| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jian Jun Chen, Shi Xi Liu, Mian Zhi Chen, Zi Yi Zha. Has‑miR‑125a and 125b are induced by treatment with cisplatin in nasopharyngeal carcinoma and inhibit apoptosis in a p53‑dependent manner by targeting p53 mRNA. Molecular medicine reports. vol 12. issue 3. 2016-05-02. PMID:26017674. |
in addition, the present demonstrated that the cisplatin‑induced expression of mir‑125a and mir‑125b inhibited cisplatin‑induced apoptosis in the tw03 cells by decreasing the protein expression levels of p53. |
2016-05-02 |
2023-08-13 |
Not clear |
| Zhilian Hu, Jochen Holzschuh, Wolfgang Drieve. Loss of DDB1 Leads to Transcriptional p53 Pathway Activation in Proliferating Cells, Cell Cycle Deregulation, and Apoptosis in Zebrafish Embryos. PloS one. vol 10. issue 7. 2016-05-02. PMID:26225764. |
loss of ddb1 leads to transcriptional p53 pathway activation in proliferating cells, cell cycle deregulation, and apoptosis in zebrafish embryos. |
2016-05-02 |
2023-08-13 |
zebrafish |
| Kai Liu, Tao Jiang, Yabo Ouyang, Ying Shi, Yunjin Zang, Ning Li, Shichun Lu, Dexi Che. Nuclear EGFR impairs ASPP2-p53 complex-induced apoptosis by inducing SOS1 expression in hepatocellular carcinoma. Oncotarget. vol 6. issue 18. 2016-04-29. PMID:25980493. |
here, aspp2 overexpression for 24 hours transiently induced apoptosis in hepatoma cells by enhancing the transactivation of p53 on pro-apoptotic gene promoters. |
2016-04-29 |
2023-08-13 |
Not clear |
| Kai Liu, Tao Jiang, Yabo Ouyang, Ying Shi, Yunjin Zang, Ning Li, Shichun Lu, Dexi Che. Nuclear EGFR impairs ASPP2-p53 complex-induced apoptosis by inducing SOS1 expression in hepatocellular carcinoma. Oncotarget. vol 6. issue 18. 2016-04-29. PMID:25980493. |
however, long-term aspp2 overexpression (more than 48 hours) failed to induce apoptosis because p53 was released from the pro-apoptotic gene promoters. |
2016-04-29 |
2023-08-13 |
Not clear |
| Ariele Viacava Follis, Fabien Llambi, Parker Merritt, Jerry E Chipuk, Douglas R Green, Richard W Kriwack. Pin1-Induced Proline Isomerization in Cytosolic p53 Mediates BAX Activation and Apoptosis. Molecular cell. vol 59. issue 4. 2016-04-29. PMID:26236013. |
pin1-induced proline isomerization in cytosolic p53 mediates bax activation and apoptosis. |
2016-04-29 |
2023-08-13 |
Not clear |
| Shang-Tao Chien, Tzu-Feng Yang, Ming-Chang Yang, Ching-Mei Hsu, Yi-Ren Hong, Tai-Min Le. Differential roles of Bcl2L12 and its short variant in breast cancer lymph node metastasis. Oncology reports. vol 34. issue 2. 2016-04-28. PMID:26082034. |
bcl2l12 plays a role in post-mitochondrial apoptosis through multiple mechanisms involving p53, αb-crystallin, caspase-3 and -7 in glioblastoma. |
2016-04-28 |
2023-08-13 |
Not clear |
| Ana T Antunes, Yvonne J Goos, Tamara C Pereboom, Dorien Hermkens, Marcin W Wlodarski, Lydie Da Costa, Alyson W MacInne. Ribosomal Protein Mutations Result in Constitutive p53 Protein Degradation through Impairment of the AKT Pathway. PLoS genetics. vol 11. issue 7. 2016-04-27. PMID:26132763. |
while the mechanisms underlying the cytopenia phenotype of patients with these mutations are not completely understood, it is believed that stabilization of the p53 tumor suppressor protein may induce apoptosis in the progenitor cells. |
2016-04-27 |
2023-08-13 |
zebrafish |
