosarcoma-derived cells. American journal of cancer research. vol 6. issue 1. 2016-04-13. PMID:27073729. |
in contrast, p53-null mg-63 cells were resistant to doxorubicin-induced apoptosis, while exogenous expression of p53 increased drug sensitivity in those cells. |
2016-04-13 |
2023-08-13 |
Not clear |
| Sanjay Kumar, Munendra Singh Tomar, Arbind Achary. Activation of p53-dependent/-independent pathways of apoptotic cell death by chelerythrine in a murine T cell lymphoma. Leukemia & lymphoma. vol 56. issue 6. 2016-04-12. PMID:25308293. |
the p53 tumor suppressor protein has been implicated as an activator of apoptosis. |
2016-04-12 |
2023-08-13 |
human |
| Refilwe P Molatlhegi, Alisa Phulukdaree, Krishnan Anand, Robert M Gengan, Charlette Tiloke, Anil A Chuturgoo. Cytotoxic Effect of a Novel Synthesized Carbazole Compound on A549 Lung Cancer Cell Line. PloS one. vol 10. issue 7. 2016-04-12. PMID:26134408. |
ecap induced a p53 mediated apoptosis of lung cancer cells due to a significant reduction in the expression of antioxidant defence proteins (nrf2 and sod), hsp70 (p < 0.02) and bcl-2 (p < 0.0006), thereby up-regulating reactive oxygen species (ros) production. |
2016-04-12 |
2023-08-13 |
Not clear |
| Yi-Hui Lee, Huei-Yu Chen, Lilly J Su, Pin Ju Chue. Sirtuin 1 (SIRT1) Deacetylase Activity and NAD⁺/NADH Ratio Are Imperative for Capsaicin-Mediated Programmed Cell Death. Journal of agricultural and food chemistry. vol 63. issue 33. 2016-04-12. PMID:26255724. |
in contrast, capsaicin decreased the intracellular nad(+)/nadh ratio, possibly through inhibition of tumor-associated nadh oxidase (tnox), and diminished sirt1 expression leading to enhanced p53 acetylation and apoptosis. |
2016-04-12 |
2023-08-13 |
human |