| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Yugandhar, V Lakshma Nayak, Sivakumar Archana, Kunta Chandra Shekar, Ajay Kumar Srivastav. Design, synthesis and anticancer properties of novel oxa/azaspiro[4,5]trienones as potent apoptosis inducers through mitochondrial disruption. European journal of medicinal chemistry. vol 101. 2016-05-24. PMID:26163220. |
furthermore, western blot analysis suggested that these compounds up-regulate the levels of p53, p21, p27 and bax, and down-regulate the level of bcl-2 confirming the apoptosis inducing properties. |
2016-05-24 |
2023-08-13 |
human |
| Jianping Bi, Ai Huang, Tao Liu, Tao Zhang, Hong M. Expression of DNA damage checkpoint 53BP1 is correlated with prognosis, cell proliferation and apoptosis in colorectal cancer. International journal of clinical and experimental pathology. vol 8. issue 6. 2016-05-24. PMID:26261485. |
after establishment of shrna-mediated knockdown stable hct-116 cell lines, cell proliferation, apoptosis and cell cycle distribution were detected by mtt and flow cytometry, and expression of up-and down-steam related proteins as γ-h2ax, chk2 and p53 were tested by western blot. |
2016-05-24 |
2023-08-13 |
Not clear |
| Ren Feng, Lei Don. Knockdown of microRNA-127 reverses adriamycin resistance via cell cycle arrest and apoptosis sensitization in adriamycin-resistant human glioma cells. International journal of clinical and experimental pathology. vol 8. issue 6. 2016-05-24. PMID:26261488. |
and runx2, p53, bcl-2 and survivin, which are important role in cell apoptosis, also markedly changed after microrna-127 silencing. |
2016-05-24 |
2023-08-13 |
human |
| Qiusheng Lan, Shoufeng Li, Wei Lai, Heyang Xu, Yang Zhang, Yujie Zeng, Wenjian Lan, Zhonghua Ch. Methyl Sartortuoate Inhibits Colon Cancer Cell Growth by Inducing Apoptosis and G2/M-Phase Arrest. International journal of molecular sciences. vol 16. issue 8. 2016-05-24. PMID:26287184. |
culture studies found that methyl sartortuoate inhibited colon cancer cell (lovo and rko) growth and caused apoptotic death in a concentration- and time-dependent manner, by activation of caspase-8, caspase-9, caspase-3, p53 and bax, and inactivation of b-cell lymphoma 2 (bcl-2) apoptosis regulating proteins. |
2016-05-24 |
2023-08-13 |
mouse |
| Qiusheng Lan, Shoufeng Li, Wei Lai, Heyang Xu, Yang Zhang, Yujie Zeng, Wenjian Lan, Zhonghua Ch. Methyl Sartortuoate Inhibits Colon Cancer Cell Growth by Inducing Apoptosis and G2/M-Phase Arrest. International journal of molecular sciences. vol 16. issue 8. 2016-05-24. PMID:26287184. |
taken together, these findings suggest that methyl sartortuoate is capable of leading to activation of caspase-8, -9, -3, increasing p53 and bax/bcl-2 ratio apoptosis through mapk-dependent apoptosis and results in g2-m phase arrest in lovo and rko cells. |
2016-05-24 |
2023-08-13 |
mouse |
| Jamie K Wong, Lei Chen, Yong Huang, Fatima A Sehba, Roland H Friedel, Hongyan Zo. Attenuation of Cerebral Ischemic Injury in Smad1 Deficient Mice. PloS one. vol 10. issue 8. 2016-05-24. PMID:26317208. |
this neuroprotective phenotype is associated with attenuated reactive astrocytosis and neuroinflammation, along with reductions in oxidative stress, p53 induction, and apoptosis. |
2016-05-24 |
2023-08-13 |
mouse |
| Kazuki Heishima, Takashi Mori, Hiroki Sakai, Nobuhiko Sugito, Mami Murakami, Nami Yamada, Yukihiro Akao, Kohji Maru. MicroRNA-214 Promotes Apoptosis in Canine Hemangiosarcoma by Targeting the COP1-p53 Axis. PloS one. vol 10. issue 9. 2016-05-24. PMID:26335793. |