| Yuting Sun, Jessica L Bell, Daniel Carter, Samuele Gherardi, Rebecca C Poulos, Giorgio Milazzo, Jason W H Wong, Rima Al-Awar, Andrew E Tee, Pei Y Liu, Bing Liu, Bernard Atmadibrata, Matthew Wong, Toby Trahair, Quan Zhao, Jason M Shohet, Ygal Haupt, Johannes H Schulte, Peter J Brown, Cheryl H Arrowsmith, Masoud Vedadi, Karen L MacKenzie, Stefan Hüttelmaier, Giovanni Perini, Glenn M Marshall, Antony Braithwaite, Tao Li. WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma. Cancer research. vol 75. issue 23. 2016-04-26. PMID:26471359. |
rnai-mediated attenuation of wdr5 upregulated expression of wild-type but not mutant p53, an effect associated with growth inhibition and apoptosis. |
2016-04-26 |
2023-08-13 |
mouse |
| Xuyi Wang, Evan R Simpson, Kristy A Brow. p53: Protection against Tumor Growth beyond Effects on Cell Cycle and Apoptosis. Cancer research. vol 75. issue 23. 2016-04-26. PMID:26573797. |
p53: protection against tumor growth beyond effects on cell cycle and apoptosis. |
2016-04-26 |
2023-08-13 |
Not clear |
| Xuyi Wang, Evan R Simpson, Kristy A Brow. p53: Protection against Tumor Growth beyond Effects on Cell Cycle and Apoptosis. Cancer research. vol 75. issue 23. 2016-04-26. PMID:26573797. |
recently, the role of p53 has been shown to go beyond its effects on cell cycle and apoptosis, with effects on metabolism emerging as a key contributor to cancer growth in situations where p53 is lost. |
2016-04-26 |
2023-08-13 |
Not clear |
| Arlene L Oei, Caspar M van Leeuwen, Rosemarie ten Cate, Hans M Rodermond, Marrije R Buist, Lukas J A Stalpers, Johannes Crezee, H Petra Kok, Jan Paul Medema, Nicolaas A P Franke. Hyperthermia Selectively Targets Human Papillomavirus in Cervical Tumors via p53-Dependent Apoptosis. Cancer research. vol 75. issue 23. 2016-04-26. PMID:26573798. |
moreover, hyperthermia combined with p53 depletion restored both the cell-cycle distribution and apoptosis to control levels. |
2016-04-26 |
2023-08-13 |
human |
| Laurie A Davidson, Evelyn S Callaway, Eunjoo Kim, Brad R Weeks, Yang-Yi Fan, Clinton D Allred, Robert S Chapki. Targeted Deletion of p53 in Lgr5-Expressing Intestinal Stem Cells Promotes Colon Tumorigenesis in a Preclinical Model of Colitis-Associated Cancer. Cancer research. vol 75. issue 24. 2016-04-26. PMID:26631266. |
in a mouse model of carcinogen (aom)-induced colon cancer, tamoxifen-inducible lgr5-driven deletion of p53 reduced apoptosis and increased proliferation of crypt stem cells, but had no effect on tumor incidence or size. |
2016-04-26 |
2023-08-13 |
mouse |
| Hailong Zhao, Liqun Yang, Hongjuan Cu. SIRT1 regulates autophagy and diploidization in parthenogenetic haploid embryonic stem cells. Biochemical and biophysical research communications. vol 464. issue 4. 2016-04-25. PMID:26208454. |
exogenous h2o2 tended to promote sirt1 expression and induce more autophagy through mtor pathway in control ph escs, by contrast more apoptosis via activation of p53 and caspase-3 in sirt1-knockdown ph escs. |
2016-04-25 |
2023-08-13 |
Not clear |
| Puyu Li, Ming Zhao, Amanda B Parris, Xiaoshan Feng, Xiaohe Yan. p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cells. Biochemical and biophysical research communications. vol 464. issue 4. 2016-04-25. PMID:26225749. |
p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cells. |
2016-04-25 |
2023-08-13 |
human |
| Puyu Li, Ming Zhao, Amanda B Parris, Xiaoshan Feng, Xiaohe Yan. p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cells. Biochemical and biophysical research communications. vol 464. issue 4. 2016-04-25. PMID:26225749. |
data from the present study demonstrated that p53 knockdown or mutation has a negative effect on metformin or phenformin-induced growth inhibition, senescence and apoptosis in breast cancer cells. |
2016-04-25 |
2023-08-13 |
human |