furthermore, p53 knockdown abolished the mir-214-cop1-mediated apoptosis; thus, mir-214 and cop1 regulated apoptosis through controlling p53 in hsa. |
2016-05-24 |
2023-08-13 |
human |
| Kazuki Heishima, Takashi Mori, Hiroki Sakai, Nobuhiko Sugito, Mami Murakami, Nami Yamada, Yukihiro Akao, Kohji Maru. MicroRNA-214 Promotes Apoptosis in Canine Hemangiosarcoma by Targeting the COP1-p53 Axis. PloS one. vol 10. issue 9. 2016-05-24. PMID:26335793. |
in conclusion, mir-214 functioned as a tumor suppressor in canine hemangiosarcoma by inducing apoptosis through recovering the function of p53. |
2016-05-24 |
2023-08-13 |
human |
| Chao Gu, Yaqing Li, Wu-Lin Xu, Jian-Ping Yan, Ying-jie Xia, Ying-Yu Ma, Chun Chen, Hui-Ju Wang, Hou-quan Ta. Sirtuin 1 Activator SRT1720 Protects Against Lung Injury via Reduction of Type II Alveolar Epithelial Cells Apoptosis in Emphysema. COPD. vol 12. issue 4. 2016-05-20. PMID:25415045. |
srt1720 treatment up-regulated the levels of surfactant protein (sp)a, spc, sirt1 and forkhead box o 3, increased sirt1 activity, down-regulated the level of p53 and inhibited aecii apoptosis. |
2016-05-20 |
2023-08-13 |
rat |
| Emma M Smith, Lei Zhang, Brian A Walker, Emma L Davenport, Lauren I Aronson, David Krige, Leon Hooftman, Alan H Drummond, Gareth J Morgan, Faith E Davie. The combination of HDAC and aminopeptidase inhibitors is highly synergistic in myeloma and leads to disruption of the NFκB signalling pathway. Oncotarget. vol 6. issue 19. 2016-05-20. PMID:26015393. |
we show the novel hdac inhibitor chr-3996 induces apoptosis in myeloma cells at concentrations in the nanomolar range and with apoptosis mediated by p53 and caspase pathways. |
2016-05-20 |
2023-08-13 |
Not clear |
| Rama P Kotipatruni, Xuan Ren, Dinesh Thotala, Jerry J Jaboi. NDRG4 is a novel oncogenic protein and p53 associated regulator of apoptosis in malignant meningioma cells. Oncotarget. vol 6. issue 19. 2016-05-20. PMID:26053091. |
ndrg4 is a novel oncogenic protein and p53 associated regulator of apoptosis in malignant meningioma cells. |
2016-05-20 |
2023-08-13 |
Not clear |
| Rama P Kotipatruni, Xuan Ren, Dinesh Thotala, Jerry J Jaboi. NDRG4 is a novel oncogenic protein and p53 associated regulator of apoptosis in malignant meningioma cells. Oncotarget. vol 6. issue 19. 2016-05-20. PMID:26053091. |
we show that apoptosis caused by p53 upregulation, phosphorylation at ser15, bax activation, bcl-2 and bcl-xl downregulation, mitochondrial cytochrome c release and execution of caspases following ndrg4 depletion. |
2016-05-20 |
2023-08-13 |
Not clear |
| Rama P Kotipatruni, Xuan Ren, Dinesh Thotala, Jerry J Jaboi. NDRG4 is a novel oncogenic protein and p53 associated regulator of apoptosis in malignant meningioma cells. Oncotarget. vol 6. issue 19. 2016-05-20. PMID:26053091. |
in addition, we demonstrate that apoptosis is mitochondrial and p53 dependent. |
2016-05-20 |
2023-08-13 |
Not clear |
| Rama P Kotipatruni, Xuan Ren, Dinesh Thotala, Jerry J Jaboi. NDRG4 is a novel oncogenic protein and p53 associated regulator of apoptosis in malignant meningioma cells. Oncotarget. vol 6. issue 19. 2016-05-20. PMID:26053091. |
the proapoptotic effect of p53 was verified by the results in which a small molecule compound pft-α, an inhibitor of p53 phosphorylation, is greatly protected against targeting ndrg4 induced apoptosis. |