| Puyu Li, Ming Zhao, Amanda B Parris, Xiaoshan Feng, Xiaohe Yan. p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cells. Biochemical and biophysical research communications. vol 464. issue 4. 2016-04-25. PMID:26225749. |
we also found that p53 reactivating agent nutlin-3α and cp/31398 promoted metformin-induced growth inhibition, senescence and apoptosis in mcf-7 (wt p53) and mda-mb-231 (mt p53) cells, respectively. |
2016-04-25 |
2023-08-13 |
human |
| Puyu Li, Ming Zhao, Amanda B Parris, Xiaoshan Feng, Xiaohe Yan. p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cells. Biochemical and biophysical research communications. vol 464. issue 4. 2016-04-25. PMID:26225749. |
the present study showed that p53 is required for metformin or phenformin-induced growth inhibition, senescence and apoptosis in breast cancer cells. |
2016-04-25 |
2023-08-13 |
human |
| Manoranjan Santra, Michael Chopp, Sutapa Santra, Ankita Nallani, Shivam Vyas, Zheng Gang Zhang, Daniel C Morri. Thymosin beta 4 up-regulates miR-200a expression and induces differentiation and survival of rat brain progenitor cells. Journal of neurochemistry. vol 136. issue 1. 2016-04-25. PMID:26466330. |
the up-regulation of mir-200a down-regulated the expression of the following targets in vitro and in vivo models: (i) growth factor receptor-bound protein 2 (grb2), an adaptor protein involved in epidermal growth factor receptor (egfr)/grb2/ras/mek/erk1/c-jun signaling pathway, which negatively regulates the expression of myelin basic protein (mbp), a marker of mature oligodendrocyte; (ii) errfi-1/mig-6, an endogenous potent kinase inhibitor of egfr, which resulted in activation/phosphorylation of egfr; (iii) friend of gata 2, and phosphatase and tensin homolog deleted in chromosome 10 (pten), which are potent inhibitors of the phosphatidylinositol-3-kinase (pi3k)/akt signaling pathway, and resulted in marked activation of akt; and (iv) transcription factor, p53, which induces pro-apoptotic genes, and possibly reduced apoptosis of the progenitor cells subjected to oxygen glucose deprivation (ogd). |
2016-04-25 |
2023-08-13 |
rat |
| Manoranjan Santra, Michael Chopp, Sutapa Santra, Ankita Nallani, Shivam Vyas, Zheng Gang Zhang, Daniel C Morri. Thymosin beta 4 up-regulates miR-200a expression and induces differentiation and survival of rat brain progenitor cells. Journal of neurochemistry. vol 136. issue 1. 2016-04-25. PMID:26466330. |
tβ4-induced micro-rna-200a (mir-200a) regulates egfr signaling pathways for mbp synthesis and apoptosis: up-regulation of mir-200a after tβ4 treatment, increases mbp synthesis after targeting grb2 and thereby inactivating c-jun from inhibition of mbp synthesis; and also inhibits ogd-mediated apoptosis after targeting egfr inhibitor (mig-6), pi3k inhibitors (fog2 and pten) and an inducer (p53) of pro-apoptotic genes, for akt activation and down-regulation of p53. |
2016-04-25 |
2023-08-13 |
rat |
| Lin Gan, Juan Li, Kun Guo, Yan Li, Hong Shu, Li Wang, Jie Song, Yin-Kun Li. [The effects of stathmin on cell proliferation and tumor-related genes expressions in HCCLM3 cells]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology. vol 19. issue 8. 2016-04-23. PMID:22152312. |
after confirming the interfering effects of stathmin sirnas through reverse transcription pcr and western blotting, the hcclm3 cells proliferation and apoptosis were detected by cell count kit-8 (cck-8) and flow cytometry analysis, and the expressions of tumor-related genes (c-myc, c-fos, p53, etc) were observed by real-time pcr. |
2016-04-23 |
2023-08-12 |
Not clear |