2016-05-20 |
2023-08-13 |
Not clear |
| Martina Magni, Vincenzo Ruscica, Michela Restelli, Enrico Fontanella, Giacomo Buscemi, Laura Zannin. CCAR2/DBC1 is required for Chk2-dependent KAP1 phosphorylation and repair of DNA damage. Oncotarget. vol 6. issue 19. 2016-05-20. PMID:26158765. |
upon dna lesions, ccar2 is phosphorylated by the apical kinases atm/atr and this phosphorylation enhances ccar2 binding to sirt1, leading to sirt1 inhibition, p53 acetylation and p53-dependent apoptosis. |
2016-05-20 |
2023-08-13 |
Not clear |
| Shatrunajay Shukla, Ankita Sharma, Vivek Kumar Pandey, Sheikh Raisuddin, Poonam Kakka. Concurrent acetylation of FoxO1/3a and p53 due to sirtuins inhibition elicit Bim/PUMA mediated mitochondrial dysfunction and apoptosis in berberine-treated HepG2 cells. Toxicology and applied pharmacology. vol 291. 2016-05-20. PMID:26712469. |
concurrent acetylation of foxo1/3a and p53 due to sirtuins inhibition elicit bim/puma mediated mitochondrial dysfunction and apoptosis in berberine-treated hepg2 cells. |
2016-05-20 |
2023-08-13 |
human |
| Shatrunajay Shukla, Ankita Sharma, Vivek Kumar Pandey, Sheikh Raisuddin, Poonam Kakka. Concurrent acetylation of FoxO1/3a and p53 due to sirtuins inhibition elicit Bim/PUMA mediated mitochondrial dysfunction and apoptosis in berberine-treated HepG2 cells. Toxicology and applied pharmacology. vol 291. 2016-05-20. PMID:26712469. |
thus, our findings suggest that berberine mediated sirtuins inhibition resulting into foxo1/3a and p53 acetylation followed by bh3-only protein bim/puma activation may in part be responsible for mitochondria-mediated apoptosis. |
2016-05-20 |
2023-08-13 |
human |
| Maria Shatz, Igor Shats, Daniel Menendez, Michael A Resnic. p53 amplifies Toll-like receptor 5 response in human primary and cancer cells through interaction with multiple signal transduction pathways. Oncotarget. vol 6. issue 19. 2016-05-18. PMID:26220208. |
the p53 tumor suppressor regulates transcription of genes associated with diverse cellular functions including apoptosis, growth arrest, dna repair and differentiation. |
2016-05-18 |
2023-08-13 |
human |
| Gina Borghetti, Adriana Aya Yamaguchi, Julia Aikawa, Ricardo Key Yamazaki, Gleisson Alisson Pereira de Brito, Luiz Claudio Fernande. Fish oil administration mediates apoptosis of Walker 256 tumor cells by modulation of p53, Bcl-2, caspase-7 and caspase-3 protein expression. Lipids in health and disease. vol 14. 2016-05-18. PMID:26303118. |
fish oil administration mediates apoptosis of walker 256 tumor cells by modulation of p53, bcl-2, caspase-7 and caspase-3 protein expression. |
2016-05-18 |
2023-08-13 |
rat |
| Lucas Lourenço Marostica, Izabella Thaís Silva, Jadel Müller Kratz, Lara Persich, Fabiana Cristina Geller, Karen Luise Lang, Miguel Soriano Balparda Caro, Fernando Javier Durán, Eloir Paulo Schenkel, Cláudia Maria Oliveira Simõe. Synergistic Antiproliferative Effects of a New Cucurbitacin B Derivative and Chemotherapy Drugs on Lung Cancer Cell Line A549. Chemical research in toxicology. vol 28. issue 10. 2016-05-18. PMID:26372186. |
dace also showed potent synergic effects with drugs, and the most potent combinations induced g2/m cell cycle arrest by modulating survivin and p53 expression, disruption of f-actin cytoskeleton, and cell death by apoptosis. |
2016-05-18 |
2023-08-13 |
Not clear |